44 research outputs found
Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: Study protocol for a randomized controlled trial
- Author
- Al-Khafaji P
- Bellamacina C
- Brown S
- Burlinson A
- Burrows J
- Cairns L
- Campbell K
- Chapman M
- Clarke A
- Collie M
- Corrigan N
- Cruickshank N
- Davies G
- Di Tanna GL
- Dixon A
- Eldridge S
- Emmanuel A
- Emmett C
- Gilbert D
- Giordano P
- Grossi U
- Hance J
- Hansen J
- Harding J
- Horrocks E
- Jayne D
- Knowles CH
- Lacy-Colson J
- Lindsey I
- Manivannan A
- Marlin N
- Mason J
- McAlees E
- McCurrach I
- McLaughlin J
- Mercer-Jones M
- Michael K
- Miller A
- Moss-Morris R
- Nisar P
- Norton C
- Ogden K
- Pares D
- Pearce R
- Pilkington S
- Praveen BVR
- Savage I
- Scott SM
- Siddiqi S
- Smalley L
- Smart N
- Stevens N
- Stoker C
- Taylor S
- Telford K
- Tincello D
- Tinkler L
- Uddin N
- Ukoumunne OC
- Vaizey C
- Vollebregt P
- Waring M
- Webb-Wilson H
- Williams A
- Yiannakou Y
- Publication venue
- Publication date
- 05/02/2018
- Field of study
Get PDFBACKGROUND: Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse is uncertain due to the lack of high-quality evidence. METHODS: An individual level, stepped-wedge randomised trial has been designed to allow observer-blinded data comparisons between patients awaiting LVMR with those who have undergone surgery. Adults with symptomatic internal rectal prolapse, unresponsive to prior conservative management, will be eligible to participate. They will be randomised to three arms with different delays before surgery (0, 12 and 24 weeks). Efficacy outcome data will be collected at equally stepped time points (12, 24, 36 and 48 weeks). The primary objective is to determine clinical efficacy of LVMR compared to controls with reduction in the Patient Assessment of Constipation Quality of Life (PAC-QOL) at 24 weeks serving as the primary outcome. Secondary objectives are to determine: (1) the clinical effectiveness of LVMR to 48 weeks to a maximum of 72 weeks; (2) pre-operative determinants of outcome; (3) relevant health economics for LVMR; (4) qualitative evaluation of patient and health professional experience of LVMR and (5) 30-day morbidity and mortality rates. DISCUSSION: An individual-level, stepped-wedge, randomised trial serves the purpose of providing an untreated comparison for the active treatment group, while at the same time allowing the waiting-listed participants an opportunity to obtain the intervention at a later date. In keeping with the basic ethical tenets of this design, the average waiting time for LVMR (12 weeks) will be shorter than that for routine services (24 weeks)
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
- Amezaga M.
- Amin A.
- Amit B.
- Anand A.
- Anantapatnaikuni S.
- Anderson L.
- Anderson M.
- Anderson N.
- Anderson R.
- Andrews A.
- Ang A.
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- Bujazia R.
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- Burda D.
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- Byrne J.
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- Byrne-Watts V.
- Cale E.
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- Callens C.
- Cameron E.
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- Carroll A.
- Carson R.
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- Carty C.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
- Chambers L.
- Chan E.
- Chan R.
- Chaplin J.
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- Charles B.
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- Chatar K.
- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
- Cheung E.
- Cheyne C.
- Chilcott S.
- Chilvers A.
- Chin K.
- Chineka R.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
- Clark G.
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- Clark R.
- Clarke A.
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- Clay K.
- Clayton-Smith J.
- Cleaver C.
- Clemente de la Torre C.
- Clifford S.
- Coakley M.
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- Cochrane P.
- Cocks S.
- Coe A.
- Coey D.
- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
- Connell L.
- Connelly K.
- Connolly G.
- Connor E.
- Conroy K.
- Conteh V.
- Conway R.
- Cook E.
- Cooke G.
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- Cooper D.
- Cooper L.
- Cooper N.
- Cooray S.
- Corbett C.
- Corbishley A.
- Cornwell J.
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- Corrigan R.
