453 research outputs found
Identifying candidate genes affecting developmental time in Drosophila melanogaster: pervasive pleiotropy and gene-by-environment interaction
- Author
- A Le Rouzic
- A Pires-daSilva
- A Robertson
- A Wallace
- AC James
- AG Petcherski
- AI McClatchey
- AJ Bardin
- AK Chippindale
- AK Chippindale
- Ana Massaldi
- AW Shingleton
- B Edgar
- BJ Zwaan
- C Mirth
- C Schlichting
- CF Fryer
- CP Kyriacou
- D Sambandan
- D Smoller
- DA Paranjpe
- EC Lai
- EG Moss
- Esteban Hasson
- F Al-Shahrour
- F Hamaratoglu
- G Davidowitz
- HF Nijhout
- IK Hariharan
- J Colombani
- J Leips
- JA Fordyce
- JJ Fanara
- JM Alonso
- JM Bateman
- Juan José Fanara
- Julián Mensch
- KK Norga
- KK Smith
- L Giot
- L Nunney
- M Angilletta
- MA Jünger
- MC Ungerer
- MD Cortese
- MJ West-Eberhard
- NG Prasad
- Nicolás Lavagnino
- O Carlborg
- O Puig
- PE Caldwell
- RC Stillwell
- RD Reed
- S Artavanis-Tsakonas
- S Carrol
- SC Stearns
- SJ Bray
- SJ Gould
- SM Chan
- ST Harbison
- T Li
- T Lukacsovich
- T Markow
- T Okada
- T Oyama
- TFC Mackay
- TFC Mackay
- The Gene Ontology Consortium
- V Garg
- V Trotta
- Valeria Paula Carreira
- W Helms
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Understanding the genetic architecture of ecologically relevant adaptive traits requires the contribution of developmental and evolutionary biology. The time to reach the age of reproduction is a complex life history trait commonly known as developmental time. In particular, in holometabolous insects that occupy ephemeral habitats, like fruit flies, the impact of developmental time on fitness is further exaggerated. The present work is one of the first systematic studies of the genetic basis of developmental time, in which we also evaluate the impact of environmental variation on the expression of the trait.</p> <p>Results</p> <p>We analyzed 179 co-isogenic single <it>P[GT1]-</it>element insertion lines of <it>Drosophila melanogaster </it>to identify novel genes affecting developmental time in flies reared at 25°C. Sixty percent of the lines showed a heterochronic phenotype, suggesting that a large number of genes affect this trait. Mutant lines for the genes <it>Merlin </it>and <it>Karl </it>showed the most extreme phenotypes exhibiting a developmental time reduction and increase, respectively, of over 2 days and 4 days relative to the control (a co-isogenic <it>P</it>-element insertion free line). In addition, a subset of 42 lines selected at random from the initial set of 179 lines was screened at 17°C. Interestingly, the gene-by-environment interaction accounted for 52% of total phenotypic variance. Plastic reaction norms were found for a large number of developmental time candidate genes.</p> <p>Conclusion</p> <p>We identified components of several integrated time-dependent pathways affecting egg-to-adult developmental time in <it>Drosophila</it>. At the same time, we also show that many heterochronic phenotypes may arise from changes in genes involved in several developmental mechanisms that do not explicitly control the timing of specific events. We also demonstrate that many developmental time genes have pleiotropic effects on several adult traits and that the action of most of them is sensitive to temperature during development. Taken together, our results stress the need to take into account the effect of environmental variation and the dynamics of gene interactions on the genetic architecture of this complex life-history trait.</p
The mediterranean dietary pattern and breast cancer risk in Greek-Cypriot women: a case-control study
- Author
- A Hadjisavvas
- A Olsen
- A Trichopoulou
- A Trichopoulou
- A Trichopoulou
- AH Wu
- AK Kant
- AL Frazier
- AL Ronco
- Andreas Hadjisavvas
- Bank of Cyprus
- CH van Gils
- Christiana A Demetriou
- D Engeset
- DB Panagiotakos
- E Couto
- E Sonestedt
- EF Taylor
- Eleni Kakouri
- EM Velie
- F Sofi
- F Visioli
- G Ravn-Haren
- Giorgos Loucaides
- I Mattisson
- Ioanna Neophytou
- JE Cade
- KB Michels
- Kyriacos Kyriacou
- LJ Vatten
- M Gago-Dominguez
- M Schutze
- MA Martínez-González
- MA Murtaugh
- Maria A Loizidou
- MD Holmes
- Nicos Middleton
- OL van der Hel
- P Toniolo
- Paolo Vineis
- PK Mills
- R Egeberg
- R Suzuki
- RG Ziegler
- S Sieri
- S Sieri
- S Zhang
- SA Smith-Warner
- Sabina Sieri
- T Psaltopoulou
- TT Fung
- V Cottet
- W Li
- Publication venue
- BioMed Central
- Publication date
- 01/03/2012
- Field of study
Background: Diet has long been suspected to impact on breast cancer risk. In this study we evaluated whether
the degree of adherence to a Mediterranean diet pattern modifies breast cancer risk amongst Greek-Cypriot
women.
