34 research outputs found
Rescuing Access to Patented Essential Medicines: Pharmaceutical Companies as Tortfeasors
- Author
- Publication venue
- Case Western Reserve University School of Law Scholarly Commons
- Publication date
- 01/01/2014
- Field of study
Get PDFPotential efficacy of mitochondrial genes for animal DNA barcoding: a case study using eutherian mammals
- Author
- A Luo
- A Richly
- A Rokas
- A Vialle
- AB Zhang
- AD Roe
- Aibing Zhang
- Arong Luo
- C Kuiken
- CBOL Plant Working Group
- Chaodong Zhu
- D Posada
- D Rubinoff
- D Rubinoff
- D Tautz
- DE Wildman
- DG Higgins
- DL Swofford
- GF Ficetola
- GF Shields
- H Song
- IJ Nijman
- J Felsenstein
- J Krause
- J Rozas
- J Waugh
- J Xu
- JC Gower
- JP Wares
- M Aliabadian
- M Hajibabaei
- M Kimura
- M Nei
- M Nei
- M Nei
- M Nei
- M Vences
- M Vences
- MC Ebach
- MJ Hickerson
- N Galtier
- ND Halbert
- O Folmer
- P Awadalla
- P Librado
- P Trontelj
- PD Hebert
- PD Hebert
- PD Hebert
- PD Hebert
- PD Hebert
- R Hanner
- R Levesque
- R Meier
- R Nichols
- R Zardoya
- RC Edgar
- RD Barrett
- RL Mueller
- RP Kelly
- RR da Fonseca
- S Cameron
- SF Altschul
- SF Altschul
- Simon YW Ho
- SL Talbot
- Stephen L Cameron
- TR Gregory
- V Nijman
- Weifeng Shi
- Weijun Xu
- WJ Kress
- WJ Murphy
- WP Maddison
- WS Moore
- XJ Min
- Yanzhou Zhang
- Z Abdo
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
Get PDF<p>Abstract</p> <p>Background</p> <p>A well-informed choice of genetic locus is central to the efficacy of DNA barcoding. Current DNA barcoding in animals involves the use of the 5' half of the mitochondrial cytochrome oxidase 1 gene (<it>CO1</it>) to diagnose and delimit species. However, there is no compelling <it>a priori </it>reason for the exclusive focus on this region, and it has been shown that it performs poorly for certain animal groups. To explore alternative mitochondrial barcoding regions, we compared the efficacy of the universal <it>CO1 </it>barcoding region with the other mitochondrial protein-coding genes in eutherian mammals. Four criteria were used for this comparison: the number of recovered species, sequence variability within and between species, resolution to taxonomic levels above that of species, and the degree of mutational saturation.</p> <p>Results</p> <p>Based on 1,179 mitochondrial genomes of eutherians, we found that the universal <it>CO1 </it>barcoding region is a good representative of mitochondrial genes as a whole because the high species-recovery rate (> 90%) was similar to that of other mitochondrial genes, and there were no significant differences in intra- or interspecific variability among genes. However, an overlap between intra- and interspecific variability was still problematic for all mitochondrial genes. Our results also demonstrated that any choice of mitochondrial gene for DNA barcoding failed to offer significant resolution at higher taxonomic levels.</p> <p>Conclusions</p> <p>We suggest that the <it>CO1 </it>barcoding region, the universal DNA barcode, is preferred among the mitochondrial protein-coding genes as a molecular diagnostic at least for eutherian species identification. Nevertheless, DNA barcoding with this marker may still be problematic for certain eutherian taxa and our approach can be used to test potential barcoding loci for such groups.</p
Experiences of Adults Abused as Children after Discharge from Inpatient Treatment: Informal Social Support and Self-Care Practices Related to Trauma Recovery
- Author
- Allen J.
- Banyard V.
- Bills L.
- Bloom S. L.
- Briere J.
- Buist A.
- Cameron G.
- Cosden M.
- Courtois C.
- Crouch J.
- Derogatis L.
- Ellason J.
- Falsetti S.
- Fetterman D.
- Gibson R.
- Herman J.
- Leenerts M.
- Leitenberg H.
- Lindy J.
- Litty C.
- Matthews J.
- McFarlane A.
- Muller R.
- Muller R.
- Ogata S.
- Palmer S.
- Pearlman L.
- Penk W.
- Procidano M.
- Resnick H.
- Ross-Gower J.
- Runtz M.
- Schaaf K.
- Stalker C.
- Strauss A.
- Walker L.
- Warren J.
- Widom C.
- Wright D. C.
- Publication venue
- 'Alliance for Children and Families'
- Publication date
- Field of study
Full text linkDimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Abdul Rasheed A.
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- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Rescuing Access to Patented Essential Medicines: Pharmaceutical Companies as Tortfeasors
- Author
- Publication venue
- Case Western Reserve University School of Law Scholarly Commons
- Publication date
- 01/01/2014
- Field of study
Get PDFThigh-length compression stockings and DVT after stroke
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Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Zinc regulation of transcriptional activity during retinoic acid-induced neuronal differentiation
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- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textStatistics and the theory of measurement - Discussion
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- 01/01/1996
- Field of study
No full textAn Exploratory Analysis on the Risk to be Offended on the Internet
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- A C Cameron
- A Tsohou
- Bm
- Bundeskriminalamt
- C Schneider
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- L Kaufman
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- Susanne Kirchner
- T Dimkov
- W H Greene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
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