The fatty acid compositions of erythrocyte and plasma polar lipids in children with autism, developmental delay or typically developing controls and the effect of fish oil intake

The erythrocyte and plasma fatty acid compositions of children with autism were compared in a case-control study with typically developing (TD) children and with children showing developmental delay (DD). Forty-five autism subjects were age-matched with TD controls and thirty-eight with DD controls. Fatty acid data were compared using paired t tests. In addition, blood fatty acids from treatment-naive autism subjects were compared with autism subjects who had consumed fish oil supplements by two-sample t tests. Relatively few differences were seen between erythrocyte fatty acids in autism and TD subjects although the former had an increased arachidonic acid (ARA):EPA ratio. This ratio was also increased in plasma samples from the same children. No changes in n-3 fatty acids or ARA:EPA ratio were seen when comparing autism with DD subjects but some SFA and MUFA were decreased in the DD subjects, most notably 24 : 0 and 24 : 1, which are essential components of axonal myelin sheaths. However, if multiple comparisons are taken into account, and a stricter level of significance applied, most of these values would not be significant. Autism subjects consuming fish oil showed reduced erythrocyte ARA, 22 : 4n-6, 22 : 5n-6 and total n-6 fatty acids and increased EPA, 22 : 5n-3, 22 : 6n-3 and total n-3 fatty acids along with reduced n-6:n-3 and ARA:EPA ratios. Collectively, the autism subjects did not have an underlying phospholipid disorder, based on erythrocyte fatty acid compositions, although the increased ARA:EPA ratio observed suggested that an imbalance of essential highly unsaturated fatty acids may be present in a cohort of autism subjects

Singing maternity through autoethnography: Making visible the musical world of myself as a mother

There is perhaps no image more maternal and musical than that of a young mother cradling a child to her breast as she softly sings a sweet lullaby. Yet the way that a mother experiences, relates to and renders meaningful the social and musical moment of singing to her children remains silent and hidden in popular and academic discourse. In this paper, I will explore how music becomes mothering; that is, the way that women sing maternity and use music to mother; what music brings to their thoughts, feelings and identities as mothers; and, what kinds of interactions and interrelationships are created with their children through music as play and performance of mothering. Through auto-ethnographic processes of reflection and research about my own experiences as the mother of two sons, and engagement with a wide array of discourses about mothering; the voices and perspectives of women take centre stage in this paper. My main concern is to make visible the musical worlds of mothers and children and make known the power of maternal song in creating places of excitement, empowerment, love and peace in the home for mothers and children

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease