59 research outputs found
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Al-Saadi Z.
- Al-Shahi Salman R.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
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- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chawla V.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
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- Church E.
- Cianci N.
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- Clark E.
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- Clifford S.
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- Coker O.
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- Collini Paul
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Fairbairn I.
- Fairclough A.
- Falconer E.
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- Fancois V.
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- Farzana S.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
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- Sanchez V.
- Sandercock Peter
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- Santosh R.
- Sarfatti A.
- Sarkar R.
- Sarwar Z.
- Sathyanarayanan L.
- Saunderson A.
- Scaletta D.
- Scanlon D.
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- Schadenberg A.
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- Schofield E.
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- Sharp L.
- Sharratt P.
- Shaw D.
- Shaw J.
- Shawcross A.
- Shea D. O.
- Sheffield J.
- Shehata Z.
- Shenton J.
- Shepherd A.
- Shepherd K.
- Shepherd L.
- Sheppeard R.
- Sheridan H.
- Sheridan R.
- Sherwin S.
- Shibly S.
- Shiham F.
- Shilladay C.
- Shillitoe B.
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- Siamia L.
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Estimation of Corynebacterium diphtheriae antitoxin in human sera: A comparison of an enzyme-linked immunosorbent assay with the toxin neutralisation test
- Publication venue
- 'Microbiology Society'
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- Field of study
No full textDavid II and the Government of Fourteenth-Century Scotland
- Publication venue
- 'JSTOR'
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No full textThe Lords of the Articles before 1540: A Reassessment
- Publication venue
- 'Edinburgh University Press'
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No full textUnwillingness and Imagination in Frederick Douglass's The Heroic Slave
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- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/2019
- Field of study
No full textOfficial Histories of Parliament and the Nature of the Union of 1707: A Forgotten Episode in Anglo-Scottish Academic Relations
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- Publication venue
- 'Edinburgh University Press'
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No full textSome Aspects of the Role of Games, Sports, and Recreational Activities in the Culture of Modern Primitive Peoples
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- Publication venue
- 'Informa UK Limited'
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- Field of study
No full textThigh-length compression stockings and DVT after stroke
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- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Making a cast-iron case: accountants and the Carron lawsuits of the 1850s and 1860s
- Author
- A. Iain Fleming
- Balfour-Melville B.
- Birch A.
- Brown R.
- Campbell R.H.
- Carr-Saunders A.M.
- Clark F.W.
- Dickens C.
- Dubois A.B.
- Edwards J.R.
- Habgood W.
- Hamilton H.
- House of Lords Library London, (HOL)
- Howitt H. Sir
- Jones E.
- Kedslie M.J.M.
- Kirsten Wallace
- Lee T.A.
- Manchester A.H.
- McCartney S.
- Parker R.H.
- Parker R.H.
- Power M.
- Sam McKinstry
- Scamell E.H.
- Stewart J.C.
- Walker S.P.
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/2002
- Field of study
No full textThe study which follows sheds light on a little-researched area of accounting history: the court work of accountants in the nineteenth century. It takes as its focus a major series of cases enacted over the 1850s and 1860s in both the English and Scottish courts and concerning the world famous Carron Company of Falkirk, Scotland, ironfounders. Prominent Scots and English accountants were employed to investigate the affairs of the company over a long period of time, providing evidence for various lawsuits involving questions of fraud, the falsification of accounts and the purchase of shares by the company at an undervalue. The paper highlights the standing of the main accountants involved, Henry Chatteris and William Quilter, and details the work they did, setting it in the context of Scots and English court procedures. It draws attention to the fact that such work could account for a substantial share of an accountancy practice’s income, as earlier studies have suggested, and further destabilises the still persistent notion that modern accountancy was founded on bankruptcy and audit work alone
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