11 research outputs found
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Jeje: repensando nações e transnacionalismo
- Author
- ABRAHAM R. C.
- AGUIRRE BELTRÁN Gonzalo
- AKINDÉLÉ A.
- AKINJOGBIN I.A.
- AKINSOWON Aki
- AMARAL Braz do
- ANDERSON Benedict
- ANDRADE LIMA Lamartine de
- APPADURAI Arjun
- APPADURAI Arjun
- ATKINS John
- BALLARD J. A.
- BARBOT Jean
- BASTIDE Roger
- BAUDIN Noel
- BORGHERO Francesco
- BOSMAN William
- BOUCHE Pierre
- BRANDON George
- BURTON Richard
- CABRERA Lydia
- CACCIATORE Olga Gudolle
- CAPO Hounkpati
- CARNEIRO DA CUNHA Manuela
- CARNEIRO DA CUNHA Marianno
- CARNEIRO Edison
- CLIFFORD James
- COSTA LIMA Vivaldo da
- COSTA LIMA Vivaldo da
- CURTIN Philip D
- D'ALBÉCA Alexandre L.
- DALZEL Archibald
- DES MARCHAIS Chevalier Étienne Renaud
- DESRIBES E
- DUNCAN John
- EADES J. S.
- ELBEIN DOS SANTOS Juana
- ELLIS A. B.
- ELLIS A. B.
- FORBES Frederick E.
- FREYRE Gilberto
- GLICK SCHILLER N.
- HANNERZ Ulf
- HARDWICKE C. Grafton
- HELG Aline
- HERSKOVITS Melville J.
- HERSKOVITS Melville J.
- HETHERSETT A. L.
- HOBSBAWM Eric
- HOLLOWAY Joseph E.
- J. Lorand Matory
- JOHNSON Rev. Samuel
- KAKÉ Ibrahima B.
- KITI Gabriel
- KUBIK Gerhard
- LABAT K.
- LABOURET Henri
- LANGLEY J. Ayodele
- LAOTAN A. B.
- LE HERISSÉ A
- LOMBARD Patrick
- MANNING Patrick
- MATORY J. Lorand
- MATTOSO Katia M. de Queiros
- MAUPOIL Bernard
- MCLEOD John
- MERCIER P.
- MÉTRAUX Alfred
- NORRIS Robert
- OGILBY John
- OLINTO Antonio
- OLINTO Antonio
- ORTIZ Fernando
- ORTIZ Fernando
- PEIXOTO Antonio da Costa
- PIRES Vicente Ferreira
- PLIYA Jean
- POLANYI Karl
- PRICE-MARS Jean
- QUÉNUM Maximilien
- RAMOS Arthur
- REIS João José
- REIS João José
- RENAUD Akindélé
- RODRIGUES Raymundo Nina
- RODRIGUES Raymundo Nina
- RUSSELL-WOOD A. J. R.
- SEGUROLA R. P. B.
- SMITH Guillaume
- SMITH William
- SNELGRAVE William
- SOMMER Doris
- TURNER Jerry Michael
- VAILLANT Janet G
- VERGER Pierre
- VERGER Pierre
- VERGER Pierre
- VERGER Pierre
- VERNEAU René
- WOOD J. Buckley
- WOOD Peter H.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Full text linkDimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
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- Byrne J.
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- Byrne-Watts V.
- Cale E.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
- Chambers L.
- Chan E.
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- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
- Cheung E.
- Cheyne C.
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- Chilvers A.
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- Chineka R.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
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- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
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- Clark R.
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- Clayton-Smith J.
- Cleaver C.
- Clemente de la Torre C.
- Clifford S.
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- Cocks S.
- Coe A.
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- Coker O.
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- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
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- Connelly K.
- Connolly G.
- Connor E.
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- Conteh V.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Cremona J.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
- Davidson N.
- Davies B.
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- Dawson A.
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- de Silva T.
- De Soyza A.
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- Dear J.
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- Desai A.
- Deshpande S.
- Dey P.
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- Dhani S.
- Dhasmana Devesh J.
- Dhillon R.
- Dicks P.
- Digby J.
- Dimitri P.
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- Dixon C.
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- Dobbie L.
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- Dolan D.
- Dolman M.
- Donald L.
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- Donohoe A.
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- Duggan A.
- Dummer S.
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- Dunleavy J.
- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
- Eades C.
- Early J.
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- Eddleston M.
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- Elgohary A.
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- Ellwood A.
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- Emberson Jonathan R.
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- Everden C.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
- Farooq H.
- Farrell B.
- Farzana S.
- Fatemi A.
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- Faust Saul N.
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- Fenton C.
- Ferenando G.
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- Ferguson V.
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- Fordham I.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Jamal A.
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- Jeebun V.
- Jeffery Katie
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- Johnstone D.
- Johnstone E.
- Jones A.
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- Judge P.
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- Kailey A.
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- Liu P.
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- Lloyd A.
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- Lo S.
- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Lockett T.
- Lodhia K.
- Lofthouse M.
- Logan M.
- Logue C. A.
- Lokanathan S.
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- Majumdar Jaydip
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- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
The Krüppel-like factor 2 and Krüppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis
- Author
- Publication venue
- VCU Scholars Compass
- Publication date
- 01/01/2013
- Field of study
Get PDFBackground Krüppel-like Factor 2 (KLF2) plays an important role in vessel maturation during embryonic development. In adult mice, KLF2 regulates expression of the tight junction protein occludin, which may allow KLF2 to maintain vascular integrity. Adult tamoxifen-inducible Krüppel-like Factor 4 (KLF4) knockout mice have thickened arterial intima following vascular injury. The role of KLF4, and the possible overlapping functions of KLF2 and KLF4, in the developing vasculature are not well-studied.
