Counterfactual Thinking and Entrepreneurial Self‐Efficacy: The Moderating Role of Self‐Esteem and Dispositional Affect

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97291/1/etap472.pd

Egg white versus Salmonella Enteritidis! A harsh medium meets a resilient pathogen

Salmonella enterica serovar Enteritidis is the prevalent egg-product-related food-borne pathogen. The egg-contamination capacity of S. Enteritidis includes its exceptional survival capability within the harsh conditions provided by egg white. Egg white proteins, such as lysozyme and ovotransferrin, are well known to play important roles in defence against bacterial invaders. Indeed, several additional minor proteins and peptides have recently been found to play known or potential roles in protection against bacterial contamination. However, although such antibacterial proteins are well studied, little is known about their efficacy under the environmental conditions prevalent in egg white. Thus, the influence of factors such as temperature, alkalinity, nutrient restriction, viscosity and cooperative interactions on the activities of antibacterial proteins in egg white remains unclear. This review critically assesses the available evidence on the antimicrobial components of egg white. In addition, mechanisms employed by S. Enteritidis to resist egg white exposure are also considered along with various genetic studies that have shed light upon egg white resistance systems. We also consider how multiple, antibacterial proteins operate in association with specific environmental factors within egg white to generate a lethal protective cocktail that preserves sterility

Exploring recruitment barriers and facilitators in early cancer detection trials: the use of pre-trial focus groups

Background Recruiting to randomized controlled trials is fraught with challenges; with less than one third recruiting to their original target. In preparation for a trial evaluating the effectiveness of a blood test to screen for lung cancer (the ECLS trial), we conducted a qualitative study to explore the potential barriers and facilitators that would impact recruitment. Methods Thirty two people recruited from community settings took part in four focus groups in Glasgow and Dundee (UK). Thematic analysis was used to code the data and develop themes. Results Three sub-themes were developed under the larger theme of recruitment strategies. The first of these themes, recruitment options, considered that participants largely felt that the invitation to participate letter should come from GPs, with postal reminders and face-to-face reminders during primary care contacts. The second theme dealt with understanding randomization and issues related to the control group (where bloods were taken but not tested). Some participants struggled with the concept or need for randomization, or for the need for a control group. Some reported that they would not consider taking part if allocated to the control group, but others were motivated to take part even if allocated to the control group by altruism. The final theme considered perceived barriers to participation and included practical barriers (such as flexible appointments and reimbursement of travel expenses) and psychosocial barriers (such as feeling stigmatized because of their smoking status and worries about being coerced into stopping smoking). Conclusions Focus groups provided useful information which resulted in numerous changes to proposed trial documentation and processes. This was in order to address participants information needs, improve comprehension of the trial documentation, enhance facilitators and remove barriers to participation. The modifications made in light of these findings may enhance trial recruitment and future trials may wish to consider use of pretrial focus groups

Situating 1816, the ‘year without summer’, in the UK

The immediate local impacts of the eruption of Mount Tambora, Sumbawa, Indonesia in April 1815 were devastating, resulting in the loss of an estimated 60 000 lives on this and neighbouring islands. However, the longer term effects of the largest known historical eruption on global weather and climate and the related consequences for human health and wellbeing have maintained the prominence of the eruption in public memory. Among the most notable effects were global weather anomalies the following year, which has come to be referred to as ‘the year without summer’. Scholars across the sciences and humanities continue to investigate the eruption, seeking insights into the likely meteorological and societal impacts of future volcanic eruptions. The bicentenary of the ‘year without summer’ in 2016 provides a timely moment to revisit this weather episode. In this paper, we draw on a range of archival materials and contemporary publications to reconstruct the weather year and explore how the summer of 1816 was experienced and recorded across the UK. We also wish to demonstrate the importance of historical contingency in understanding the potential implications of the event at the local level, and of situating events within their appropriate temporal context. We do this by considering the summer of 1816 as set against the wider weather and cultural contexts of the 1810s. Our findings illustrate that in a UK context, summer 1816 was characterised by unusual and extreme weather events. Importantly it also took place within a sequence of years that were similarly replete with anomalous and challenging weather conditions

The twilight of the Liberal Social Contract? On the Reception of Rawlsian Political Liberalism

This chapter discusses the Rawlsian project of public reason, or public justification-based 'political' liberalism, and its reception. After a brief philosophical rather than philological reconstruction of the project, the chapter revolves around a distinction between idealist and realist responses to it. Focusing on political liberalism’s critical reception illuminates an overarching question: was Rawls’s revival of a contractualist approach to liberal legitimacy a fruitful move for liberalism and/or the social contract tradition? The last section contains a largely negative answer to that question. Nonetheless the chapter's conclusion shows that the research programme of political liberalism provided and continues to provide illuminating insights into the limitations of liberal contractualism, especially under conditions of persistent and radical diversity. The programme is, however, less receptive to challenges to do with the relative decline of the power of modern states

Constitutivism

A brief explanation and overview of constitutivism

Atmospheric Affect as a Tool for Creating Value and Gaining Share of Customer

Can the retail atmosphere be useful in developing long-lasting relationships many retailers inhabit, success driven retailers must find ways to maintain stability and grow in order to survive.with consumers? This research addresses this question by investigating the impact of positive and negative affect associated with ambient environ- At a basic level, retailers ' lifeblood is the revenue developed through relationships with customers. This revenue can bemental conditions. A key dependent variable is conceptualized and vali-dated and captures the proportion of business a customer spends in one expanded and developed through cultivating relationships with new customers, encouraging current customers to spendlocation relative to a store's direct competitors. Structural equation results suggest that both positive affect and negative affect impact this measure, a larger proportion of their dollars with the retailer, and by extending the length of time or duration of the relationshipÐbut the impact is facilitated through both feelings ' relationship with hedonic and utilitarian shopping value. J BUSN RES 2000. 49.91±99. Ó 2000 seeking customers for life. A Canadian grocery chain explored these avenues for increasing profitability and observed that ifElsevier Science Inc. All rights reserved. each customer purchased one additional produce item, profit-ability would increase by more than 40%. Similarly, current customers who substituted two store-brand items for two Survival through continuous acquisition of consumer re- national brand items each store visit, would increase profitabil-ity by 55%. Furthermore, if these improvements were achievedsources is the most paramount goal and most appro-priate orientation of a firm (Anderson, 1982). Retailers simultaneously, future gross profits could be improved dra-matically (Grant and Schlesinger, 1995). Thus, expanding aand service providers have offered various incentive program

Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice

Epidemiological studies indicate that intellectual activity prevents or delays the onset of Alzheimer's disease (AD). Similarly, cognitive stimulation using environmental enrichment (EE), which increases adult neurogenesis and functional integration of newborn neurons into neural circuits of the hippocampus, protects against memory decline in transgenic mouse models of AD, but the mechanisms involved are poorly understood. To study the therapeutic benefits of cognitive stimulation in AD we examined the effects of EE in hippocampal neurogenesis and memory in a transgenic mouse model of AD expressing the human mutant β-amyloid (Aβ) precursor protein (APPSw,Ind). By using molecular markers of new generated neurons (bromodeoxiuridine, NeuN and doublecortin), we found reduced neurogenesis and decreased dendritic length and projections of doublecortin-expressing cells of the dentate gyrus in young APPSw,Ind transgenic mice. Moreover, we detected a lower number of mature neurons (NeuN positive) in the granular cell layer and a reduced volume of the dentate gyrus that could be due to a sustained decrease in the incorporation of new generated neurons. We found that short-term EE for 7 weeks efficiently ameliorates early hippocampal-dependent spatial learning and memory deficits in APPSw,Ind transgenic mice. The cognitive benefits of enrichment in APPSw,Ind transgenic mice were associated with increased number, dendritic length and projections to the CA3 region of the most mature adult newborn neurons. By contrast, Aβ levels and the total number of neurons in the dentate gyrus were unchanged by EE in APPSw,Ind mice. These results suggest that promoting the survival and maturation of adult generated newborn neurons in the hippocampus may contribute to cognitive benefits in AD mouse models