Theory of highly loaded coal-water slurries

There has been analyzed the existing schemes of strapping of circulated system of drilling set during drilling with well washing by the foam and argued the necessity of its efficient raising; there has been chosen the scheme of strapping of circulated system during drilling with well washing by the foam for the possibility of the most rational usage of existing foamgenerating equipment.В статті проаналізовані існуючі схеми обв'язки циркуляційної системи бурової установки при бурінні з промиванням свердловини піною та обґрунтована необхідність підвищення їх ефективності; для можливості найбільш раціонального використання існуючого піногенеруючого устаткування передбачена схема обв'язки циркуляційної системи при бурінні з промиванням свердловини піною

Evaluation of bacteriophage as an adjunct therapy for treatment of peri-prosthetic joint infection caused by Staphylococcus aureus

Phage therapy offers a potential alternate strategy for the treatment of peri-prosthetic joint infection (PJI), particularly where limited effective antibiotics are available. We undertook preclinical trials to investigate the therapeutic efficacy of a phage cocktail, alone and in combination with vancomycin, to reduce bacterial numbers within the infected joint using a clinically-relevant model of Staphylococcus aureus-induced PJI. Infected animals were randomised to 4 treatment groups, with treatment commencing 21-days post-surgery: bacteriophage alone, vancomycin alone, bacteriophage and vancomycin, and sham. At day 28 post-surgery, animals were euthanised for microbiological and immunological assessment of implanted joints. Treatment with phage alone or vancomycin alone, led to 5-fold and 6.2-fold reductions, respectively in bacterial load within peri-implant tissue compared to shamtreated animals. Compared to sham-treated animals, a 22.5-fold reduction in S. aureus burden was observed within joint tissue of animals that were administered phage in combination with vancomycin, corresponding with decreased swelling in the implanted knee. Microbiological data were supported by evidence of decreased inflammation within the joints of animals administered phage in combination with vancomycin, compared to sham-treated animals. Our findings provide further support for phage therapy as a tolerable and effective adjunct treatment for PJI

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals – a cross-sectional observational study

Background: Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear. Methods: Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% aged 60+; median HIV duration 20 years, \u3e95% plasma and CSF HIV RNA \u3c50 cp/mL, on cART for a median 24 months). All underwent standard neuropsychological testing (61% had HAND), APOE genotyping (30.9% carried APOE ε4 and 7.1% were ε4 homozygotes) and a lumbar puncture. Concentrations of Aβ1-42, t-tau and p-tau were assessed in the CSF using commercial ELISAs. Current neurocognitive status was defined using the continuous Global Deficit Score, which grades impairment in clinically relevant categories. History of HAND was recorded. Univariate correlations informed multivariate models, which were corrected for nadir CD4-T cell counts and HIV duration. Results: Carriage of APOE ε4 predicted markedly lower levels of CSF Aβ1-42 in univariate (r = -.50; p = .001) and multivariate analyses (R2 = .25; p \u3c .0003). Greater levels of neurocognitive impairment were associated with higher CSF levels of p-tau in univariate analyses (r = .32; p = .03) and multivariate analyses (R2 = .10; p = .03). AD risk prediction cut-offs incorporating all three CSF biomarkers suggested that 12.5% of participants had a high risk for AD. Having a CSF-AD like profile was more frequent in those with current (p = .05) and past HIV-associated dementia (p = .03). Conclusions: Similarly to larger studies, APOE ε4 genotype was not directly associated with HAND, but moderated CSF levels of Aβ1-42 in a minority of participants. In the majority of participants, increased CSF p-tau levels were associated with current neurocognitive impairment. Combined CSF biomarker risk for AD in the current HIV+ sample is more than 10 times greater than in the Australian population of the same age. Larger prospective studies are warranted

Amyloid and tau cerebrospinal fluid biomarkers in HIV infection

<p>Abstract</p> <p>Background</p> <p>Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients.</p> <p>Methods</p> <p>In this cross-sectional study we measured soluble amyloid precursor proteins alpha and beta (sAPPα and sAPPβ), amyloid beta fragment 1-42 (Aβ_1-42), and total and hyperphosphorylated tau (t-tau and p-tau) in CSF of 86 HIV-infected (HIV+) subjects, including 21 with AIDS dementia complex (ADC), 25 with central nervous system (CNS) opportunistic infections and 40 without neurological symptoms and signs. We also measured these CSF biomarkers in 64 uninfected (HIV-) subjects, including 21 with Alzheimer's disease, and both younger and older controls without neurological disease.</p> <p>Results</p> <p>CSF sAPPα and sAPPβ concentrations were highly correlated and reduced in patients with ADC and opportunistic infections compared to the other groups. The opportunistic infection group but not the ADC patients had lower CSF Aβ_1-42in comparison to the other HIV+ subjects. CSF t-tau levels were high in some ADC patients, but did not differ significantly from the HIV+ neuroasymptomatic group, while CSF p-tau was not increased in any of the HIV+ groups. Together, CSF amyloid and tau markers segregated the ADC patients from both HIV+ and HIV- neuroasymptomatics and from Alzheimer's disease patients, but not from those with opportunistic infections.</p> <p>Conclusions</p> <p>Parallel reductions of CSF sAPPα and sAPPβ in ADC and CNS opportunistic infections suggest an effect of CNS immune activation or inflammation on neuronal amyloid synthesis or processing. Elevation of CSF t-tau in some ADC and CNS infection patients without concomitant increase in p-tau indicates neural injury without preferential accumulation of hyperphosphorylated tau as found in Alzheimer's disease. These biomarker changes define pathogenetic pathways to brain injury in ADC that differ from those of Alzheimer's disease.</p

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a variety of pathogens, including many not normally controlled by the IRG system. This phenotype is associated with lymphopenia, hemopoietic collapse, and death of the mouse.Deutscher Akademischer Austausch Dienst (DAAD); International Graduate School in Development Health and Disease (IGS-DHD); Deutsche For-schungsgemeinschaft (SFBs 635, 670, 680); Max-Planck-Gesellschaft (Max Planck Fellowship)

навчальний посібник

Правове регулювання адміністративних послуг (у схемах) : навч. посіб. / [О. В. Брусакова, К. О. Крут, І. В. Панова та ін.]; за заг. ред. В. В. Сокуренка; МВС України, Харків. нац. ун-т внутр. справ. – Харків : ХНУВС, 2021. – 120 с. – ISBN 978-966-610-252-5.У навчальному посібнику у вигляді структурно-логічних схем розкрито процедури надання адміністративних послуг посадовими особами органів державної влади та органів місцевого самоврядування, розкрито теоретичні та практичні аспекти проблематики адміністративних послуг з акцентом на створення та організацію центрів надання адміністративних послуг тощо. Для студентів, аспірантів, викладачів закладів різного рівня акредитації, наукових і практичних працівників та всіх, хто цікавиться питаннями адміністративного права.The textbook reveals the procedures for providing administrative services by officials of public authorities and local governments, theoretical and practical aspects of administrative services with an emphasis on the creation and organization of centers for administrative services and more. For students, graduate students, teachers of institutions of different levels of accreditation, researchers and practitioners and anyone interested in administrative law.В учебном пособии раскрыты процедуры предоставления административных услуг должностными лицами органов государственной власти и органов местного самоуправления, раскрыты теоретические и практические аспекты проблематики административных услуг с акцентом на создание и организацию центров предоставления административных услуг. Для студентов, аспирантов, преподавателей заведений разного уровня аккредитации, научных и практических работников и всех, кто интересуется вопросами административного права

навчальний посібник

Адміністративне право України. Загальна частина у схемах : навч. посіб. / МВС України, Харків. нац. ун-т внутр. справ ; за заг. ред. В. В. Сокуренка. – Харків : ХНУВС, 2019. – 236 с. – ISBN 978-966-610-138-2.У навчальному посібнику у вигляді структурно-логічних схем розкрито зміст норм загальної частини адміністративного права України: сутність публічного адміністрування, його принципи; предмет, метод, принципи і систему адміністративного права; систему суб’єктів адміністративного права; публічну службу та iнше. Для студентів, аспірантів, викладачів закладів різного рівня акредитації, наукових і практичних працівників та всіх, хто цікавиться питаннями адміністративного права.The textbook in the form of structural and logical schemes discloses the content of the norms of the general part of administrative law of Ukraine: the essence of public administration, its principles, subject, method, principles and system of administrative law; system of subjects of administrative law; public service and so on. For students, graduate students, teachers of institutions of different levels of accreditation, scientists and practitioners and anyone interested in administrative law.В учебном пособии в виде структурно-логических схем раскрыто содержание норм общей части административного права Украины: сущность публичного администрирования, его принципы, предмет, метод, принципы и систему административного права; систему субъектов административного права; публичную службу и прочее. Для студентов, аспирантов, преподавателей учреждений разного уровня аккредитации, научных и практических работников и всех, кто интересуется вопросами административного права