817 research outputs found
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
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- Abulaiti Y
- Acharya BS
- Achkar B
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- Winkels E
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- Winter BT
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- Wolf A
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- Wolter MW
- Wolters H
- Wong VWS
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- Worm SD
- Wosiek BK
- Wozniak KW
- Wraight K
- Wu SL
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- Xu D
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- Yamazaki T
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- Yao W-M
- Yap YC
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- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
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- Zaitsev AM
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- Zakharchuk N
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- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zhang B
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- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside
- Author
- A Kimmoun
- A Pedoto
- A Pedoto
- A Yaghi
- AI Arieff
- AM Kahn
- Antoine Kimmoun
- B Jian
- B Jung
- B Levy
- B Levy
- B Levy
- Bruno Levy
- C Aalkjaer
- C Austin
- C Austin
- C Giunti
- C Steenbergen
- CG Morris
- CG Morris
- CH Orchard
- CL McCaul
- D Fernandes
- D Juneja
- D Mathieu
- D Otter
- D Sessler
- D Sirieix
- D Wu
- D Wu
- DG Allen
- DJ Cooper
- DJ Cooper
- DM Bers
- DS Berger
- DS Rosenbaum
- DT Noritomi
- E Boedtkjer
- EA Hoste
- EA Richter
- EJ Crampin
- EM Blanchard
- Emmanuel Novy
- F Kajbaf
- F Valenza
- G Siegel
- H Graf
- H Graf
- H Ishizaka
- H Kin
- H Schotola
- HB Nielsen
- HE Refsum
- HJ Adrogue
- HJ Kim
- HK Tan
- HS Choi
- I Smith
- J Bakker
- J DeSantiago
- J Levraut
- J Sonett
- JA Kraut
- JA Kraut
- JD Marsh
- JH Boyd
- JH Kuo
- JH Mitchell
- JI Shapiro
- JM Leung
- JP Gardner
- JS Beech
- K Hagiya
- K Klouche
- K Nakashima
- K Teplinsky
- KH Rhee
- L Cole
- LA Kubasiak
- LL Wu
- LW Dong
- M Cecconi
- M Fujita
- M Garcia-Alvarez
- M Tani
- MH Tsai
- MH Weil
- MJ Ming
- NH Mark
- Nicolas Ducrocq
- PE Bollaert
- PF Moon
- PJ Little
- PJ Sikes
- PL Hope
- PS Chan
- PW Stacpoole
- R Bellomo
- R Ratanarat
- RB Jennings
- RF Wilson
- RM Bersin
- RM Bersin
- RM Graham
- RM Lang
- RP Dellinger
- RRTS Investigators
- RV Dimlich
- RW Barbee
- RW Neumar
- S Broer
- S Fanconi
- S Friesecke
- S Kapur
- S Kumar
- S Uchino
- SJ Ives
- SM Harrison
- T Langer
- T Naka
- T Regueira
- TG Gabig
- Thomas Auchet
- TJ Iberti
- W Toller
- X Lin
- XM Yang
- Y Wutrich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Prenatal exposures and exposomics of asthma
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi
Autophagy: Regulation and role in disease
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- Adhami F
- Aguilar V
- Alfred J. Meijer
- Araki M
- Arico S
- Avruch J
- Avruch J
- Axe EL
- Azad MB
- Baquet A
- Bassham DC.
- Bergamini E
- Bergamini E
- Bernales S
- Berry DL
- Beugnet A
- Billington RA
- Blommaart EF
- Blommaart EF
- Blommaart EF
- Boland B
- Bolster DR
- Bonnet S
- Bosoi CR
- Boulahbel H
- Boya P
- Brady NR
- Brunet A
- Byfield MP
- Cadwell K
- Cao Y
- Carloni S
- Carobbio S
- Chan EY
- Chen Y
- Cheng J
- Choi SE
- Choi SL
- Christie GR
- Ciechanover A
- Codogno P
- Cohen E
- Comes F
- Corcelle E
- Corradetti MN
- Corradetti MN
- Cuervo AM.
- Dagda RK
- Daido S
- Dann SG
- Dann SG
- Dardevet D
- De Meyer GR
- Desai BN
- Deter RL
- Ding WX
- Djavaheri-Mergny M
- Drenan RM
- Droge W
- Drummond MJ
- Dubbelhuis PF
- Dumitru CA
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- Ebato C
- Eisenberg-Lerner A
- Eskelinen EL
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- Espert L
- Espert L
- Evans JL
- Fahien LA
- Fang N
- Fang Y
- Farre JC
- Fass E
- Feng Z
- Finlay GA
- Frojdo S
- Fumarola C
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- Gleason CE
- Gohla A
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- Greer EL
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- Guenther GG
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- Gustafsson AB
- Gwinn DM
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- Roccio M
- Rubinsztein DC.
