DOES A SINGLE BOLUS DOSE OF TRANEXAMIC ACID REDUCE BLOOD LOSS AND TRANSFUSION REQUIREMENTS DURING HIP FRACTURE SURGERY? A PROSPECTIVE RANDOMEZED DOUBLE BLIND STUDY IN 67 PATIENTS

Extensive blood loss in total hip surgery is well known and is associated with a high transfusion rate of allogeneic blood. The aim of this study is to assess the effects of intraoperative tranexamic acid on post-operative bleeding and need for allogeneic transfusion during hip fracture surgery. We investigated 67 patients undergoing hip fracture surgery in a prospective, randomized, double-blinded study. 32 patients received tranexamic acid (TA) given in a bolus dose of 15 mg/kg before surgical incision. The remaining, 35 patients were allocated as control group. Postoperative bleeding, transfusions, complications, and hospital stay were recorded. The intraoperative bleeding was significantly lower in the TA group (652 ± 228 ml vs. 1108 ± 372 ml, p <0.003). Post operative drainage was lower in TA group (296 ± 85 ml vs. 375 ± 110 ml, p <0.195). There were no differences in coagulation parameters. The rates of transfused patients in TA and control groups were 37 % and 57 %. In TA group, hospital stay was 4.3 ± 1.6 days (vs. 5.8 ± 1.5 days in control group; p< 0.05). There is one in hospital mortality in control group. We conclude that tranexamic acid significantly reduces blood loss during hip fracture surgery

A Randomized Control Trial to Verify the Efficacy of Pre-Operative Intra Venous Tranexamic Acid in the Control of Tonsillectomy Bleeding

Tonsillectomy is an age old surgery which is still very commonly done. Bleeding related to surgery is the major problem. This study is done to verify by randomized control trial the efficacy of preoperative intravenous tranexamic acid in the control of tonsillectomy bleeding. Hundred cases undergoing tonsillectomy were randomized into two groups, one of which received pre-operatively intra venous tranexamic acid, 10 mg kg−1. The other group patients were given a placebo. Amount of bleeding was assessed in each case. The study group had statistically highly significant reduction in bleeding. There were no side effects of the drug. This finding is similar to that in other studies for tonsillectomy, other surgeries and other hemorrhagic conditions. Tranexamic acid in the dose of 10 mg kg−1 given intra venous pre-operatively is effective in the control of tonsillectomy bleeding