89 research outputs found
CLU blocks HDACI-mediated killing of neuroblastoma
- Author
- Anthony W. Opipari
- C Subramanian
- C Subramanian
- Chitra Subramanian
- CR Yang
- DE Jenne
- DE Jenne
- F Rizzi
- H Miyake
- H Miyake
- H Shimada
- H Shimada
- H Zhang
- HV Silva de
- IP Trougakos
- JA Sensibar
- Jason A. Jarzembowski
- K Shedden
- KN Chi
- KS Leskov
- L Kirszbaum
- M Sawada
- O Blaschuk
- O Chayka
- RA Ross
- RA Ross
- Roland P. S. Kwok
- Rork Kuick
- S Pucci
- Sonja M. Halsey
- SR Sylvester
- T Zellweger
- TJ Giordano
- V Cappelletti
- Valerie P. Castle
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2010
- Field of study
Clusterin is a ubiquitously expressed glycoprotein with multiple binding partners including IL-6, Ku70, and Bax. Clusterin blocks apoptosis by binding to activated Bax and sequestering it in the cytoplasm, thereby preventing Bax from entering mitochondria, releasing cytochrome c, and triggering apoptosis. Because increased clusterin expression correlates with aggressive behavior in tumors, clusterin inhibition might be beneficial in cancer treatment. Our recent findings indicated that, in neuroblastoma cells, cytoplasmic Bax also binds to Ku70; when Ku70 is acetylated, Bax is released and can initiate cell death. Therefore, increasing Ku70 acetylation, such as by using histone deacetylase inhibitors, may be therapeutically useful in promoting cell death in neuroblastoma tumors. Since clusterin, Bax, and Ku70 form a complex, it seemed likely that clusterin would mediate its anti-apoptotic effects by inhibiting Ku70 acetylation and blocking Bax release. Our results, however, demonstrate that while clusterin level does indeed determine the sensitivity of neuroblastoma cells to histone deacetylase inhibitor-induced cell death, it does so without affecting histone deacetylase-inhibitor-induced Ku70 acetylation. Our results suggest that in neuroblastoma, clusterin exerts its anti-apoptotic effects downstream of Ku70 acetylation, likely by directly blocking Bax activation
Lineage-Specific Restraint of Pituitary Gonadotroph Cell Adenoma Growth
- Author
- A Fernandez
- A Thomas-Tikhonenko
- Alfredo Fusco
- Anat Ben-Shlomo
- AP Heaney
- Bernd Scheithauer
- BS Ellsworth
- BW Scheithauer
- C Michaloglou
- C Nerlov
- Cuiqi Zhou
- DE Jenne
- DL Kleinberg
- DP Ramji
- ET Alarid
- F Panico
- F Rizzi
- F Rizzi
- F Salehi
- G Vlotides
- H Zou
- HJ Kim
- I Donangelo
- IP Trougakos
- JA Bernal
- JA Janovick
- JS Nam
- K Kovacs
- Kalman Kovacs
- KC Shen
- KN Chi
- Kolja Wawrowsky
- L Flanagan
- L Kirszbaum
- L Pei
- LM Wakefield
- M Braig
- M Collado
- M Collado
- M Cuadrado
- M Filippella
- M Narita
- M Serrano
- M Serrano
- M Thangaraju
- N Egashira
- N Sivamurthy
- NA Ciccone
- NE Sharpless
- O Chayka
- OA Sedelnikova
- RA Abbud
- S Bettuzzi
- S Bettuzzi
- S Gery
- S Melmed
- Shlomo Melmed
- SJ Frost
- SM Swanson
- Svetlana Zonis
- T Chen
- T Criswell
- T Kuilman
- T Kuilman
- TY Chou
- V Chesnokova
- V Chesnokova
- V Goffin
- Vera Chesnokova
- X Zhang
- YH Hsu
- Yoel Toledano
- Yunguang Tong
- Z Cao
- Z Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Although pituitary adenomas are usually benign, unique trophic mechanisms restraining cell proliferation are unclear. As GH-secreting adenomas are associated with p53/p21-dependent senescence, we tested mechanisms constraining non-functioning pituitary adenoma growth. Thirty six gonadotroph-derived non-functioning pituitary adenomas all exhibited DNA damage, but undetectable p21 expression. However, these adenomas all expressed p16, and >90% abundantly expressed cytoplasmic clusterin associated with induction of the Cdk inhibitor p15 in 70% of gonadotroph and in 26% of somatotroph lineage adenomas (p = 0.006). Murine LβT2 and αT3 gonadotroph pituitary cells, and αGSU.PTTG transgenic mice with targeted gonadotroph cell adenomas also abundantly expressed clusterin and exhibited features of oncogene-induced senescence as evidenced by C/EBPβ and C/EBPδ induction. In turn, C/EBPs activated the clusterin promoter ∼5 fold, and elevated clusterin subsequently elicited p15 and p16 expression, acting to arrest murine gonadotroph cell proliferation. In contrast, specific clusterin suppression by RNAis enhanced gonadotroph proliferation. FOXL2, a tissue-specific gonadotroph lineage factor, also induced the clusterin promoter ∼3 fold in αT3 pituitary cells. As nine of 12 pituitary carcinomas were devoid of clusterin expression, this protein may limit proliferation of benign adenomatous pituitary cells. These results point to lineage-specific pathways restricting uncontrolled murine and human pituitary gonadotroph adenoma cell growth
Epigenetic Transcriptional Regulation of the Growth Arrest-Specific gene 1 (Gas1) in Hepatic Cell Proliferation at Mononucleosomal Resolution
- Author
- A Evdokiou
- A Evdokiou
- A Gimelbrant
- A Lennartsson
- A Lennartsson
- A Zamorano
- A Zamorano
- AL Gartel
- Antonio Espert
- B Li
- B Mellstrom
- BJ Venters
- BJ Venters
- BR Cairns
- C Jiang
- C Jiang
- C Schneider
- CL Peterson
- CR Vakoc
- CR Vakoc
- DE Schones
- DE Schones
- E Segal
- E Segal
- Esteban Ballestar
- F Rizzi
- FL Kuanga
- G Del Sal
- G Del Sal
- G Dominguez-Monzon
- Gerardo López-Rodas
- GK Michalopoulos
- GK Michalopoulos
- GM Higgins
- I Wierstra
- J Sandoval
- J Sandoval
- JA Benitez
- JK Kim
- JK Wiencke
- JL Rodriguez
- JL Rodriguez
- JL Thorne
- Josefa Castillo
- K Nimura
- KK Lee
- L Zhao
- Luis Franco
- M Grossi
- N Fausto
- N Fausto
- N Fausto
- N Kaplan
- N Mosammaparast
- Natalia Sacilotto
- P Chi
- R de Martin
- Riddle
- S Gobeil
- S Kurinna
- T Kouzarides
- TC Lee
- TN Mavrich
- TN Mavrich
- VM Weake
- Z Wang
- Publication venue
- Public Library of Science
- Publication date
- 09/08/2011
- Field of study
BACKGROUND: Gas1 (growth arrest-specific 1) gene is known to inhibit cell proliferation in a variety of models, but its possible implication in regulating quiescence in adult tissues has not been examined to date. The knowledge of how Gas1 is regulated in quiescence may contribute to understand the deregulation occurring in neoplastic diseases. METHODOLOGY/PRINCIPAL FINDINGS: Gas1 expression has been studied in quiescent murine liver and during the naturally synchronized cell proliferation after partial hepatectomy. Chromatin immunoprecipitation at nucleosomal resolution (Nuc-ChIP) has been used to carry out the study preserving the in vivo conditions. Transcription has been assessed at real time by quantifying the presence of RNA polymerase II in coding regions (RNApol-ChIP). It has been found that Gas1 is expressed not only in quiescent liver but also at the cell cycle G(1)/S transition. The latter expression peak had not been previously reported. Two nucleosomes, flanking a nucleosome-free region, are positioned close to the transcription start site. Both nucleosomes slide in going from the active to the inactive state and vice versa. Nuc-ChIP analysis of the acquisition of histone epigenetic marks show distinctive features in both active states: H3K9ac and H3K4me2 are characteristic of transcription in G(0) and H4R3me2 in G(1)/S transition. Sequential-ChIP analysis revealed that the "repressing" mark H3K9me2 colocalize with several "activating" marks at nucleosome N-1 when Gas1 is actively transcribed suggesting a greater plasticity of epigenetic marks than proposed until now. The recruitment of chromatin-remodeling or modifying complexes also displayed distinct characteristics in quiescence and the G(1)/S transition. CONCLUSIONS/SIGNIFICANCE: The finding that Gas1 is transcribed at the G(1)/S transition suggests that the gene may exert a novel function during cell proliferation. Transcription of this gene is modulated by specific "activating" and "repressing" epigenetic marks, and by chromatin remodeling and histone modifying complexes recruitment, at specific nucleosomes in Gas1 promoter
Density functional theory based screening of ternary alkali-transition metal borohydrides: A computational material design project
- Author
- Adamska L.
- Ande C.K.
- Andersin J.
- Baran J.D.
- Barmparis G.D.
- Bell F.
- Benzanilla A.L.
- Bjork J,
- Björketun Mårten
- Bleken F.
- Bligaard Thomas
- Bork Nicolai Christian
- Buchter F.
- Burton P.D.
- Buus Bjarke Brink
- Bürkle M.
- Calborean A.
- Calle Vallejo Federico
- Casolo S.
- Chandler B.
- Chi D.H.
- Czekaj I.
- Datta S.
- Datye A.
- DeLaRiva A.
- Despoja V.
- Dobrin Sergey
- Dulak Marcin
- Engelund Mads
- Ferrighi L
- Frondelius P.
- Fu Q.
- Fuentes A.
- Fürst Joachim Alexander
- Garcia-Fuente A.
- Gavnholt Jeppe
- Goeke R.
- Gudmundsdottir S.
- Hammond K.D.
- Hansen Heine Anton
- Hibbitts D.
- Howalt Jakob Geelmuyden
- Hruby S. L.
- Hummelshøj Jens Strabo
- Huth A.
- Isaeva L.
- Jacobsen Karsten Wedel
- Jelic J.
- Jensen I.J.T.
- Jensen Mogens O Stibius
- Jiang Tao
- Junior E.H.
