Knowledge-based industry and regional growth

One of the most important but less understood phenomena in the beginning of the 21st century has been a shift toward knowledge-based economic activity in the comparative advantage of modern industrialized countries. Two broad trends has been observed in the global economy. That is, the output from the world's science and technology system has been growing rapidly and the nature of investment has been changed (MILLER, 1996). The relative proportions of physical and intangible investment have changed considerably with the relative increase of intangible investments since the 1980s. In addition, there has been increased complementarity between physical and intangible investments and more important role of high technology in both kinds of investment (MILLER, 1996). Even in the newly industrialized countries, the growth of technology intensive industries, the increase of R&D activities and the growth of the knowledge intensive producer services have been common feature in recent years. In this change of the structure of productive assets, the role of knowledge is well recognized as the most fundamental resources in recent years (OECD, 1996; WORLD BANK, 1998). The development of information and communication technology (ICT) and globalisation trend have promoted this shift toward knowledge-based economy

Development of a laser foaming process for high throughput three-dimensional tissue model devices

A three-dimensional (3D) porous structure on biodegradable or biocompatible polymers have attracted tremendous attention in numerous bio-related areas including 3D cell culturing and tissue engineering because of their microenvironment similar to ones in vivo. In this study, a novel fabrication process, named selective laser foaming, was developed to create localized 3D porous structure on a polymer chip. The effects of laser power and lasing time on the porous structure were studied both experimentally and through finite element modeling. A high throughput two-chamber tissue model platform was developed using the proposed selective laser foaming process. For comparison, cell culture studies were conducted with both selective laser foamed and unfoamed polylactic acid (PLA) samples using T98G cells. The results show that by laser foaming gas-impregnated polylactic acid it is possible to generate an array of inverse cone-shaped wells with porous walls. The size of the foamed region can be controlled with laser power and exposure time, while the pore size of the scaffold can be manipulated with the saturation pressure. The finite element modeling results showed good agreement with the experimental data; therefore, the model could be used to optimize and control the selective foaming process. T98G cells grew well in the foamed scaffolds, forming clusters that have not been observed in 2D cell cultures. Cells were more viable in the 3D scaffolds than in the 2D cell culture cases, suggesting that the 3D porous microarray could be used for parallel studies of drug toxicity, guided stem cell differentiation, and DNA binding profiles. As an example, a high-throughput two-chamber 3D tissue model platform driven by the centrifugal force was developed for drug screening. The selective laser foaming process was calibrated to fabricate 3D scaffold on a commercially available compact disc (CD) made of polycarbonate (PC). Laser foaming of gas saturated polycarbonate created inverse cone-shaped wells with micro-sized porous structure underneath the surface. The open pores were hundreds of micrometers in diameter and depth. The pore size of the underneath porous structure was several tens of micrometers. The size of the well was dependent on the laser power and laser exposure time. Two laser-foamed scaffolds were fabricated in tandem and two mechanically-machined chambers were placed adjacent to the scaffolds, respectively. All scaffolds and chambers were in line and all of them were connected with micro-channels. The surface was coated with polydopamine (PDA) in order to increase the hydrophilicity and biocompatibility. After sterilization, human glioblastoma multiforme (M059K) and hepatoblastoma (C3A sub28) were seeded in the two 3D scaffolds separately and cultured for up to four weeks. These cells grew well in the scaffolds and cell aggregates were observed, suggesting that the developed two-chamber tissue model array could be useful for high-throughput biochemical assays.Mechanical Engineerin

Design of linear transmitters for wireless applications

Wireless standards for high data-rate communications typically employ complex modulation schemes that have large peak-to-average power ratios (PAPR), along with a significant bandwidth requirement. Transmitters for such applications often employ off-chip power amplifiers (PAs), that are typically operated in back-off, such that the peak output power is less than the output 1-dB compression point (P1dB), in order to minimize distortion. In mobile systems, architectures that can enhance the linearity of the transmit chain are highly attractive since these can reduce the PA's back-off requirement, which helps to enhance efficiency. In this dissertation, linearization techniques for mobile transmitters are explored. A Cartesian feedback-feedforward transmitter is proposed for linearity enhancement. The transmit path in the architecture is placed in a Cartesian feedback loop. The feedback error signal is applied to a Cartesian feedforward path for further linearity improvement. Linearity of the feedback-feedforward system is analyzed by using a Volterra series representation. System simulations using two-tone signals and modulated signals are also presented and are used to verify the linearity enhancement provided by the proposed architecture. A prototype transmitter IC that employs the Cartesian feedback-feedforward approach is implemented in a 0.13 μm CMOS process. Design considerations for critical transmitter circuits are discussed. A proof-of-concept Cartesian feedback-feedforward architecture that includes the prototype IC and external components is demonstrated. The implementation allows for a 8.7 dB improvement in the adjacent channel leakage ratio (ACLR), compared to an open-loop transmitter, for an output power of 16.6 dBm at 2.4 GHz while employing a 16-QAM LTE signal with 1.4 MHz bandwidth. The linearity of the Cartesian feedback-feedforward system is found to depend primarily on the loop gain of the Cartesian feedback and the linearity of the Cartesian feedforward path, which introduces a trade-off with power consumption. To enhance the linearity of the Cartesian feedback-feedforward transmitter even further within the Cartesian feedback loop, two modified Cartesian feedback-feedforward architectures are explored. System simulations show that both modified configurations can help to enhance linearity compared to the above Cartesian feedback-feedforward transmitter.Electrical and Computer Engineerin

Jean-Paul Sartre\u27s Concepts of Praxis and History in his \u3cem\u3e Critique of Dialectical Reason\u3c/em\u3e

The primary problem of this study is to clarify Sartre\u27s concept of praxis as a projective action of human consciousness which creates history and makes it intelligible. I focus on Sartre\u27s attempt to combine an existential humanism with a theory of history as a progressive movement generated by individual actors, their social groups, and their environmental surroundings. Sartre\u27s Critique provides the philosophical basis for understanding social institutions and behavior, and describes human action as a complex totality comprising free subjectivity and its unavoidable environment. This inquiry focuses on the existential root of Sartre\u27s theory of history and the problematic nature of his position. Although he allocates priority to an actor\u27s consciousness and actions, his explanation, at times, is vague and unconvincing. While he emphasizes human freedom he inadvertly illustrates the enormous influence of a material world which is beyond our control