Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood

The absorption efficiency of any drug in blood is of prime importance. Compounds having the general formula: K(n)[M(FO)(2)(H(2)O)(2)] · xH(2)O, where (M = Cu(II) or Fe(III), n = 2 or 1, FO = folate anion, x = 2 or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined. The obtained compounds were characterized by elemental analysis, infrared as well as thermogravimetric analysis and polarization of light. The results suggest that the two folate complexes were formed in 1 : 2 molar ratio (metal : folic acid) which acted as a bidentate ligand through both carboxylic groups. Polarization of light proved that the folate complexes have symmetric geometry. Biological application proved that Cu(II) and Fe(III) complexes were absorbed more efficiently in rodent blood than folic acid itself

Heat Transfer Performance of a Gasketed Plate Heat Exchanger Subjected to Mechanical Vibration

Heat transfer characteristics in terms of heat transfer coefficient, overall heat transfer coefficient and heat exchanger effectiveness of a vertical counter flow Gasket plate heat exchanger (GPHE) are experimentally investigated. The tested PHE is made of stainless-steel plates with 30° chevron angle (β=30°). The surface enlargement factor, Ф for all plates was 1.17. Six plates were installed; providing two hot channels and three cold channels in counter flow arrangement. The vibration effect on tested GPHE has been performed and compared with non-vibration model. Vibration frequencies (ω) are in the range of 13.33 to 46.67 cps and vibrational dimensionless amplitude (A/De) varied from 9.14*10-3 to 52.66*10-3 at various oscillating Reynolds numbers were employed. It is found that the heat transfer performance of the GPHE is enhanced when vibration is applied. The maximum enhancement percentage of the GPHE heat transfer coefficient, overall heat transfer coefficient and effectiveness due to vibration are 43%, 31% and 18%, respectively. These maximums are occurred at oscillation Reynolds number of 211.34 and A/De = 52.66*10-3 which after the resonance condition. The GPHE performance after and before resonance condition are obtained. Finally, correlations for GPHE Nusselt number, when vibration is and is not applied, are obtained with an acceptable error of 3.99%

Heat Transfer Performance of a Gasketed Plate Heat Exchanger Subjected to Mechanical Vibration أداء إنتقال الحرارة لمبادل حراري من النوع اللوحي مجهز بمانع تسريب يهتز إهتزازا ميکانيکيا

Heat transfer characteristics in terms of heat transfer coefficient, overall heat transfer coefficient and heat exchangereffectiveness of a vertical counter flow Gasket plate heat exchanger (GPHE) are experimentally investigated. The testedPHE is made of stainless-steel plates with 30° chevron angle (β=30°). The surface enlargement factor, Ф for all plateswas 1.17. Six plates were installed; providing two hot channels and three cold channels in counter flow arrangement.The vibration effect on tested GPHE has been performed and compared with non-vibration model. Vibration frequencies(ω) are in the range of 13.33 to 46.67 cps and vibrational dimensionless amplitude (A/De) varied from 9.14*10-3 to52.66*10-3 at various oscillating Reynolds numbers were employed. It is found that the heat transfer performance of theGPHE is enhanced when vibration is applied. The maximum enhancement percentage of the GPHE heat transfercoefficient, overall heat transfer coefficient and effectiveness due to vibration are 43%, 31% and 18%, respectively.These maximums are occurred at oscillation Reynolds number of 211.34 and A/De = 52.66*10-3 which after theresonance condition. The GPHE performance after and before resonance condition are obtained. Finally, correlationsfor GPHE Nusselt number, when vibration is and is not applied, are obtained with an acceptable error of 3.99%

Diagnostic efficacy of monoclonal antibody based sandwich enzyme linked immunosorbent assay (ELISA) for detection of Fasciola gigantica excretory/secretory antigens in both serum and stool

<p>Abstract</p> <p>Background</p> <p>This research was carried out to develop a reliable monoclonal antibody (MoAb)-based sandwich enzyme linked immunosorbent assay (ELISA) for the diagnosis of active <it>Fasciola gigantica </it>infection in both serum and stool for comparative purposes.</p> <p>Methods</p> <p>From a panel of MoAbs raised against <it>F. gigantica </it>excretory/secretory antigens (ES Ags), a pair (12B/11D/3F and 10A/9D/10G) was chosen due to its high reactivity and strict specificity to <it>F. gigantica </it>antigen by indirect ELISA.</p> <p>Results</p> <p>The two MoAbs were of the IgG₁and IgG_2asubclasses, respectively. Using SDS-PAGE and EITB, the selected MoAbs recognized 83, 64, 45 and 26 kDa bands of ES Ags. The lower detection limit of ELISA assay was 3 ng/ml. In stool, the sensitivity, specificity and diagnostic efficacy of ELISA was 96%, 98.2 and 97.1%; while in serum they were 94%, 94.6% and 94.3%, respectively. Moreover, a positive correlation was found between ova count in stool of <it>F. gigantica </it>infected patients and the OD readings of ELISA in both stool and serum samples (<it>r </it>= 0.730, p < 0.01 and r = 0.608; p < 0.01, respectively).</p> <p>Conclusions</p> <p>These data showed that the use of MoAb-based sandwich ELISA for the detection of <it>F. gigantica </it>coproantigens in stool specimens was superior to serum samples; it provides a highly efficient, non-invasive technique for the diagnosis of active <it>F. gigantica </it>infection.</p

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.

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2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.

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withdrawn 2017 hrs ehra ecas aphrs solaece expert consensus statement on catheter and surgical ablation of atrial fibrillation

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