Nuevas ocurrencias y descripción del hábitat de la rana endémica del sur de Ecuador Atelopus exiguus (Anura: Bufonidae) en un punto crítico de conservación en los altos Andes

Atelopus species are classified as a priority taxon for monitoring and conservation, of these A. exiguus is endemic to southern Ecuador and is classified as critically endangered, however, within its known geographic range, little attention has been given to identifying new localities particularly across the páramo ecosystem (> 3500 m a.s.l.). Therefore, in the páramo landscape of Macizo del Cajas Biosphere Reserve, a conservation hotspot, we intensively searched for A. exiguus across 15 localities (elevation range: 3550 – 3800 m a.s.l.). In one year of monitoring (2020 – 2021), we recorded four individuals of A. exiguus (two were tadpoles) in two localities. The localities are characterized by a higher proportion of páramo grassland in association with shrubby páramo as well as cushion páramo; this riparian habitat is related to relatively good water quality (according to Andean Biotic Index), relatively low water temperatures and relatively low water flow. Our findings, accompanied by a detailed monitoring protocol, suggest habitat requirements for A. exiguus. Further intensive surveys beyond the limits of protected areas of Azuay province, especially across the páramos, is emerging as an urgent step to improve conservation decisions.Las especies del género Atelopus están clasificadas como un taxón prioritario para su monitoreo y conservación, de ellas A. exiguus es endémica del sur de Ecuador y está clasificada como en peligro crítico de extinción. Sin embargo, dentro de su área de distribución geográfica conocida, poca atención se ha prestado en identificar nuevas localidades, especialmente en el ecosistema del páramo (> 3500 m de altitud). Por lo tanto, en el paisaje de páramo de la Reserva de la Biosfera Macizo del Cajas, un punto caliente de conservación, buscamos intensamente la especie en 15 localidades (rango de elevación: 3550 – 3800 m de altitud). En un año de monitoreo (2020 – 2021), registramos cuatro individuos de A. exiguus (dos fueron renacuajos) en dos localidades. Las localidades se caracterizan por una mayor proporción de pastizales de páramo en asociación con páramo arbustivo, así como páramo de almohadilla; este hábitat ribereño está relacionado con una calidad de agua relativamente buena (según el Índice Biótico Andino), temperaturas de agua relativamente bajas, así como un flujo de agua relativamente bajo. Nuestros hallazgos, acompañados de un protocolo de monitoreo detallado, sugieren los requerimientos de hábitat para A. exiguus. La realización de más estudios intensivos más allá de los límites de las áreas protegidas de la provincia de Azuay, especialmente a través de los páramos, se considera como urgente para mejorar las decisiones de conservación

Primeros reportes de Myotis riparius (Chiroptera: Vespertilionidae) en los altos Andes del sur del Ecuador

The Vespertilionidae family is widely distributed in South America. In Ecuador, there are 20 species including Myotis riparius. The species has been recorded between 10 to 1240 m a.s.l. on the both eastern and western sides of the Andes cordillera. In this work we reported two new localities for southern Ecuador which include the highest records for the species and increasing in 1077 m the limit elevation previously known in Ecuador.La familia Vespertilionidae está ampliamente distribuida en América del Sur. En Ecuador habitan 20 especies incluyendo a Myotis riparius. Esta especie ha sido registrada entre 10 y 1240 metros de elevación en las estribaciones de la cordillera de los Andes. En este trabajo reportamos dos nuevas localidades para el sur del Ecuador las cuales incluyen los registros de mayor elevación para la especie e incrementan 1077 metros el límite altitudinal conocido en Ecuador

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Using surrogate species and MaxEnt modeling to prioritize areas for conservation of a páramo bird community in a tropical high Andean biosphere reserve

ABSTRACTThe páramo grassland ecosystem in the high Andes requires definition of spatially explicit and large-scale priorities for bird conservation, especially for lands outside of protected areas. Using surrogate species such as habitat specialists (e.g., páramo specialists), endemic species, or threatened species to identify potential habitat can support conservation decisions. We used MaxEnt to generate habitat suitability models for eighteen surrogate bird species in a high Andean biosphere reserve, the Macizo del Cajas (MCB). The areas of estimated suitable habitat range from 115,500 to 312,700 ha; the proportion predicted inside the national system of protected areas of MCB ranged from 12 to 29 percent. The consolidated map (i.e., the coincidence of predicted pixels for all eighteen surrogate bird species) predicted an area of 94,800 ha, with 70 percent outside the national system of protected areas. The models reveal that there are large suitable areas of MCB potentially occupied by these species outside of protected areas, especially along the eastern flank of the study area. MaxEnt models as a proxy facilitate the recognition of locations of possible habitat suitability for páramo-specialized birds and therefore identify areas of the MCB outside of the protected areas that should be considered for more formal protection

Southernmost records of Hyalinobatrachium fleischmanni (Anura: Centrolenidae)

We present new records for Fleischmann’s Glassfrog, Hyalinobatrachium fleischmanni (Boettger, 1893), which extend the distribution of this species into central and southwestern Ecuador and thus represent the southernmost known localities. These new reports are based on specimens collected at Cerro de Hayas, province of Guayas, and Macul, province of Los Ríos. These new localities extend the known geographic range of H. fleischmanni by approximately 250 km south of previous known occurrences

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease