Effect of exercise intervention on vestibular related impairments in hearing-impaired children

Objective: To analyze the methodological quality and compile the evidence from studies, which examined the efficacy of exercise interventions in the treatment of vestibular-related deficits in hearing-impaired children.Sources: Extensive search of computerized bibliographic databases (MEDLINE, CINHAL, EMBASE, SCOPUS, ISI of web science, Cochrane Library, and AMED) was performed from earliest to February 7, 2011.Data extraction: Potential articles were retained and analyzed by a single investigator to ensure the eligibility criteria. Methodological quality was analyzed using the PEDro scale.Results: Our search yielded 8326 articles. Finally, two potential citations were retained for inclusion after removing duplicates, and excluding articles that do not fulfill the criteria.Conclusion: Exercise programs that enhances the visual–motor and somatosensory abilities that enable substitution are more effective in improving the vestibular related deficits in children with hearing-impairment.Keywords: Vestibular impairment/hypofunction; Exercise/rehabilitation; Hearing impairment; Children; Review (publication type

Brain Neoplasm Classification & Detection of Accuracy on MRI Images

The abnormal, uncontrolled cell growth in the brain, commonly known n as a brain tumor, can lead to immense pressure on the various nerves and blood vessels, causing irreversible harm to the body. Early detection of brain tumors is the key to avoiding such compilations. Tumour detection can be done through various advanced Machine Learning and Image Processing algorithms. Mind Brain tumors have demonstrated testing to treat, to a great extent inferable from the organic qualities of these diseases, which frequently plan to restrict progress. To begin with, by invading one of the body's most significant organs, these growths are much of the time situated past the compass of even the most gifted neurosurgeon. These cancers are likewise situated behind the blood-cerebrum boundary (BBB), a tight intersection and transport proteins that shield fragile brain tissues from openness to factors in the overall flow, subsequently obstructing openness to foundational chemotherapy [6,7]. Besides, the interesting formative, hereditary, epigenetic and micro environmental elements of the cerebrum much of the time render these tumors impervious to ordinary and novel medicines. These difficulties are accumulated by the uncommonness of cerebrum growths comparative with numerous different types of disease, restricting the degree of subsidizing and interest from the drug business and drawing in a moderately little and divided research local area

Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-Analysis

PMCID: PMC3686792This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction

INTRODUCTION: Chemokine-directed migration is crucial for homing of regenerative cells to the infarcted heart and correlates with outcomes of cell therapy trials. Hence, transplantation of chemokine-responsive bone marrow cells may be ideal for treatment of myocardial ischemia. To verify the therapeutic activity of bone marrow mononuclear cells (BM-MNCs) selected by in vitro migration towards the chemokine stromal cell-derived factor-1 (SDF-1) in a mouse model of myocardial infarction (MI), we used BM-MNCs from patients with previous large MI recruited in the TransACT-1&2 cell therapy trials. METHODS: Unfractioned BM-MNCs, SDF-1-responsive, and SDF-1-nonresponsive BM-MNCs isolated by patients recruited in the TransACT-1&2 cell therapy trials were tested in Matrigel assay to evaluate angiogenic potential. Secretome and antigenic profile were characterized by flow cytometry. Angiogenin expression was measured by RT-PCR. Cells groups were also intramyocardially injected in an in vivo model of MI (8-week-old immune deficient CD1-FOXN1(nu/nu) mice). Echocardiography and hemodynamic measurements were performed before and at 14 days post-MI. Arterioles and capillaries density, infiltration of inflammatory cells, interstitial fibrosis, and cardiomyocyte proliferation and apoptosis were assessed by immunohistochemistry. RESULTS: In vitro migration enriched for monocytes, while CD34(+) and CD133(+) cells and T lymphocytes remained mainly confined in the non-migrated fraction. Unfractioned total BM-MNCs promoted angiogenesis on Matrigel more efficiently than migrated or non-migrated cells. In mice with induced MI, intramyocardial injection of unfractionated or migrated BM-MNCs was more effective in preserving cardiac contractility and pressure indexes than vehicle or non-migrated BM-MNCs. Moreover, unfractioned BM-MNCs enhanced neovascularization, whereas the migrated fraction was unique in reducing the infarct size and interstitial fibrosis. In vitro studies on isolated cardiomyocytes suggest participation of angiogenin, a secreted ribonuclease that inhibits protein translation under stress conditions, in promotion of cardiomyocyte survival by migrated BM-MNCs. CONCLUSIONS: Transplantation of bone marrow cells helps post-MI healing through distinct actions on vascular cells and cardiomyocytes. In addition, the SDF-1-responsive fraction is enriched with angiogenin-expressing monocytes, which may improve cardiac recovery through activation of cardiomyocyte response to stress. Identification of factors linking migratory and therapeutic outcomes could help refine regenerative approaches. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13287-015-0028-y) contains supplementary material, which is available to authorized users

A review of economic evaluation models for cardiac resynchronization therapy with implantable cardioverter defibrillators in patients with heart failure

Objectives Cardiac resynchronization therapy with a biventricular pacemaker (CRT-P) is an effective treatment for dyssynchronous heart failure (DHF). Adding an implantable cardioverter defibrillator (CRT-D) may further reduce the risk of sudden cardiac death (SCD). However, if the majority of patients do not require shock therapy, the cost-effectiveness ratio of CRT-D compared to CRT-P may be high. The objective of this study was to systematically review decision models evaluating the cost-effectiveness of CRT-D for patients with DHF, compare the structure and inputs of these models and identify the main factors influencing the ICERs for CRT-D. Methods A comprehensive search strategy of Medline (Ovid), Embase (Ovid) and EconLit identified eight cost-effectiveness models evaluating CRT-D against optimal pharmacological therapy (OPT) and/or CRT-P. Results The selected economic studies differed in terms of model structure, treatment path, time horizons, and sources of efficacy data. CRT-D was found cost-effective when compared to OPT but its cost-effectiveness became questionable when compared to CRT-P. Conclusions Cost-effectiveness of CRT-D may increase depending on improvement of all-cause mortality rates and HF mortality rates in patients who receive CRT-D, costs of the device, and battery life. In particular, future studies need to investigate longer-term mortality rates and identify CRT-P patients that will gain the most, in terms of life expectancy, from being treated with a CRT-D.This work was supported by the Center for Translational Molecular Medicine and The Netherlands Heart Foundation under the ‘Biomarkers to predict cardiac failure, arrhythmias and success of treatment’ (COHFAR) projec

withdrawn 2017 hrs ehra ecas aphrs solaece expert consensus statement on catheter and surgical ablation of atrial fibrillation

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