- Kacprzak K.A.
- Kelkkanen Kari André
- Kelsey D.
- Kesanakurthi D.S.
- Kleis Jesper
- Klüpfel P.J.
- Konstantinov I.
- Korytar R.
- Koskinen P.
- Kunkes E.
- Landis David
- Larsen Ask Hjorth
- Lastra J.M.G.
- Lin H.
- Lopez-Acevedo O.
- Mantega M.
- Martinez Jose Ignacio
- Mesa I.N.
- Mortensen Jens Jørgen
- Mowbray Duncan
- Mýrdal J.S.G.
- Natanzon Y.
- Nistor A.
- Nørskov Jens Kehlet
- Olsen Thomas
- Park H.
- Pedersen Jess Wellendorff
- Pedroza L.S.
- Petzold Vivien Gabriele
- Plaisance C.
- Rasmussen J.A.
- Ren H.
- Rizzi M.
- Ronco A.S.
- Rossmeisl Jan
- Rostgaard Carsten
- Saadi Souheil
- Salguero L.A.
- Santos E.J.G.
- Schoenhalz A.L.
- Shen Juan
- Smedemand M.
- Stausholm-Møller O.J.
- Strange Mikkel
- Su H.B.
- Tekin Adem
- Temel B.
- Thygesen Kristian Sommer
- Toftelund Anja
- Tripkovic Vladimir
- Vanin Marco
- Vegge Tejs
- Viswanathan V.
- Vojvodic Aleksandra
- Voss Johannes
- Wang Shengguang
- Publication venue
- 'AIP Publishing'
- Publication date
- 01/01/2009
- Field of study
The dissociation of molecules, even the most simple hydrogen molecule, cannot be described accurately within density functional theory because none of the currently available functionals accounts for strong on-site correlation. This problem led to a discussion of properties that the local Kohn-Sham potential has to satisfy in order to correctly describe strongly correlated systems. We derive an analytic expression for the nontrivial form of the Kohn-Sham potential in between the two fragments for the dissociation of a single bond. We show that the numerical calculations for a one-dimensional two-electron model system indeed approach and reach this limit. It is shown that the functional form of the potential is universal, i.e., independent of the details of the two fragments.We acknowledge funding by the Spanish MEC (Grant No. FIS2007-65702-C02-01), “Grupos Consolidados UPV/EHU del Gobierno Vasco” (Grant No. IT-319-07), and the European Community through e-I3 ETSF project (Grant Agreement No. 211956).Peer reviewe
Density functional theory based screening of ternary alkali-transition metal borohydrides: A computational material design project
- Author
- Adamska L.
- Ande C.K.
- Andersin J.
- Baran J.D.
- Barmparis G.D.
- Bell F.
- Benzanilla A.L.
- Bjork J,
- Björketun Mårten
- Bleken F.
- Bligaard Thomas
- Bork Nicolai Christian
- Buchter F.
- Burton P.D.
- Buus Bjarke Brink
- Bürkle M.
- Calborean A.
- Calle Vallejo Federico
- Casolo S.
- Chandler B.
- Chi D.H.
- Czekaj I.
- Datta S.
- Datye A.
- DeLaRiva A.
- Despoja V.
- Dobrin Sergey
- Dulak Marcin
- Engelund Mads
- Ferrighi L
- Frondelius P.
- Fu Q.
- Fuentes A.
- Fürst Joachim Alexander
- Garcia-Fuente A.
- Gavnholt Jeppe
- Goeke R.
- Gudmundsdottir S.
- Hammond K.D.
- Hansen Heine Anton
- Hibbitts D.
- Howalt Jakob Geelmuyden
- Hruby S. L.
- Hummelshøj Jens Strabo
- Huth A.
- Isaeva L.
- Jacobsen Karsten Wedel
- Jelic J.
- Jensen I.J.T.
- Jensen Mogens O Stibius
- Jiang Tao
- Junior E.H.
- Kacprzak K.A.
- Kelkkanen Kari André
- Kelsey D.
- Kesanakurthi D.S.
- Kleis Jesper
- Klüpfel P.J.
- Konstantinov I.
- Korytar R.
- Koskinen P.
- Kunkes E.
- Landis David
- Larsen Ask Hjorth
- Lastra J.M.G.
- Lin H.
- Lopez-Acevedo O.
- Mantega M.
- Martinez Jose Ignacio
- Mesa I.N.
- Mortensen Jens Jørgen
- Mowbray Duncan
- Mýrdal J.S.G.
- Natanzon Y.
- Nistor A.
- Nørskov Jens Kehlet
- Olsen Thomas
- Park H.
- Pedersen Jess Wellendorff
- Pedroza L.S.
- Petzold Vivien Gabriele
- Plaisance C.
- Rasmussen J.A.
- Ren H.
- Rizzi M.
- Ronco A.S.
- Rossmeisl Jan
- Rostgaard Carsten
- Saadi Souheil
- Salguero L.A.
- Santos E.J.G.
- Schoenhalz A.L.
- Shen Juan
- Smedemand M.
- Stausholm-Møller O.J.
- Strange Mikkel
- Su H.B.
- Tekin Adem
- Temel B.
- Thygesen Kristian Sommer
- Toftelund Anja
- Tripkovic Vladimir
- Vanin Marco
- Vegge Tejs
- Viswanathan V.
- Vojvodic Aleksandra
- Voss Johannes
- Wang Shengguang
- Publication venue
- Publication date
- 01/01/2009
- Field of study
Measurement of differential cross sections and W + /W − cross-section ratios for W boson production in association with jets at √s =8 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Alberich L Cerda
- Albert J
- Albicocco P
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amoroso S
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Bakker PJ
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee Sw
- Bannoura AAE
- Barajas CA Chavez
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo JT
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behr JK
- Bell AS
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertram IA
- Bertsche C
- Besjes GJ
- Bessner M
- Besson N
- Bethani A
- Bethke S
- Betti A
- Bevan AJ
- Beyer J
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bilokon H
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Bisanz T
- Bittrich C
- Bjergaard DM
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blunier S
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Bock C
- Boehler M
- Boeriu OE Vickey
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev AS
- Bolz AE
- Bomben M
- Bona M
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Bortolotto V
- Boscherini D
- Bosman M
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bozson AJ
- Bracinik J
- Brandt A
- Brandt G
- Brandt O
- Braren F
- Bratzler U
- Brau B
- Brau JE
- Bravo A Gascon
- Brendlinger K
- Brennan AJ
- Brenner L
- Brenner R
- Bressler S
- Briglin DL
- Bristow TM
- Britton D
- Britzger D
- Brochu FM
- Brock I
- Brock R
- Brooijmans G
- Brooks T
- Brooks WK
- Brost E
- Broughton JH
- Bruncko D
- Bruni A
- Bruni G
- Bruni LS
- Bruno S
- Brunt BH
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
- Bugge MK
- Bulekov O
- Bullock D
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burka K
- Burke S
- Burmeister I
- Burr JTP
- Buscher D
- Buscher V
- Bussey P
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bylund O Bessidskaia
- Caforio D
- Cai H
- Cairo VM
- Cakir I Turk
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvet D
- Calvet S
- Calvet TP
- Camarda S
- Camarri P
- Cameron D
- Camincher C
- Campana S
- Campanelli M
- Camplani A
- Campoverde A
- Canale V
- Cano Bret M
- Cantero J
- Cao T
- Caprini I
- Caprini M
- Capua M
- Carbone RM
- Cardarelli R
- Cardillo F
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carra S
- Carrillo-Montoya GD
- Casadei D
- Casado MP
- Casha AF
- Casolino M
- Casper DW
- Castelijn R
- Castillo I Santoyo
- Castillo LR Flores
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Caudron J
- Cavaliere V
- Cavallaro E
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chafaq A
- Chakraborty D
- Chan SK
- Chan WS
- Chan YL
- Chang P
- Chapman JD
- Charlton DG
- Chau CC
- Che S
- Cheatham S
- Chegwidden A
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen C
- Chen H
- Chen J
- Chen S
- Chen S
- Chen X
- Chen Y
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cheu E
- Cheung K
- Chevalier L
- Chi A
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chouridou S
- Chow YS
- Christodoulou V
- Chu MC
- Chudoba J
- Chuinard AJ
- Chwastowski JJ
- Chytka L
- Ciftci AK
- Cinca D
- Cindro V
- Cioara IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubancan M
- Clark A
- Clark MR
- Clark PJ
- Clarke RN
- Clement C
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Colasurdo L
- Cole B
- Colijn AP
- Collaboration Atlas
- Collot J
- Colombo T
- Coniavitis E
- Connell SH
- Connelly IA
- Constantinescu S
- Conti G
- Conventi F
- Cooke M
- Cooper-Sarkar AM
- Corga K De Vasconcelos
- Cormier F
- Cormier KJR
- Corradi M
- Correia AM Henriques
- Corrigan EE
- Corriveau F
- Cortes-Gonzalez A
- Costa G
- Costa MJ
- Costanzo D
- Cottin G
- Coutinho Y Amaral
- Cowan G
- Cox BE
- Cranmer K
- Crawley SJ
- Creager RA
- Cree G
- Crepe-Renaudin S
- Crescioli F
- Cribbs WA
- Cristinziani M
- Croft V
- Crosetti G
- Cueto A
- Cukierman AR
- Cummings J
- Curatolo M
- Cuth J
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- Zhemchugov A
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- Zibell A
- Zieminska D
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- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
This paper presents a measurement of the W boson production cross section and the W + /W − cross-section ratio, both in association with jets, in proton--proton collisions at s √ =8 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is performed in final states containing one electron and missing transverse momentum using data corresponding to an integrated luminosity of 20.2 fb −1 . Differential cross sections for events with one or two jets are presented for a range of observables, including jet transverse momenta and rapidities, the scalar sum of transverse momenta of the visible particles and the missing transverse momentum in the event, and the transverse momentum of the W boson. For a subset of the observables, the differential cross sections of positively and negatively charged W bosons are measured separately. In the cross-section ratio of W + /W − the dominant systematic uncertainties cancel out, improving the measurement precision by up to a factor of nine. The observables and ratios selected for this paper provide valuable input for the up quark, down quark, and gluon parton distribution functions of the proto
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
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- Zhou Shan
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- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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- Publication venue
- Publication date
- 22/09/2015
- Field of study
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
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- Banerjee Sudeshna
- Banerjee Sunanda
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- Banzuzi Kukka
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- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
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- Bauer Julia
- Bauerdick Lothar A. T.
- Baumgartel Darin
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- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Cepeda Maria
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- Ceron Cristobal
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- Chabert Eric Christian
- Chadwick Matthew
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- Chamizo Llatas Maria
- Chan Matthew
- Chandra Avdhesh
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Chen Zhiling
- Cheng Teh Lee
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chierici Roberto
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
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- Choudhury Rajani Kant
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- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Conway John
- Cooper Seth
- Cooper William
- Cortina Gil Eduardo
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cuplov Vesna
- Curé Benoît
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- Cussans David
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Cunha Marinho Franciole
- Dahmes Bryan
- Dahms Torsten
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Dammann Dirk
- Danielson Thomas
- Darmenov Nikolay
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- David Tinoco Mendes Andre
- Davids Martina
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Favereau De Jeneret Jerome
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delgado Peris Antonio
- Deliomeroglu Mehmet
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
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- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Dermenev Alexander
- Dero Vincent
- Devroede Olivier
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
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- Di Matteo Leonardo
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- Diemoz Marcella
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- Dietz-Laursonn Erik
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- Dimitrov Anton
- Dimitrov Lubomir
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- Dittmar Michael
- Djordjevic Milos
- Dobrzynski Ludwik
- Dobur Didar
- Doesburg Robert
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- Dominguez Aaron
- Dominik Wojciech
- Domínguez Vázquez Daniel
- Dorigo Tommaso
- Dorney Brian
- Doroba Krzysztof
- Dosselli Umberto
- Dozen Candan
- Draeger Jula
- Dragicevic Marko
- Dragoiu Cosmin
- Drell Brian Robert
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- Drouhin Frédéric
- Drozdetskiy Alexey
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- Yun Jae Chul
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- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
Measurement of differential cross sections and W⁺/W⁻ cross-section ratios for W boson production in association with jets at √s=8 TeV with the ATLAS detector
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- Miano F
- Middleton RP
- Miglioranzi S
- Miguens JM
- Mijovic L
- Mikenberg G
- Mikestikova M
- Mikuz M
- Milesi M
- Milic A
- Millar DA
- Miller DW
- Mills C
- Milosavljevic MV
- Milov A
- Milstead DA
- Minaenko AA
- Minami Y
- Minashvili IA
- Mincer AI
- Mindur B
- Mineev M
- Minegishi Y
- Ming Y
- Miotto GL
- Mir LM
- Mirto A
- Mistry KP
- Mitani T
- Mitrevski J
- Mitsou VA
- Miucci A
- Miyagawa PS
- Mizukami A
- Mjoernmark JU
- Mkrtchyan T
- Mlynarikova M
- Moa T
- Mochizuki K
- Mogg P
- Mohapatra S
- Molander S
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- Mondragon MC
- Monig K
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- Monticelli F
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- Morange N
- Moreno D
- Morettini P
- Morgenstern M
- Morgenstern S
- Mori D
- Mori T
- Morii M
- Morinaga M
- Morisbak V
- Morley AK
- Mornacchi G
- Morris JD
- Morvaj L
- Moschovakos P
- Mosidze M
- Moss HJ
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- Muenstermann D
- Muino PC
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- Musheghyan H
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- Naryshkin I
- Naumann T
- Navarro G
- Navarro JEG
- Navarro JLLR
- Navarro LB
- Nayyar R
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- Nechaeva PY
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- Nektarijevic S
- Nellist C
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- Nelson ME
- Nemecek S
- Nemethy P
- Nessi M
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- Newman PR
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- Nikolaenko V
- Nikolic-Audit I
- Nikolopoulos K
- Nilsson P
- Ninomiya Y
- Nisati A
- Nishu N
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- Nitsche I
- Nitta T
- Nobe T
- Noccioli EB
- Noguchi Y
- Nomachi M
- Nomidis I
- Nomura MA
- Nooney T
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- Novgorodova O
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- Nurse E
- Nuti F
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- Oakham FG
- Oberlackl H
- Obermann T
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- Oide H
- Okawa H
- Okumura Y
- Okuyama T
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- Oleiro Seabra LF
- Olivares Pino SA
- Olsson MJR
- Olszewski A
- Olszowska J
- Onofre A
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- Onyisill PUE
- Oppen H
- Oreglia MJ
- Oren Y
- Orestano D
- Orlando N
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- Ortiz NGG
- Osculati B
- Ospanov R
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- Otono H
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- Ozturk N
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- Pacheco Pages A
- Padilla Aranda C
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- Paige F
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- Palestini S
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- Panagiotopoulou ES
- Panagoulias I
- Pandini CE
- Pani P
- Panitkin S
- Pantea D
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- Papadopoulou TD
- Papageorgiou K
- Paramonov A
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- Parker KA
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- Parodi F
- Parsons JA
- Parzefall U
- Pascual JAG
- Pascuzzi VR
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- Pasqualucci E
- Passaggio S
- Pastor ET
- Pastor OE
- Pastore F
- Pataraia S
- Pater JR
- Pauly T
- Paz IL
- Pearson B
- Pedraza Lopez S
- Pedro R
- Peleganchuk SV
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- Peralva BS
- Perego MM
- Perepelitsa DV
- Perez MV
- Peri F
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- Pernegger H
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- Peschke R
- Peshekhonov VD
- Peters K
- Peters RFY
- Petersen BA
- Petersen TC
- Petit E
- Petridis A
- Petridou C
- Petroff P
- Petrolo E
- Petrov M
- Petrucci F
- Pettersson NE
- Peyaud A
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- Piacquadio G
- Pianori E
- Picazio A
- Pickering MA
- Piegaia R
- Pilcher JE
- Pilkington AD
- Pinamonti M
- Pineda AS
- Pinfold JL
- Piqueras DA
- Pirumov H
- Pitt M
- Plazak L
- Pleier M-A
- Pleskot V
- Plotnikova E
- Pluth D
- Podberezko P
- Poettgen R
- Poggi R
- Poggioli L
- Pogrebnyak I
- Pohl D
- Pokharel I
- Polesello G
- Poley A
- Policicchio A
- Polifka R
- Polini A
- Pollard CS
- Polychronakos V
- Pommes K
- Ponce JMI
- Ponomarenk D
- Pontecorvo L
- Popeneciu GA
- Pospisil S
- Potamianos K
- Potrap IN
- Potter CJ
- Potti H
- Poulsen T
- Poveda J
- Pralavorio P
- Pranko A
- Prell S
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- Primavera M
- Prince S
- Proklova N
- Prokofiev K
- Prokoshin F
- Protopopescu S
- Proudfoot J
- Przybycienn M
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- Puzo P
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- Quilty D
- Quintero DMP
- Raddum S
- Radeka V
- Radescu V
- Radhakrishnan SK
- Radloff P
- Rados P
- Ragusa F
- Rahal G
- Raine JA
- Rajagopalan S
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- Rashid T
- Raspopov S
- Ratti MG
- Rauch DM
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- Rave S
- Ravinovich I
- Rawling JH
- Raymond M
- Read AL
- Readioff NP
- Reale M
- Rebuzzi DM
- Redelbach A
- Redlinger G
- Reece R
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- Resconi S
- Resseguie ED
- Rettie S
- Reynolds E
- Rezanova OL
- Reznicek P
- Rezvani R
- Richter R
- Richter S
- Richter-Was E
- Ricken O
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- Rieck P
- Riegel CJ
- Rieger J
- Rifki O
- Rijssenbeek M
- Rimoldi A
- Rimoldi M
- Rinaldi L
- Ripellino G
- Ristic B
- Ritsch E
- Riu I
- Rizatdinova F
- Rizvi E
- Rizzi C
- Roberts RT
- Robertson SH
- Robichaud-Veronneau A
- Robinson D
- Robinson JEM
- Robson A
- Rocco E
- Roda C
- Rodina Y
- Rodriguez Bosca S
- Rodriguez Perez A
- Rodriguez Rodriguez D
- Rodriguez LP
- Roe S
- Rogan CS
- Rohne O
- Roloff J
- Romaniouk A
- Romano M
- Romero Adam E
- Rompotis N
- Ronzani M
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- Rosien N-A
- Rossi E
- Rossi LP
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- Rosten R
- Rotaru M
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- Rozas AJ
- Rozen Y
- Ruan X
- Rubbo F
- Ruehr F
- Ruettinger EM
- Ruiz-Martinez A
- Rurikova Z
- Rusakovich NA
- Russell HL
- Rutherfoord JP
- Ruthmann N
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- Rybar M
- Rybkin G
- Ryu S
- Ryzhov A
- Rzehorz GF
- Saadi DS
- Saavedra AF
- Sabato G
- Sacerdoti S
- Sadrozinski HF-W
- Sadykov R
- Saez SMR
- Saha P
- Sahinsoy M
- Saimpert M
- Saito M
- Saito T
- Sakamoto H
- Sakurai Y
- Salamanna G
- Salazar Loyola JE
- Salek D
- Salihagic D
- Salnikov A
- Salt J
- Salvatore D
- Salvatore F
- Salvucci A
- Salzburger A
- Sammel D
- Sampsonidis D
- Sampsonidou D
- Sanchez CAS
- Sanchez FJM
- Sanchez J
- Sandaker H
- Sandbach RL
- Sander CO
- Sandhoff M
- Sandoval C
- Sankey DPC
- Sannino M
- Sano Y
- Sansoni A
- Santoni C
- Santos H
- Santurio EV
- Sapronov A
- Saraiva JG
- Sasaki O
- Sato K
- Sauvan E
- Savage G
- Savard P
- Savic N
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- Sawyer L
- Sbarra C
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- Scanlon T
- Scannicchio DA
- Schaarschmidt J
- Schacht P
- Schachtner BM
- Schaefer D
- Schaefer L
- Schaefer U
- Schaeffer J
- Schaepe S
- Schaetzel S
- Schaffer AC
- Schaile D
- Schamberger RD
- Schegelsky VA
- Scheirich D
- Schenck F
- Schernau M
- Schiavi C
- Schier S
- Schildgen LK
- Schillo C
- Schioppa M
- Schlenker S
- Schmidt-Sommerfeld KR
- Schmieden K
- Schmitt C
- Schmitt S
- Schmitz S
- Schnoor U
- Schoeffel L
- Schoening A
- Schoenrock BD
- Schopf E
- Schott M
- Schouwenberg JFP
- Schovancova J
- Schramm S
- Schroeder TV
- Schuh N
- Schulte A
- Schultens MJ
- Schultz-Coulon H-C
- Schumacher M
- Schumm BA
- Schune P
- Schwartzman A
- Schwarz TA
- Schweiger H
- Schwemling P
- Schwienhorst R
- Schwindling J
- Sciandra A
- Sciolla G
- Scornajenghi M
- Scuri F
- Scutti F
- Searcy J
- Seema P
- Seidel SC
- Seiden A
- Seixas JM
- Sekhniaidze G
- Sekhon K
- Sekula SJ
- Semprini-Cesari N
- Senkin S
- Serfon C
- Serin L
- Serkin L
- Sessa M
- Seuster R
- Severini H
- Sfiligoj T
- Sforza F
- Sfyrla A
- Shabalina E
- Shaikh NW
- Shan LY
- Shang R
- Shank JT
- Shapiro M
- Shatalov PB
- Shaw K
- Shaw SM
- Shcherbakova A
- Shehu CY
- Shen Y
- Sherafati N
- Sherman AD
- Sherwood P
- Shi L
- Shimizu S
- Shimmin CO
- Shimojima M
- Shipsey IPJ
- Shirabe S
- Shiyakova M
- Shlomi J
- Shmeleva A
- Shochet MJ
- Shojaii S
- Shope DR
- Shrestha S
- Shulga E
- Shupe MA
- Sicho P
- Sickles AM
- Sidebo PE
- Sidiropoulou O
- Sidoti A
- Siegert F
- Sijacki D
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- Silverstein SB
- Simak V
- Simic L
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- Simioni E
- Simmons B
- Simon M
- Sinervo P
- Sinev NB
- Sioli M
- Siragusa G
- Siral I
- Sivoklokov SY
- Sjolin J
- Skinner MB
- Skubic P
- Slater M
- Slavicek T
- Slawinska M
- Sliwa K
- Slovak R
- Smakhtin V
- Smart BH
- Smieskoa J
- Smirnov N
- Smirnov SY
- Smirnov Y
- Smirnova LN
- Smirnova O
- Smith JW
- Smith MNK
- Smith RW
- Smizanska M
- Smolek K
- Snesarev AA
- Snyder IM
- Snyder S
- Sobie R
- Socher F
- Soffer A
- Sogaard A
- Soh DA
- Sokhrannyi G
- Sola JDB
- Solar M
- Soldatov EY
- Soldevila U
- Solis AL
- Solodkov AA
- Soloshenko A
- Solovyanov OV
- Solovyev V
- Sommer P
- Son H
- Sopczak A
- Sosa D
- Sotiropoulou CL
- Sottocornola S
- Soualah R
- Soukharev AM
- South D
- Sowden BC
- Spagnolo S
- Spalla M
- Spangenberg M
- Spano F
- Sperlich D
- Spettel F
- Spieker TM
- Spighi R
- Spigo G
- Spiller LA
- Spousta M
- Stabile A
- Stamen R
- Stamm S
- Stanecka E
- Stanek RW
- Stanescu C
- Stanitzki MM
- Stapf BS
- Stapnes S
- Starchenko EA
- Stark GH
- Stark J
- Stark SH
- Staroba P
- Starovoitov P
- Starz S
- Staszewski R
- Stegler M
- Steinberg P
- Stelzer B
- Stelzer HJ
- Stelzer-Chilton O
- Stenzel H
- Stevenson TJ
- Stewart GA
- Stockton MC
- Stoebe M
- Stoicea G
- Stolte P
- Stonjek S
- Stradling AR
- Straessner A
- Stramaglia ME
- Strandberg J
- Strandberg S
- Strauss M
- Strizenec P
- Strohmer R
- Strom DM
- Stroynowski R
- Strubig A
- Stucci SA
- Stugu B
- Styles NA
- Su D
- Su J
- Suchek S
- Sugaya Y
- Suk M
- Sulin VV
- Sultan DMS
- Sultansoy S
- Sumida T
- Sun S
- Sun X
- Suruliz K
- Suster CJE
- Sutton MR
- Suzuki S
- Svatos M
- Swiatlowski M
- Swift SP
- Sykora I
- Sykora T
- Ta D
- Tackmann K
- Taenzer J
- Taffard A
- Tafirout R
- Tahirovic E
- Taiblum N
- Takai H
- Takashima R
- Takasugi EH
- Takeda K
- Takeshita T
- Takubo Y
- Talby M
- Talyshev AA
- Tanaka J
- Tanaka M
- Tanaka R
- Tanioka R
- Tannenwald BB
- Tapia Araya S
- Tapprogge S
- Tarem S
- Tartarelli GF
- Tas P
- Tasevsky M
- Tashiro T
- Tassi E
- Tavares Delgado A
- Tayalati Y
- Taylor AC
- Taylor AJ
- Taylor GN
- Taylor PTE
- Taylor W
- Tehrani FS
- Teixeira-Dias P
- Temple D
- Ten Kate H
- Teng PK
- Teoh JJ
- Tepe F
- Terada S
- Terashi K
- Terron J
- Terzo S
- Testa M
- Teuscher RJ
- Thais SJ
- Theenhausen HMZ
- Theveneaux-Pelzer T
- Thiele F
- Thomas JP
- Thomas-Wilsker J
- Thompson AS
- Thompson PD
- Thomsen LA
- Thomson E
- Tian Y
- Tibbetts MJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
- Tipton P
- Tisserant S
- Tobon CAM
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- Todorova-Nova S
- Todt S
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- Tong B
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- Toro RC
- Torrence E
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- Torres RET
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- Tovey DR
- Treado CJ
- Trefzger T
- Tresoldi F
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Tripiana MF
- Trischuk W
- Trocme B
- Trofymov A
- Troncon C
- Trovatelli M
- Truong L
- Trzebinski M
- Trzupek A
- Tsang KW
- Tseng JC-L
- Tsiareshka PV
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tu Y
- Tudorache A
- Tudorache V
- Tulbure TT
- Tuna AN
- Turchikhin S
- Turgeman D
- Turra R
- Tuts PM
- Ucchielli G
- Ueda I
- Ughetto M
- Ukegawa F
- Una G
- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Uno K
- Urban SC
- Urbar J
- Urquijo P
- Urrejola P
- Usai G
- Usui J
- Vacavant L
- Vacek V
- Vachon B
- Vadla KOH
- Vaidya A
- Valderanis C
- Valente M
- Valentinetti S
- Valero A
- Valery L
- Vallier A
- Van den Wollenberg W
- van der Graaf H
- van Gemmeren P
- Van Nieuwkoop J
- van Vulpen I
- van Woerden MC
- Vanadia M
- Vandelli W
- Vaniachine A
- Vankov P
- Vardanyan G
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Varrli C
- Vartapetian A
- Varvell KE
- Vasquez GA
- Vasquez JG
- Vazeille F
- Vazquez Furelos D
- Vazquez JGP
- Veatch J
- Veeraraghavan V
- Veloce LM
- Veloso F
- Veneziano S
- Ventura A
- Venturi M
- Venturi N
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen AT
- Vermeulen JC
- Verzini MJA
- Vetterli MC
- Viaux Maira N
- Viazlo O
- Vichou I
- Vickey T
- Vie S
- Viehhauser GHA
- Vigani L
- Villa M
- Villar DIN
- Vilucchi E
- Vincter MG
- Vinogradov VB
- Vishwakarma A
- Vittori C
- Vivarelli I
- Vlachos S
- Vogel M
- Vokac P
- Volpi G
- von der Schmitt H
- von Toerne E
- Vorobe V
- Vorobev K
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahlberg H
- Wahrmund S
- Wakamiya K
- Walder J
- Walker R
- Walkowiak W
- Wallangen V
- Walls FMG
- Wang C
- Wang C
- Wang F
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- Wang H
- Wang J
- Wang J
- Wang Q
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- Wang R-J
- Wang SM
- Wang T
- Wang W
- Wang W
- Wang Z
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Washbrook A
- Watkins PM
- Watson AT
- Watson MF
- Watts G
- Watts S
- Waugh BM
- Webb AF
- Webb S
- Weber MS
- Weber SA
- Weber SM
- Weber SW
- Webster JS
- Weidberg AR
- Weinert B
- Weingarten J
- Weirich M
- Weiser C
- Wells PS
- Wenaus T
- Wengler T
- Wenig S
- Wermes N
- Werner MD
- Werner P
- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
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- White MJ
- White R
- Whiteson D
- Whitmore BW
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wiglesworth C
- Wiik-Fuchs LAM
- Wildauer A
- Wilk F
- Wilkens HG
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson JA
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobischu M
- Wolf A
- Wolf TMH
- Wolff R
- Wolter MW
- Wolters H
- Wong KHY
- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
- Wotschack J
- Wozniak KW
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xu D
- Xu L
- Xu T
- Xu W
- Yabsley B
- Yacoob S
- Yamaguchi D
- Yamaguchi Y
- Yamamoto A
- Yamamoto S
- Yamanaka T
- Yamane F
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang Y
- Yang Z
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yu J
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/05/2018
- Field of study
This paper presents a measurement of the W boson production cross section and the W⁺/W⁻ cross-section ratio, both in association with jets, in proton-proton collisions at √s=8 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is performed in final states containing one electron and missing transverse momentum using data corresponding to an integrated luminosity of 20.2 fb⁻¹. Differential cross sections for events with at least one or two jets are presented for a range of observables, including jet transverse momenta and rapidities, the scalar sum of transverse momenta of the visible particles and the missing transverse momentum in the event, and the transverse momentum of the W boson. For a subset of the observables, the differential cross sections of positively and negatively charged W bosons are measured separately. In the cross-section ratio of W⁺/W⁻ the dominant systematic uncertainties cancel out, improving the measurement precision by up to a factor of nine. The observables and ratios selected for this paper provide valuable input for the up quark, down quark, and gluon parton distribution functions of the proton
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