Measuring the mass accretion rates of Herbig Ae/Be stars with X-shooter

We present the results of our observations of eight magnetic Herbig Ae/Be stars obtained with the X-shooter spectrograph mounted on UT2 at the VLT. X-shooter provides a simultaneous, medium-resolution and high-sensitivity spectrum over the entire wavelength range from 300 to 2500 nm. We estimate the mass accretion rates M_acc of the targets from 13 different spectral diagnostics using empiric calibrations derived previously for T Tauri-type stars and brown dwarfs. We have estimated the mass accretion rates of our targets, which range from 2x10^-9 to 2x10^-7 M_sun/yr. Furthermore, we have found accretion rate variability with amplitudes of 0.10-0.40 dex taking place on time scales from one day to tens of days. Additional future night-to-night observations need to be carried out to investigate the character of M_acc variability in details. Our study shows that the majority of the calibrational relations can be applied to Herbig Ae/Be stars, but several of them need to be re-calibrated on the basis of new spectral data for a larger number of Herbig Ae/Be stars.Comment: 19 pages, 13 figures, nine tables, accepted for publication in Astronomische Nachrichte

Searching for a link between the magnetic nature and other observed properties of Herbig Ae/Be stars and stars with debris disks

Among the 21 Herbig Ae/Be stars studied, new detections of a magnetic field were achieved in six stars. For three Herbig Ae/Be stars, we confirm previous magnetic field detections. The largest longitudinal magnetic field, = -454+-42G, was detected in the Herbig Ae/Be star HD101412 using hydrogen lines. No field detection at a significance level of 3sigma was achieved in stars with debris disks. Our study does not indicate any correlation of the strength of the longitudinal magnetic field with disk orientation, disk geometry, or the presence of a companion. We also do not see any simple dependence on the mass-accretion rate. However, it is likely that the range of observed field values qualitatively supports the expectations from magnetospheric accretion models giving support for dipole-like field geometries. Both the magnetic field strength and the X-ray emission show hints for a decline with age in the range of ~2-14Myrs probed by our sample supporting a dynamo mechanism that decays with age. However, our study of rotation does not show any obvious trend of the strength of the longitudinal magnetic field with rotation period. Furthermore, the stars seem to obey the universal power-law relation between magnetic flux and X-ray luminosity established for the Sun and main-sequence active dwarf stars.Comment: 21 pages, 16 figures, 7 tables, accepted for publication in A&

Spectroscopic monitoring of the Herbig Ae star HD 104237. II. Non-radial pulsations, mode analysis and fundamental stellar parameters

Herbig Ae/Be stars are intermediate-mass pre-main sequence (PMS) stars showing signs of intense activity and strong stellar winds, whose origin is not yet understood in the frame of current theoretical models of stellar evolution for young stars. The evolutionary tracks of the earlier Herbig Ae stars cross a recently discovered PMS instability strip. Many of these stars exhibit pulsations of delta Scuti type. HD 104237 is a well-known pulsating Herbig Ae star. In this article, we reinvestigated an extensive high-resolution quasi-continuous spectroscopic data set in order to search for very faint indications of non-radial pulsations in the line profile. To do this, we worked on dynamical spectra of equivalent photospheric (LSD) profiles of HD 104237. A 2D Fourier analysis (F2D) was performed of the entire profile and the temporal variation of the central depth of the line was studied with the time-series analysis tools Period04 and SigSpec. We present a mode identification corresponding to the detected dominant frequency. We perform a new accurate determination of the fundamental stellar parameters in view of a forthcoming asteroseismic modeling. Following the previous studies on this star, our analysis of the dynamical spectrum of recentered LSD profiles corresponding to the 22nd -25th of April 1999 nights spectra has confirmed the presence of multiple oscillation modes of low-degree l in HD 104237 and led to the first direct detection of a non-radial pulsation mode in this star: the dominant mode F1 was identified by the Fourier 2D method having a degree l value comprised between 1 and 2, the symmetry of the pattern variation indicating an azimuthal order of +1 or -1. The detailed study of the fundamental stellar parameters has provided a Teff, log g and iron abundance of 8550 +/- 150K, 3.9 +/- 0.3 and -4.38 +/- 0.19 (i.e. [Fe/H]=+0.16 +/- 0.19), respectively

On the origin of the X-ray emission from Herbig Ae/Be stars

We performed a systematic search for Chandra archival observations of Herbig Ae/Be stars. These stars are fully radiative and not expected to support dynamo action analogous to their convective lower-mass counterparts, the T Tauri stars. Their X-ray emission has remained unexplained. The superior spatial resolution of Chandra with respect to previous X-ray instrumentation has allowed us to examine the possible role of late-type companions in generating the observed X-rays. In the total sample of 17 Herbig Ae/Be stars, 8 are resolved from X-ray emitting faint companions or other unrelated X-ray bright objects within 10". The detection fraction of Herbig Ae/Be stars is 76 %, but lowers to 35 % if all emission is attributed to further known and unresolved companions. The spectral analysis confirms the high X-ray temperatures (~ 20 MK) and large range of fractional X-ray luminosities (log L_x/L_star) of this class derived from earlier studies of individual objects. Radiative winds are ruled out as emission mechanism on basis of the high temperatures. The X-ray properties of Herbig Ae/Be stars are not vastly different from those of their late-type companion stars (if such are known), nor from other young late-type stars used for comparison. Therefore, either a similar kind of process takes place on both classes of objects, or there must be as yet undiscovered companion stars.Comment: accepted for publication by Astronomy & Astrophysic

Clinical Trials in Head Injury

Traumatic brain injury (TBI) remains a major public health problem globally. In the United States the incidence of closed head injuries admitted to hospitals is conservatively estimated to be 200 per 100,000 population, and the incidence of penetrating head injury is estimated to be 12 per 100,000, the highest of any developed country in the world. This yields an approximate number of 500,000 new cases each year, a sizeable proportion of which demonstrate signficant long-term disabilities. Unfortunately, there is a paucity of proven therapies for this disease. For a variety of reasons, clinical trials for this condition have been difficult to design and perform. Despite promising pre-clinical data, most of the trials that have been performed in recent years have failed to demonstrate any significant improvement in outcomes. The reasons for these failures have not always been apparent and any insights gained were not always shared. It was therefore feared that we were running the risk of repeating our mistakes. Recognizing the importance of TBI, the National Institute of Neurological Disorders and Stroke (NINDS) sponsored a workshop that brought together experts from clinical, research, and pharmaceutical backgrounds. This workshop proved to be very informative and yielded many insights into previous and future TBI trials. This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63185/1/089771502753754037.pd

A systematic review of economic analyses of telehealth services using real time video communication

Background: Telehealth is the delivery of health care at a distance, using information and communication technology. The major rationales for its introduction have been to decrease costs, improve efficiency and increase access in health care delivery. This systematic review assesses the economic value of one type of telehealth delivery - synchronous or real time video communication - rather than examining a heterogeneous range of delivery modes as has been the case with previous reviews in this area. Methods A systematic search was undertaken for economic analyses of the clinical use of telehealth, ending in June 2009. Studies with patient outcome data and a non-telehealth comparator were included. Cost analyses, non-comparative studies and those where patient satisfaction was the only health outcome were excluded. Results 36 articles met the inclusion criteria. 22(61%) of the studies found telehealth to be less costly than the non-telehealth alternative, 11(31%) found greater costs and 3 (9%) gave the same or mixed results. 23 of the studies took the perspective of the health services, 12 were societal, and one was from the patient perspective. In three studies of telehealth to rural areas, the health services paid more for telehealth, but due to savings in patient travel, the societal perspective demonstrated cost savings. In regard to health outcomes, 12 (33%) of studies found improved health outcomes, 21 (58%) found outcomes were not significantly different, 2(6%) found that telehealth was less effective, and 1 (3%) found outcomes differed according to patient group. The organisational model of care was more important in determining the value of the service than the clinical discipline, the type of technology, or the date of the study. Conclusion Delivery of health services by real time video communication was cost-effective for home care and access to on-call hospital specialists, showed mixed results for rural service delivery, and was not cost-effective for local delivery of services between hospitals and primary care

Neuroprotective Actions of Estradiol and Novel Estrogen Analogs in Ischemia: Translational Implications

This review highlights our investigations into the neuroprotective efficacy of estradiol and other estrogenic agents in a clinically relevant animal model of transient global ischemia, which causes selective, delayed death of hippocampal CA1 neurons and associated cognitive deficits. We find that estradiol rescues a significant number of CA1 pyramidal neurons that would otherwise die in response to global ischemia, and this is true when hormone is provided as a long-term pretreatment at physiological doses or as an acute treatment at the time of reperfusion. In addition to enhancing neuronal survival, both forms of estradiol treatment induce measurable cognitive benefit in young animals. Moreover, estradiol and estrogen analogs that do not bind classical nuclear estrogen receptors retain their neuroprotective efficacy in middle-aged females deprived of ovarian hormones for a prolonged duration (8 weeks). Thus, non-feminizing estrogens may represent a new therapeutic approach for treating the neuronal damage associated with global ischemia

Estrogen Receptor β-Selective Agonists Stimulate Calcium Oscillations in Human and Mouse Embryonic Stem Cell-Derived Neurons

Estrogens are used extensively to treat hot flashes in menopausal women. Some of the beneficial effects of estrogens in hormone therapy on the brain might be due to nongenomic effects in neurons such as the rapid stimulation of calcium oscillations. Most studies have examined the nongenomic effects of estrogen receptors (ER) in primary neurons or brain slices from the rodent brain. However, these cells can not be maintained continuously in culture because neurons are post-mitotic. Neurons derived from embryonic stem cells could be a potential continuous, cell-based model to study nongenomic actions of estrogens in neurons if they are responsive to estrogens after differentiation. In this study ER-subtype specific estrogens were used to examine the role of ERα and ERβ on calcium oscillations in neurons derived from human (hES) and mouse embryonic stem cells. Unlike the undifferentiated hES cells the differentiated cells expressed neuronal markers, ERβ, but not ERα. The non-selective ER agonist 17β-estradiol (E2) rapidly increased [Ca2+]i oscillations and synchronizations within a few minutes. No change in calcium oscillations was observed with the selective ERα agonist 4,4′,4″-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT). In contrast, the selective ERβ agonists, 2,3-bis(4-Hydroxyphenyl)-propionitrile (DPN), MF101, and 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3 benzoxazol-5-ol (ERB-041; WAY-202041) stimulated calcium oscillations similar to E2. The ERβ agonists also increased calcium oscillations and phosphorylated PKC, AKT and ERK1/2 in neurons derived from mouse ES cells, which was inhibited by nifedipine demonstrating that ERβ activates L-type voltage gated calcium channels to regulate neuronal activity. Our results demonstrate that ERβ signaling regulates nongenomic pathways in neurons derived from ES cells, and suggest that these cells might be useful to study the nongenomic mechanisms of estrogenic compounds

Discourse and religion in educational practice

Despite the existence of long-held binaries between secular and sacred, private and public spaces, school and religious literacies in many contemporary societies, the significance of religion and its relationship to education and society more broadly has become increasingly topical. Yet, it is only recently that the investigation of the nexus of discourse and religion in educational practice has started to receive some scholarly attention. In this chapter, religion is understood as a cultural practice, historically situated and embedded in specific local and global contexts. This view of religion stresses the social alongside the subjective or experiential dimensions. It explores how through active participation and apprenticeship in culturally appropriate practices and behaviors often mediated intergenerationally and the mobilisation of linguistic and other semiotic resources but also affective, social and material resources, membership in religious communities is constructed and affirmed. The chapter reviews research strands that have explored different aspects of discourse and religion in educational practice as a growing interdisciplinary field. Research strands have examined the place and purpose of religion in general and evangelical Christianity in particular in English Language Teaching (ELT) programmes and the interplay of religion and teaching and learning in a wide range of religious and increasingly secular educational contexts. They provide useful insights for scholars of discourse studies to issues of identity, socialisation, pedagogy and language policy