18 research outputs found
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The Industrial Park: A Landscape-Based Vision for the Turners Falls Canal District
This design study examines the history and economic context that defines Turners Falls as a de-industrialized mill town. It reviews the social, economic, locational, physical, and historical obstacles the town has faced redeveloping the mill buildings within its Canal District and proposes a landscape-based approach for addressing redevelopment. Landscape redevelopment is offered as an alternative to traditional redevelopment of buildings for non-affluent mill towns, like Turners Falls, because the costs associated with landscape upgrades are much lower and can provide multifunctional and multi-purpose spaces for many types of people. Additionally, it is a pathway for inviting community involvement that allows for different groups to take ownership of various aspects of the programming that happens there. Landscape-based redevelopment does not replace redevelopment of mill buildings, it ought to be conducted in tandem with a variety of redevelopment efforts. The project focuses on a strategic area of the Canal District that proceeding planning studies have identified as good locations for open space and recreational uses. The design proposal integrates passive, active, and commercial recreation, historic and ecological education, cultural spaces for non-profit and community groups, and creative venues for supporting the budding creative economy in town, such as artists, performers, and musicians. It uses the industrial ruins and landscape as opportunities to create a unique place that improves quality of life in Turners Falls, which this study argues is important for improving the real estate market for redeveloping the wider Canal District over time
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Placemaking in Metro East Springfield - Creating a Landscape Framework
PLACEMAKING IN METRO EAST SPRINGFIELD - Creating a Landscape Framework
Placemaking in Metro East Springfield â Creating a Landscape Framework provides strategies to use the landscape as a framework for rebuilding community in a downtown urban area that has âgood bonesâ but has been neglected and overlooked for decades. A catalyst for the development of project area is the recent acquisition of the historical 1916 Willys Overland building through a developer. The Graduate Urban Design Studio 2018 developed five proposals for urban revitalization in the area that are centered on the landscape. The programming of the proposals was developed in collaboration with neighborhood representatives and stakeholders of the area. The public response was very positive and the project got recognized in the local press and media.
The Landscape Framework is interwoven with cultural activities such as public art and education, new opportunities for small neighborhood commerce, future employment and possibilities for new housing. The Landscape Framework will bring expand urban greening and will reduce heat island effects to reduce the impact of climate change. The presented Landscape Framework will guide the future of the area as overlapping and simultaneous measures.
They encompass: Tangible tactile interventions on streets, facades and underutilized lots that change the perception of the landscape at low cost but are highly effective. New parks that create areas for recreation and contemplation. Greenway promenades connect to shorten long blocks and create a network to the neighboring residential areas. Establishment of urban agriculture activities to build community, provide food security and education. Collaboration with existing organizations in Springfield that are actively involved with urban agriculture: Gardening the Community (GTC) Springfield, Wellspring Harvest first commercial hydroponic greenhouse, UMass Extension and UMass Permaculture, Springfield Technical Community College (STCC). Walkable streets through extensive street tree plantings, widening of sidewalks, adding bicycle lanes and introducing shared multi-functional streets for community events. Stormwater Management through bioswales along streets, green roofs, larger infiltration areas in new parks and porous pavement. Promotion of alternative stormwater management through education and artistic interventions.
People want to connect culturally and socially. Creating a sense of place, common ownership, and connectivity are a vital part of a sustainable community. This includes: Complimentary cultural, art, craft and education at new Maker-Spaces. Daycare Center and other childcare services. Outdoor pop-up business opportunities for food vendors such as food carts and trucks. Indoor pop-up business opportunities in abandoned or underutilized buildings. Adaptive reuse of existing architecture and infill. Diversification of housing market with inclusion of market-rate housing to create a more balanced economy. Legal framework through zoning changes and permitting that supports small businesses, reduces bureaucratic burdens and secures public open green space
The khmer software package: enabling efficient nucleotide sequence analysis
The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at https://github.com/dib-lab/khmer/
The khmer software package: enabling efficient nucleotide sequence analysis [version 1; referees: 2 approved, 1 approved with reservations]
The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at https://github.com/dib-lab/khmer/
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; pâ=â0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; pâ=â0.40). There was no significant effect of DMF on any secondary outcome
Thigh-length compression stockings and DVT after stroke
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
The khmer software package: enabling efficient nucleotide sequence analysis [version 1; referees: 2 approved, 1 approved with reservations]
The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at https://github.com/dib-lab/khmer/