Apoyos para aprender, instancias para enseñar

En el trabajo describimos una experiencia pedagógica que desarrollamos en asignaturas de los profesorados del Centro Regional Universitario Bariloche de la Universidad Nacional del Comahue. Dicha experiencia refiere a la implementación de dispositivos áulicos diseñados con el fin de acompañar y andamiar trayectorias formativas universitarias iniciales. Estas estructuras de apoyo, necesarias y transitorias, que se complementan con otras de tipo institucional, procuran generar instancias de construcción de conocimiento así como propiciar y promover el aprendizaje universitario. Surgen a partir de algunos análisis y reflexiones sobre los procesos formativos estudiantiles, lo que nos brinda marcos de abordaje que orientan la toma de decisiones prácticas. En este sentido, habilitamos apoyos para aprender e instancias de enseñanza que propician transitar hacia la autonomización. Los dispositivos presentan diversos formatos y variedad de características, algunos se desarrollan con el grupo total en las clases habituales y otros requieren espacios de enseñanza en grupos reducidos. Reflejan intervenciones docentes desplegadas en las prácticas pedagógicas cotidianas y constituyen condiciones de enseñanza que impactan en el proceso de ingreso universitario en particular y en los itinerarios formativos en general.Trabajo publicado en Giordano, Carlos José y Morandi, Glenda (comps.). Memorias de las 2º Jornadas sobre las Prácticas Docentes en la Universidad Pública. La enseñanza universitaria a 100 años de la reforma: legados, transformaciones y compromisos. Universidad Nacional de La Plata: La Plata, 2019.Presidenci

Apoyos para aprender, instancias para enseñar

En el trabajo describimos una experiencia pedagógica que desarrollamos en asignaturas de los profesorados del Centro Regional Universitario Bariloche de la Universidad Nacional del Comahue. Dicha experiencia refiere a la implementación de dispositivos áulicos diseñados con el fin de acompañar y andamiar trayectorias formativas universitarias iniciales. Estas estructuras de apoyo, necesarias y transitorias, que se complementan con otras de tipo institucional, procuran generar instancias de construcción de conocimiento así como propiciar y promover el aprendizaje universitario. Surgen a partir de algunos análisis y reflexiones sobre los procesos formativos estudiantiles, lo que nos brinda marcos de abordaje que orientan la toma de decisiones prácticas. En este sentido, habilitamos apoyos para aprender e instancias de enseñanza que propician transitar hacia la autonomización. Los dispositivos presentan diversos formatos y variedad de características, algunos se desarrollan con el grupo total en las clases habituales y otros requieren espacios de enseñanza en grupos reducidos. Reflejan intervenciones docentes desplegadas en las prácticas pedagógicas cotidianas y constituyen condiciones de enseñanza que impactan en el proceso de ingreso universitario en particular y en los itinerarios formativos en general.Trabajo publicado en Giordano, Carlos José y Morandi, Glenda (comps.). Memorias de las 2º Jornadas sobre las Prácticas Docentes en la Universidad Pública. La enseñanza universitaria a 100 años de la reforma: legados, transformaciones y compromisos. Universidad Nacional de La Plata: La Plata, 2019.Presidenci

Apoyos para aprender, instancias para enseñar

En el trabajo describimos una experiencia pedagógica que desarrollamos en asignaturas de los profesorados del Centro Regional Universitario Bariloche de la Universidad Nacional del Comahue. Dicha experiencia refiere a la implementación de dispositivos áulicos diseñados con el fin de acompañar y andamiar trayectorias formativas universitarias iniciales. Estas estructuras de apoyo, necesarias y transitorias, que se complementan con otras de tipo institucional, procuran generar instancias de construcción de conocimiento así como propiciar y promover el aprendizaje universitario. Surgen a partir de algunos análisis y reflexiones sobre los procesos formativos estudiantiles, lo que nos brinda marcos de abordaje que orientan la toma de decisiones prácticas. En este sentido, habilitamos apoyos para aprender e instancias de enseñanza que propician transitar hacia la autonomización. Los dispositivos presentan diversos formatos y variedad de características, algunos se desarrollan con el grupo total en las clases habituales y otros requieren espacios de enseñanza en grupos reducidos. Reflejan intervenciones docentes desplegadas en las prácticas pedagógicas cotidianas y constituyen condiciones de enseñanza que impactan en el proceso de ingreso universitario en particular y en los itinerarios formativos en general.Trabajo publicado en Giordano, Carlos José y Morandi, Glenda (comps.). Memorias de las 2º Jornadas sobre las Prácticas Docentes en la Universidad Pública. La enseñanza universitaria a 100 años de la reforma: legados, transformaciones y compromisos. Universidad Nacional de La Plata: La Plata, 2019.Presidenci

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Probiotics and their efficacy for depression: a systematic mini review protocol

This is a systematic mini review protocol aimed to summarize the evidence regarding probiotics and their efficacy as add-on therapy for depression in the last four years. </p