Oral Self Care Practices, Oral Health status and treatment needs of Diabetic and Non diabetic patients: A Comparative study.

BACKGROUND: Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting either from defects in insulin secretion, insulin action, or both. It affects almost all tissues in the body, including those in the oral cavity and hence the aim of this study is to assess the oral self care practices, oral health status and treatment needs of diabetic and non diabetic patients. METHODOLOGY: A cross sectional descriptive study was conducted among 350 diabetic patients and a similar number of non diabetic ranging from 18-78 years. Data was collected using a pre tested questionnaire for oral self care practices and WHO proforma (1997) was used for assessing oral health status and treatment needs. Data was analyzed using SPSS version 17. RESULTS: The present study revealed that there was not much difference in the oral hygiene practices among diabetic and non diabetic. Percentage of oral mucosal lesions was high among diabetic group (11.8%) when compared to non diabetics (7.4%).The pocket formation of 4-6 mm was seen in 124 (35.4%) diabetics and 100 (28.6%) non diabetics.Loss of attachment of 4-5 mm was found among116(33.1%) and 6-8 mm 40 (11.4%)of diabetic when compared to non diabetics loss of attachment of 4-5 mm was 84 (24.0%)and 6-8 mm was 35 (10.0%). Excluded sextants were found to be high in diabetics (19.5%) when compared to non diabetic group (14.7%).The mean DMFT was high among diabetic (4.014) than non diabetic (3.020). CONCLUSION: Since the prevalence of periodontitis is more among diabetic the oral hygiene practices has to be improved. The oral complications of diabetes can be prevented by combined effect of dentist and the Physician by emphasizing the patients for periodic review to dentist for improving the oral health

MOSQUITO OVICIDAL PROPERTIES OF AGERATINA ADENOPHORA (FAMILY: ASTERACEAE) AGAINST FILARIASIS VECTOR, CULEX QUINQUEFASCIATUS (DIPTERA: CULICIDAE)

ABSTRACT Mosquito-borne diseases with an economic impact create loss in commercial and labor outputs, particularly in countries with tropical and subtropical climates. Mosquito control is facing a threat because of the emergence of resistance to synthetic insecticides. Extracts from plants may be alternative sources of mosquito control agents because they constitute a rich source of bioactive compounds that are biodegradable into nontoxic products and potentially suitable for use to control mosquitoes. Insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. In view of the recently increased interest in developing plant origin insecticides as an alternative to chemical insecticide, this study was undertaken to assess the ovicidal potential of the crude hexane, benzene, chloroform, ethyl acetate, and methanol solvent extracts from the medicinal plant Ageratina adenophora (A. adenophora) against the filariasis vector, Culex quinquefasciatus (Cx. quinquefasciatus) (Diptera: Culicidae). Ovicidal activity was determined against Cx. quinquefasciatus mosquito to various concentrations ranging from 75-450 mg/L under the laboratory conditions. All the five solvents extracts showed moderate ovicidal activity; however, the methanol extract showed the highest ovicidal activity. One hundred percent mortality was observed at 375 mg/L. These results suggest that the plant extracts have the potential to be used as an ideal eco-friendly approach for the control of mosquitoes. This study provides first report on the mosquito ovicidal activity of A. adenophora plant extracts against filariasis vector, Cx. quinquefasciatus

DIMENSIONS OF CULTURAL CRISIS IN CONTEMPORARY HINDI POETRY

HindiCUSATDepartrnent of Hindi, Cochin University of Science and Technolog

Citrullus colocynthis loaded zinc nanoparticle (C.cZnO): A potential gout healer in modulating antioxidant status and lysosoaml enzymes in MSU crystal Induced PBMC cells

The aim of the present investigation is to study the effect of C.colocynthis loaded zinc nanoparticle (C.cZnO) on the antioxidant status and lysozomal enzymes in PBMC cells induced with monosodium urate crystals. The Zinc nano particles of C.colocynthis was prepared. Approximately 1×106 cells/well seeded human PBMC were divided in to   five  groups and treated in the following manner. Group I served as control, Group II cells were treated with 1mg/ml MSU crystals, Group III and Group IV cells were induced with MSU crystals and received 250µg/ml and 500 µg/ml of C. colosynthis   zinc nanoparticle (C.cZno) respectively and were incubated at 37°C for 24 hrs in the CO2 incubator. Group-IV cells were treated with colchicine (1µg/ml) the positive control used in the present study. The enzymatic and non enzymatic antioxidants as well as lysosomal enzymes were analysed using the established procedures. The extent of   lipid peroxidation was also measured

Anti-Gout arthritic activity of ethanolic and methanolic seed extracts of Pedalium Murex: An in vitro and in silico studies

The present investigation is undertaken to evaluate the comparative anti gout activity of the ethanolic (EEPM) and methanolic (MEPM) seed extracts of Pedalium murex. The Invitro anti gout arthritic activity of the plant extracts was evaluated using xanthine oxidase and protease enzyme inhibition as well as membrane stabilization using well established protocols. In silico anti arthritic activity was studied using molecular docking analysis from 10 GCMS derived compounds with that of the immunuo stimulatory proteins TLR2, TLR4, MMP2 and MMP7 to find out the suitable antagonistic ligand for these proteins. In the present investigation the EEPM extract showed better anti gout activity comparable to the MEPM extract in terms of xanthine oxidase and protease enzyme inhibition as well as membrane stabilization. The anti out arthritic activity of EEPM was comparable to the positive control used in the present study. In the In silico studies among the 10 compounds docked for the proteins TLR2, TLR4, MMP2 and MMP7, three compounds namely 11 -Eicosenoic Acid Methyl ester, Docosanoic Acid, Methyl ester and 1,2Benzendicarboxylic Acid, mono (2-ethylhexyl) ester could inhibit the above mentioned immuno stimulatory proteins and there by suppress the reactions observed in the gouty arthritis

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease