Development of a novel extraction technique based on combination of molecular imprinted polymers and liquid membrane for biomedical and environmental applications

In this study a novel technique for extraction of biological and environmental samples was investigated. The developed technique is based on the combination of liquid membrane and molecular imprinted polymers technologies referred to as liquid membrane-molecular imprinting polymers extraction technique. As a model compound, 17β-estradiol was chosen, a hormone known to produce adverse effect in wild life and humans. A precipitation and bulk polymerization methods which produces easily, cleanly and in good yield polymers was used for the synthesis of the molecularly imprinted polymers. The model compound was extracted from aqueous sample through the hydrophobic porous membrane which was impregnated with toluene which also formed part of the acceptor solution. In the acceptor phase, the compound was re-extracted onto MIP beads which were also part of the organic phase. The selectivity of the new technique was demonstrated by extracting river water, waste water and fruit sample. In all different samples extracted clean chromatograms were obtained. The new technique therefore combines extraction and clean-up in one step. The enrichment factors were low and around one but can still be improved

Molecular imprinting science and technology : A survey of the literature for the years 2004 - 2011

Herein, we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004-2011. In total, 3779 references to the original papers, reviews, edited volumes and monographs from this period are included, along with recently identified uncited materials from prior to 2004, which were omitted in the first instalment of this series covering the years 1930-2003. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by sections describing fundamental aspects of molecular imprinting including the development of novel polymer formats. Thereafter, literature describing efforts to apply these polymeric materials to a range of application areas is presented. Current trends and areas of rapid development are discussed. Copyright © 2014 John Wiley & Sons, Ltd