Results Endothelial breaks are observed in a major vessel, the primary head vein (PHV), in KLF2-/-KLF4-/- embryos at E9.5. KLF2-/-KLF4-/- embryos die by E10.5, which is earlier than either single knockout. Gross hemorrhaging of multiple vessels may be the cause of death. E9.5 KLF2-/-KLF4+/- embryos do not exhibit gross hemorrhaging, but cross-sections display disruptions of the endothelial cell layer of the PHV, and these embryos generally also die by E10.5. Electron micrographs confirm that there are gaps in the PHV endothelial layer in E9.5 KLF2-/-KLF4-/- embryos, and show that the endothelial cells are abnormally bulbous compared to KLF2-/- and wild-type (WT). The amount of endothelial Nitric Oxide Synthase (eNOS) mRNA, which encodes an endothelial regulator, is reduced by 10-fold in E9.5 KLF2-/-KLF4-/- compared to KLF2-/- and WT embryos. VEGFR2, an eNOS inducer, and occludin, a tight junction protein, gene expression are also reduced in E9.5 KLF2-/-KLF4-/- compared to KLF2-/- and WT embryos.
Conclusions This study begins to define the roles of KLF2 and KLF4 in the embryonic development of blood vessels. It indicates that the two genes interact to maintain an intact endothelial layer. KLF2 and KLF4 positively regulate the eNOS, VEGFR2 and occludin genes. Down-regulation of these genes in KLF2-/-KLF4-/- embryos may result in the observed loss of vascular integrity
Thigh-length compression stockings and DVT after stroke
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Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Recognition characters and new records of two species of Phylloscyrtini (Orthoptera, Gryllidae, Trigonidiinae) from southern Brazil
- Author
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Get PDFThe Phylloscyrtini occurs from eastern United States to Argentina and includes 21 valid species. It is a highly neglected group of crickets and little is known about its biology and distribution. Cranistus colliurides Stål, 1861 and Phylloscyrtus amoenus (Burmeister, 1880) were recorded for the state of Rio Grande do Sul, southern Brazil, and information on calling song, stridulatory file and recognition characters were provided
Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer
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- A Azmi
- A Cristancho
- B Dirat
- B Fowble
- Benjamin Wolfson
- C Tebbe
- C Théry
- E Spangenburg
- G Eades
- Gabriel Eades
- GD Leonard
- J Lee
- J Van den Boorn
- K Christoph
- K Denzer
- L Bochet
- L Delort
- L Tessitore
- M Barcellos-Hoff
- M Yang
- Nadire Duru
- P Iyengar
- Peixin Yang
- Q Li
- Q Li
- Q Li
- Qun Zhou
- Ramkishore Gernapudi
- RJ Simpson
- S Miyaki
- Sanchita Roy
- Y Wang
- Y Yao
- Y Yao
- Y Zhang
- Y Zhang
- Yongshu Zhang
- Yuan Yao
- Publication venue
- 'Springer Science and Business Media LLC'
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No full textMiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
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- A Acharya
- A Agoston
- A Barve
- A Dinkova-Kostova
- A Eulalio
- A Singh
- A Zimmerman
- B Malzkorn
- C Corcoran
- C Havens
- C Sangokoya
- CJ Harvey
- CJ Henderson
- F Gottardo
- G Rachakonda
- Gabriel Eades
- H Zhou
- J Kaspar
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- J Winter
- L Li
- M Furukawa
- M Girardot
- M Kobayashi
- M Kwak
- M Kwak
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- M Ramos-Gomez
- M Ramos-Gomez
- Muhua Yang
- N Rosenfeld
- N Wakabayashi
- PM Voorhoeve
- Qun Zhou
- S Nottrott
- S Yu
- S Yu
- SK Niture
- T Farazi
- T Hsieh
- T Kensler
- T Ohta
- W Fan
- W Filipowicz
- W Miao
- W Xu
- WR Fields
- X Wang
- Y Yao
- Yongshu Zhang
- Yuan Yao
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- 'Springer Science and Business Media LLC'
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No full textTracking past mining activity using trace metals, lead isotopes and compositional data analysis of a sediment core from Longemer Lake, Vosges Mountains, France
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- A Martínez Cortizas
- A-L Mariet
- AM Kreiser
- Anne-Lise Mariet
- Anne-Véronique Walter-Simonnet
- B Forel
- C Cloquet
- C Cloquet
- C Meyer
- C Pasquet
- C Yafa
- CA Cooke
- Carole Bégeot
- CF Boutron
- Christophe Cloquet
- D Muynck De
- Damien Rius
- F Monna
- F Monna
- F Monna
- F Monna
- F Thevenon
- F Vleeschouwer De
- F Vleeschouwer De
- Fabrice Monna
- Frédéric Gimbert
- G Faure
- G Manhès
- H Kempter
- HC Moor
- I Renberg
- I Renberg
- I Renberg
- J Aitchison
- J Aitchison
- J Aitchison
- JG Farmer
- JG Farmer
- JJ Meriläinen
- JO Nriagu
- KJR Rosman
- KR Gabriel
- Laurent Millet
- LJ Eades
- M Blaauw
- M Bäckström
- M Lahd Geagea
- M Roodbergen
- M-L Brännvall
- M-L Brännvall
- MF Thirlwall
- N Walraven
- P Filzmoser
- P Fluck
- PG Appleby
- PM Outridge
- R Bindler
- R Bindler
- S Aebischer
- S Belle
- S Hong
- Simon Belle
- T Mighall
- W Shotyk
- W Shotyk
- WM White
- X Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
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No full textAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Get PDFBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research
