31 research outputs found

    Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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    Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

    Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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    Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

    Nota editorial, abril 1954

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    Esta sección recoge una diversidad de textos que dan cuenta de la contribución de expertos analistas que desde distintos enfoques se han referido sobre los acontecimientos financieros y económicos más relevantes ocurridos en Colombia y otros países. Se halla, en especial, noticias relativas a la producción y comercio del café dentro del panorama nacional y mundial; análisis sobre la propiedad raíz en diversos lugares de Colombia; cifras de interés; también se rememora el contenido de revistas anteriores. En esta sección se compilan, además, reseñas, reflexiones, cartas y notas sobre la pluralidad de eventos académicos, sociales y culturales que han configurado el escenario económico nacional.En esta edición se tratan los siguientes temas:-       Relaciones internacionales; la situación general; la situación fiscal; el cambio exterior; la banca y el mercado monetario; el petróleo; el mercado bursátil; la propiedad raíz; el café-       El museo de oro en los Estados Unidos, por Grayson Kirk-       Comunicados de la Cancillería colombiana-       El mercado de café en Nueva York-       Veinticinco años atrás (número 18, abril 1929)-       Banco Internacional de Reconstrucción y Fomento. Discurso del presidente del Banco Internacional de Reconstrucción y Fomento, señor Eugene R. Black en la XVII sesión del Consejo Económico y Social de las Naciones Unidas-       Civilización de vertiente y civilización de llanura en Colombia (parte III- La geología de la llanura oriental), por Luis Alberto Sarmiento-       Exposición del doctor Raúl Prebisch, director principal a cargo de la secretaria ejecutiva de la Comisión Económica para América Latina, en la sesión del Comité Plenario del 8 de febrero de 1954-       El mercado del oro en Londres-       La Bolsa de Bogotá. Mercado de enero, febrero y marzo de 1954-       El movimiento de la propiedad raíz en Bogotá en el primer trimestre de 1954-       El movimiento de la propiedad raíz en Medellín en el primer trimestre de 1954-       Comentarios bibliográficos: El factor humano en la actividad económic

    Thigh-length compression stockings and DVT after stroke

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    Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
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