4 research outputs found
Quanteneffekte am Auge
- Author
- A. Dollfuss
- A. Kanellis
- A. Meesmann
- Alfred Vogt
- Christel Roggenbau
- Erich Regener
- Erwin BĂĽnning
- Felix Jendralski
- H. Davids
- H. Stubbe
- Hans Goldmann
- Hoffmann
- I. B. Panschin
- Jakob Schmidt
- Jercy Grzedzielski
- Karl Sommermeyer
- Max BĂĽcklers
- N. Magnus
- P. Jordan
- Paul Knapp
- Pätau Klaus
- Rauno Aulamo
- Robert Jäger
- S. Vries de
- Seidel
- Th. Förster
- W. Götsch
- W. Minder
- W. Rohrschneider
- Wolfgang Luther
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1948
- Field of study
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells
- Author
- Amir
- Andrew Flatley
- Asakura
- Aversa
- Aversa
- Bendle
- Bendle
- Berger
- Blazar
- Bruce R. Blazar
- Chakraverty
- Christoph Klein
- Ciceri
- Ciceri
- Cooke
- Cornberg
- Dario A. Vignali
- Elmar Jaeckel
- Friedman
- Gattinoni
- Ghosh
- Ghosh
- Haspot
- Heemskerk
- Heemskerk
- Heemskerk
- Holst
- Isogawa
- Jessica Herbst
- Joerg Fruehauf
- Johnson
- Karl Welte
- Keir
- Mapara
- Martin G. Sauer
- Martin Hapke
- Matthias Hardtke-Wolenski
- Matzinger
- Morgan
- Pannetier
- Peng
- Rosenberg
- Sha
- Sommermeyer
- Vago
- van Loenen
- Vintersten
- Viola
- Wolfgang Koestner
- Zhang
- Zhou
- Zhou
- Publication venue
- American Society of Hematology
- Publication date
- 01/01/2011
- Field of study
Adoptive transfer (AT) of T cells forced to express tumor-reactive T-cell receptor (TCR) genes is an attractive strategy to direct autologous T-cell immunity against tumor-associated antigens. However, clinical effectiveness has been hampered by limited in vivo persistence. We investigated whether the use of major histocompatibility complex–mismatched T cells would prolong the in vivo persistence of tumor-reactive TCR gene expressing T cells by continuous antigen-driven proliferation via the endogenous potentially alloreactive receptor. Donor-derived CD8+ T cells engineered to express a TCR against a leukemia-associated antigen mediated strong graft-versus-leukemia (GVL) effects with reduced graft-versus-host disease (GVHD) severity when given early after transplantation. AT later after transplantation resulted in a complete loss of GVL. Loss of function was associated with reduced expansion of TCR-transduced T cells as assessed by CDR3 spectratyping analysis and PD-1 up-regulation on T cells in leukemia-bearing recipients. PD-L1 blockade in allogeneic transplant recipients largely restored the GVL efficacy without triggering GVHD, whereas no significant antileukemia effects of PD-L1 blockade were observed in syngeneic controls. These data suggest a clinical approach in which the AT of gene-modified allogeneic T cells early after transplantation can provide a potent GVL effect without GVHD, whereas later AT is effective only with concurrent PD-L1 blockade
Radiosiderazione Della Ipofisi Nel Cancro Metastatizzato Della Mammella
- Author
- Badellino F.
- Baron D.M.
- Bauer K. H.
- Bauer K. H.
- Bauer K. H.
- Bauer K. H.
- Becker J.
- Dogliotti A. M.
- Dogliotti A. M.
- Dudley H. C.
- Eschr F.
- Evans J. P.
- Fergusson J. D.
- Forrest A. P. M.
- Forrest A. P. M.
- Freitag A. B.
- Gibson S.
- Graves G. Y.
- Greening W. P.
- Grumrich H.
- Harper P. V.
- Harper P. V.
- Huggins Ch
- Ironside W. M. S.
- Karl W.
- Kelly K. H.
- Kelly V. A.
- Kennedy T.
- Lacassagne A.
- Lacassagne A.
- Laurence J. H.
- Le Beau J.
- Luft R.
- Luft R.
- Margottini M.
- Markus B.
- Molinatti G. M.
- Perrault M.
- Rasmussen T.
- Riechert T.
- Riechert T.
- Ruffo A.
- Scheer K. E.
- Scheer K. E.
- Sommermeyer K.
- Tobias C A.
- Tobias C. A.
- Tobias C. A.
- Tochilin E.
- TroTT N. G.
- Weinbren M.
- Zanella E.
- Zanella E.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
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- Snider
- Sobering
- Sochor
- Sole
- Sommermeyer
- Sparney
- Spealman
- Sponer
- Staats
- Stabler
- Stabler
- Stacey
- Stacey
- Stair
- Stair
- Stanley
- Stanley
- Stanley
- Stanton
- Starr
- Starr
- Stebbing
- Stebbings
- Stebbings
- Stebbings
- Steiner
- Stewart
- Stewart
- Stewart
- Stewart
- Stoebner
- Stoebner
- Stoebner
- Storr
- Strand
- Strehlow
- Strutt
- Strutt
- Strutt
- Strutt
- Strutt
- Strutt
- Strutt
- Strutt
- Strutt
- Strutt
- Strutt
- Suhrmann
- Sullivan
- Sun
- Symons
- Takayanagi
- Takezawa
- Takezawa
- Talrose
- Tamaru
- Tamaru
- Tamaru
- Tanaka
- Tanaka
- Tanaka
- Tanaka
- Tanaka
- Tanaka
- Tanaka
- Tanaka
- Tanaka
- Tanaka
- Tawde
- Tawde
- Tawde
- Tawde
- Tawde
- Taylor
- Taylor
- Taylor
- Temkin
- Teter
- Teyssier
- Tholl
- Thomas
- Thompson
- Thompson
- Thorburn
- Thrush
- Thrush
- Thrush
- Tiede
- Tiede
- Tiede
- Tiede
- Tietz
- Tikhomirov
- Tilford
- Tilford
- Tozer
- Trapnell
- Trautz
- Treanor
- Trick
- Tsuchiya
- Tsukamoto
- Tsukamoto
- Turkdogan
- Turner
- Turner
- Turner
- Tyte
- Tyte
- Tyte
- Tyte
- Ufford
- Ultee
- Ultee
- Ultee
- Ung
- Unterwald
- Uri
- Utterback
- Utterback
- Utterback
- Utterback
- Utterback
- Vadlamudy
- Vainu Bappu
- Valentin
- van Angerer
- van der Ziel
- van Hardeveld
- van Oostrom
- Van Thiel
- Vance
- Vanderslice
- Vanderslice
- Vanderslice
- Vanderslice
- Varney
- Varney
- Varney
- Vegard
- Vegard
- Vegard
- Verdier
- Versteeg
- Versteeg
- Villermaux
- Villermaux
- Vladov
- Vlastaras
- von Engel
- von Mosengeil
- von Weyssenhoff
- Waber
- Wager
- Wagner
- Wahl
- Wahl
- Wall
- Wallace
- Wallace
- Walsh
- Walsh
- Walsh
- Walton
- Walton
- Warburg
- Ward
- Ward
- Warke
- Warneck
- Warneck
- Warneck
- Warren
- Watson
- Weill
- Weiner
- Weiner
- Weininger
- Weininger
- Weininger
- Weissler
- Welge
- Welge
- Wentink
- Wentink
- Wentink
- Westbury
- Westenberg
- White
- White
- Whitten
- Whitten
- Wiles
- Wiles
- Wilkinson
- Wilkinson
- Wilkinson
- Wilkinson
- Wilkinson
- Wilkinson
- Wilkinson
- Willey
- Willey
- Willey
- Willey
- Willey
- Willey
- Willey
- Willey
- Willey
- Wilson
- Wilson
- Wilson
- Winkler
- Winters
- Winters
- Winters
- Winters
- Witteman
- Wittkower
- Wobschall
- Wojtczak
- Wolf
- Wolf
- Woo
- Wood
- Worley
- Worley
- Worthing
- Woznick
- Wray
- Wray
- Wrede
- Wright
- Wright
- Wright
- Wright
- Wright
- Wright
- Wright
- Wulf
- Wurster
- Wurster
- Wyse
- Yano
- Yates
- Yates
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Yungman
- Yura
- Zabolotny
- Zabolotny
- Zabolotny
- Zabolotny
- Zabolotny
- Zare
- Zeeman
- Zelikoff
- Zelikoff
- Zinman
- Zinman
- Zipf
- Zipf
- Zipf
- Zipf
- öpik
- Čermák
- Čermák
- Čermák
- Čermäk
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1968
- Field of study