Poly-Victimization in Polish Adolescents: Risk Factors and the Moderating Role of Coping

This study aimed to investigate the prevalence of poly-victimization in Polish adolescents and assess factors associated with poly-victimization risk across different ecological levels. This study further examined whether coping styles could moderate the impact of poly-victimization on emotional well-being. Participants were 454 adolescents, aged between 13 and 19 years, from an urban region of Poland. Adolescents completed self-report measures assessing community, school, and family risks, along with a peer nomination task measuring social preference. Teachers also completed a measure assessing adolescent problem behaviors. Findings revealed that the majority of the sample (70%) experienced more than one type of victimization in the past year, and 35.7% were classified as poly-victims (≥ 6 victimizations). As hypothesized, community disorganization, low commitment to school, poor family management, family conflict, peer social preference, and teacher-rated withdrawn and disruptive behavioral problems were predictive of poly-victimization. In addition, the relationship between poly-victimization and emotional well-being was moderated by problem-solving coping, in that greater use of problem-solving strategies lessened the negative impact of poly-victimization on positive affect and life satisfaction. Other investigated coping strategies (social support-seeking, internalizing, externalizing, and distraction) failed to demonstrate any moderation effect. Findings highlight the high rate of victimization experienced by adolescents in Poland and have implications for the identification of those at risk of poly-victimization, suggesting that there is a need to consider factors related to the adolescent themselves, their relationships with family and peers, and school and community factors. Results also indicate that there may be value in training victims in the use of problem-solving coping styles as a source of resilienc

The twilight of the Liberal Social Contract? On the Reception of Rawlsian Political Liberalism

This chapter discusses the Rawlsian project of public reason, or public justification-based 'political' liberalism, and its reception. After a brief philosophical rather than philological reconstruction of the project, the chapter revolves around a distinction between idealist and realist responses to it. Focusing on political liberalism’s critical reception illuminates an overarching question: was Rawls’s revival of a contractualist approach to liberal legitimacy a fruitful move for liberalism and/or the social contract tradition? The last section contains a largely negative answer to that question. Nonetheless the chapter's conclusion shows that the research programme of political liberalism provided and continues to provide illuminating insights into the limitations of liberal contractualism, especially under conditions of persistent and radical diversity. The programme is, however, less receptive to challenges to do with the relative decline of the power of modern states

Constitutivism

A brief explanation and overview of constitutivism

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies

Philosophy of action

The philosophical study of human action begins with Plato and Aristotle. Their influence in late antiquity and the Middle Ages yielded sophisticated theories of action and motivation, notably in the works of Augustine and Aquinas.1 But the ideas that were dominant in 1945 have their roots in the early modern period, when advances in physics and mathematics reshaped philosophy

DIGITAL SOLUTIONS FOR THE EVOLUTION OF ANALOG MANUFACTURING RESOURCE PLANNING SYSTEMS

The development of an Automated Manufacturing Resource Planning (MRP) System has been established by Team 21051 for Ruda Cardinal Inc. Products had previously been serialized in which tracking, report organization, and communication maintained in a mix of analog and digital forms. Digitizing the production system is a great need to Ruda to allow for greater production volume and reduce production time. Therefore, the need arose for a way to track location of hardware throughout product lifecycle, provide on-demand reports of the product, and allow intercommunication between all involved departments at different points in the development process. The created MRP streamlines the manufacturing process allowing for employees to minimize bookkeeping and spend more time manufacturing products. The system features a uniform process that can be followed and replicated for the production of each product of a high-volume contract. Additional features improve ease of use: barcode scanners to allow for products to be easily and concretely tracked through the manufacturing process; automated notifications to update individuals when a product is ready to move to the next steps; and templated Excel sheets to minimize operator error. The MRP was created using agile work methodologies, so three functional iterations of the product were created and delivered to the sponsor throughout the year