11 research outputs found
An Orientation to the United States
- Publication venue
- SIT Digital Collections
- Publication date
- 01/01/1981
- Field of study
The main purpose of this text is to provide a format through which a foreign student can gain a better understanding of the United States and its people. A secondary goal is to encourage students to use and improve their aural/oral skills. Due to the nature of the topic of the lessons, students should find it easy to contribute to active discussions. At times, the students are forced to mix with the target culture through activities provided at the end of each lesson.
The text consists of fifty lessons with each lesson having a single topic as focus of contrast, discussion and investigation. The topics fall into the following general categories: Home and Daily Activities, Social Customs, Transportation, Education and Miscellaneous. The first page of each lesson provides the student with a contrast between Iran and the United States. The second page of each lesson supplies additional information on the United States, and offers a variety of activities designed to further the students\u27 understanding of the United States. A majority of the lessons are accompanied by slides to be presented as an introduction to the topics. These slides serve to illustrate a particular aspect of the United States or its culture
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
- Abu H.
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- Acton C.
- Adam F.
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- Adams C.
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- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
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- Al Aaraj A.
- Al Balushi A.
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- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
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- Cherrie M.
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- Chilvers A.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
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- Clare E.
- Clark E.
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- Clemente de la Torre C.
- Clifford S.
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- Coe A.
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- Coker O.
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- Collier D.
- Collini Paul
- Collins J.
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- Colton H.
- Condliffe R.
- Connell E.
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- Connor E.
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- Conteh V.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Desai A.
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- Dhani S.
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- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
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- D’Mello A.
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- Elgohary A.
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- Everden C.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Fenton C.
- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Motivating the Physical Education Program for High School Girls
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- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Conservative Management of Acoustic Neuroma: An Outcome Study
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- Ballance
- Bederson
- Brackmann
- Charabi
- Charles W. Beatty
- Clark
- Dandy
- Ebersold
- Fischer
- Gardner
- Glasscock
- Glasscock
- Gordon H. Deen
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- House
- House
- J. Douglas Green
- Luetje
- Michael J. Ebersold
- Mitchell S. Marion
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- Ojemann
- Pollock
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- Samii
- Silverstein
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- Stefphen G. Harner
- Strasnick
- Wayman
- Wazen
- Wiet
- Wiet
- Wilms
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Thigh-length compression stockings and DVT after stroke
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
A Study of Differences in Selected Physical Performance Test Scores of Women in Tennessee Colleges
- Author
- Alden Florence D.
- Bennett Collen L.
- Collins V. D.
- Cozens Frederick W.
- Duggan Anne Schley
- Espenschade Anna
- Garfiel Evelyn
- Kraus Hans
- Lee Mabel
- McCloy Charles H.
- Mitchell Viola
- Mohr Dorothy
- Petroskey Helen M.
- Phillips Marjorie
- Powell Margaret
- Scott M. Gladys
- Steinhaus Arthur H.
- Turnbull Jenny E.
- U. S. Office of Education Federal Security Agency.
- U. S. Women's Army Corps.
- Wayman Agnes R.
- Wedemeyer Ross
- Wilson Marjorie
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Canada
- Author
- A. Appenzell
- A. Bevan
- A. Bevan
- A. Dueck
- A. Mitcham
- A. Mitcham
- A. Parkin
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- Acorn Milton.
- Alianuk .Hrant.
- Amprimoz Alexandre.
- Anderson Patrick.
- Aquin Hubert.
- Atwood Margaret.
- Aubert de Gaspé Philippe.
- B. Amtmann.
- B. Barrie
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- Bowering George.
- Boxer Avi.
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- Boyle Harry J.
- Braithwaite Max.
- Brewster Elizabeth.
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- Dalrymple Andrew Angus.
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- De Felice James.
- De Lissa Richard
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- DeMille James.
- Denham Alice.
- Denison Merrill.
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- Dlugacz Yosek.
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- Dunham Lynne.
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- Everson R.G.
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- Freeman David.
- French David.
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- Friedman Irene.
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- G. Amabile
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- Georges Bugnet
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- Gustafson Ralph.
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- Harris Christie.
- Harrison Susan Frances.
- Heath Terrence.
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- Heavysege Charles.
- Helwig David.
- Hendry Tom.
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- Hodder Blanche.
- Hodgins Jack.
- Hollingsworth Mike.
- Holmes Abraham S.
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- Howe Joseph.
- Hubert Cam.
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- I. Bassett
- I. Montagnes
- I. Nadel
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- Ignatow Rose Graubart.
- J. Ayre
- J. Gibbs
- J. Grifhth
- J. Harcourt
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- J. Zilber
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- J.W. Lennox
- Jack Donald.
- Jacques Ferron
- Jameson Anna.
- Jean Barbeau
- Johnson Linda Wilkene.
- Johnston George.
- Julian Marilyn.
- K. Dewar
- K. Mulhallen
- K. Thompson
- Kartzmark Ross.
- Keeling Nora.
- Kelly Arthur J.
- Kent Valerie.
- Kinch Martin.
- King David.
- Kirby William.
- Klein A.M.
- Klinck Carl.
- Knight David.
- Kowal Vic.
- Kroetsch Robert.
- L. Dudek
- L. Ricou
- L. Vernon
- Lachance Bertrand.
- Ladoo Harold Sonny.
- Lambert Rick.
- Lampman Archibald.
- Laurence Margaret.
- Laurentian U.
- Layton Irving.
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- Leacock Stephen.
- Leckner Carol H.
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- Lee Ronald.
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- Leslie Kenneth.
- Livesay Dorothy.
- Loby Louis.
- Lonneberg Lyle.
- Lord Peter.
- Lowry Malcolm.
- M. Atwood
- M. Atwood
- M. Atwood
- M. Brown
- M. Dawe
- M. Dixon
- M. Dorsinville
- M. Doyle
- M. Dyment
- M. Estok
- M. J. Edwards
- M. Lalonde
- M. Lane
- M. Laurence
- M. Martin
- M. Potts
- M. Primeau
- M. Wilson
- M. Wolfe
- M. Wolfe
- M. Wolfe
- M. Wolfe
- M.H. Scargill
- M.J. Ward
- M.L. Ross
- MacCormack Terry.
- MacEwen Gwendolyn.
- MacKenzie Alan.
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- MacLeod Alistair.
- MacMillan Ian.
- MacSkimming Roy.
- MacSween R.J.
- Mandel Eli.
- Margoshes Dave.
- Martindale Herb.
- Mason Michael.
- McCulloch Thomas.
- McDorxald David.
- McFadden David.
- McGillivray Judy.
- McIntyre James.
- McKenna Robert Ivan.
- McKinnon Barry.
- McLachlan Richard J.
- McNamara Eugene.
- Metcalf John.
- Michel Tremblay
- Miller Lily Poritz.
- Mirolla Michael.
- Mitchell Ken.
- Mitchell Ken.
- Mitchell W.O.
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- Monk Douglas.
- Montgomery L.M.
- Moore Brian.
- Moore Mavor.
- Moore Peter.
- Morissey Philip.
- Mowat Farley.
- Munro Alice.
- N. Kattan
- N.B. Annual sub.
- New W.H.
- Newlove John.
- Newlove John.
- Newman C.J.
- Newman Jerry.
- Nichol B.
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- P. Grosskurth
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- Palomba Lauro.
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- Parker Gilbert.
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- Perrault E.G.
- Petch Steve.
- Pifler Phil.
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- Plourde Marc.
- Pollock Sharon.
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- Powell D. Reid.
- Pratt E.J.
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- R. Brandeis
- R. Brown
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- R. MacSkimming
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- R. Skelton
- R. Smith
- R. Sutherland
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- R.T. Robertson
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- Rafferty Larry.
- Ravel Aviva.
- Reaney James.
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- Renner Vivian.
- Rhind Pauline Elizabeth.
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- Richler Mordecai.
- Rikki.
- Robert Gurik
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- Roberts Kevin.
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- Rooke Leon.
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- Rosenthal Helene.
- Rosqui Carolyn.
- Ross James.
- Ross Sinclair.
- Rosta Helen.
- Roy Gabrielle.
- S. Atherton
- S. Djwa
- S. Djwa
- S. Djwa
- S. Djwa
- S. Djwa
- S. Grace
- S. Mayne
- S. McCutcheon
- S. Repo
- S. Scobie
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- Salutin Rick.
- Sangster Charles.
- Schleich David.
- Schull Joseph.
- Scobie Stephen.
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- Scott Munroe.
- Seton Ernest
- Shein Brian.
- Sherman Kenneth.
- Sherra Connie.
- Shovella Brock.
- Simons Beverley.
- Smith Goldwin.
- Smith Ray.
- Smith Robert.
- Smyth Donna E.
- Solokoff Steven.
- Solway David.
- Stead Robert J.
- Stegmayer Nancy.
- Stein David Lewis.
- Such Peter.
- Sutherland Ronald.
- Sutherland Barry.
- Sutherland Fraser.
- Sutherland John.
- Svoboda Terese.
- Swerdlow Robert.
- T. Hendry
- T. Marshall
- Tata Saam.
- Taylor Ron.
- Theatre Passe Muraille
- Thomas Audrey.
- Thompson Kent.
- Thomson Edward William.
- Thornton Joan.
- Thériault Yves.
- Todd Chris.
- Tomlinson Randy.
- Trent U.
- Tyhurst Rob.
- Ursell Barbara.
- V. Reid
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- W. Aide
- W. Francis
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- W.F.E. Morley
- W.H. New
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- W.J. Keith
- Waddington Miriam.
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- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Canada
- Author
- A. Amprimoz
- A. Amprimoz
- A. Blott
- A. Boutelle
- A. Brodie
- A. Feder
- A. Gandolfo
- A. Purdy
- A. Roche
- A.C. Stewart
- A.D. Armitage
- A.E. Davidson
- A.W. Riley
- Acland Lois
- Alianak Hrant
- Allen Robert
- Amprimoz Alexandre
- Andrus David
- Annand Alan Mark
- Aquin Hubert
- Ardies Tom
- Atwood Margaret
- Atwood Margaret
- Aubert Rosemary
- Austin Don
- Avery Martin
- Avison Margaret
- Avison Margaret
- B. Cameron
- B. Daurio
- B. Davies
- B. Fawcett
- B. Godard
- B. Hehner
- B. Kingstone with
- B. Rasporich
- B. Wood
- B. Wood
- B.M. Ewing
- Bailey Alfred G.
- Bailey Bill
- Barbour Douglas
- Bartlett Brian
- Bartlette Sandra
- Bauer William
- Beissel Henry
- Beresford-Howe Constance
- Berton Pierre
- Biderman Ruth
- Bonnie Fred
- Bowering George
- Bowie Douglas
- Boyarsky Abraham
- Brownlow Edward William
- Bullock Michael
- Burns Mary
- Buyukmihci H.S.
- C. Belkin
- C. Hosek
- C. Pagnoulle
- C. Pollack
- C. Rosen
- C. Thomas
- C.H. Gervais
- C.L. Smiley
- C.T. Bissell
- Calder Ruth
- Callaghan Morley
- Canadian
- Carman Bliss
- Carr Emily
- Castillo Charles
- Clark Joan
- Clute John
- Cohen Leonard
- Cohen Matt
- Collier Diana G.
- Colson Theodore
- Corning Emilia
- Crowe Eleanor
- Crowell Peter
- Cuevas Ernesto
- Cull David
- D. Arnason
- D. Barbour
- D. Barbour
- D. Barbour
- D. Bessai
- D. Bessai
- D. Day
- D. Edmonds
- D. Godfrey
- D. Kent
- D. Ketterer
- D. Latham
- D. Livesay
- D. Livesay
- D. Mantz
- D. Mantz
- D. Rubin.
- D.E.D. Downey
- D.J. Dooley
- D.W. Russell
- D.W. Russell
- Dabydeen Cyril
- Dagg Mel
- Davies Ken
- Davies Robertson
- Davies Robertson
- Dawson Fielding
- Denison Merrill
- Deverell Rex
- Dewdney Chris
- Dickinson Don
- Dickinson Mary Lou
- Doran Jane
- Doubt Bryan
- Drabek Jan
- Dudek Louis
- Duncan Sara Jeannette
- Dunmore Spencer
- E. Cameron
- E. Jewinski
- E. Mandel
- E. Mandel
- E. Seidner
- E. Wachtel
- Eggleston Wilfrid
- Egyedi Bela
- Eirikson Irene
- Elves Hazel
- Engel Howard
- Engel Marian
- Enright William
- Evans Cicely Louise
- Everson R.G.
- F. Birbalsingh
- F. Cogswell
- F. Davey
- F. Spitzer
- F. Spoerly
- F. Teague
- Fagan Cary
- Fawcett Brian
- Fawcett Brian
- Fawcett Brian
- Ferguson Trevor
- Ferron Jacques
- Finkenbine Mark
- Fischman Sheila
- Fletcher Peggy
- Fobes Greg
- Ford Cathy
- Frye Northrop
- Frye Northrop
- Fuchs Terry
- G. Geddes
- G. Geddes
- G. Hancock
- G. Hancock
- G. Hancock
- G. Marcotte
- G. McWhirter
- G. Melnyk
- G. Murray
- G. Ryga
- G. Ryga
- G. Woodcock
- G. Woodcock
- G. Woodcock
- Gallant Mavis
- Galt John
- Garsonnin Eric
- Garwood Lana
- Gatenby Greg
- Gauvreau Claude
- Gibbs Robert
- Gilbert Gerry
- Gillis Susan
- Godfrey Dave
- Goldsmith Oliver
- Gorman LeRoy
- Gould Terry
- Govier Katherine
- Gregg John
- Greig Hugh
- Grove Frederick Philip
- Gutteridge Don
- Gérin-Lajoie Antoine
- H. de Santana
- H. Porter
- H.G. Edinger
- Haggerty Joan
- Haig-Brown Roderick
- Haliburton Thomas Chandler
- Haliburton Thomas Chandler
- Halko Irene
- Hall Chipman
- Halperin Irving
- Hamilton Pierce Stevens
- Hamilton Susan L.
