19 research outputs found
Relationship Between Work-Family Conflict, Job Embeddedness, Workplace Flexibility, and Turnover Intentions
- Publication venue
- 'Universitas Islam Indonesia (Islamic University of Indonesia)'
- Publication date
- 01/12/2017
- Field of study
Full text linkThe present study seeks to propose and test a research model that investigates job embeddedness as a mediator and workplace flexibility as a moderator of the effect of family-work conflict on turnover intentions. This study uses a survey method and a structured questionnaire to collect data from 187 nurses working in various hospitals in Islamabad, Pakistan. The results showed that on-the-job embeddedness partially mediated the effect of work-family conflict on nurses\u27 turnover intention. Furthermore, workplace flexibility moderated the relationship between work-family conflict and turnover intention. Management of the hospitals should take decisive steps to establish and maintain a supportive and flexible work environment because such an environment would help nurses to balance their work (family) and family (work) roles and lead to increased job embeddedness. Otherwise, it would be very difficult to retain high performing nurses in the workplace. The current study contributes to the existing knowledge base by testing job embeddedness as a mediator and workplace flexibility as a moderator of the impact of work-family conflict on turnover intentions of nurses
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Adam F.
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- Addo A.
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- Al-Shahi Salman R.
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- Byrne J.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chauhan R.
- Chawla V.
- Chen F.
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- Cherrie M.
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- Chilvers A.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
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- Clare E.
- Clark E.
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- Clayton-Smith J.
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- Clemente de la Torre C.
- Clifford S.
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- Coe A.
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- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
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- Colton H.
- Condliffe R.
- Connell E.
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- Connor E.
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- Conteh V.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Desai A.
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- Dhani S.
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- Dimitri P.
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- Duffy H.
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- Dunn A.
- Duran B.
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- Duru I.
- Dymond H.
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- D’Mello A.
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- Elgohary A.
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- Emberson Jonathan R.
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- Essa F.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Fenton C.
- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Residual impact of biochar on cadmium uptake by rice (Oryza sativa L.) grown in Cd-contaminated soil
- Author
- A Mosa
- A Mosa
- D Yin
- G Murtaza
- HK Lichtenthaler
- IM Lima
- J Liu
- M Rizwan
- M Rizwan
- M Rizwan
- M Rizwan
- M Uchimiya
- MF Qayyum
- Mohammad I. Al-Wabel
- MU Khan
- Muhammad Rizwan
- Muhammad Zia ur Rehman
- MZ Rehman
- MZ Rehman
- PR Ryan
- S Ali
- S Ali
- S Jeffery
- Shafaqat Ali
- SM Gallego
- SM Shaheen
- T Abbas
- Tahir Abbas
- U Younis
- Y Xiao
- Y Zhang
- YS Ok
- Z Abbas
- Z Ahmad
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textMechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids:Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis
- Author
- Akinc A.
- Behr J.
- Behr J. P.
- Benjaminsen R. V.
- Boussif O.
- Cho Y. W.
- Conese M.
- Dick Hoekstra
- Eliyahu H.
- Funhoff A. M.
- Godbey W. T.
- Guo X.
- Hafez I. M.
- Inge S. Zuhorn
- Kopatz I.
- Lewis R. N.
- Lukacs G. L.
- Nguyen J.
- Oberle V.
- Paris S.
- Pichon C.
- Pollard H.
- Rehman Z. U.
- Rejman J.
- Semple S. C.
- Sonawane N. D.
- Tang M. X.
- ur Rehman Z.
- Wasungu L.
- Xu Y.
- Zia ur Rehman
- Publication venue
- Publication date
- 01/05/2013
- Field of study
No full text<p>Lipoplexes and polyplexes are widely applied as nonviral gene delivery carriers. Although their efficiencies of transfection are comparable, their mechanisms of delivery, specifically at the level of nudeic acid release from endosomes, are different. Thus, lipoplex-mediated release is proposed to rely on lipid mixing, as occurs between lipoplex and endosomal target membrane, the ensuing membrane destabilization leading to nucleic add delivery into the cytosol. By contrast, the mechanism by which polyplexes, particularly those displaying a high proton buffering capacity, release their nucleic acid cargo from the endosome, is thought to rely on a so-called "proton sponge effect", in essence an osmotically induced rupturing of the endosomal membrane. However, although a wealth of Indirect insight supports both these mechanisms, direct evidence Is still lacking. Therefore, to further clarify these mechanisms, we have investigated the interaction of lipo- and polyplexes with Hela cells by live cell imaging. As monitored over an incubation period of 2 h, our data reveal that in contrast to the involvement of numerous nanocarriers in case of lipoplex-mediated delivery, only a very limited number of polyplexes, that is, as few as one up to four/five nanocarriers per cell, with an average of one/two per cell, contribute to the release of nudeic acids from endosomes and their subsequent accumulation into the nucleus. Notably, in neither case complete rupture of endosomes nor release of intact polyplexes or lipoplexes into the cytosol was observed. Rather, at the time of endosomal escape both the polymer and its genetic payload are separately squirted into the cytoplasm, presumably via (a) local pore(s) within the endosomal membrane. Specifically, an almost Instantaneous and complete discharge of nucleic acids and carrier (remnants) from the endosomes is observed. In case of lipoplexes, the data suggest the formation of multiple transient pores over time within the same endosomal membrane, via which the cargo is more gradually transferred into the cytosol.</p>
Effect of Job Rewards on Job Satisfaction, Moderating Role of Age Differences: Emperical Evidence from Pakistan
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2008
- Field of study
No full textThigh-length compression stockings and DVT after stroke
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- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
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- Abouibrahim M
- Abraham M
- Abraham T
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- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
- Ahmed L
- Ahmed L
- Ahmed M
- Ahmed M Cecilia
- Ahmed N
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- Ahmed R
- Ahmed RA
- Ahmed S
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- Ail D
- Ainsley A
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- Wilson K
- Wilson L
- Wilson T
- Win M
- Winder L
- Winder P
- Winn S
- Winstanley M
- Winter H
- Winter J
- Wiselka M
- Wittes J
- Wolodimeroff E
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- Xia Z
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- Yasmin S
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- Yates D
- Yates H
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- Yip K
- Ynter I
- Yorke J
- Youssouf S
- Yousuf A
- Yung B
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- Zdanaviciene A
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- Zin E Thant
- Zinyemba V
- Zipitis C
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- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
An acute outbreak of natural Trypanosoma evansi infection in camel (Camelus dromedarius) herds in the southwestern Iran
- Author
- A Delafosse
- A Khosravi
- A Rafiee
- A Raoofi
- A Sazmand
- AAA El-Baky
- Amir Zakian
- C Gutierrez
- DG Godfrey
- GJ Losos
- Houman Kahroba
- JM Ngaira
- M Ahmadi-hamedani
- M Desquesnes
- MA Saleh
- Majid Mohammad-Sadegh
- MN Abo-Shehada
- Mohammad Nouri
- Mohammad-Reza Mokhber-Dezfouli
- OF Al-Rawashdeh
- OF Al-Rawashdeh
- OH Omer
- Pegah Safaei
- R Boid
- R Yagil
- Rezvan Moallemian
- SA Reid
- TEG Rutter
- U Wernery
- VM Nantulya
- X Pacholek
- Z Chaudhary
- Zia-ur-Rehman
- ZK Njiru
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textIntelligent churn prediction for telecom using GP-AdaBoost learning and PSO undersampling
- Author
- A Amin
- A Amin
- A Lemmens
- A. Keramati
- Adnan Amin
- Adnan Amin
- Adnan Idris
- Aksam Iftikhar
- B Huang
- B Huang
- BQ Huang
- E Lima
- G Mikel
- GM Khan
- I Adnan
- I Adnan
- I Bose
- J Burez
- J Hadden
- K Kyoungok
- KW Bock De
- KWD Bock
- L Ning
- L Rokach
- M Owczarczuk
- P Kisioglu
- P Wang
- P Yang
- PC Pendharkar
- PG Espejo
- U Bhowan
- W Verbeke
- W Verbeke
- WB Langdon
- WH Au
- Y Huang
- YH Shin
- Z-Y Chen
- Zia ur Rehman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textSoil Salinity Research in 21 st
- Author
- Abdelgadir E. M.
- Abdullah D. Z.
- Ahmad M.
- Ahmad M. J.
- Ahmed K.
- Ahmed M.
- Ahmed S.
- Akram M.
- Akram M.
- Ali M.
- Ali M.
- Ashraf M.
- Aslam M.
- Aslam R.
- Athar H. R.
- Azhar A. H.
- Batool N.
- Bhatti M. A.
- Diacono M.
- Government of Pakistan [GoP]
- Hameed M.
- Hollington P.
- Husain I.
- Khan A. A.
- Khan M. A.
- Mahmood I. A.
- Mahmood K.
- Manzoor M. Z.
- Maqsood M. A.
- Maqsood T.
- Mufti S. A.
- Munns R.
- Qureshi A. S.
- Qureshi A. S.
- Rahman M. U.
- Rajpar I.
- Shafi M.
- Shahid S. A.
- Sharma D. K.
- Siyal A. A.
- Sonon L. S.
- Wasti S. E.
- Zafar S. A.
- Zaka M. A.
- Zaman S. B.
- Zia-Ur-Rehman M.
- Zulfiqar I.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full text
