10 research outputs found
Gb/s visible light communications with colloidal quantum dot color converters
- Author
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- 01/09/2017
- Field of study
Get PDFThis paper reports the utilization of colloidal semiconductor
quantum dots as color converters for Gb/s visible light
communications. We briefly review the design and properties of
colloidal quantum dots and discuss them in the context of fast
color conversion of InGaN light sources, in particular in view of
the effects of self-absorption. This is followed by a description of
a CQD/polymer composite format of color converters. We show
samples of such color-converting composite emitting at green, yellow/orange
and red wavelengths, and combine these with a blueemitting
microsize LED to form hybrid sources for wireless visible
light communication links. In this way data rates up to 1 Gb/s over
distances of a few tens of centimeters have been demonstrated. Finally,
we broaden the discussion by considering the possibility for
wavelength division multiplexing as well as the use of alternative
colloidal semiconductor nanocrystals
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Adam F.
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- Addo A.
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- Al-Shahi Salman R.
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- Byrne J.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chauhan R.
- Chawla V.
- Chen F.
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- Cherrie M.
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- Chilvers A.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
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- Clare E.
- Clark E.
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- Clayton-Smith J.
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- Clemente de la Torre C.
- Clifford S.
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- Coe A.
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- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
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- Colton H.
- Condliffe R.
- Connell E.
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- Connor E.
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- Conteh V.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Desai A.
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- Dhani S.
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- Dimitri P.
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- Duffy H.
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- Dunn A.
- Duran B.
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- Duru I.
- Dymond H.
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- D’Mello A.
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- Elgohary A.
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- Emberson Jonathan R.
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- Essa F.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Fenton C.
- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Publication venue
- Nature Publishing Group
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- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Gb/s Visible Light Communications With Colloidal Quantum Dot Color Converters
- Author
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- Field of study
No full textFlexible glass hybridized colloidal quantum dots for Gb/s visible light communications
- Author
- Publication venue
- Publication date
- 01/02/2018
- Field of study
No full textColor converting films of colloidal quantum dots (CQDs) encapsulated with flexible glass are integrated with microsize GaN LEDs (μLEDs) in order to form optical sources for high-speed visible light communications (VLC). VLC is an emerging technology that uses white and/or colored light from LEDs to combine illumination and display functions with the transmission of data. The flexible glass/CQD format addresses the issue of limited modulation speed of typical phosphor-converted LEDs while enhancing the photostability of the color converters and facilitating their integration with the μLEDs. These structures are less than 70 μm in total thickness and are directly placed in contact with the polished sapphire substrate of 450-nm-emitting μLEDs. Blue-to-green, blue-to-orange and blue-to-red conversion with respective forward optical power conversion efficiencies of 13%, 12% and 5.5% are reported. In turn, free-space optical communications up to 1.4 Gb/s VLC is demonstrated. Results show that CQD-converted LEDs pave the way for practical digital lighting/displays with multi-Gb/s capability
Thigh-length compression stockings and DVT after stroke
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Neurosurgery activity levels in the United Kingdom and republic of Ireland during the first wave of the covid-19 pandemic–a retrospective cross-sectional cohort study
- Author
- Ahmed A
- Albanese E
- Aly A
- Ammar A
- Amoo M
- Bhatt H
- Bodkin P
- Corr P
- Coulter I
- Elmaadawi I
- Elserius A
- Fountain DM
- George KJ
- Gillespie CS
- Goel A
- Grundy PL
- Gurusinghe N
- Hartley J
- Hasan MDT
- Islim AI
- Javadpour M
- Jenkinson MD
- Kalra N
- Mallucci C
- Millward CP
- Mohamed B
- Mohamed S
- Mustafa MA
- Nannapaneni R
- Nolan D
- Patel UJ
- Piper RJ
- Prasad M
- Rajaraman C
- Raza-Knight S
- Rehman K
- Richardson GE
- Rominiyi O
- Sage W
- Sharouf F
- Sinha S
- Sitaraman M
- Smith S
- Solth A
- Stokes S
- Taweel BA
- Tyagi A
- Zaben M
- Publication venue
- Taylor and Francis Ltd.
- Publication date
- 01/01/2021
- Field of study
No full textNeurosurgery activity levels in the United Kingdom and republic of Ireland during the first wave of the covid-19 pandemic - a retrospective cross-sectional cohort study
- Author
- Ahmed Ahmed
- Albanese Erminia
- Aly Ahmed
- Ammar Amr
- Amoo Michael
- Bhatt Harsh
- Bodkin Peter
- Corr Paula
- Coulter Ian
- Elmaadawi Ibrahim
- Elserius Anne
- Fountain Daniel M
- George K Joshi
- Gillespie Conor S
- Goel Aimee
- Grundy Paul L
- Gurusinghe Nihal
- Hartley Jessica
- Hasan MD Tanvir
- Islim Abdurrahman I
- Javadpour Mohsen
- Jenkinson Michael D
- Kalra Neeraj
- Mallucci Conor
- Millward Christopher P
- Mohamed Belal
- Mohamed Saffwan
- Mustafa Mohammad A
- Nannapaneni Ravindra
- Nolan Deirdre
- Patel Umang J
- Piper Rory J
- Prasad Manjunath
- Rajaraman Chittoor
- Raza-Knight Saba
- Rehman Kafeel
- Richardson George E
- Rominiyi Ola
- Sage William
- Sharouf Feras
- Sinha Saurabh
- Sitaraman Murugan
- Smith Stuart
- Solth Anna
- Stokes Stuart
- Taweel Basel A
- Tyagi Atul
- Zaben Malik
- Publication venue
- 'Informa UK Limited'
- Publication date
- 02/09/2021
- Field of study
No full textThe impact of Covid-19 on surgical patients worldwide has been substantial. In the United Kingdom (UK) and the Republic of Ireland (RoI), the first wave of the pandemic occurred in March 2020. The aims of this study were to: (1) evaluate the volume of neurosurgical operative activity levels, Covid-19 infection rate and mortality rate in April 2020 with a retrospective cross-sectional cohort study conducted across 16 UK and RoI neurosurgical centres, and (2) compare patient outcomes in a single institution in April-June 2020 with a comparative cohort in 2019. Across the UK and RoI, 818 patients were included. There were 594 emergency and 224 elective operations. The incidence rate of Covid-19 infection was 2.6% (21/818). The overall mortality rate in patients with a Covid-19 infection was 28.6% (6/21). In the single centre cohort analysis, an overall reduction in neurosurgical operative activity by 65% was observed between 2020 (n = 304) and 2019 (n = 868). The current and future impact on UK neurosurgical operative activity has implications for service delivery and neurosurgical training
External validation and recalibration of an incidental meningioma prognostic model - IMPACT: protocol for an international multicentre retrospective cohort study
- Author
- Aaron Cohen-Gadol
- Abdurrahman I Islim
- Abdurrahman I Islim
- Abdurrahman I Islim
- Adham M Khalafallah
- Aditaya Kumar
- Adithya Varma
- Aditya Ragunathan
- Adrian Jimenez
- Agbolahan Sofela
- Aimee Goel
- Alessia D'Amico
- Alexander Smedley
- Ali Usama
- Allan Hall
- Amir H Zamanipoor Najafabadi
- Amit Persad
- Amro Abuleil
- Ana Castro
- Andranik Kahramanian
- Andrea Mingoli
- Andrea Perera
- Andrea Saladino
- Andreas Fahlström
- Andreas Von Deimling
- Andrew Gvozdanovic
- Andrew Morokoff
- Andrew R Brodbelt
- Andrew Sloan
- Angelos Kolias
- Anil Varma
- Anna Craig-McQuade
- Annabel Butcher
- Antonio Santacroce
- Antonio Santoro
- Antony Kevin Scafa
- Arie Perry
- Arousa Ali
- Asgeir S Jakola
- Aswin Chari
- Athanasios Grivas
- Bassam Dabbous
- Benjamin Price
- Bente Sandvei Skeie
- Bianco Pollo
- Bobby Sachdev
- Boris Krischek
- Brodbelt Andrew R
- Bryony Ford
- Calan Mathieson
- Caterina Giannini
- Catherine Zhang
- Chaya Brodie
- Chloé Gelder
- Chris Barrett
- Christel Herold-Mende
- Christian Lafougere
- Christian Mawrin
- Christian Schichor
- Christine Jungk
- Christopher P Millward
- Christopher P Millward
- Clarissa Alfonso
- Craig Erker
- Craig Horbinski
- Daisy Evans
- Damian Holliman
- Daniel Brown
- Daniel Lachance
- Daniel M Fountain
- Daniel M Fountain
- Daniel M Fountain
- Darmanin Lora-Kay
- David O Kamson
- David Raleigh
- David Rowland
- Debraj Mukherjee
- Elizabeth Culpin
