Investigating heuristic and meta-heuristic algorithms for solving pickup and delivery problems

The development of effective decision support tools that can be adopted in the transportation industry is vital in the world we live in today, since it can lead to substantial cost reduction and efficient resource consumption. Solving the Vehicle Routing Problem (VRP) and its related variants is at the heart of scientific research for optimizing logistic planning. One important variant of the VRP is the Pickup and Delivery Problem (PDP). In the PDP, it is generally required to find one or more minimum cost routes to serve a number of customers, where two types of services may be performed at a customer location, a pickup or a delivery. Applications of the PDP are frequently encountered in every day transportation and logistic services, and the problem is likely to assume even greater prominence in the future, due to the increase in e-commerce and Internet shopping. In this research we considered two particular variants of the PDP, the Pickup and Delivery Problem with Time Windows (PDPTW), and the One-commodity Pickup and Delivery Problem (1-PDP). In both problems, the total transportation cost should be minimized, without violating a number of pre-specified problem constraints. In our research, we investigate heuristic and meta-heuristic approaches for solving the selected PDP variants. Unlike previous research in this area, though, we try to focus on handling the difficult problem constraints in a simple and effective way, without complicating the overall solution methodology. Two main aspects of the solution algorithm are directed to achieve this goal, the solution representation and the neighbourhood moves. Based on this perception, we tailored a number of heuristic and meta-heuristic algorithms for solving our problems. Among these algorithms are: Genetic Algorithms, Simulated Annealing, Hill Climbing and Variable Neighbourhood Search. In general, the findings of the research indicate the success of our approach in handling the difficult problem constraints and devising simple and robust solution mechanisms that can be integrated with vehicle routing optimization tools and used in a variety of real world applicationsEThOS - Electronic Theses Online ServiceGBUnited Kingdo

Investigating heuristic and meta-heuristic algorithms for solving pickup and delivery problems

The development of effective decision support tools that can be adopted in the transportation industry is vital in the world we live in today, since it can lead to substantial cost reduction and efficient resource consumption. Solving the Vehicle Routing Problem (VRP) and its related variants is at the heart of scientific research for optimizing logistic planning. One important variant of the VRP is the Pickup and Delivery Problem (PDP). In the PDP, it is generally required to find one or more minimum cost routes to serve a number of customers, where two types of services may be performed at a customer location, a pickup or a delivery. Applications of the PDP are frequently encountered in every day transportation and logistic services, and the problem is likely to assume even greater prominence in the future, due to the increase in e-commerce and Internet shopping. In this research we considered two particular variants of the PDP, the Pickup and Delivery Problem with Time Windows (PDPTW), and the One-commodity Pickup and Delivery Problem (1-PDP). In both problems, the total transportation cost should be minimized, without violating a number of pre-specified problem constraints. In our research, we investigate heuristic and meta-heuristic approaches for solving the selected PDP variants. Unlike previous research in this area, though, we try to focus on handling the difficult problem constraints in a simple and effective way, without complicating the overall solution methodology. Two main aspects of the solution algorithm are directed to achieve this goal, the solution representation and the neighbourhood moves. Based on this perception, we tailored a number of heuristic and meta-heuristic algorithms for solving our problems. Among these algorithms are: Genetic Algorithms, Simulated Annealing, Hill Climbing and Variable Neighbourhood Search. In general, the findings of the research indicate the success of our approach in handling the difficult problem constraints and devising simple and robust solution mechanisms that can be integrated with vehicle routing optimization tools and used in a variety of real world applicationsEThOS - Electronic Theses Online ServiceGBUnited Kingdo

Investigating heuristic and meta-heuristic algorithms for solving pickup and delivery problems

The development of effective decision support tools that can be adopted in the transportation industry is vital in the world we live in today, since it can lead to substantial cost reduction and efficient resource consumption. Solving the Vehicle Routing Problem (VRP) and its related variants is at the heart of scientific research for optimizing logistic planning. One important variant of the VRP is the Pickup and Delivery Problem (PDP). In the PDP, it is generally required to find one or more minimum cost routes to serve a number of customers, where two types of services may be performed at a customer location, a pickup or a delivery. Applications of the PDP are frequently encountered in every day transportation and logistic services, and the problem is likely to assume even greater prominence in the future, due to the increase in e-commerce and Internet shopping. In this research we considered two particular variants of the PDP, the Pickup and Delivery Problem with Time Windows (PDPTW), and the One-commodity Pickup and Delivery Problem (1-PDP). In both problems, the total transportation cost should be minimized, without violating a number of pre-specified problem constraints. In our research, we investigate heuristic and meta-heuristic approaches for solving the selected PDP variants. Unlike previous research in this area, though, we try to focus on handling the difficult problem constraints in a simple and effective way, without complicating the overall solution methodology. Two main aspects of the solution algorithm are directed to achieve this goal, the solution representation and the neighbourhood moves. Based on this perception, we tailored a number of heuristic and meta-heuristic algorithms for solving our problems. Among these algorithms are: Genetic Algorithms, Simulated Annealing, Hill Climbing and Variable Neighbourhood Search. In general, the findings of the research indicate the success of our approach in handling the difficult problem constraints and devising simple and robust solution mechanisms that can be integrated with vehicle routing optimization tools and used in a variety of real world application

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

The single vehicle pickup and delivery problem with time windows: Intelligent operators for heuristic and metaheuristic algorithms

The single vehicle pickup and delivery problem with time windows is an important practical problem, yet only a few researchers have tackled it. In this research, we compare three different approaches to the problem: a genetic algorithm, a simulated annealing approach, and a hill climbing algorithm. In all cases, we adopt a solution representation that depends on a duplicate code for both the pickup request and its delivery. We also present an intelligent neighborhood move, that is guided by the time window, aiming to overcome the difficult problem constraints efficiently. Results presented herein improve upon those that have been previously published

Surgical site infection after gastrointestinal surgery in children : an international, multicentre, prospective cohort study

Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings. Methods A multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI). Results Of 1159 children across 181 hospitals in 51 countries, 523 (45 center dot 1%) children were from high HDI, 397 (34 center dot 2%) from middle HDI and 239 (20 center dot 6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12 center dot 8% (51/397) in middle HDI and 24 center dot 7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI. Conclusion The odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.Peer reviewe