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- Coston C.
- Cotterill D.
- Coull A.
- Courtney E.
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- Crasta S.
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- Creagh-Brown B.
- Cremona J.
- Cribb M.
- Crichton C.
- Crisp L.
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- Dalgleish H.
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- Darbyshire Janet
- Darnell S.
- Darton T.
- Das S.
- Dasgin J.
- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
- Davidson N.
- Davies B.
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- Dawson A.
- Day Jeremy
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- de Silva T.
- De Soyza A.
- de Vos J.
- Dean K.
- Deane J.
- Dear J.
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- Deery J.
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- Denis E.
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- Desai A.
- Deshpande S.
- Dey P.
- Dhaliwal K.
- Dhani S.
- Dhasmana Devesh J.
- Dhillon R.
- Dicks P.
- Digby J.
- Dimitri P.
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- Ditchfield L.
- Dixon C.
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- Dobbie L.
- Dobson C.
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- Docherty M.
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- Dolan D.
- Dolman M.
- Donald L.
- Donaldson D.
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- Donlon S.
- Donohoe A.
- Donohoe G.
- Dosani M.
- Dosanjh D.
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- Downey R.
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- Drewett O.
- Drogan H.
- Drummond G.
- Druryk K.
- Du Thinh A.
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- Duffield E.
- Duffy H.
- Duggan A.
- Dummer S.
- Duncan C.
- Duncan F.
- Duncan G.
- Duncan R.
- Dunleavy J.
- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
- Eades C.
- Early J.
- Eatough R.
- Eddleston M.
- Edgerley K.
- Edmond N.
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- Ekoi M.
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- Elgohary A.
- Ellis C.
- Ellwood A.
- Elokl M.
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- Elyoussfi S.
- Emberson Jonathan R.
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- Emonts M.
- Essa F.
- Evans B.
- Evans G.
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- Evans R.
- Everden C.
- Everden S.
- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
- Farooq H.
- Farrell B.
- Farzana S.
- Fatemi A.
- Fatemi M.
- Faust S. N.
- Faust Saul N.
- Fearby S.
- Felton T.
- Fenlon K.
- Fenn A.
- Fenner I.
- Fenton C.
- Ferenando G.
- Ferguson C.
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- Ferguson V.
- Fernandez Lopez S.
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- Fethers N.
- Fielding J.
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- Fiouni S.
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- Flaherty J.
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- Fordham I.
- Forrest A.
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- Foster R.
- Fowler Robert
- Fowler S.
- Fox A.
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- Fullerton D.
- G N.
- Gabbitas E.
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- George V.
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- Haynes Richard
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- Headon E.
- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
- Henry J.
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- Hum R.
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- Hutton P.
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- Ijaz M.
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- Irons R.
- Irving R.
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- Islim A.
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- Iwanikiw S.
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- Jackman S.
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- Jafar A.
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- Jaly Y.
- Jama R.
- Jamal A.
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- Jeebun V.
- Jeffery Katie
- Jeffreys N.
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- Jerry D.
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- Johnstone D.
- Johnstone E.
- Jones A.
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- Jordache R.
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- Josiah B.
- Ju Wen Kwek A.
- Judge P.
- Juszczak Edmund
- Kailey A.
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- Little J.
- Liu P.
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- Lloyd A.
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- Lo S.
- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Lockett T.
- Lodhia K.
- Lofthouse M.
- Logan M.
- Logue C. A.
- Lokanathan S.
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- Majumdar Jaydip
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2002
- Field of study
Full text linkThigh-length compression stockings and DVT after stroke
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- Segovia M
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- Sohail B
- Sohail B
- Solesbury A
- Somalanka S
- Somashekar C
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- Sorice V
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- Streit D
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- Suarez C
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- Suliman A
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- Sundar S
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- Swithenbank L
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- Thorpe S
- Thozthumparambil P
- Thrasyvoulou L
- Thraves H
- Thwaites G
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- Tierney C
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- Topham K
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- Trafford MT
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- Trudgill N
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- Tsakiridou K
- Tsang C
- Tsilimpari K Karali
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- Turnbull A
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- Turner S
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- Tyagi B
- Tyagi V
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- Tzavaras P
- Uddin M Saif
- Ul Hassan W
- Ullah S
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- Umaipalan A
- Umeojiako W
- Unsworth A
- Uppal V Singh
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- Vaccari L Cheyenne
- Valeria B
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- van de Venne M
- van der Meer A
- van der Stelt N
- van Someren C
- Vankayalapati P
- Vara S
- Varghese A
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- Varnier G
- Vasadi V
- Vasu V
- Vasudevan V
- Vathenen R
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- Vattekkat R Renu
- Vayalaman H
- Vaz C
- Veale N
- Velan B
- Velauthar L
- Vella N
- Venables I
- Venditti M
- Venkataramakrishnan R
- Veres M
- Vergnano S
- Verma A
- Vertue M
- Vethanayagam N
- Vilimiene N
- Vinay S
- Vincent R
- Vincent R
- Visentin E
- Vithian K
- Vyras E
- Wadd S
- Waddington N
- Wadsworth K
- Wafa SEI
- Wagstaff D
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- Wahbi Z
- Wake R
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- Waller R
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- Warmington J
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- Watson E
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- Wayman E
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- Weeratunga J
- Weetman M
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- Whittaker E
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- Wiesender C
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- Wilkinson S
- Wilkinson S
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- Willis J
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- Wilson D
- Wilson J
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- Wilson K
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- Wilson T
- Win M
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- Winn S
- Winstanley M
- Winter H
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- Wiselka M
- Wittes J
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- Wood F
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- Woodford J
- Woodhead L
- Woodland P
- Woodward Z
- Wooldridge G
- Woollen L
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- Wootton D
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- Wyness K
- Wynter I
- Xavier B
- Xia Z
- Yan M
- Yanney M
- Yasmin S
- Yates B
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- Yates D
- Yates H
- Yein K
- Yelnoorkar F
- Yip K
- Ynter I
- Yorke J
- Youssouf S
- Yousuf A
- Yung B
- Zafar A-M
- Zaher S
- Zalewska K
- Zaman M
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- Zammit-Mangion M
- Zdanaviciene A
- Zehnde D
- Zhixin J
- Zhu D
- Zia M
- Zin E Thant
- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: Study protocol for a randomized controlled trial
- Author
- Al-Khafaji P.
- Bellamacina C.
- Brown S.
- Burlinson A.
- Burrows J.
- Cairns L.
- Campbell K.
- Chapman M.
- Clarke A.
- Collie M.
- Corrigan N.
- Cruickshank N.
- Davies G.
- Di Tanna G. L.
- Dixon A.
- Eldridge S.
- Emmanuel A.
- Emmett C.
- Gilbert D.
- Giordano P.
- Grossi U.
- Hance J.
- Hansen J.
- Harding J.
- Horrocks E.
- Jayne D.
- Knowles C. H.
- Lacy-Colson J.
- Lindsey I.
- Manivannan A.
- Marlin N.
- Mason J.
- McAlees E.
- McCurrach I.
- McLaughlin J.
- Mercer-Jones M.
- Michael K.
- Miller A.
- Moss-Morris R.
- Nisar P.
- Norton C.
- Ogden K.
- Pares D.
- Pearce R.
- Pilkington S.
- Praveen B. V. R.
- Savage I.
- Scott S. M.
- Siddiqi S.
- Smalley L.
- Smart N.
- Stevens N.
- Stoker C.
- Taylor S.
- Telford K.
- Tincello D.
- Tinkler L.
- Uddin N.
- Ukoumunne O. C.
- Vaizey C.
- Vollebregt P.
- Waring M.
- Webb-Wilson H.
- Williams A.
