18 research outputs found
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Al-Saadi Z.
- Al-Shahi Salman R.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
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- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chawla V.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
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- Church E.
- Cianci N.
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- Clark E.
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- Clifford S.
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- Coker O.
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- Collini Paul
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Fairbairn I.
- Fairclough A.
- Falconer E.
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- Fancois V.
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- Farzana S.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Clinical recommendations for defining platinum unsuitable head and neck cancer patient populations on chemoradiotherapy : a literature review
- Author
- Publication venue
- Publication date
- 01/01/2016
- Field of study
No full textSummaryToxicities resulting from platinum based chemotherapy in head and neck cancer is a cause for much concern. There is a lack of clinical criteria for defining these patient populations, which has posed serious problems associated with increased morbidity and consequently an adverse effect on patients’ quality of life. In addition, there is a lack of consensus on clinical criteria for defining such patient populations, who may be unsuitable for concurrent chemoradiotherapy. A group of experts in the field of head and neck cancer from the Asia Pacific Region convened in August 2014 in Korea to discuss the development of a set of clinical criteria in order to fill the knowledge gap and provide a reference tool for head and neck oncologists. This paper reports the final output from this meeting and the accompanying literature review, with the aim of aiding clinical decision making with the help of some clinical criteria to identify platinum unsuitable patient populations in head and neck cancer management. Some alternative treatment options are also discussed in this paper
Thigh-length compression stockings and DVT after stroke
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- Publication date
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- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Metastatic squamous cell carcinoma to the cervical lymph nodes from an unknown primary cancer : management in the HPV era
- Author
- Civantos Francisco J.
- Coca-Pelaz Andres
- Corry June
- de Bree Remco
- Ferlito Alfio
- Hartl Dana M.
- Hernandez-Prera Juan
- Hinni Michael
- Kowalski Luiz P.
- Langendijk Johannes A.
- Makitie Antti A.
- Mendenhall William
- Olsen Kerry
- Paleri Vinidh
- Piazza Cesare
- Rinaldo Alessandra
- Robbins K. Thomas
- Rodrigo Juan P.
- Sanabria Alvaro
- Shah Jatin P.
- Shaha Ashok R.
- Strojan Primoz
- Suarez Carlos
- Takes Robert P.
- Tong Ng Wai
- Vermorken Jan Baptist
- Publication venue
- Publication date
- 01/01/2020
- Field of study
No full textSocial Work at the Chinese Medicine System in Hong Kong
- Author
- Abramson J. S.
- Abramson J. S.
- Bruner C.
- Chiu H. F.
- Cowles L.
- Cowles L.
- Hong Kong Baptist University
- Hong Kong Chief Executive
- Ka-Ying Ng
- Kai-Fong Chan
- Lau J. T. F.
- Lee R. P. L.
- Leung P. W. L.
- Lister L.
- Liu Y.
- McCaffrey R.
- Schnyer R. N.
- Siu-Ping Lee
- Wang X. D.
- Wong T. W.
- Woodham A.
- Yan Shi
- Yat-Nam Ng
- Yip K. S.
- Zhang B. H.
- Zhang L.
- Zhao-Xiang Bian
- Publication venue
- 'The Haworth Press'
- Publication date
- Field of study
No full textDevelopment of a Health Empowerment Programme to improve the health of working poor families: protocol for a prospective cohort study in Hong Kong
- Author
- Anderson
- Anderson
- Avery
- Axelrod
- Barry
- Baum
- Birch
- Brooks-Gunn
- Chan
- Cheng
- Choi
- Craig
- Deng
- Duncan
- Farmer
- Fine
- Fong
- Friedewald
- Fung
- Funnell
- Goodman
- Hirschberg
- Hodkinson
- Hong Kong Baptist University
- Howie
- Huang
- Ip
- Ip
- Jaeschke
- Katz
- Kroenke
- Lai
- Lam
- Lam
- Lam
- Lam
- Landgraf
- Lazarus
- Lovibond SH
- Ng
- Nutbeam
- Podsiadlo
- Schwarzer
- Steinhardt
- Sturm
- Swann
- Tiwari
- Wagstaff
- Wallerstein
- Wang
- Wechsler
- WHO
- World Health Organization
- Yoshikawa
- Yu
- Zhang
- Publication venue
- 'BMJ'
- Publication date
- Field of study
No full textEffects of coconut product–caffeine interactions on liver cells in Wistar albino rats
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textUptake and correlates of cervical cancer screening among HIV-infected women attending HIV care in Uganda
- Author
- Bansil P
- Bazargan M
- Bukirwa A
- Campos NG
- Coghill AE
- De Vuyst H
- Dickson Kasozi
- Finocchario-Kessler S
- Fred Makumbi
- Hopwood P
- Huchko MJ
- Jim Arinaitwe
- John Baptist Bwanika
- Jolly Beyeza-Kashesya
- Joseph K. B. Matovu
- Justine Bukenya
- Kumakech E
- Msyamboza KP
- Mugisha E
- Mwaka AD
- Mwaka AD
- Ndejjo R
- Ngabo F
- Ogilvie GS
- Paul P
- Rhoda K. Wanyenze
- Shaban Mugerwa
- Tathiah N
- Thunga S
- Tilburt JC
- Tominski D
- Turiho AK
- Violet Gwokyalya
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textVaricella-Zoster Virus Fc Receptor Component gI Is Phosphorylated on Its Endodomain by a Cyclin-Dependent Kinase
- Author
- Alconada A.
- Assouline J. G.
- Banham A.
- Baptist M.
- Bosc D. G.
- Davison A. J.
- De Azevedo W. F.
- Fuerst F. R.
- Grana X.
- Grana X.
- Guan K.
- Hall F. L.
- Kimura H.
- Kozak M.
- Lew J.
- Lin S.
- Litchfield D. W.
- Litchfield D. W.
- Litchfield D. W.
- Marshall N. F.
- Marshall N. F.
- McGeoch D. J.
- Meijer L.
- Meyerson M.
- Moreno S.
- Moss B.
- Nagasawa M.
- Nasmyth K.
- Ng T. I.
- Nigg E. A.
- Pear W. S.
- Peng J.
- Phelps D. E.
- Pines J.
- Reynisdottir I.
- Sherr C. J.
- Traugh J.
- Yao Z.
- Zhu Y.
- Publication venue
- American Society for Microbiology
- Publication date
- 01/01/1999
- Field of study
Get PDFVaricella-zoster virus (VZV) glycoprotein gI is a type 1 transmembrane glycoprotein which is one component of the heterodimeric gE:gI Fc receptor complex. Like VZV gE, VZV gI was phosphorylated in both VZV-infected cells and gI-transfected cells. Preliminary studies demonstrated that a serine 343-proline 344 sequence located within the gI cytoplasmic tail was the most likely phosphorylation site. To determine which protein kinase catalyzed the gI phosphorylation event, we constructed a fusion protein, consisting of glutathione-S-transferase (GST) and the gI cytoplasmic tail, called GST-gI-wt. When this fusion protein was used as a substrate for gI phosphorylation in vitro, the results demonstrated that GST-gI-wt fusion protein was phosphorylated by a representative cyclin-dependent kinase (CDK) called P-TEFb, a homologue of CDK1 (cdc2). When serine 343 within the serine-proline phosphorylation site was replaced with an alanine residue, the level of phosphorylation of the gI fusion protein was greatly reduced. Subsequent experiments with individually immunoprecipitated mammalian CDKs revealed that the VZV gI fusion protein was phosphorylated best by CDK1, to a lesser degree by CDK2, and not at all by CDK6. Transient-transfection assays carried out in the presence of the specific CDK inhibitor roscovitine strongly supported the prior results by demonstrating a marked decrease in gI phosphorylation while gI protein expression was unaffected. Finally, the possibility that VZV gI contained a CDK phosphorylation site in its endodomain was of further interest because its partner, gE, contains a casein kinase II phosphorylation site in its endodomain; prior studies have established that CDK1 can phosphorylate casein kinase II
