16 research outputs found
Quantitative investigation of cardiac motion effects on in vivo diffusion tensor parameters: a simulation study
Functional diversity and co-operativity between subclonal populations of paediatric glioblastoma and diffuse intrinsic pontine glioma cells
The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to quantitatively assess the extent to which this was present in these tumors through subclonal genomic analyses and to determine whether distinct tumor subpopulations may interact to promote tumorigenesis by generating subclonal patient-derived models in vitro and in vivo. Analysis of 142 sequenced tumors revealed multiple tumor subclones, spatially and temporally coexisting in a stable manner as observed by multiple sampling strategies. We isolated genotypically and phenotypically distinct subpopulations that we propose cooperate to enhance tumorigenicity and resistance to therapy. Inactivating mutations in the H4K20 histone methyltransferase KMT5B (SUV420H1), present in <1% of cells, abrogate DNA repair and confer increased invasion and migration on neighboring cells, in vitro and in vivo, through chemokine signaling and modulation of integrins. These data indicate that even rare tumor subpopulations may exert profound effects on tumorigenesis as a whole and may represent a new avenue for therapeutic development. Unraveling the mechanisms of subclonal diversity and communication in pGBM and DIPG will be an important step toward overcoming barriers to effective treatments
Intravoxel Incoherent Motion applied to Cardiac diffusion weighted MRI using breath-hold acquisitions in healthy volunteers
Poster presentationInternational audiencen.
Workshop on using natural language processing applications for enhancing clinical decision making: an executive summary
Generalized, Adsorbent-Agnostic, Artificial Neural Network Framework for Rapid Simulation, Optimization, and Adsorbent Screening of Adsorption Processes
High-resolution imaging reveals a limit in spatial resolution of blood flow measurements by microspheres
Assessment of Cardiac Motion Effects on the Fiber Architecture of the Human Heart In Vivo
Thigh-length compression stockings and DVT after stroke
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease