Impacts des barrages sur les débits annuels minimums en fonction des régimes hydrologiques artificialisés au Québec (Canada)

Les débits annuels minimums des rivières déterminent le volume d’habitat minimum disponible pour assurer la survie des espèces aquatiques en période d’étiage. Dans cette étude, nous comparons les impacts de barrages sur les caractéristiques (période d’occurrence, magnitude, amplitude de variation et asymétrie) de ces débits dans trois régimes hydrologiques artificialisés d’une part, et les débits annuels minimums mesurés en aval des barrages aux normes de débits réservés pour protéger les habitats du poisson au Québec, d’autre part. Nous avons analysé 72 stations appartenant aux régimes artificialisés d’Inversion (26 stations), d’Homogénéisation (18 stations) et de Type Naturel (28 stations). Toutes ces stations appartiennent au bassin versant du fleuve Saint-Laurent. La présente analyse est fondée sur la comparaison des débits mesurés en rivières naturelles (75 stations) à ceux mesurés en aval des barrages au moyen des méthodes de proportionnalité et graphique. Il ressort de ces comparaisons les principaux résultats suivants.En régime artificialisé d’Inversion caractérisé par les débits mensuels maximums en hiver et les débits mensuels minimums au printemps, les impacts des barrages se traduisent par une hausse significative de fréquence des débits annuels minimums au printemps au moment de la fonte des neiges mais une baisse en été, une diminution significative de la magnitude des débits pour les bassins versants de taille 10 000 km2.Annual minimum discharges represent a crucial hydrologic parameter for the health of aquatic ecosystems. They determine the volume of available habitat for aquatic species and influence the concentration of pollutant within the fluvial system during low flows. They are also of importance for instream infrastructures and for the regulation of fluvial transport. For these reasons, the minimum discharges constitute the main hydrologic parameters for which clear regulation have been defined in several countries. In the province of Québec, albeit the large amount of dams on several important fluvial systems, there seems to exist a lack of studies examining their effects on the annual minimum discharges. This paper is aiming at highlighting the effects of dams (1) by examining their effect on the characteristics of annual minimum discharges for artificialised flow regimes in Québec, and (2) by comparing those discharges with recommended instream flows to protect fish habitats.Firstly, the effect of dams on annual minimum discharges is examined for the three types of artificialised flow regimes found in Québec. From the analysis of seasonal and monthly discharges, ASSANI et al. (2004) documented the three types of artificialised hydrologic regime downstream from dams: the inversion, the homogenization, and the natural type flow regimes. The inversion flow regime presents high monthly discharge values in winter and low monthly discharge values during spring. This type of regime occurs solely on the north shore of the St-Lawrence River and pertains to rivers with large reservoirs feeding in hydropower stations. The homogenization flow regime presents small annual fluctuations of the monthly discharge. The maximum monthly discharges are recorded during spring where- as the minimum monthly discharges frequently occur during fall. This type of regime is often associated with reservoirs created on large streams for which the storage of spring water is less important. This regime is observed mainly on the north shore of the St-Lawrence river. In the natural type flow regime, the maximum monthly discharges take place during spring snowmelt while minimum monthly discharges occur either during summer or winter. The annual natural flow characteristics are thus conserved albeit the existence of the dam. This regime pertains to dams with small reservoirs and it is found on both side of the St-Lawrence River.Secondly, annual mimimum discharges are compared with minimum instream flows recommended by BELZILE et al. (1997). These ones defined the minimum instream flows based on the different species of fish and their life cycle. Downstream from dams, the instream flows (Qr) can be estimated using the following relation:Qr = ek.Sawhere S represents the drainage area upstream from the dam; a and k are respectively regional and seasonal parameters. These parameters are associated to the ecohydrological region, to the season as well as to the critical phases of life cycle for the fish species found within the ecohydrological regions.From the Historical Stream Flow Summary of Environmental Canada, the distribution of discharge from 107 stations were selected and analysed. From those, 72 were located on rivers with dams and 75 on rivers with no regulation. On regulated rivers, 26, 18 and 28 were identified as belonging to the inversed, homogeneous and natural type regimes, respectively. All stations were located in the St-Lawrence drainage area. To highlight the effect of dams, we performed a comparison between the annual minimum discharges for stations on artificialised rivers to those from stations belonging to rivers with no regulation. The comparison is performed according to the size of the drainage basins (proportionality method) and uses a set of parametric and non-parametric statistical tests depending on the type of data. The proportionality method was chosen because of the non-availability of the discharges for the pre-dam periods. According to RICHTER et al. (1996), river flows can be described using several parameters relating to the daily discharges: the magnitude, the frequency, the duration, the timing and the rate of change (amplitude of the variability). The daily discharges required to compute these parameters were not available. The date of occurrence of annual minimum discharges, their magnitude, the interannual variability of the magnitude and the skewness of the distribution could however be obtained from the Historical Stream Flow Summary of Environmental Canada.The analysis of annual minimum discharges for the three types of artificialised flow regimes highlights several key elements associated with the effect of dams. For the inversion flow regime, the presence of dams increases and decreases significantly the occurrence of annual minimum discharges during spring and summer, respectively. For drainage area smaller than 10 000 km2, the magnitude of the annual minimum discharge is decreased significantly. Finally, the between-year variability is increased and the distribution presents a strong skewness. For the natural type flow regime, an increase in annual minimum discharges during the period between November and January can be observed as well as a significant decrease in magnitude for the small fluvial systems (drainage area 10 000 km2

Genetic disorders of vitamin B12 metabolism: eight complementation groups – eight genes

Vitamin B12 (cobalamin, Cbl) is an essential nutrient in human metabolism. Genetic diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn disease. Functionally, B12 is the cofactor for methionine synthase and methylmalonyl CoA mutase. To function as a cofactor, B12 must be metabolised through a complex pathway that modifies its structure and takes it through subcellular compartments of the cell. Through the study of inherited disorders of vitamin B12 utilisation, the genes for eight complementation groups have been identified, leading to the determination of the general structure of vitamin B12 processing and providing methods for carrier testing, prenatal diagnosis and approaches to treatment

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

SummaryThe importance of maternal folate consumption for normal development is well established, yet the molecular mechanism linking folate metabolism to development remains poorly understood. The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle. We found that a hypomorphic mutation of the mouse Mtrr gene results in intrauterine growth restriction, developmental delay, and congenital malformations, including neural tube, heart, and placental defects. Importantly, these defects were dependent upon the Mtrr genotypes of the maternal grandparents. Furthermore, we observed widespread epigenetic instability associated with altered gene expression in the placentas of wild-type grandprogeny of Mtrr-deficient maternal grandparents. Embryo transfer experiments revealed that Mtrr deficiency in mice lead to two distinct, separable phenotypes: adverse effects on their wild-type daughters’ uterine environment, leading to growth defects in wild-type grandprogeny, and the appearance of congenital malformations independent of maternal environment that persist for five generations, likely through transgenerational epigenetic inheritance.PaperFlic

The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time

Peer reviewedPreprin

Mice Doubly-Deficient in Lysosomal Hexosaminidase A and Neuraminidase 4 Show Epileptic Crises and Rapid Neuronal Loss

Tay-Sachs disease is a severe lysosomal disorder caused by mutations in the HexA gene coding for the α-subunit of lysosomal β-hexosaminidase A, which converts GM2 to GM3 ganglioside. Hexa−/− mice, depleted of β-hexosaminidase A, remain asymptomatic to 1 year of age, because they catabolise GM2 ganglioside via a lysosomal sialidase into glycolipid GA2, which is further processed by β-hexosaminidase B to lactosyl-ceramide, thereby bypassing the β-hexosaminidase A defect. Since this bypass is not effective in humans, infantile Tay-Sachs disease is fatal in the first years of life. Previously, we identified a novel ganglioside metabolizing sialidase, Neu4, abundantly expressed in mouse brain neurons. Now we demonstrate that mice with targeted disruption of both Neu4 and Hexa genes (Neu4−/−;Hexa−/−) show epileptic seizures with 40% penetrance correlating with polyspike discharges on the cortical electrodes of the electroencephalogram. Single knockout Hexa−/− or Neu4−/− siblings do not show such symptoms. Further, double-knockout but not single-knockout mice have multiple degenerating neurons in the cortex and hippocampus and multiple layers of cortical neurons accumulating GM2 ganglioside. Together, our data suggest that the Neu4 block exacerbates the disease in Hexa−/− mice, indicating that Neu4 is a modifier gene in the mouse model of Tay-Sachs disease, reducing the disease severity through the metabolic bypass. However, while disease severity in the double mutant is increased, it is not profound suggesting that Neu4 is not the only sialidase contributing to the metabolic bypass in Hexa−/− mice

withdrawn 2017 hrs ehra ecas aphrs solaece expert consensus statement on catheter and surgical ablation of atrial fibrillation

n/