Methods: Subjects included 935 cases and 817 controls, all participating in the MASTOS case-control study in
Cyprus. The study was approved by the Cyprus National Bioethics Committee. Information on dietary intakes was
collected using an interviewer administered 32-item Food Frequency Questionnaire. Information on demographic,
anthropometric, lifestyle, and other confounding factors was also collected. Adherence to the Mediterranean Diet
pattern was assessed using two a-priory defined diet scores. In addition, dietary patterns specific to our population
were derived using Principal Component Analysis (PCA). Logistic regression models were used to assess the
association between the dietary patters and breast cancer risk.
Results: There was no association with breast cancer risk for either score, however, higher consumptions of
vegetables, fish and olive oil, were independently associated with decreased risk. In addition, the PCA derived
component which included vegetables, fruit, fish and legumes was shown to significantly reduce risk of breast
cancer (ORs across quartiles of increasing levels of consumption: 0.89 95%CI: 0.65-1.22, 0.64 95%CI: 0.47-0.88, 0.67 95%CI: 0.49-0.92, P trend < 0.0001), even after adjustment for relevant confounders.
Conclusions: Our results suggest that adherence to a diet pattern rich in vegetables, fish, legumes and olive oil
may favorably influence the risk of breast cancer. This study is the first investigation of dietary effects on breast
cancer risk in Cyprus, a country whose population has traditionally adhered to the Mediterranean diet
Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome
- Author
- A Craig
- A Färnert
- A Färnert
- A Heddini
- A Liljander
- A Pain
- A Rowe
- A van de Stolpe
- AK Biswas
- Alister G. Craig
- Anne Liljander
- AR Berendt
- B Maubert
- BC Urban
- Bethsheba R. Siddondo
- BM Cooke
- Britta C. Urban
- C Gray
- C Gray
- C Newbold
- C Xiao
- CF Ockenhouse
- CF Ockenhouse
- CJ McCormick
- CM Waterfall
- Colin J. Sutherland
- D Fernandez-Reyes
- DE Greenwalt
- DJ Roberts
- DJ Roberts
- Eva N. Kimani
- F al-Yaman
- F Engelbrecht
- FS Touré
- G Feng
- GD Turner
- Harold Ocholla
- HM Kyriacou
- ID McGilvray
- J Chilongola
- J Montgomery
- J Veenemans
- JA Rowe
- JA Rowe
- JA Rowe
- JC Reeder
- JC Reeder
- JCJ Calis
- JD Smith
- JF Kun
- JG Beeson
- JG Beeson
- JN Waitumbi
- Johnstone O. Makale
- JW Barnwell
- K Blomqvist
- K Marsh
- K Marsh
- K Marsh
- K Marsh
- K Silamut
- Kevin Marsh
- L Meerman
- L Serghides
- LH Miller
- Lucy B. Ochola
- M Aidoo
- M Dahlbäck
- M Febbraio
- M Fried
- M Ho
- M Ho
- M Ho
- M Mo
- ME Molyneux
- MM Klein
- MT Tse
- N Horata
- NE Jenkins
- P Pradhan
- PA Buffet
- PC Bull
- PC Bull
- Pete C. Bull
- PR Kolatkar
- Q Chen
- R Bellamy
- R Cholera
- R Degen
- RM Fairhurst
- RW Snow
- S Adams
- S Cojean
- SC Chaiyaroj
- Siana Nkya
- SJ Chakravorty
- SJ Rogerson
- SO Akech
- SR Elliott
- SS Chong
- T Staalsoe
- T Staalsoe
- Tadge Szestak
- TG Smith
- Thomas N. Williams
- TJ Aitman
- W Trager
- WP O'Meara
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
- Casanova S
- Casasola V
- Casella P
- Casentini C
- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
- Cesarini E
- Chakraborty N
- Chamberlin SJ
- Chambers KC
- Chan M
- Chandra P
- Chang S-W
- Chang Z
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee D
- Chatterjee D
- Chatziioannou K
- Chaves RCG
- Chavez AG
- Chavushyan V
- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
- Chen L
- Chen T-W
- Chen TX
- Chen X
- Chen Y
- Chen Y
- Chen YB
- Chen YP
- Chenevez J
- Cheng H-P
- Cherry ML
- Cheung CC
- Cheung E
- Chevalier J
- Chia H
- Chiang J
- Chiarusi T
- Chincarini A
- Chinellato JA
- Chirkin D
- Chiummo A
- Chmiel T
- Cho HS
- Cho M
- Choi C
- Choi J-S
- Chornock R
- Chow JH
- Christensen N
- Christov A
- Chu Q
- Chua AJK
- Chua S
- Chudoba J
- Chung AKW
- Chung S
- Ciani G
- Cikota A
- Ciolfi R
- Ciprini S
- Circella M
- Cirelli CE
- Cirone A
- Clara F
- Clark JA
- Clark K
- Clark P
- Clarke TE
- Classen L
- Clay RW
- Clearwater P
- Cleva F
- Cleveland WH
- Cline T
- Cobb BE
- Cocchieri C
- Coccia E
- Coelho JAB
- Coelho P
- Coenders S
- Cohadon P-F
- Cohen D
- Cohen-Tanugi J
- Colafrancesco S
- Colafrancesco S
- Colalillo R
- Colazo C
- Coleiro A
- Coleman A
- Colla A
- Collaboration ALMA
- Collaboration ANTARES
- Collaboration BOOTES
- Collaboration CALET
- Collaboration DLT40
- Collaboration HAWC
- Collaboration HESS
- Collaboration IceCube
- Collaboration IKI-GW Follow-up
- Collaboration Insight-Hxmt
- Collaboration IPN
- Collaboration KU
- Collaboration LOFAR
- Collaboration MASTER
- Collaboration Pi Sky
- Collaboration Pierre Auger
- Collaboration Swift
- Collaboration VINROUGE
- Collette CG
- Collica L
- Collin GH
- Colmenero E Romero
- Coluccia MR
- Cominsky LR
- Cominsky LR
- Conceicao R
- Concu R
- Condon B
- Coniglione R
- Connaughton V
- Conrad J
- Conrad JM
- Consolati G
- Consortium TZAC
- Constancio M
- Conti L
- Contreras F
- Cook DO
- Cook ER
- Cooke J
- Cooper MJ
- Cooper SJ
- Copperwheat C
- Corban P
- Corbitt TR
- Cordero-Carrion I
- Corley KR
- Cornish N
- Corongiu A
- Corral-Santana JM
- Corsi A
- Cortese S
- Costa CA
- Costa CF Da Silva
- Costa E
- Costa-Duarte MV
- Costantin D
- Costantini H
- Cotti U
- Cotzomi J
- Coughlin M
- Coughlin MW
- Coughlin SB
- Coulon J-P
- Coulter DA
- Countryman ST
- Courvoisier TJ-L
- Coutu S
- Couvares P
- Covas PB
- Covault CE
- Covino S
- Cowan EE
- Coward DM
- Coward DM
- Cowart MJ
- Cowen DF
- Cowperthwaite P
- Coyle P
- Coyne DC
- Coyne R
- Crawford S
- Creighton JDE
- Creighton TD
- Creusot A
- Cripe J
- Crisp H
- Crocce M
- Cronin J
- Cross R
- Crosse B
- Crowder SG
- Cucchiara A
- Cui W
- Cui WW
- Cullen TJ
- Cumming A
- Cunha CE
- Cunniffe R
- Cunningham L
- Cuoco A
- Cuoco E
- Cusumano G
- Cutter R
- Cwiek A
- Cwiok M
- Czyrkowski H
- D'Al A
- D'Amico F
- D'Amico S
- D'Ammando F
- D'Andrea CB
- D'Antonio S
- D'Avanzo P
- D'Elia V
- D'Olivo JC
- Da Costa LN
- Dabrowski R
- Dadina M
- Dal Canton T
- Daniel B
- Danilishin SL
- Danzmann K
- Dasgupta A
- Dasso S
- Dattilo V
- Daumiller K
- Dave I
- Davids ID
- Davier M
- Davis C
- Davis D
- Daw EJ
- Dawson BR
- Day B
- Day JA
- Day M
- De Almeida RM
- De Andre JPAM
- De Bonis G
- De Carvalho W Rodrigues
- De Cesare G
- De Cia A
- De Clercq C
- De Gois JS
- De Gregorio-Monsalvo I
- De Jong M
- De Jong SJ
- De la Fuente E
- De laurentis M
- De Leon C
- De Leon S Coutio
- De Mauro G
- De Mitri I
- De Naurois M
- de Oliveira C Mendes
- De Oliveira J
- De Oliveira MA Leigui
- de Oliveira R Lopes
- De Palma F
- De Pasquale M
- De Pietri R
- De Ridder S
- De Rosa R
- De Rossi C
- De Souza V
- De Ugarte-Postigo A
- De Varona O
- De Vries KD
- De Wasseige G
- De With M
- De K
- De S
- Debatin J
- Debra D
- Decock J
- Degallaix J
- Deiana GL
- Deil C
- Del Monte E
- Del Pozzo W
- Del Pulgar C Perez
- DeLaunay JJ
- Deleglise S
- Deligny O
- Della Valle M
- Deller AT
- Dembinski H
- Demos N
- Deng JK
- Denker T
- Denneau L
- Dennefeld M
- Dent T
- Depoy DL
- Dergachev V
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- Milia Sabrina
- Miller AA
- Miller CJ
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- Monzani ME
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- Moore CJ
- Moore RW
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- Moreno E
- Moreno G
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- Morita K
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- Morris D
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- Morselli A
- Morselli A
- Moskalenko IV
- Moskvitin AS
- Mostaf M
- Motohara K
- Moulai M
- Moulin E
- Mours B
- Moussa A
- Mow-Lowry CM
- Mrka S
- Mrka Z
- Mueller AL
- Mueller AL
- Mueller BB
- Mueller G
- Mueller G
- Mueller MA
- Mueller S
- Muir AW
- Muir J
- Mukherjee Arunava
- Mukherjee D
- Mukherjee S
- Mukund N
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- Munch J
- Mundell CG
- Muniz EA
- Muoz A Gonzolez
- Muoz RR
- Murach T
- Murata KL
- Muratore M
- Murguia-Berthier A
- Murphy T
- Murray PG
- Mussa R
- Myers ST
- Nagai H
- Nagashima H
- Nagayama T
- Nahnhauer R
- Nakahira S
- Nakajima M
- Nakamura Y
- Nakaoka T
- Nakar E
- Nakarmi P
- Nakashima S
- Nakata F
- Nang Y
- Napier K
- Naranjo I
- Nardecchia I
- Natalucci L
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- Naumann U
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- Navarrini Alessandro
- Navas S
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- Negro M
- Neilsen E
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- Nie JY
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- Nielsen AB
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- North C
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- Nuttall LK
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- Nynka M
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- O'Shaughnessy R
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- Oda S
- Odaka H
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- Ohm S
- Ohme F
- Ohsawa R
- Ohshima T