- Elliot Tilling
- Erik Sulman
- Erminia Albanese
- Esther Wu
- Eva Galanis
- Farshad Nassiri
- Fawaz E Marhoom
- Felix Behling
- Felix Sahm
- Ferran Brugada-Bellsolà
- Fleur L Fisher
- Fountain Daniel M
- Fozia Saeed
- Francesco Dimeco
- Francesco Gaillard
- Franz Ricklefs
- Gabriel Zada
- Gelareh Zadeh
- Georgious Theo
- Gerhard Jungwirth
- Ghazaleh Tabatabai
- Gildas Patet
- Giles Critchley
- Giuseppa Zancana
- H K Ng
- Hanan Akbari
- Hani J Marcus
- Helen Shih
- Houtan Noushmehr
- Howra Ktayen
- Hytham Hamid
- Ian Dunn
- Ibrahim Elmaadawi
- Ieva Sataite
- Imran Noorani
- Islim Abdurrahman I
- Ismail Ughratdar
- Jack Henry
- Jacob Young
- James Robins
- James Ulrich
- Jarnail Bal
- Javier Martin-Alonso
- Jenkinson
- Jennifer Brown
- Jennifer Moliterno-Gunel
- Jens Schittenhelm
- Jerome St George
- Jill Barnholtz-Sloan
- Jim Snyder
- Jing Xian Lee
- Jonathan Pollock
- Jorg-Christian Tonn
- Josephine Jung
- Julie Woodfield
- Jun Yi Lau
- Justin Z Wang
- Kareem Austin
- Karolyn Au
- Katharine J Drummond
- Katherine J Drummond
- Katrin Lamszus
- Keiko Fox
- Kevin Agyemang
- Khaled Badran
- Kolamunnage-Dona Ruwanthi
- Koszdin Shelli Diane
- Laila Poisson
- Likhith Alakandy
- Linda Bi
- Liv Hartrick
- Luke Hnenny
- Mahmoud Saleh
- Manfred Westphal
- Manjul Tripathi
- Marco Timmer
- Marcos Tatagiba
- Maria Velicu
- Marta Couce
- Martin Proescholdt
- Mathew Ryan K
- Matija Snuderl
- Mazin Elsharif
- Mehta Shaveta
- Melissa Gough
- Michael Amoo
- Michael Canty
- Michael Cearns
- Michael D
- Michael D Jenkinson
- Michael D Jenkinson
- Michael McDermott
- Michael T C Poon
- Michael Vogelbaum
- Michelle Felicella
- Mills Samantha J
- Millward Christopher P
- Minh Nguyen
- Mirjam Renovanz
- Mohamed A R Arbab
- Mohamed Abdelsadg
- Mohamed Draz
- Mohsen Javadpour
- Mohsen Javadpour
- Muhammed Elhadi
- Mujtaba Mohammad
- Mustafa El Sheikh
- Mutiu Asha
- Nathan McSorley
- Neeraj Kalra
- Neeraj Kalra
- Nicholas Butowski
- Nigel Suttner
- Nils Schimdt
- Norbert Galldiks
- Ola Rominiyi
- Oliver Hanemann
- Oliver Kennion
- Olivia Näslund
- Omar Elmandouh
- Omar N Pathmanaban
- Omar N Pathmanaban
- Parameswaran Bhattathiri
- Patricia Littlechild
- Patrick Wen
- Paul M Brennan
- Pedro David Delgado-López
- Peter Crossley
- Philip Theodosopoulos
- Pierfrancesco Lapolla
- Pietro Familiari
- Piper Rory J
- Placido Bruzzaniti
- Priscilla Brastianos
- Raymond Huang
- Rebecca Chave-Cox
- Richard Pullicino
- Roland Goldbrunner
- Rory J Piper
- Rory Piper
- Rory S Cairns
- Rusiru T Ekanayaka
- Ruwanthi Kolamunnage-Dona
- Ryan K Mathew
- Ryan Leyden
- Sachiv Chakravarti
- Samantha J Mills
- Samih Hassan
- Sanjeeva Jeyaretna
- Santarius Thomas
- Sara Venturini
- Sarah Kingdon
- See Yung Phang
- Serge Makarenko
- Shamayitri Ghosh
- Shaveta Mehta
- Shelli Diane Koszdin
- Simon Lammy
- Simon Walling
- Sophie Liu
- Stephen T Magill
- Stephen Yip
- Suganth Suppiah
- Suhaib Abualsaud
- Syed Wajahat Shah
- Sylvia Kurz
- Tamara Ali
- Tathiana Malta
- Theo Georgious
- Thomas Santarius
- Thomas Santarius
- Tiit Illimar Mathiesen
- Timothy Kaufmann
- Tobias Mederer
- Tobias Walbert
- Torbjørn Strømsnes
- Torstien R Meling
- Usama Ali
- Verena Schadewaldt
- Viktor Zherebitskiy
- Vivia Lung
- Warren Selman
- William Taylor
- Yasir Chowdhury
- Zenab Sher
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2022
- Field of study
No full textIntroduction: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an estimated prevalence of 3/1000. The management of incidental meningioma varies widely with active clinical-radiological monitoring being the most accepted method by clinicians. Duration of monitoring and time intervals for assessment, however, are not well defined. To this end, we have recently developed a statistical model of progression risk based on single-centre retrospective data. The model Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests (IMPACT) employs baseline clinical and imaging features to categorise the patient with an incidental meningioma into one of three risk groups: low, medium and high risk with a proposed active monitoring strategy based on the risk and temporal trajectory of progression, accounting for actuarial life expectancy. The primary aim of this study is to assess the external validity of this model. Methods and analysis: IMPACT is a retrospective multicentre study which will aim to include 1500 patients with an incidental intracranial meningioma, powered to detect a 10% progression risk. Adult patients ≥16 years diagnosed with an incidental meningioma between 1 January 2009 and 31 December 2010 will be included. Clinical and radiological data will be collected longitudinally until the patient reaches one of the study endpoints: intervention (surgery, stereotactic radiosurgery or fractionated radiotherapy), mortality or last date of follow-up. Data will be uploaded to an online Research Electronic Data Capture database with no unique identifiers. External validity of IMPACT will be tested using established statistical methods. Ethics and dissemination: Local institutional approval at each participating centre will be required. Results of the study will be reported through peer-reviewed articles and conferences and disseminated to participating centres, patients and the public using social media
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
- Acheson J
- Acosta A
- Acosta A
- Acton C
- Adam M
- Adams C
- Adams K
- Adamus M
- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
- Ahmed L
- Ahmed L
- Ahmed M
- Ahmed M Cecilia
- Ahmed N
- Ahmed N
- Ahmed R
- Ahmed RA
- Ahmed S
- Ahmed S Haris
- Ail D
- Ainsley A
- Ainsworth M
- Aitken L
- Ajibode A
- Ajmi A
- Ajmi A
- Akhtar N
- Akili S
- Akindolie O
- Al Balushi A
- Al-Asadi A
- Al-Hakim B
- Al-Jibury M
- Al-Rabahi A
- Al-Ramadhani B
- Al-Shamkhani W
- Al-Sheklly B
- Alam S
- Aldana A
- Aldouri R
- Aldridge N
- Alegria A
- Alexander A
- Alexander J
- Alexander PDG
- Ali F Runa
- Ali M
- Ali O
- Ali S
- Ali S
- Ali S
- Alkhusheh M
- Alkhusheh M
- Allanson A
- Allen L
- Allen R
- Allen S
- Allison K
- Allsop L
- Alomari L
- Alzetani M
- Ambler S
- Ambrogetti R
- Ambrose C
- Amezaga M
- Amin A
- Amosun V
- Amosun V
- Amsha K
- Anand A
- Anderson J
- Anderson L
- Anderson N
- Anderson R
- Andreou P
- Andrews A
- Andrews J
- Aneke K
- Ang A
- Angel T
- Antill P
- Antonina Z
- Anu V
- Appleby S
- Appleyard D
- Archer A
- Ardley C
- Arimoto R
- Arkley C
- Armah C
- Armstrong C
- Armstrong S
- Armtrong P
- Arnison-Newgass C
- Arora D
- Arter A
- Arter A
- Asghar A
- Ashbrook-Raby C
- Ashish A
- Ashish A
- Ashraf S
- Ashton D
- Asrar A
- Assaf O
- Astin-Chamberlain R
- Athorne D
- Atkinson J
- Atkinson V
- Aubrey P
- Aung K Thu
- Aung N
- Aung Z Myo
- Austin E
- Avery M
- Avram C
- Awadzi G
- Aya A
- Ayaz E
- Azam J
- Aziz G
- Azzopardi G
- Babatunde F
- Babi M
- Babi M
- Babingto G
- Babs-Osibodu A Obaloluwa
- Bacon G
- Bacon J
- Bacon J
- Bagley G
- Bahadori K
- Baijiu G
- Bailey K
- Bailey K
- Bailey L
- Baillie H
- Baillie JK
- Baillie JK
- Baillie K
- Baird D
- Bajandouh A
- Baker E
- Baker-Moffatt M
- Bakoulas P
- Balachandran N
- Balachandran N
- Balan A
- Balaskas T
- Balasubramaniam M
- Balcombe A
- Baldwin A
- Baldwin D
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- Balfour J
- Ball C
- Bamfo S Danso
- Bamford A
- Bamford A
- Bamford P
- Bamgboye A
- Bancroft H
- Banda J
- Bandi S
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- Bandla N
- Bandyopadhyam S
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- Banerjee R
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- Barclay A
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Get PDFBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research
