39 research outputs found
Socio-economic status and menarcheal age in urban african schoolgirls in the western cape, South Africa
- Publication venue
- University of Stellenbosch Business School
- Publication date
- 01/01/2008
- Field of study
The impact of different socio-economic levels, height, weight and sum of four skinfolds on the menarcheal age of 302 Black, South African school girls ranging in age from 8 to 17 years was researched. Socioeconomic status was obtained by means of a questionnaire that focused on the education, income, and occupations of the parents of the participants and the accommodation in which they were reared. Menarcheal age was obtained by means of a questionnaire. When restricted to those girls who had reached menarche, the mean age was found to be 14.34 years (SD=0.93). The application of survival analysis revealed an estimated median age of 14.25 years with a 95% confidence interval estimate of 14.08 and 14.58. Based on the log-rank statistic, significant differences were found in the survival curves of the different SES categories (p=0.0098). It was found that lower SES corresponded to curves having longer survival times, i.e. later ages of menarche. Differences were found in weight (p=0.037) and in height (p=0.0042), but no difference in SUM4 (p=0.44), between girls who have reached menarche and those who have not.DHE
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
- Abdul Manap H.
- Abdul Rahim A. A.
- Abdulkader F.
- Abdulla A. H. K.
- AbdulWahab M. Z.
- Abduvalieva V.
- Abele S.
- Aboyans V.
- Abreu P. E.
- Adam-Blanpain M.
- Adamaszek K.
- Adamczyk-Kot D.
- Adamkiewicz-Piejko A.
- Adda M.
- Aftab A.
- Agrawal A.
- Aguiar C.
- Ahuad Guerrero A.
- Ahuja R.
- Ai F.
- Aimouch N.
- Aiyegbayo O.
- Ajani A.
- Akbar M.
- Aksyutina N.
- Al Dhanki M.
- Al Ghool S.
- Al Kandari F.
- Al Lawati A.
- Al Mahmeed W.
- Al Radaideh G.
- Al Rashdan I.
- Al Sousi A.
- Al Suwaidi J.
- Al Tamimi F.
- Al Wahshi Y.
- Al Yazeedi J.
- Al Zaibag M.
- Al-Baker H.
- Al-Faleh H.
- Al-Hersi A.
- Al-Khalidi B.
- Al-Shamiri M.
- Al-Zaibag M.
- Alam A.
- Alanazy M.
- Alanbaei M.
- Albero Martinez V.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
- Andrews L
- Andrews R
- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
- Archer A
- Armitage J
- Armstrong L
- Armstrong M
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- Arnold M
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- Arp H
- Asbill B
- Ashbrook-raby C
- Ashton L
- Assarsson E
- Audet K
- Augenbraun C
- Aung HNIN THANDA
- Auscher S
- Ausner J
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- Awasty V
- Axelsson U
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- Baghiana S
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- Bai J
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- Baker S
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Recurrent, life-threatening atrioventricular dissociation associated with toxoplasma myocarditis.
- Publication venue
- 'BMJ'
- Publication date
- Field of study
Mechanisms of impaired excretion of a fluid load after cardiac denervation in dogs
- Author
- Publication venue
- 'American Physiological Society'
- Publication date
- Field of study
Thigh-length compression stockings and DVT after stroke
- Author
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Treatment of milrinone — associated tachycardia with ß-blockers
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Coarctation of the aorta life and health 20-44 years after surgical repair.
- Author
- Publication venue
- 'BMJ'
- Publication date
- Field of study
Pacemaker syndrome: an iatrogenic condition
- Author
- AJ De Bold
- Alicandri C.
- Amikam S.
- Ausubel K.
- Barold S.S.
- Bathen J.
- C. M Travill
- Carswell F.
- Cunningham T.M.
- Edis A.J.
- Erbel R.
- Erlebacher J.A.
- Fitzpatrick A.P.
- Floro J.
- Johnson A.D.
- K Den Dulk
- Klementowicz P.
- Kruse I.
- Levine P.A.
- Liebert H.P.
- MIH El Gamal
- Mitsui T.
- Naito M.
- Noll B.
- Perrins E.J.
- Preston T.A.
- R. Sutton
- Ryden L.
- Stangl K.
- Stewart W.J.
- Sutton R.
- Torresani J.
- Travill C.M.
- Vardas P.E.
- Werres R.
- Wish M.
- Wish M.
- Witte J.
- Publication venue
- 'BMJ'
- Publication date
- Field of study