- Hardy Isabeth
- Harlow Robert
- Harris John
- Harris Paula
- Harrison Devin
- Hayman Robert
- Heide Christopher
- Heide Christopher
- Hekkanen Ernest
- Hendry Tom
- Hendry Tom
- Hendry Tom
- Hiebert Paul
- Hill Kathy
- Hine Daryl
- Hodgins Jack
- Hollingshead Greg
- Hollingsworth Margaret
- Hood Hugh
- Hooper Mollie
- Horst Roger
- Hosein Jennifer
- Howe Joseph
- Howells Annie
- Hubert Cam
- Hubert Cam
- Huggan Isabel
- Huser Glen
- Hutchison Joe
- Hébert Anne
- I. Balfour
- I. Carrington
- I. Young
- Ingram Alyce
- Ireland Ann
- J. Ball
- J. Baxter
- J. David
- J. Hofsess
- J. Hofsess
- J. Lye
- J. Mallinson
- J. Neufeld
- J. Pivato
- J. Reaney
- J. Sowby
- J.C. Green
- J.H. Rosenburg
- J.M. Kertzer
- J.M. Yates
- J.M. Zezulka
- J.R. Struthers
- J.W. Foster
- J.W. Watson
- Jarvis Thomas Stinson
- Jewinski Hans
- Jiles Paulette
- Johnson G. Bertha
- Jonas George
- Jonas George
- Julian Marilyn
- K. Echlin
- K. Norris
- K. Norris
- K. Radu
- K. Russell
- K. Thompson
- K.J. Hughes
- K.P. Stich
- Keenleyside T.A.
- Kemp Penny
- Kemp Penny
- Kertes Joseph
- Kidd Flora
- Kirby William
- Kleiman Ed'
- Klein A.M.
- Knox Alexander
- Konyves Tom
- Konyves Tom
- Kreisel Henry
- Kreisel Henry
- Kroetsch Robert
- Kumin Maxine
- L. McMullen
- L. Sandler
- L.B. Meckler
- L.C. Gottlieb
- L.M. Shirinian
- Lamb Murray
- Landy Francis
- Lane John
- Lauder Scott
- Laurence Margaret
- Lavoie Stephanie
- Layton Aviva
- Layton Irving
- Layton Irving
- Leacock Stephen
- Leckie Keith
- Lee Dennis
- Lemm Richard
- Leprohon Rosanna
- LeSueur William
- Levis Deanna
- Lewis Ruth C.
- Lipkis Jeff
- Livesay Dorothy
- Longmore George
- Loomer L.S.
- Lowry Margerie Bonner
- Lowther Pat
- M. Acorn
- M. Acorn
- M. Anderson
- M. Atwood
- M. Atwood
- M. Bowering
- M. Boweririg
- M. Dorsinville
- M. Ford
- M. Kennedy
- M. Macina
- M. McLuhan
- M. Micros
- M. Page
- M. Page
- M. Ross
- M. Vipond
- M. Zola
- M.B. Oliver
- M.C. Wilson
- M.G. Hesse
- MacCormack Terry
- Macphail Andrew
- Madott Darlene
- Mahood Maurice
- Mandel Eli
- Mandrake Jill
- Marcotte Gilles
- Margoshes Dave
- Marlatt Daphne
- Marlatt Daphne
- Marshall Joyce
- Marshall Tom
- Mason Mike
- Mathews Laurence
- Mayhew Vic
- McClellan Pat
- McClung Nellie
- McCurry Jim
- McFadden David
- McFadden David
- McKenzie Earl
- McKinnon Barry
- McLean Anne
- McLean James S.
- McLuhan Marshall
- Metcalf John
- Metcalf John
- Mills John
- Minions Stephen
- Mitchell Ken
- Mitchell W.O.
- Mombourquette Michael
- Moore Brian
- Moore Brian
- Moore Ken
- Morton Lionel
- Mowat Farley
- Mrkich Dan
- Munro Alice
- Munro Alice
- Murphy Jeremiah V.
- Musgrave Susan
- N. Carson
- N.W. Fraser
- Neil Al
- Newlove. John
- Nichol B.P.
- Nichol B.P.
- Nichol B.P.
- Nightingale Christine
- Nowlan Alden
- Nowlan Alden
- Nutting Leslie
- O'Flaherty Patrick
- Oates Joyce
- Oates Joyce Carol
- Okun Nicole
- Ondaatje Michael
- Ondaatje Michael
- Ord Douglas
- Orde Lewis
- P. Baltensperger
- P. Hay
- P. Hunt
- P. Monk
- P. Morley
- P. Morley
- P. Quartermain
- P. Stevens
- P. Stevens
- P. Thompson.
- P.F. McNally
- Palmer John
- Parsons Fay
- Petersen Olive MacKay
- Plantos Ted
- Powell Craig
- Pratt E.J.
- Purdy A.
- R. Cameron
- R. Cluett
- R. Fulford
- R. Huebert
- R. LaBonte
- R. Mathews
- R. Page
- R. Siemens
- R. Skelton
- R. Smith
- R. Stuart
- R. Sutherland
- R.A. Lecker
- R.A. Lecker
- R.D. MacDonald
- Raddall Thomas H.
- Radu Kenneth
- Reaney James
- Richards David
- Riches Brenda
- Richler Mordecai
- Riddell John
- Riis Sharon
- Ringwood Gwen Pharis
- Ritter Erika
- Roberts Charles G.D.
- Roberts Charles G.D.
- Roberts Kevin
- Robertson Don
- Robin Skelton
- Robin Donald M.
- Robinson Spider
- Rogers Linda
- Rohmer Richard
- Rooke Constance
- Rose Mildred A.
- Ross D.
- Ross James
- Ross Veronica
- Ross W.W.E.
- Rosta Helen
- Rowdon Larry
- S. Bonnycastle
- S. Clarkson
- S. Djwa
- S. Hatfield
- S. Martin
- S. Morrison
- S. Nagarajan
- S. Solecki
- S. Solecki
- S. Symons
- S.E. Grace
- S.J. Wilson
- Salmaniw Stephen
- Sandor Karl
- Sangster Charles
- Saul John
- Schoemperlen Diane
- Schroeder Andreas
- Schweers Gordon
- Scott Duncan Campbell
- Scott Duncan Campbell
- Scott F.R.
- Seal Graham
- Service Robert W.
- Seton Ernest Thompson
- Seán Virgo
- Sharpe. David
- Sherman K.J.
- Sherman Ken
- Sherrin Robert G.
- Shields Carol
- Shirinian Lorne M.
- Simmie Lois
- Simpson Gregg
- Simpson Leo
- Slater Ian
- Smith A.J.M.
- Smith D.C.
- Smith D.L.M.
- Souster Raymond
- Stange Kenneth
- Staniforth Richard
- Station F.
- Stead Robert
- Stein David
- Stein Louise
- Stenson Fred
- Stephen Sid
- Stevens Peter
- Stevenson Lionel
- Stewart A.C.
- Sturmanis Dona
- Such
- Suthren Victor
- Symons Scott
- Symons T.H.B.
- Szumigalski Anne
- T. Hendry
- T. Marshall
- T. Marshall
- T. Marshall
- T. Marshall
- T. Quigley
- T. Stephenson
- T. Wayman
- T.D. MacLulich
- T.D. MacLulich
- T.E. Tausky
- T.Q. Dombrowski
- Teed Roy
- Templeton Charles
- Thomas Audrey
- Thompson James
- Thompson John R.
- Thompson Kent
- Tippett Maria
- Tocque Philip
- Traill Catherine Parr
- Tupper Dorothy
- V. Boland
- Valgardson W.D.
- Valgardson W.D.
- Van der Schel Sjors
- Van Dyck Henry
- Van Rjndt Philippe
- Virgo Sean
- Vlahov Ed
- W. Cude
- W. Cude
- W. Kirkconnell
- W. Pache
- W.H. New
- W.H. New
- Wade John Stevens
- Walker Doris
- Walters Harold N.
- Waltner-Toews David
- Ward Frederick
- Watmough David
- Watt F.W.
- Weinzweig Helen
- Wheatley Patience
- White Marilyn
- Whyte Don
- Wiebe Armin
- Wiebe Rudy
- Wilford M.
- Wilson Ethel
- Windsor Robert
- Woodcock George
- Wreggitt Andrew
- Wright Doug
- Wright Richard B.
- Wynand Derk
- Young David
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research