The University of Hawaii Institute for Astronomy CCD camera control system

The University of Hawaii Institute for Astronomy CCD Camera Control System consists of a NeXT workstation, a graphical user interface, and a fiber optics communications interface which is connected to a San Diego State University CCD controller. The UH system employs the NeXT-resident Motorola DSP 56001 as a real time hardware controller. The DSP 56001 is interfaced to the Mach-based UNIX of the NeXT workstation by DMA and multithreading. Since the SDSU controller also uses the DPS 56001, the NeXT is used as a development platform for the embedded control software. The fiber optic interface links the two DSP 56001's through their Synchronous Serial Interfaces. The user interface is based on the NeXTStep windowing system. It is easy to use and features real-time display of image data and control over all camera functions. Both Loral and Tektronix 2048 x 2048 CCD's have been driven at full readout speeds, and the system is intended to be capable of simultaneous readout of four such CCD's. The total hardware package is compact enough to be quite portable and has been used on five different telescopes on Mauna Kea. The complete CCD control system can be assembled for a very low cost. The hardware and software of the control system has proven to be quite reliable, well adapted to the needs of astronomers, and extensible to increasingly complicated control requirements

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Inflammatory disease processes and interactions with nutrition

Inflammation is a stereotypical physiological response to infections and tissue injury; it initiates pathogen killing as well as tissue repair processes and helps to restore homeostasis at infected or damaged sites. Acute inflammatory reactions are usually self-limiting and resolve rapidly, due to the involvement of negative feedback mechanisms. Thus, regulated inflammatory responses are essential to remain healthy and maintain homeostasis. However, inflammatory responses that fail to regulate themselves can become chronic and contribute to the perpetuation and progression of disease. Characteristics typical of chronic inflammatory responses underlying the pathophysiology of several disorders include loss of barrier function, responsiveness to a normally benign stimulus, infiltration of inflammatory cells into compartments where they are not normally found in such high numbers, and overproduction of oxidants, cytokines, chemokines, eicosanoids and matrix metalloproteinases. The levels of these mediators amplify the inflammatory response, are destructive and contribute to the clinical symptoms. Various dietary components including long chain ?-3 fatty acids, antioxidant vitamins, plant flavonoids, prebiotics and probiotics have the potential to modulate predisposition to chronic inflammatory conditions and may have a role in their therapy. These components act through a variety of mechanisms including decreasing inflammatory mediator production through effects on cell signaling and gene expression (?-3 fatty acids, vitamin E, plant flavonoids), reducing the production of damaging oxidants (vitamin E and other antioxidants), and promoting gut barrier function and anti-inflammatory responses (prebiotics and probiotics). However, in general really strong evidence of benefit to human health through anti-inflammatory actions is lacking for most of these dietary components. Thus, further studies addressing efficacy in humans linked to studies providing greater understanding of the mechanisms of action involved are require

2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac deat