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- Oikonomou F
- Ojha R
- Okada MA
- Okita H
- Oleynik Ph P
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- Onken CA
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- Opiela R
- Oppermann P
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- Organokov M
- Orienti M
- Orlando E
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- Ortega LF
- Ortu P
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- Oslowski S
- Ossokine S
- Ostrowski M
- Ottaway DJ
- Ou G
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- Owen BJ
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- Ozawa S
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- Pace AE
- Paciesas WS
- Padilla N
- Padovani M
- Pagani C
- Page J
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- Page MA
- Pai A
- Pai SA
- Pal-Singh A
- Palamos JR
- Palashov O
- Palatiello M
- Palatka M
- Palazzi E
- Palczewski T
- Paliya VS
- Palliyaguru N
- Palliyaguru NT
- Pallot D
- Pallotta J
- Palmas S
- Palmer DM
- Palmerio JT
- Palmese A
- Palomba C
- Pan Howard
- Pan Huang-Wei
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- Pandey SB
- Pandya H
- Paneque D
- Pang B
- Pang PTH
- Pankova DV
- Pankow C
- Pannarale F
- Pant BC
- Panter M
- Paoletti F
- Paoletti F
- Paoli A
- Papa MA
- Papenbreer P
- Paragi Z
- Parente G
- Parida A
- Park IH
- Parker W
- Parkinson PM Saz
- Parmiggiani N
- Parra A
- Parsons RD
- Pascucci D
- Pasqualetti A
- Passaquieti R
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- Patil M
- Patricelli B
- Paul T
- Pavalas GE
- Pavana M
- Paxman J
- Paz-Chinchn F
- Pea-Rodriguez J
- Pearlstone BL
- Pech M
- Pedraza M
- Pedreira F
- Pedurand R
- Peiffer P
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- Pekeur NW
- Pekowsky L
- Pelayo R
- Pele A
- Pellegrino C
- Pelletier G
- Pellizzoni A
- Penacchioni AV
- Penn S
- Penuela T
- Pepper JA
- Pereira LAS
- Perennes C
- Perez CJ
- Perez-Perez EG
- Perley DA
- Perlin M
- Perreca A
- Perri LM
- Perri M
- Perrina C
- Perrodin D
- Perrone L
- Pescalli A
- Pesce-Rollins M
- Peters C
- Peters WM
- Petrera S
- Petrucci P-O
- Peyaud B
- Pfeiffer HP
- Phelps M
- Phlhofer G
- Phuntsok J
- Pian E
- Piano G
- Piattelli P
- Piccinni OJ
- Pichot M
- Picozza P
- Piel Q
- Pieloth D
- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
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- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
- Placco VM
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- Plum M
- Podesta F
- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
- Poon H
- Popa V
- Popolizio P
- Poppi S
- Porowski C
- Porter EK
- Porter TA
- Possenti A
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- Potter SB
- Powell J
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- Poznanski D
- Pradier T
- Prado RR
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- Preece RD
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- Prestegard T
- Pretz J
- Price LR
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- Prijatelj M
- Principe G
- Principe M
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- Privitera P
- Privitera S
- Prochaska JX
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- Prokhorov D
- Prokhorov LG
- Prokoph H
- Prouza M
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- Przybylski GT
- Pulone L
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- Punch M
- Puncken O
- Punturo M
- Puppo P
- Qi H
- Qi H
- Qu JL
- Quataert E
- Quel EJ
- Querchfeld S
- Querel R
- Quetschke V
- Quimby RM
- Quinn L
- Quinn S
- Quinones C
- Quintero EA
- Quirrenbach A
- Quispe ID Vergara
- Quitzow-James R
- Raab C
- Raab FJ
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- Rabeling DS
- Rabus M
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- Racusin J
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- Rain S
- Raja S
- Raja W
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- Ramirez KE
- Ramirez-Ruiz E
- Ramos-Buades A
- Ramos-Pollan R
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- Rando R
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- Rapagnani P
- Rappoldi A
- RATIR RIMAS
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- Raymond V
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- Razzano M
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- Regimbau T
- Rei L
- Reichart DE
- Reid S
- Reimann R
- Reimer A
- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
- Relich M
- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
- Reynolds T
- Rho CD
- Rhode W
- Ribeiro T
- Ricci F
- Ricci R
- Ricciarini S
- Riccobene G
- Richman M
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- Ridky J
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- Rios-Lopez E
- Risse M
- Ristori P
- Rivera A Ramirez
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- Rizi V
- Rizzo M
- Roberts OJ
- Robertson NA
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- Robie R
- Robinet F
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- Rosell A Carnero
- Rosenberg M
- Rosetti S
- Rosinska D
- Ross MP
- Rossi A
- Rosswog S
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- Roth M
- Rott C
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- Rovero AC
- Rowan S
- Rowell G
- Rowlinson A
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- Roy R
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- Rulten CB
- Rumyantsev VV
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- Ryan K
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- Rykoff ES
- Rysewyk D
- Saba A
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- Sadler EM
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- Saffe C
- Saffi SJ
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- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
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- Salafia OS
- Salamida F
- Salazar H
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- Saleem M
- Saleh A
- Salemi F
- Salina G
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- Salvadori I
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- Sammut L
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- Sanchez B
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- Sanchez E
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- Sanchez LE
- Sanchez-Losa A
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- Sanchis-Gual N
- Sand DJ
- Sandberg V
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- Sandoval A
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- Sapienza P
- Sarazin F
- Sarkar S
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- Sarmiento-Cano C
- Sasaki M
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- Sassolas B
- Satalecka K
- Sathyaprakash BS
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- Saulson PR
- Sauseda M
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- Savchenko V
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- Scheuer J
- Schieler H
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- Schindler R
- Schipani P
- Schlegel DJ
- Schlickeiser R
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- Schmidt J
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- Schmidt T
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- Schneider A
- Schneider M
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- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
- Schubnell M
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- Schulz A
- Schulz A
- Schulze S
- Schumacher J
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- Schutz BF
- Schwalbe SG
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- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
- Scott J
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- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
- Selsing J
- Sengupta AS
- Sentenac D
- Sequino V
- Sergeev A
- Sergienko Yu P
- Serino M
- Serra G
- Serra-Ricart M
- Serrau M
- Settimo M
- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
- Sgro C
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- Shadkam A
- Shaffer TJ
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- Shapiro B
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- Shidatsu M
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- Shimomukai R
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- Siemens X
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- Sigg D
- Sigl G
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- Steinke M
- Steinlechner J
- Steinlechner S
- Steinmeyer D
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- Stubbs CW
- Sturani R
- Stuttard T
- Stuver AL
- Suarez F
- Suarez-Duran M
- Suchyta E
- Sudholz T
- Sugawara Y
- Sugita S
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- Sutherland M
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- Swain J
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- Szadkowski Z
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- Szegedi H
- Szomoru A
- Taboada A
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- Tacca M
- Tachibana Y
- Taddia F
- Tagliaferri G
- Tait SC
- Taiuti M
- Tajitsu A
- Takahashi I
- Takahashi J
- Takahashi M
- Takahashi T
- Takao Y
- Takayama M
- Talbot C
- Talukder D
- Tamura T
- Tamura Y
- Tan Y
- Tanaka I
- Tanaka M
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- Tanimoto A
- Tanner DB
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- Tao C
- Tao L
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- Taracchini A
- Tarle G
- Tartaglia L
- Tasson JD
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- Tenholt F
- Ter Veen S
- Ter-Antonyan S
- Terai T
- Terliuk A
- Terreran G
- Terrier R
- Tesic G
- Testa V
- Tewari SV
- Thayer JB
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- Theeg T
- Thene CC
- Thierry P
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- Thies F
- Thomas EG
- Thomas M
- Thomas P
- Thomas RC
- Thompson DJ
- Thorne KA
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- Thrane E
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- Tibolla O
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- Timmermans C
- Tingay SJ
- Tiwari S
- Tiwari V
- Tiziani D
- Tjus J Becker
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- Tlatov AG
- Tluczykont M
- Toale PA
- Tobin MN
- Tohuvavohu A
- Tokmakov KV
- Toland K
- Tollefson K
- Toma K
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- Tome B
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- Tonelli M
- Tonnis C
- Tonry J
- Torii S
- Tornasi Z
- Tornatore M
- Torres DF
- Torres I
- Torres-Flores S
- Torres-Forn A
- Torresi E
- Torrie CI
- Toscano S
- Tosi D
- Towner MC
- Toyr D
- Tpai M
- Travasso F
- Travnicek P
- Traylor G
- Trichard C
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- Trinastic J
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- Trois A
- Troja E
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- Troxel MA
- Trozzo L
- Tsai J
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- Tsuji N
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- Tsuna D
- Tsunemi H
- Tsvetkova AE
- Tucker BE
- Tucker DL
- Tueros M
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- Tung CF
- Tungalag N
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- Turatto M
- Turcati A
- Turley CF
- Turpin D
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- Tuyenbayev D
- Ty B
- Tyurina NV
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Search for Dark Matter and Supersymmetry with a Compressed Mass Spectrum in the Vector Boson Fusion Topology in Proton-Proton Collisions at root s=8 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
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- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
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- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
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- Abdellatif M
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- Ευσταθίου Η
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
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- Österberg K
- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2020
- Field of study
We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ¯
Search for the production of W^{\pm} W^{\pm} W^{\mp} events at \sqrt{s} = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
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- Adams MR
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- Adan DP
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- Zecchinelli AG
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- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 01/07/2019
- Field of study
A search for the production of events containing three W bosons predicted by the standard model is reported. The search is based on a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the CERN LHC and corresponding to a total integrated luminosity of 35.9 fb^{-1}. The search is performed in final states with three leptons (electrons or muons), or with two same-charge leptons plus two jets. The observed (expected) significance of the signal for W^{\pm} W^{\pm} W^{\mp} production is 0.60 (1.78) standard deviations, and the ratio of the measured signal yield to that expected from the standard model is 0.34_{-0.34}^{+0.62}. Limits are placed on three anomalous quartic gauge couplings and on the production of massive axionlike particles
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