Changes of metabolism in animals due to conditions of a purulent wound process while using photomineralisation as dressing tools

The aim of our research was to study the dynamics of the General biochemical parameters of blood of laboratory rats in accordance with the phases of the wound process using phytomineralsorbent

Prospects for the use of “protected fats” in cattle feed additives

The article reviews the use and physiological effects of fats protected from decay in the rumen of ruminants, as well as types of feed additives containing “protected fats”, presents their comparative characteristics of fatty acid composition, indicators of exchange and pure lactation energy. Summarized data indicate the prospects of the technology of “protected fats” and their use in animal husbandr

Influence of L-lysine sulfate on containing of vitamins and minerals in the body of broiler chickens

Experimental researches have shownthatthe L-lysine sulfate (the product of microbiological synthesis) has a positive effect on metabolism of vitamins A, E, C in the liver and minerals calcium and phosphorus in the blood and bones of broiler chickens. The dose of L-lysine sulfate of 800 mg-kg" 1 and 1000 mg-kg-1 weight body has influence on increasing vitamins level in the liver. Was observed, that indexes of calcium and phosphorus are increased in the blood but it’s decreased in the bones of broiler chickens. This results are necessary for Veterinary Pharmacology Consults and official practically using in agricultural sectors of Russian Federatio

Research of wound healing effect of phytomineralsorbent on the basis of montmorillonite

The results of preclinical investigation of the wound healing effect of phytomineralsorbent (PMS) based on montmorillonite are presented. Objectives: Study of the possibilities of pharmacological correction of purulent wound process with the help of various medicinal forms of phytomineral sorbent based on montmorillonit

Enterosorbent based on montmorillonite as a promising tool in the treatment and prevention of intestinal disorders in pigs

The article discusses the treatment and prevention of feed toxicosis of pigs. A composition based on montmorillonite-containing minerals is considered as a promising enterosorbent in combination with the drug vievitin in the treatment of pig dysentery. Studies have shown that the complex use of vievitin with a sorbent by giving individually in 100 ml of drinking water at doses of 5.6 (second group) and 11.1 (third group) mg/kg body weight for vievitin and 400 mg/kg body weight bodies for the sorbent provided a high therapeutic effect in the treatment of piglets suffering from dysentery. Recovery, respectively, was 90.8 an

Testing for the ability to modify antibiotics of Panus tigrinus 8/18 Lentinus strigosus 1566 laccase

In advanced biotechnology, the utilization of enzymes to achieve new or modified compounds with antibacterial, fungicidal, and anti-cancer specifications is crucial. Mushroom lactases are a hopeful biocatalyst for the synthesis and modification of different compounds. They are an accessible and inexpensive enzyme for the preparation of reaction objects and have recently received attentio

Determination of mycotoxins in the seeds of sunflower, soybean and corn by enzyme immunoassay

The implementation of the enzyme-linked immunosorbent assay is based on a highly specific reaction "antigen-antibody", the detection of which occurs due to a change in the color of the corresponding substrate with the introduction of the enzymatic component. To study the contamination of mycotoxins of various varieties of crops (soybean, sunflower, corn) cultivated in the Central Сhernozemregion region of Russia. The study was conducted by a direct competitive enzyme immunoassay using the Multiskan FC microbiological analyze

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Amyloid and tau cerebrospinal fluid biomarkers in HIV infection

<p>Abstract</p> <p>Background</p> <p>Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients.</p> <p>Methods</p> <p>In this cross-sectional study we measured soluble amyloid precursor proteins alpha and beta (sAPPα and sAPPβ), amyloid beta fragment 1-42 (Aβ_1-42), and total and hyperphosphorylated tau (t-tau and p-tau) in CSF of 86 HIV-infected (HIV+) subjects, including 21 with AIDS dementia complex (ADC), 25 with central nervous system (CNS) opportunistic infections and 40 without neurological symptoms and signs. We also measured these CSF biomarkers in 64 uninfected (HIV-) subjects, including 21 with Alzheimer's disease, and both younger and older controls without neurological disease.</p> <p>Results</p> <p>CSF sAPPα and sAPPβ concentrations were highly correlated and reduced in patients with ADC and opportunistic infections compared to the other groups. The opportunistic infection group but not the ADC patients had lower CSF Aβ_1-42in comparison to the other HIV+ subjects. CSF t-tau levels were high in some ADC patients, but did not differ significantly from the HIV+ neuroasymptomatic group, while CSF p-tau was not increased in any of the HIV+ groups. Together, CSF amyloid and tau markers segregated the ADC patients from both HIV+ and HIV- neuroasymptomatics and from Alzheimer's disease patients, but not from those with opportunistic infections.</p> <p>Conclusions</p> <p>Parallel reductions of CSF sAPPα and sAPPβ in ADC and CNS opportunistic infections suggest an effect of CNS immune activation or inflammation on neuronal amyloid synthesis or processing. Elevation of CSF t-tau in some ADC and CNS infection patients without concomitant increase in p-tau indicates neural injury without preferential accumulation of hyperphosphorylated tau as found in Alzheimer's disease. These biomarker changes define pathogenetic pathways to brain injury in ADC that differ from those of Alzheimer's disease.</p

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a variety of pathogens, including many not normally controlled by the IRG system. This phenotype is associated with lymphopenia, hemopoietic collapse, and death of the mouse.Deutscher Akademischer Austausch Dienst (DAAD); International Graduate School in Development Health and Disease (IGS-DHD); Deutsche For-schungsgemeinschaft (SFBs 635, 670, 680); Max-Planck-Gesellschaft (Max Planck Fellowship)