- Yiannakou Y.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Get PDFBackground: Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse is uncertain due to the lack of high-quality evidence. Methods: An individual level, stepped-wedge randomised trial has been designed to allow observer-blinded data comparisons between patients awaiting LVMR with those who have undergone surgery. Adults with symptomatic internal rectal prolapse, unresponsive to prior conservative management, will be eligible to participate. They will be randomised to three arms with different delays before surgery (0, 12 and 24 weeks). Efficacy outcome data will be collected at equally stepped time points (12, 24, 36 and 48 weeks). The primary objective is to determine clinical efficacy of LVMR compared to controls with reduction in the Patient Assessment of Constipation Quality of Life (PAC-QOL) at 24 weeks serving as the primary outcome. Secondary objectives are to determine: (1) the clinical effectiveness of LVMR to 48 weeks to a maximum of 72 weeks; (2) pre-operative determinants of outcome; (3) relevant health economics for LVMR; (4) qualitative evaluation of patient and health professional experience of LVMR and (5) 30-day morbidity and mortality rates. Discussion: An individual-level, stepped-wedge, randomised trial serves the purpose of providing an untreated comparison for the active treatment group, while at the same time allowing the waiting-listed participants an opportunity to obtain the intervention at a later date. In keeping with the basic ethical tenets of this design, the average waiting time for LVMR (12 weeks) will be shorter than that for routine services (24 weeks)
Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
- Author
- A Gougeon
- A Kaipia
- AH Wyllie
- AM Chinnaiyan
- BS Reichman
- C Familiari
- C Yin
- CM Knudson
- DP Lane
- DS Alberts
- DW Nicholson
- E Wang
- E Yang
- Emad S Alnemri
- F Tchang
- HL Ried
- I Keren-Tal
- J Waxman
- J Xiang
- JA Flaws
- JC Reed
- JL Tilly
- JL Tilly
- JL Tilly
- JL Tilly
- JP Jaffrezou
- JP Witty
- K Schulze-Osthoff
- KI Tilly
- LJ Ko
- MD Jacobson
- MD Jacobson
- ME McCurrach
- MJ Tucker
- O Cuvillier
- PA Speth
- QL Deveraux
- R Bose
- S Martimbeau
- S Spiegel
- SW Lowe
- T Miyashita
- T Patel
- VS Ratts
- YA Hannun
- ZN Oltvai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textThe gene encoding the splicing factor SF2/ASF is a proto-oncogene
- Author
- A Hammes
- A Kumar
- A Mayeda
- Adrian R Krainer
- AJ Waskiewicz
- AR Venkitaraman
- C Ghigna
- C Ghigna
- C Patry
- CF Bourgeois
- CS Sinclair
- D Hanahan
- D Sakamuro
- David Mu
- DC Fischer
- DL Black
- E de Stanchina
- Elisa de Stanchina
- GC Scheper
- GC Scheper
- H Harada
- HA Steinman
- HY Wang
- I Topisirovic
- J Stolarov
- JB DuHadaway
- JF Cáceres
- JF Cáceres
- JM Johnson
- JP Venables
- JR Sanford
- JY Wu
- K Ge
- L Zender
- M Blanchette
- M Kim
- M Mixon
- MA Bjornsti
- ME McCurrach
- MK Holz
- MS Tockman
- Q Xu
- R Karni
- Rahul Sinha
- Rotem Karni
- S Kim
- Scott W Lowe
- SK Hanks
- SS Schalm
- T Sjöblom
- T Tennenbaum
- X He
- X Li
- X Xu
- Y Huang
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2007
- Field of study
No full textAlternative splicing modulates the expression of many oncogene and tumor-suppressor isoforms. We have tested whether some alternative splicing factors are involved in cancer. We found that the splicing factor SF2/ASF is upregulated in various human tumors, in part due to amplification of its gene, SFRS1. Moreover, slight overexpression of SF2/ASF is sufficient to transform immortal rodent fibroblasts, which form sarcomas in nude mice. We further show that SF2/ASF controls alternative splicing of the tumor suppressor BIN1 and the kinases MNK2 and S6K1. The resulting BIN1 isoforms lack tumor-suppressor activity; an isoform of MNK2 promotes MAP kinase-independent eIF4E phosphorylation; and an unusual oncogenic isoform of S6K1 recapitulates the transforming activity of SF2/ASF. Knockdown of either SF2/ASF or isoform-2 of S6K1 is sufficient to reverse transformation caused by the overexpression of SF2/ASF in vitro and in vivo. Thus, SF2/ASF can act as an oncoprotein and is a potential target for cancer therapy
