SOCIAL MEDIA: THE IMPACT ON SPIRITUAL FORMATION AMONG GENERATION Z FRESHMAN COLLEGE STUDENTS

The purpose of this study was to understand the impact of social media on the spiritual formation of Generation Z freshmen college students. Social media app usage has become prevalent within society, and Gen Z members are the first to grow up their entire lives with Internet access. Christian universities must understand the impact of social media apps on incoming freshman students, as they develop spiritual formation strategies aimed at the college population. In addition, the students’ own perceptions of how they are being impacted is important to identify, in order for them to make the necessary changes towards spiritual growth. The data collection instrument used was an online survey, distributed via email to freshmen students. Out of 300 eligible freshmen students, 134 completed the survey. The survey asked questions about spiritual formation activities and social media app usage. Data analysis of the survey is reported in the results portion of this study. The findings of this study were that social media technology has altered the spiritual formation process of Gen Z students at the university, as they are not able to be fully present during spiritual formation activities, with Bible reading, quiet time, and prayer life being significantly impacted by these apps. Additionally, the social media app Instagram was found to have the greatest impact on student spiritual formation, over the three other most popular apps (Facebook, YouTube, Twitter) at the time of this study

Long-term operation of a laser frequency comb with the Habitable Zone Planet Finder

Laser frequency combs are an ideal calibration source for precision astronomical spectrographs. We report on the demonstrated long term operation of a laser frequency comb that we designed and built as the primary calibrator for the Habitable Zone Planet Finder (HPF). The core technology of the comb is based on robust, polarization maintaining fiber coupled electro-optic modulators and broadband supercontinuum generation spanning 700-1600 nm in an efficient silicon nitride waveguide. The comb is continuously maintained on and ready to use, and since May 2018 the laser frequency comb has had a total uptime of 97%

Solar Contamination in Extreme Precision Radial Velocity Measurements: Deleterious Effects and Prospects for Mitigation

Solar contamination, due to moonlight and atmospheric scattering of sunlight, can cause systematic errors in stellar radial velocity (RV) measurements that significantly detract from the ~10cm/s sensitivity required for the detection and characterization of terrestrial exoplanets in or near Habitable Zones of Sun-like stars. The addition of low-level spectral contamination at variable effective velocity offsets introduces systematic noise when measuring velocities using classical mask-based or template-based cross-correlation techniques. Here we present simulations estimating the range of RV measurement error induced by uncorrected scattered sunlight contamination. We explore potential correction techniques, using both simultaneous spectrometer sky fibers and broadband imaging via coherent fiber imaging bundles, that could reliably reduce this source of error to below the photon-noise limit of typical stellar observations. We discuss the limitations of these simulations, the underlying assumptions, and mitigation mechanisms. We also present and discuss the components designed and built into the NEID precision RV instrument for the WIYN 3.5m telescope, to serve as an ongoing resource for the community to explore and evaluate correction techniques. We emphasize that while "bright time" has been traditionally adequate for RV science, the goal of 10cm/s precision on the most interesting exoplanetary systems may necessitate access to darker skies for these next-generation instruments

Stellar Spectroscopy in the Near-infrared with a Laser Frequency Comb

The discovery and characterization of exoplanets around nearby stars is driven by profound scientific questions about the uniqueness of Earth and our Solar System, and the conditions under which life could exist elsewhere in our Galaxy. Doppler spectroscopy, or the radial velocity (RV) technique, has been used extensively to identify hundreds of exoplanets, but with notable challenges in detecting terrestrial mass planets orbiting within habitable zones. We describe infrared RV spectroscopy at the 10 m Hobby-Eberly telescope that leverages a 30 GHz electro-optic laser frequency comb with nanophotonic supercontinuum to calibrate the Habitable Zone Planet Finder spectrograph. Demonstrated instrument precision <10 cm/s and stellar RVs approaching 1 m/s open the path to discovery and confirmation of habitable zone planets around M-dwarfs, the most ubiquitous type of stars in our Galaxy

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Three-dimensional structure of the single domain cupredoxin AcoP

Cupredoxins are widely occurring copper-binding proteins with a typical Greek-key beta barrel fold. They are generally described as electron carriers that rely on a T1 copper center coordinated by four ligands provided by the folded polypeptide. The discovery of novel cupredoxins demonstrates the high diversity of this family, with variations in term of copper-binding ligands, copper center geometry, redox potential, as well as biological function. AcoP is a periplasmic protein belonging to the iron respiratory chain of the acidophilic bacterium Acidithiobacillus ferrooxidans . AcoP presents original features: highly resistant to acidic pH, it possesses a constrained green-type copper center of high redox potential. To understand the unique properties of AcoP, we undertook structural and biophysical characterization of wild-type AcoP and of two Cu-ligand mutants (H166A and M171A). The crystallographic structure of AcoP at 1.65 Å resolution unveils a typical cupredoxin fold with extended loops, never observed in previously characterized cupredoxins, that might be involved in the interaction of AcoP with its physiological partners. Moreover, the structure shows that the green color of AcoP cannot be attributed to nonclassical copper ligands, its green-colored copper center raising from a long Cu-S (Cys) bond, determined by both X-ray diffraction and EXAFS. The crystal structures of two AcoP mutants confirm that the active center of AcoP is highly constrained. Comparative analysis with other cupredoxins of known structures, suggests that in AcoP the second coordination sphere might be an important determinant of active center rigidity due to the presence of an extensive hydrogen bond network

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease

The Extreme Stellar-Signals Project III. Combining Solar Data from HARPS, HARPS-N, EXPRES, and NEID

We present an analysis of Sun-as-a-star observations from four different high-resolution, stabilized spectrographs—HARPS, HARPS-N, EXPRES, and NEID. With simultaneous observations of the Sun from four different instruments, we are able to gain insight into the radial velocity precision and accuracy delivered by each of these instruments and isolate instrumental systematics that differ from true astrophysical signals. With solar observations, we can completely characterize the expected Doppler shift contributed by orbiting Solar System bodies and remove them. This results in a data set with measured velocity variations that purely trace flows on the solar surface. Direct comparisons of the radial velocities measured by each instrument show remarkable agreement with residual intraday scatter of only 15–30 cm s−1. This shows that current ultra-stabilized instruments have broken through to a new level of measurement precision that reveals stellar variability with high fidelity and detail. We end by discussing how radial velocities from different instruments can be combined to provide powerful leverage for testing techniques to mitigate stellar signals.Publisher PDFPeer reviewe