Spontaneous Creation of Inflationary Universes and the Cosmic Landscape

We study some gravitational instanton solutions that offer a natural realization of the spontaneous creation of inflationary universes in the brane world context in string theory. Decoherence due to couplings of higher (perturbative) modes of the metric as well as matter fields modifies the Hartle-Hawking wavefunction for de Sitter space. Generalizing this new wavefunction to be used in string theory, we propose a principle in string theory that hopefully will lead us to the particular vacuum we live in, thus avoiding the anthropic principle. As an illustration of this idea, we give a phenomenological analysis of the probability of quantum tunneling to various stringy vacua. We find that the preferred tunneling is to an inflationary universe (like our early universe), not to a universe with a very small cosmological constant (i.e., like today's universe) and not to a 10-dimensional uncompactified de Sitter universe. Such preferred solutions are interesting as they offer a cosmological mechanism for the stabilization of extra dimensions during the inflationary epoch.Comment: 52 pages, 7 figures, 1 table. Added discussion on supercritical string vacua, added reference

Comment on "Resolving the 180-deg Ambiguity in Solar Vector Magnetic Field Data: Evaluating the Effects of Noise, Spatial Resolution, and Method Assumptions"

In a recent paper, Leka at al. (Solar Phys. 260, 83, 2009)constructed a synthetic vector magnetogram representing a three-dimensional magnetic structure defined only within a fraction of an arcsec in height. They rebinned the magnetogram to simulate conditions of limited spatial resolution and then compared the results of various azimuth disambiguation methods on the resampled data. Methods relying on the physical calculation of potential and/or non-potential magnetic fields failed in nearly the same, extended parts of the field of view and Leka et al. (2009) attributed these failures to the limited spatial resolution. This study shows that the failure of these methods is not due to the limited spatial resolution but due to the narrowly defined test data. Such narrow magnetic structures are not realistic in the real Sun. Physics-based disambiguation methods, adapted for solar magnetic fields extending to infinity, are not designed to handle such data; hence, they could only fail this test. I demonstrate how an appropriate limited-resolution disambiguation test can be performed by constructing a synthetic vector magnetogram very similar to that of Leka et al. (2009) but representing a structure defined in the semi-infinite space above the solar photosphere. For this magnetogram I find that even a simple potential-field disambiguation method manages to resolve the ambiguity very successfully, regardless of limited spatial resolution. Therefore, despite the conclusions of Leka et al. (2009), a proper limited-spatial-resolution test of azimuth disambiguation methods is yet to be performed in order to identify the best ideas and algorithms.Comment: Solar Physics, in press (19 pp., 5 figures, 2 tables

Femoral and obturator neuropathy secondary to retroperitoneal hemorrhage the value of the ct scan

A man developed signs of femoral and obturator neuropathy due to spontaneous retroperitoneal hemorrhage while taking anticoagulant drugs for suspected thrombophlebitis. The hemorrhage was demonstrated by CT scan. CT scans should be used in all patients developing signs of peripheral nerve entrapment during anticoagulant therapy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24328/1/0000595.pd

Intracellular trafficking and replication of Burkholderia cenocepacia in human cystic fibrosis airway epithelial cells

We investigated the trafficking of Burkholderia cenocepacia , an opportunistic respiratory pathogen of persons with cystic fibrosis (CF), in immortalized CF airway epithelial cells in vitro . Our results indicate that bacteria enter cells in a process involving actin rearrangement. Whereas both live and heat-killed bacteria reside transiently in early endosomes, only live bacteria escape from late endosomes to colocalize in vesicles positive for lysosomal membrane marker LAMP1, endoplasmic reticulum (ER) membrane marker calnexin, and autophagosome marker monodansylcadavarine (MDC). Twenty-four hours after infection, microcolonies of live bacteria were observed in the perinuclear area colocalizing with calnexin. In contrast, after ingestion, dead bacteria colocalized with late endosome marker Rab7, and lysosome markers LAMP1 and cathepsin D, but not with calnexin or MDC. Six to eight hours after ingestion of dead bacteria, degraded bacterial particles were observed in the cytoplasm and in vesicles positive for cathepsin D. These results indicate that live B. cenocepacia gain entry into human CF airway cells by endocytosis, escape from late endosomes to enter autophagosomes that fail to fuse with mature lysosomes, and undergo replication in the ER. This survival and replication strategy may contribute to the capacity of B. cenocepacia to persist in the lungs of infected CF patients.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75744/1/j.1462-5822.2006.00724.x.pd

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b}, and b\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K. Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D. Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A. Petrov, P. Robbe, A. Vair

Moments of inertia, nucleon axial-vector coupling, the {\bf 8}, {\bf 10}, 10ˉ\bar{\bf 10} and 273/2{\bf 27}_{3/2} mass spectrums and the higher SU(3)_f representation mass splittings in the Skyrme model

The broad importance of a recent experimental discovery of pentaquarks requires more theoretical insight into the structure of higher representation multiplets. The nucleon axial-vector coupling, moments of inertia, the {\bf 8}, {\bf 10}, $\bar{\bf 10}$, and ${\bf 27}_{3/2}$ absolute mass spectra and the higher SU(3)$_f$ representation mass splittings for the multiplets ${\bf 8}$, ${\bf 10}$, $\bar{\bf 10}$, ${\bf 27}$, ${\bf 35}$, $\bar{\bf 35}$, and $\bf 64$ are computed in the framework of the minimal ${\rm SU(3)_f}$ extended Skyrme model by using only one free parameter, i.e., the Skyrme charge $e$. The analysis presented in this paper represents simple and clear theoretical estimates, obtained without using any experimental results for higher ($\bar{\bf 10}$,...) multiplets. The obtained results are in good agreement with other chiral soliton model approaches that more extensively use experimental results as inputs.Comment: 22 pages, 12 figures, 9 tables, version accepted in JHE

Treatment Outcomes of Patients With Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis According to Drug Susceptibility Testing to First- and Second-line Drugs: An Individual Patient Data Meta-analysis

The clinical validity of drug susceptibility testing (DST) for pyrazinamide, ethambutol, and second-line antituberculosis drugs is uncertain. In an individual patient data meta-analysis of 8955 patients with confirmed multidrug-resistant tuberculosis, DST results for these drugs were associated with treatment outcome

Photonic hydrogel sensors

Analyte-sensitive hydrogels that incorporate optical structures have emerged as sensing platforms for point-of-care diagnostics. The optical properties of the hydrogel sensors can be rationally designed and fabricated through self-assembly, microfabrication or laser writing. The advantages of photonic hydrogel sensors over conventional assay formats include label-free, quantitative, reusable, and continuous measurement capability that can be integrated with equipment-free text or image display. This Review explains the operation principles of photonic hydrogel sensors, presents syntheses of stimuli-responsive polymers, and provides an overview of qualitative and quantitative readout technologies. Applications in clinical samples are discussed, and potential future directions are identified

Measurement of the cross section for isolated-photon plus jet production in pp collisions at √s=13 TeV using the ATLAS detector

The dynamics of isolated-photon production in association with a jet in proton–proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb−1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon–jet invariant mass and the scattering angle in the photon–jet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements