319 research outputs found
Predicting effective pro-apoptotic antileukaemic drug combinations using cooperative dynamic BH3 profiling
- Author
- A Kotschy
- A Nogami
- AA Borisy
- Adam Graham
- AJ Souers
- Andrei L. Gartel
- CC Thoreen
- Claire Seedhouse
- D Krige
- D Nijhawan
- D Yecies
- DA Luedtke
- DC Phillips
- DJ Goff
- DK Perry
- G Tamamyan
- GW Foight
- J Bodo
- J Deng
- J Montero
- J Ryan
- JD Leverson
- JK Brunelle
- JP Jaffrezou
- JS Lee
- KW Adams
- L Chen
- L Galluzzi
- Liban Elmi
- M Konopleva
- M Konopleva
- M Larrayoz
- M Pallis
- M Pallis
- M Pallis
- M Perez-Salvia
- M Rahmani
- M Stahl
- MA Dawson
- Martin Grundy
- MF van Delft
- Michael Hall
- MK Kashyap
- Monica Pallis
- N Pallisgaard
- N Philpott
- Nigel Russell
- P Bose
- PD Kottaridis
- PE Czabotar
- PP Ruvolo
- R Cencic
- R Pan
- RM Mohammad
- RW Rooswinkel
- RW Rooswinkel
- S Basu
- S Busacca
- S Chen
- S Iacovelli
- S Kitada
- S Varadarajan
- SC Lee
- T Oltersdorf
- T Yang
- Thomas Jones
- V Del Gaizo Moore
- W Fiskus
- W Fiskus
- W Zhang
- WR Greco
- X Niu
- YT Tai
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2018
- Field of study
The BH3-only apoptosis agonists BAD and NOXA target BCL-2 and MCL-1 respectively and co-operate to induce apoptosis. On this basis, therapeutic drugs targeting BCL-2 and MCL-1 might have enhanced activity if used in combination. We identified anti-leukaemic drugs sensitising to BCL-2 antagonism and drugs sensitising to MCL-1 antagonism using the technique of dynamic BH3 profiling, whereby cells were primed with drugs to discover whether this would elicit mitochondrial outer membrane permeabilisation in response to BCL-2-targeting BAD-BH3 peptide or MCL-1-targeting MS1-BH3 peptide. We found that a broad range of anti-leukaemic agents–notably MCL-1 inhibitors, DNA damaging agents and FLT3 inhibitors–sensitise leukaemia cells to BAD-BH3. We further analysed the BCL-2 inhibitors ABT-199 and JQ1, the MCL-1 inhibitors pladienolide B and torin1, the FLT3 inhibitor AC220 and the DNA double-strand break inducer etoposide to correlate priming responses with co-operative induction of apoptosis. ABT-199 in combination with pladienolide B, torin1, etoposide or AC220 strongly induced apoptosis within 4 hours, but the MCL-1 inhibitors did not co-operate with etoposide or AC220. In keeping with the long half-life of BCL-2, the BET domain inhibitor JQ1 was found to downregulate BCL-2 and to prime cells to respond to MS1-BH3 at 48, but not at 4 hours: prolonged priming with JQ1 was then shown to induce rapid cytochrome C release when pladienolide B, torin1, etoposide or AC220 were added. In conclusion, dynamic BH3 profiling is a useful mechanism-based tool for understanding and predicting co-operative lethality between drugs sensitising to BCL-2 antagonism and drugs sensitising to MCL-1 antagonism. A plethora of agents sensitised cells to BAD-BH3-mediated mitochondrial outer membrane permeabilisation in the dynamic BH3 profiling assay and this was associated with effective co-operation with the BCL-2 inhibitory compounds ABT-199 or JQ1
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
- Author
- Adoue D
- Agard C
- Ahmadi K
- Airo P
- Aizpuru EM
- Akanay-Diesel S
- Albertsson K
- Almeida I
- Alsheimer B
- Alves J
- Andersen M
- Anderson M
- Andresen J
- Angeles Aquirre M
- Antivalle M
- Aries P
- Aslanidis S
- Aslkaksen HK
- Assmann G
- Assous N
- Athanassiou P
- Athiveer P.
