Assessment of Strain and Strain Rate in Patients with Coronary Artery Disease Before and After Percutaneous Intervention on Left Anterior Descending Coronary Artery

Introduction: Strain (S) and Strain Rate (SR) as echocardiography parameters are important in assessing changes in myocardial tissue and global and regional evaluation of systolic and diastolic functions and in detection of myocardial disorders as they change in early stages of myocardial ischemia. Therefore, the aim of this study was to compare changes of S and SR indices in systolic phase in patients with a significant stenosis of left anterior descending (LAD) before and after percutaneous coronary intervention (PCI).Methods: 48 patients candidate for PCI with significant lesion in LAD were enrolled in this study. Echocardiographic images taken one day before and a week after PCI. Echocardiographic scope of the LAD was defined as mid, basal, anteroseptal and mid-septal and apical segments then, S and SR parameters in all segments measured separately during systolic phase before and after PCI and compared together.Results: there was a significant increase after PCI only in two segments and SR values showed significant increase after PCI in four segments. In the analysis of sum of mean parameters, a significant increase was observed in SR values (10.12 to 11.30; P = 0.001), but not in S values (149.54 to 143.36; P = 0.1)Conclusions: The remedial effect of PCI on deformation values was observed in the first week. In early reperfusion period, S/SR indices have potential to be used as determinants of favorable response to revascularization therapy

Comparison of clinical outcomes of patients treated with Cre8TM versus Resolute Onyx™ stent

Introduction: This study aims to compare the clinical outcomes of patients treated with Cre8TM versus Resolute Onyx™ stent. Material and Methods: In this retrospective study, all patients who underwent Stenting in the catheterization department of ShahidMadani Hospital between 2015 and 2018, were included. Angiographic and angioplasty findings were recorded. The primary end point, which includes total mortality, myocardial infarction, revascularization (adverse events) were recorded. Results: The mortality rates were similar in both groups. Moreover the myocardial infarction and repeated revascularization did not differ in both groups (p>0.05).The rates of adverse events wasn't   significantly different between the two groups. Conclusion: Our study showed that efficacy and safety of Cre8™ stents is non-inferior to the Resolute Onyx™ stent

The assessment of functional indices of left ventricular wall layers in cases with normal and high blood pressure by layer-specific strain methods

Introduction: The arterial hypertension leading to left ventricular remodeling induces accentuated ventricular wall thickness because of higher afterload. The several surveys about myocardial function in such cases were conducted by imaging studies for the evaluation of myocardial wall thickness without separating the different layers of each other. The aim of this investigation was the evaluation of the functional indices of each layer of the left ventricular myocardium by staining analysis of layers and demonstration of the relationship between ventricular structural remodeling and the functional changes of the ventricle myocardial layers in persons with normal and high blood pressure. Methods: 88 cases (46.6% normotensive and 53.4% hypertensive) were studied by two-dimensional echocardiography and longitudinal and circumferential strain indices. These differentiated variables of heart layers (epicardium, mid myocardium, endocardium) were evaluated. All of them had been analyzed and compared in terms of diastolic dysfunction were compared. Normal diastolic function was defined as: E/A=1 to 2 and deceleration time=150 to 200 ms. Results: Global longitudinal strain (GLS) and global circumferential strain (GCS) strains remarkably declined in epicardial and middle layers of myocardial in hypertensive cases with diastolic dysfunction, although this alternation did not reveal in cases without diastolic dysfunction. Conclusion: The decreasing of GLS and GCS indices of mid-myocardial and epicardial layers have been predicted in cases with high pressure, and the evidences of this situation had been observed in cases with ventricular diastolic dysfunction