49 research outputs found

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

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    Wireless sensor network simulator (the SimuLItor)

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    Wireless sensor networks (WSN) simulators are used for testing and learning, the simulator a theoretical substitute of a real WSN. Problems may occur after setting the WSN or there could be some minor errors which were not seen in the planning phase, if this would happen the WSN proposal needs to be remodeled and tested again to ensure quality of the product. There are a lot of wireless sensor network simulators available, but most of the simulators are limited to certain protocols which are not present with others. This results in the need for many simulators to test different protocols for their network. Using different simulators will make the researchers sit up their network repeatedly for each simulator. This is very time consuming and it is also inaccurate because each simulator has its own way of simulation, data cannot be gathered accurately. The goal of this research is to develop a simulation framework for WSN that includes the commonly used protocols in WSN. This framework is easy to use and open to extension. Other researcher can easily add protocols that are not yet implemented to cope with future advancements. The goal is not to create a finished product but a foundation for others to build upon

    A model-based analysis of evacuation strategies in hospital emergency departments

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    Evacuation planning for emergency incidents is an essential preparedness for Emergency Departments (ED) which normally contains patients with severe illness and limited mobility. However, the preparedness can be challenging due to a lack of empirical data and difficulties conducting physical drills. We propose an agent-based model to simulate the evacuation process in the EDs containing medical staff, rescuers, visitors and various types of patients. In a case study, we apply the model to a peak hour scenario of the ED of the largest hospital in Singapore. Two rescue strategies with different behavior sequences of medical staff as suggested by the practitioners are evaluated. The simulation results show that prioritizing preparation of all the patients generates less total evacuation time but leads to fewer evacuated cases in the first 20 minutes and more serious congestion compared to one-by-one transfer of individual patients.National Research Foundation (NRF)Submitted/Accepted versionThis research is supported by National Research Foundation (NRF) Singapore, GOVTECH under its Virtual Singapore program Grant No. NRF2017VSG-AT3DCM001-031

    Thigh-length compression stockings and DVT after stroke

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    Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease

    MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients

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    BACKGROUND: MicroRNAs (miRNAs) regulate the biological properties of colorectal cancer (CRC) cells and might serve as potential prognostic factors and therapeutic targets. In this study, we therefore globally profiled miRNAs associated with E-cadherin expression in CRC cells in an attempt to identify miRNAs that are associated with aggressive clinical course in CRC patients. METHODS: Two CRC cell lines (Caco-2 and HRT-18) with different E-cadherin expression pattern were profiled for differences in abundance for more than 1000 human miRNAs using microarray technology. One of the most differentially expressed miRNAs, miR-200a was evaluated for its prognostic role in a cohort of 111 patients and independently validated in 217 patients of the Cancer Genome Atlas data set. To further characterise the biological role of miR-200a expression in CRC, in vitro miR-200a inhibition and overexpression were performed and the effects on cellular growth, apoptosis and epithelial–mesenchymal transition (EMT)-related gene expression were explored. RESULTS: In situ hybridisation specifically localised miR-200a in CRC cells. In both cohorts, a low miR-200a expression was associated with poor survival (P<0.05). Multivariate Cox regression analysis identified low levels of miR-200a expression as an independent prognostic factor with respect to cancer-specific survival (HR=2.04, CI=1.28–3.25, P<0.002). Gain and loss of function assays for miR-200a in vitro led to a significantly differential and converse expression of EMT-related genes (P<0.001.) A low expression of miR-200a was also observed in cancer stem cell-enriched spheroid growth conditions (P<0.05). CONCLUSIONS: In conclusion, our data suggest that low miR-200a expression is associated with poor prognosis in CRC patients. MiR-200a has a regulatory effect on EMT and is associated with cancer stem cell properties in CRC
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