- Baguley E
- Bajoochi G
- Bakkeheim V
- Bakland G
- Balquiere S
- Barbado J
- Barca BA
- Barnd A
- Barth S
- Battaglia E
- Baudaoin P
- Baumann C
- Becerra ND
- Becker M
- Becvar R
- Bekou V
- Belin E
- Bellido D
- Bellisai F
- Bellissimo S
- Belloli L
- Belloni B
- Bendvold A
- Beneton N
- Berezne A
- Berthier S
- Bessis D
- Beyer C
- Bezanahary H
- Bijl M
- Bitter H
- Blaise S
- Blanco JJ
- Blanco JS
- Blank N
- Bloching HH
- Blum L
- Blume J
- Boesenberg I
- Bohmova J
- Bootsma H
- Boro D
- Bortoluzzi A
- Boulon C
- Boussely N
- Bracin T
- Brand H
- Bravetti V
- Brodmann M
- Broll H
- Brouwer L
- Brown S
- Bruckner L
- Bruyn G
- Bucci R
- Caamano M
- Cabane J
- Callejas JL
- Calvo J
- Camara I
- Camps MT
- Cantatore F
- Carpentier P
- Cartry O
- Castellvi I
- Castellvi I
- Cazalets-lacoste C
- Chakravarty K
- Charlanne H
- Chatelus E
- Chiffot H
- Choong LM
- Chromik S
- Cipriani P
- Coelho P
- Cohen JD
- Colaci M
- Cole S
- Coleman JV
- collet E
- Colonna L
- Constans J
- Coppere B
- Cordeiro A
- Corteguera M
- Costa J
- Couraud A
- Couret B
- Cozzi F
- Crespo M
- Cruz A
- Cruz J
- Cuomo G
- D'Cruz D
- Dadban A
- De Angeli R
- de Bois M
- De la Puente C
- de la Torre RG
- de Long AJ
- de Ramon E
- de Vicuna RG
- De Vita S
- Deboves O
- Decaux O
- Deininger F
- del Carmen Ortega de la O M
- del Carmen Torres Martin M
- del la Pena Lefebvre PG
- del Mar Ripoll Macias M
- Del Papa N
- del Rio AH
- Delgado EG
- den Hengst C
- Denton C
- Denton CP
- Deppermann N
- Desmurs-Clavel H
- Deuschle K
- Diaz JJ
- Dietl S
- Dimitroulas T
- Diot E
- Distler J
- Distler O
- Dobson J
- Doeffel-hantz V
- Dohse A
- Dolhain R
- Dolnicar AS
- Doutre MS
- Doveri M
- Droitcourt C
- Dumonteil S
- DUO Registry investigators. Collaborators: Stetter M
- Durant C
- Duval-modeste AB
- Dyballa J
- Ebel J
- Eiden E
- Eilbacher P
- Elezoglou A
- Enderlein M
- Erfurt-berge C
- Espinosa G
- Espinposa G
- Ewals J
- Faggioli P
- Faizal A
- Farcas C
- Farge D
- Fauchais AL
- Faustini F
- Federow I
- Feldmann R
- Fell I
- Fernandez AS
- Fernandez C
- Fernandez NC
- Fernandez S
- Ferraccioli G
- Ferrandiz D
- Ferri C
- Fiene M
- Fierlbeck G
- Filloy JA
- Flaig W
- Fojtik Z
- Foti R
- Frambach Y
- Frances C
- Fretter P
- Freundlieb C
- Frey P
- Funkert A
- Fusaro E
- Fuzibet JG
- Gabrielli A
- Gaches F
- Galanopoulo V
- Galanopoulos N
- Galeazzi M
- Galluccio F
- Garcia A
- Garcia PV
- Garyfallos A
- Gatti S
- Gaubitz M
- Gause A
- Gawlik A
- Gerards AH
- Gerber A
- Gerdes V
- Gernot Scheibl E
- Geurts M
- Gil JG
- Gines Martinez F
- Girard-Madoux MH
- Gjessdal CG
- Glaeser R
- Goekoop R
- Gonzales MF
- Gordon P
- Goudran G
- Grandauent B
- Granel B
- Granel-brocard F
- Grassi W
- Greco M
- Grier A
- Groenendael JH
- Groenendael J
- Guenzel J
- Guertler I
- Guillevin L
- Guillevin L
- Hachulla E
- Hafner F
- Hahn K
- Hak AE
- Hall F
- Hallecker A
- Hallermann C
- Hamberger N
- Hamilton A
- Hampson R
- Han KH
- Hapke S
- Harmuth W
- Harris H
- Hartmann F
- Hassel R
- Hatron PY
- Haust M
- Hazenbiller A
- Hein R
- Hellmich B
- Hellstrom H
- Henkemeier U
- Hermanns G
- Hermansson E
- Hernan MG
- Herr U
- Herrgott I
- Herrick A
- Heurkens AH
- Hildebrandt B
- Hillebrecht C
- Himsel A
- Hirschl M
- Hjertaker SL
- Hoff NP
- Hoffmann-Vold AM
- Holzer G
- Hot A
- Houben H
- Huegel R
- Huertas MP
- Huettig B
- Huizinga TW
- Hulsmans H
- Hundstorfer M
- Hurkens T
- Illmer X
- Imbert B
- Insua SA
- Iversen LV
- Jacobs PJ
- Jahangier de Veen ZN
- Jahnke K
- James J
- Jansen P
- Janssen M
- Jego P
- Jourdain N
- Kaarto A
- Kaasjager HA
- Kaczmarczyk A
- Kaeding U
- Kahl S
- Kalstad S
- Kamali S
- Kampe-Juzak E
- Kanter MD
- Karaenke P
- Karlsmark T
- Karlsson ML
- Katzemich A
- Kayser M
- Kellner C
- Kelsey C
- Kern S
- Keshtmand H
- Kettenbach A
- Keynote A
- Khau van Kien A
- Kirchberg S
- Kirschke J
- Klein E
- Kleiner HJ
- Klings D
- Kneitz C
- Knifjj-Dutmer E
- Knoebel K
- Knudsen JB
- Koch M
- Koldingsnes W
- Kolle H
- Kostrzwewa E
- Koutroumbas A
- Krause Rostock JO
- Kremer K
- Krieg T
- Kritikos I
- Krog B
- Krupp E
- Kuen-Spiegel M
- Kuiper-geertsma DG
- Kunze S
- Kurthen R
- Kyndt X
- Lackner K
- Lamb J
- Lambert M
- Landewe RM
- Lanting P
- Lapadula G
- Launay D
- Laurin CU
- Lauterwein B
- Lazareth I
- Le Quellec A
- Lebrun C
- Leguy-Seguin V
- Letremy A
- Liljequist E
- Lind I
- Lind K
- Linke M
- Loeffler C
- Lok C
- Lombardi S
- Lopez JC
- Lopez MR
- Losada L
- Loustaud-ratti V
- Luethke K
- Lukac J
- Lunardi C
- Lupaschko S
- Maceiras F
- Madaule S
- Madhok F
- Madland TM
- Maglione W
- Magy-Bertrand N
- Maillard H
- Makinen H
- Malavolta N
- Manea P
- Maneiro JR
- Manning J
- Manzanedo VS
- Margeta C
- Marhuenda AR
- Marina P
- Martin I
- Marucci A
- Marx J
- Mascaro JM
- Masolini P
- Mateo FJ
- Matucci-Cerinic M
- Maurer B
- May D
- Mayer L
- Mazzone A
- Mazzuca S
- Mchugh N
- Meier L
- Meier U
- Mendoza AZ
- Mengden T
- Mensing C
- Mensing H
- Mera A
- Merk B
- Mesaric P
- Messall J
- Messer G
- Mettler S
- Metz S
- Metzler C
- Michon-Pasturel U
- Midtvedt O
- Miguelez R
- Minmair G
- Misery L
- Mitchell A
- Mittag M
- Mohammad A
- Moinzadeh P
- Moiton MP
- Molders N
- Moline T
- Monshausen M
- Monshi B
- Montecucco CM
- Montes IC
- Montes J
- Moolenburgh JD
- Moore T
- Moosig F
- Moots R
- Morell S
- Moritz D
- Morrison C
- Mosquera JA
- Mota R
- Moulis G
- Mouthon L
- Mueglich C
- Muhlack A
- Muller WH
- Munoz J
- Murphy K
- Murray M
- Mussi A
- Naderi Y
- Neek G
- Nemec P
- Neul S
- Ngcozana T
- Nichelmann V
- Nicolas GM
- Niedermeier A
- Niefanger K
- Nielen C
- Nigro A
- Ninet J
- Noordzij M
- Nordin A
- Nordvag BY
- O'Rourke M
- Ochiel R
- Ochs W
- Oelsner M
- Ogunbambi G O
- Oliveira S
- Olivieri I
- Olsen AB
- Oltmann-Schroeder J
- Ortego N
- Ostenson A
- Paassen P
- Pallotta S
- Pampin EP
- Parker L
- Pedersen T
- Pellerito R
- Perlat A
- Peters AJ
- Peters J
- Pfeiffer C
- Pflugfelder J
- Pfoehler C
- Pirkhammer D
- Plaumann K
- Podda M
- Podobinska M
- Ponte C
- Prey S
- Priollet P
- Prochazkova L
- Pros A
- Puppo F
- Quemeneur T
- Queyrel V
- Rabaneda EV
- Rabe B
- Raffier B
- Ramos PC
- Rapp P
- Rasche C
- Rauen T
- Reemtsen R
- Reguiai Z
- Reinhart V
- Reischel N
- Remans J
- Resende C
- Riccieri V
- Richez C
- Richter L
- Riemekasten G
- Rintelen B
- Riviere S
- Rizk M
- Robakidze-Torbahn M
- Rodriguez MA
- Rodriguez TR
- Roman Ivorra J
- Ronday K
- Rosato E
- Rosenberg D
- Rubio M
- Ruchenburg J
- Rueda A
- Rullier P
- Rumbaur C
- Rumpel H
- Rushentsova U
- Rydvald Y
- Sadeghlar F
- Saez L
- Sailler L
- Salerno R
- Salsano F
- Sanchez J
- Sanchez MD
- Sanchez PS
- Sancho Alegre JJ
- Sandoval AA
- Santo MP
- Santos C
- Saracco M
- Sardy M
- Sassolas B
- Sautner J
- Schaefer C
- Schanz S
- Schildt K
- Schleenbecker H
- Schmeiser T
- Schmidt K
- Schmidt P
- Schmidt-Bosshard R
- Schneider K
- Scholz J
- Schuart T
- Schuch F
- Schuerwegh A
- Schuetz N
- Schult S
- Schultz L
- Schulze K
- Schuster J
- Schwarting A
- Schweda K
- Schwierin B
- Schwuerzer-Voit M
- Scorza R
- Seidel M
- Seip M
- Semmelweis K
- Semmler M
- Serafino L
- Severino A
- Seys P
- Sheikh N
- Sibillia J
- Siebel C
- Siewertsz van Reesema D
- Silkey M
- Silva I
- Simeon CP
- Skingle S
- Skomsvoll J
- Skowron F
- Skyes H
- SMIT A
- Smrzova A
- Soderlin M
- Sondergaard KH
- Sonnaville PB
- Sordet C
- Soukup T
- Spars A
- Sperling S
- Starz H
- Stein T
- Steinbrink K
- Sticherling M
- Stisi S
- Stoeckl F
- Stolk JN
- Storck-Mueller K
- Stran EK
- Stroes ES
- Suchy D
- Taieb A
- Takacs M
- Tasende JA
- Terlizzi N
- Thomsen RS
- Thonhofer R
- Thorsson C
- Tiev K
- Tiggers C
- Toeller S
- Toledano C
- Tomi N
- Ton E
- Tony HP
- Trautinger F
- Trenado MS
- Triolo G
- Trotta F
- Trummer M
- Tsifetaki N
- Ubels F
- Ughi N
- Uhlig S
- Ullrich-Guenther C
- Unholzer A
- Uson J
- Vacca A
- Valentijn R
- van Hagen M
- van Daele P
- van den Hoogen F
- van der Lubbe P
- van der Veen MJ
- van Gameren I
- Van Guldener C
- Van Krugten M
- Van Neer F
- van Paassen H
- van Woerkom JM
- van Zeben D
- Varcasia G
- Vasilopoulos D
- Vazquez JL
- Vengemyr K
- Vercoutere W
- Verner D
- Victoria Egurbide M
- Vidal E
- Villaverde V
- Vincent R
- Vingren T
- Visser H
- Vlachoyannopoulos P
- von Bildering PB
- von Elling A
- von Oelhafen J
- Vonk M
- Vos P
- Voskuyl A
- Voss B
- Vosswinkel J
- Wagner N
- Wahl D
- Wahn H
- Waldheim E
- Weiss E
- Welzel J
- Wernitzsch H
- Westedt ML
- Westra R
- White-Alao B
- Wilhelm HU
- Willems H
- Willfort-Ehringer A
- Wipff J
- Wlarvens M
- Woijtasik G
- Wollersdorfer E
- Worm M
- Wragg E
- Wuerzburg I
- Xu Y
- Zabel M
- Zemanova I
- Zeni S
- Zenone T
- Zeuner R
- Ziai M
- Zijlstra TR
- Zimba S
- Zuily S
- Zultak M
- Zuper R
- Zwenger S
- Publication venue
- BMJ Group
- Publication date
- 01/01/2012
- Field of study
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- Bodí M
- Boer C
- Bogossian E
- Bonet S
- Bonn M
- Bonnet M
- Borges FK
- Bouadma L
- Boucekine M
- Bougouin W
- Bourenne J
- Boyd JG
- Boyd JG
- Bozbay S
- Bozza F
- Bradac O
- Brandon RA
- Brandon RB
- Braschi A
- Braschi A
- Braschi A
- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
- Brochard L
- Brochard L
- Brochard L
- Brock N
- Brody DL
- Brook R
- Brousseau C
- Brown K
- Brugger SC
- Brugger SC
- Bruno F
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- Cameron C
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- Cannesson M
- CAPCRI Study
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- Cardenas CL
- Cariou A
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- Carlesso E
- Carmona AF
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- Carpio D
- Carratalá A
- Carreira MM
- Carrero-Gómez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- Catalán RM
- Catena E
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- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
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- Champigneulle B
- Champigneulle B
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- Charron C
- Chatelon J
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- Chaussard M
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- Chelly J
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- Cheng CC
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- Chernyshuk S
- Chevret S
- Chhor V
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- Chiappa C
- Chiou KR
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- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
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- Choi JY
- Choi JY
- Choi KS
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- Chok L
- Cholkraisuwat J
- Cholley B
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- Chou W
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- Chumaev A
- Chung CR
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- Chytas A
- Cinel I
- Cinnella G
- Citerio G
- Citerio G
- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
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- Colson P
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- Concha P
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- Constan A
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- Constan A
- Conte V
- Conti G
- Conti G
- Contreras KM
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- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- Cordón J
- Corona A
- Corona A
- Corradi F
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- Corte FD
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- Coss-Bu JA
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- Creteur J
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- Cron N
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- Cui N
- Cunha MM
- Curiel-Balsera E
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- Curinga M
- Curtis A
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- Cutuli SL
- Câmara M
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- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
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- De Pascale G
- De Rosa S
- De Sanctis F
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- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
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- Delgado MJ
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- Demirkiran O
- Demoule A
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- Descotte E
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- Desmard M
- Desmard M
- Deveugele M
- Deye N
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- Di Giancamillo M
- Di Gravio V
- Di Gregorio A
- Di Mussi R
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- Diaz P
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- Dimitrov BD
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- Dimopoulou IK
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- Divatia JV
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- Dougall PC
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- Drover J
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- Durand M
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- Durrant J
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- Díaz M
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- Dünser MW
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- E YY
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- Echeverri JE
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- Ediboglu O
- Ediboglu O
- Egea-Guerero JJ
- Egginton JS
- Egi M
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- El Hamid MA
- El Hossainy R
- El Sayed E
- El Sayed F
- El Sayed I
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- El-Keraie A
- Eladawy S
- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
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- Escórcio S
- Eslami S
- Espinasse F
- Espinel E
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- Esteban A
- Estella A
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- Fave G
- Feehan A
- Feijoo AM
- Feliot E
- Ferez MA
- Fernandes MJ
- Fernandes N
- Fernandez NG
- Fernandez R
- Fernandez-Zamora MD
- Fernández IF
- Fernández L
- Fernández MV
- Fernández PA
- Fernández-Barat L
- Fernández-Mondéjar E
- Fernández-Ortega JF
- Ferraz AB
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- Ferri F
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- Ferré A
- Ferrón FR
- Ferrón FR
- Fiks T
- Fiks T
- Fileković S
- Filho CA
- Filho CA
- Filho CA
- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
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- Follin A
- Follin A
- Fong KY
- Fontaiña LP
- Fontana V
- Fontenot T
- Forel JM
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- Forni L
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- Fox B
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- Frat JP
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- Frithiof R
- Fritz C
- FROG ICU Investigators
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- Frontera PR
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- Gavrychenko D
- Gayat E
- Geantot MA
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- Genc D
- Genève C
- Georgopoulos D
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Giesinger RE
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- Hernández A
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- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
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- Hernández-Tejedor A
- Herpain A
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- Hung WT
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- Ignacio ML
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- Imanaka H
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- Ince C
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
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- Jensen JU
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- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- Juliarena A
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- Kim HJ
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- Kim JM
- Kim JW
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- Ko SB
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- Koco E
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- Kodate A
- Kodate A
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- Kolnikova I
- Komuro T
- Kondili E
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- Kosuk ME
- Kotsopoulos A
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- Kouatchet A
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- Krishna B
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- Kulkarni AP
- Kumari BK
- Kumbamu A
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- Kurmukov IA
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- Kwon HM
- Kwon WY
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- Kyle UG
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- Labra C
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- Lafuente E
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- Lai CH
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- Latini R
- Latini R
- Latorre J
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- Lee WY
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- Liao X
- Lichtenstein D
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- Limuti R
- Lin KC
- Lin KC
- Lin KC
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- Lin KL
- Lin PH
- Lin SC
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- Lin WC
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- Lischinsky A
- Lissonde F
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- Liu CP
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- Llorente B
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- Lobo-Civico A
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- Lombardo MD
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- Loudet CI
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- Maghsoudi B
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- Martín-Loeches I
- Martín-Loeches I
- Martínez F
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- Martínez M
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- Martínez MV
- Martínez NA
- Martínez-Carmona JF
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- Vinje LJ
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- Vittone F
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- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
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- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
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- Wood M
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- Xie Z
- Xini A
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- Xu M
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- Yaguchi A
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- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
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- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
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- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
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- Alexander KD
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- Allekotte I
- Allen B
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- Angus CR
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- Arcavi I
- Arceo R
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- Array MWA Murchison Widefield
- Arrieta M
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- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
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- Furusawa H
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- Zimnukhov DS
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Localization and broadband follow-up of the gravitational-wave transient GW150914
- Author
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla FB
- Abe F
- Abernathy MR
- Acernese F
- Ackermann M
- Ackley K
- Adame JA
- Adams C
- Adams T
- Addesso P
- Adhikari RX
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- Zweizig J
- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
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- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
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- Turner W
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- Ulla Mr
- Updegrove J
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- Uriasyev O
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- Valdes Depeda A
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- Ygpuara Mdl
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- Yu X
- Yumita W
- Yupanqui H
- Zaidman Cj
- Zalunardo N
- Zamarripa Escobedo R
- Zanata Petry Tb
- Zanella Mt
- Zaniewski-Singh M.
- Zanoli L
- Zaoui P
- Zateyshchikova A
- Zateyshshikov D
- Zaviriukha V
- Zemek S
- Zhang H
- Zhang Hong
- Zhao M
- Zheng H
- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Wu Ds
- Wysocki Dm
- Xiao S
- Xu R
- Yamamoto H
- Yancey Cc
- Yang L
- Yang Y
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- Yap Mj
- Yazback M
- Yeeles Dw
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- Yu Hc
- Yuen Shr
- Zadrozny A
- Zadrozny Ak
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- Zelenova T
- Zendri Jp
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhao G
- Zhou M
- Zhou Z
- Zhu Xj
- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- van den Brand Jfj
- Van Den Broeck C
- van der Schaaf L
- van Veggel Aa
- Vander-Hyde Dc
- VanHeijningen Jv
- Vardaro M
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- Willke B
- Winkler W
- Wipf Cc
- Wittel H
- Woan G
- Woehler J
- Wofford Jk
- Wright Jl
- Wu Ds
- Wysocki Dm
- Xiao S
- Xu R
- Yamamoto H
- Yancey Cc
- Yang L
- Yang Y
- Yang Z
- Yap Mj
- Yazback M
- Yeeles Dw
- Yu H
- Yu Hc
- Yuen Shr
- Zadrozny A
- Zadrozny Ak
- Zanolin M
- Zelenova T
- Zendri Jp
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhao G
- Zhou M
- Zhou Z
- Zhu Xj
- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO’s second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h95%0=3.47×10−25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering
Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A
- Author
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- Abbott R
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- Ackley K
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- Woan G
- Woehler J
- Wofford J
- Wong KWK
- Worden J
- Wright JL
- Wu DS
- Wysocki DM
- Xiao S
- Yamamoto H
- Yancey CC
- Yang L
- Yap MJ
- Yazback M
- Yu H
- Yu H
- Yvert M
- Zadrozny A
- Zanolin M
- Zelenova T
- Zendri J-P
- Zertuche LM
- Zevin M
- Zhang L
- Zhang M
- Zhang T
- Zhang Y-H
- Zhao C
- Zhou M
- Zhou Z
- Zhu SJ
- Zhu XJ
- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is 5.0×10−8. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of (+1.74±0.05)s between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between −3×10−15 and +7×10−16 times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1-1.4 per year during the 2018-2019 observing run and 0.3-1.7 per year at design sensitivity
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
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- Zhemchugov A
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
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