- Russell SJ
- Sakiyama T
- Salih DA
- Samari HR
- Sancak Y
- Sandoval H
- Sarkar S
- Scarlatti F
- Scarlatti F
- Scarlatti F
- Scherz-Shouval R
- Scherz-Shouval R
- Schiaffino S
- Schriner SE
- Schweers RL
- Scott RC
- Scott RC
- Seglen PO
- Seglen PO
- Selman C
- Sener A
- Settembre C
- Shibata M
- Shigemitsu K
- Shigenaga MK
- Shimizu S
- Smith EM
- Smith EM
- Starkov AA.
- Stemke-Hale K
- Suh Y
- Sun Q
- Sun Y
- Suzuki K
- Suzuki K
- Takagi H
- Tal R
- Talloczy Z
- Tang X
- Tasdemir E
- Tassa A
- Tatar M
- Thoreen CC
- Todde V
- Tracy K
- Tremblay F
- Tsuboi Y
- Tsuchihara K
- Twig G
- Tzatsos A
- Uchiyama Y
- Uhlmann EJ
- Um SH
- Um SH
- Urban J
- van der Horst A
- van Sluijters DA
- vande Velde C
- Veenhuis M
- Vellai T.
- Viana R
- Villena J
- Wang X
- Watson RT
- Wei M
- Willcox BJ
- Wouters BG
- Wu H
- Wullschleger S
- Xiao G.
- Xu G
- Yan Y
- Yen WL
- Yorimitsu T
- Yorimitsu T
- Yorimitsu T
- Yorimitsu T
- Yousefi S
- Yu L
- Yu L
- Yuan H
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- Zalckvar E
- Zeng X
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- Zhang H
- Zhang W
- Zhao J
- Zhao Z
- Zheng W
- Zhou D
- Zini R
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
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- A Chattopadhyay
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- A Scalbert
- A Scalbert
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- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
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- A Wong
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- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Multi-messenger observations of a binary neutron star merger
- Author
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
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- Zhuang H
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- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
QCD and strongly coupled gauge theories : challenges and perspectives
- Author
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- X-F Chen
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- X-N Wang
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- XH Mo
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- Y Akaishi
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- Y Koma
- Y Li
- Y Liu
- Y Liu
- Y Nambu
- Y Nambu
- Y Sakaki
- Y Zhu
- Y-J Zhang
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- Y-Q Ma
- Y-Q Ma
- Y-Q Ma
- Y-Q Ma
- Y-Q Ma
- Y-T Chien
- Y-Y Bu
- Y-Y Keum
- YA Karpenko
- YA Simonov
- YL Dokshitzer
- YL Dokshitzer
- YM Antipov
- YM Antipov
- YV Kovchegov
- YV Kovchegov
- YV Kovchegov
- YV Stadnick
- YY Keum
- Z Bern
- Z Bern
- Z Bern
- Z Chacko
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fodor
- Z Fu
- Z Fu
- Z Komargodski
- Z Komargodski
- Z Ligeti
- Z Ligeti
- Z-B Kang
- Z-B Kang
- Z-B Kang
- Z-G He
- Z-G He
- Z-H Li
- Z-W Lin
- Z-W Lin
- Z. Fodor
- Publication venue
- Publication date
- 01/01/2014
- Field of study
We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe
Search for High-Mass Resonances Decaying to τν in pp Collisions at √s=13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
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- Abreu H
- Abulaiti Y
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- Zhemchugov A
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- Zibell A
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- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
A search for high-mass resonances decaying to τν using proton-proton collisions at √s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouzeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
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- Affolder AA
- Afik Y
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- Akatsuka S
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
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- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
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- Anders JK
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- Anelli CR
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- Angelozzi I
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- Armbruster AJ
- Armitage LJ
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- Asimakopoulou EM
- Asquith L
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- Atlas Collaboration
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- Capeans Garrido MDM
- Caprini I
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- Capua M
- Carbone RM
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- Cheu E
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- Christodoulou V
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- Yacoob S
- Yajima K
- Yallup DP
- Yamaguchi D
- Yamaguchi Y
- Yamamoto A
- Yamanaka T
- Yamane F
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang Y
- Yang Z
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yu J
- Yue X
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeitnitz C
- Zeißner SV
- Zemaityte G
- Zeng JC
- Zeng Q
- Zenin O
- Zerwas D
- Zgubič M
- Zhang D
- Zhang DF
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
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