Bias and Scale Effects of Decoupled Farm Payments

Agricultural and Food Policy, International Relations/Trade, Production Economics,

Pathways to Coastal Resiliency: The Adaptive Gradients Framework

Current and future climate-related coastal impacts such as catastrophic and repetitive flooding, hurricane intensity, and sea level rise necessitate a new approach to developing and managing coastal infrastructure. Traditional “hard” or “grey” engineering solutions are proving both expensive and inflexible in the face of a rapidly changing coastal environment. Hybrid solutions that incorporate natural, nature-based, structural, and non-structural features may better achieve a broad set of goals such as ecological enhancement, long-term adaptation, and social benefits, but broad consideration and uptake of these approaches has been slow. One barrier to the widespread implementation of hybrid solutions is the lack of a relatively quick but holistic evaluation framework that places these broader environmental and societal goals on equal footing with the more traditional goal of exposure reduction. To respond to this need, the Adaptive Gradients Framework was developed and pilot-tested as a qualitative, flexible, and collaborative process guide for organizations to understand, evaluate, and potentially select more diverse kinds of infrastructural responses. These responses would ideally include natural, nature-based, and regulatory/cultural approaches, as well as hybrid designs combining multiple approaches. It enables rapid expert review of project designs based on eight metrics called “gradients”, which include exposure reduction, cost efficiency, institutional capacity, ecological enhancement, adaptation over time, greenhouse gas reduction, participatory process, and social benefits. The framework was conceptualized and developed in three phases: relevant factors and barriers were collected from practitioners and experts by survey; these factors were ranked by importance and used to develop the initial framework; several case studies were iteratively evaluated using this technique; and the framework was finalized for implementation. The article presents the framework and a pilot test of its application, along with resources that would enable wider application of the framework by practitioners and theorists

The Herschel Virgo Cluster Survey. IX. Dust-to-gas mass ratio and metallicity gradients in four Virgo spiral galaxies

Using Herschel data from the Open Time Key Project the Herschel Virgo Cluster Survey (HeViCS), we investigated the relationship between the metallicity gradients expressed by metal abundances in the gas phase as traced by the chemical composition of HII regions, and in the solid phase, as traced by the dust-to-gas mass ratio. We derived the radial gradient of the dust-to-gas mass ratio for all galaxies observed by HeViCS whose metallicity gradients are available in the literature. They are all late type Sbc galaxies, namely NGC4254, NGC4303, NGC4321, and NGC4501. We examined different dependencies on metallicity of the CO-to-H$_2$ conversion factor (\xco), used to transform the $^{12}$CO observations into the amount of molecular hydrogen. We found that in these galaxies the dust-to-gas mass ratio radial profile is extremely sensitive to choice of the \xco\ value, since the molecular gas is the dominant component in the inner parts. We found that for three galaxies of our sample, namely NGC4254, NGC4321, and NGC4501, the slopes of the oxygen and of the dust-to-gas radial gradients agree up to $\sim$0.6-0.7R$_{25}$ using \xco\ values in the range 1/3-1/2 Galactic \xco. For NGC4303 a lower value of \xco$\sim0.1\times$ 10$^{20}$ is necessary. We suggest that such low \xco\ values might be due to a metallicity dependence of \xco (from close to linear for NGC4254, NGC4321, and NGC4501 to superlinear for NGC4303), especially in the radial regions R$_G<$0.6-0.7R$_{25}$ where the molecular gas dominates. On the other hand, the outer regions, where the atomic gas component is dominant, are less affected by the choice of \xco, and thus we cannot put constraints on its value.Comment: 13 pages, 8 figures, A&A accepte

Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates

Activation of toll-like receptors (TLRs) on cells of the innate immune system initiates, amplifies, and directs the antigen-specific acquired immune response. Ligands that stimulate TLRs, therefore, represent potential immune adjuvants. In this study, a potent TLR7 agonist was conjugated to phospholipids, poly(ethylene glycol) (PEG), or phospholipid-PEG via a versatile benzoic acid functional group. Compared to the unmodified TLR7 agonist, each conjugate displayed a distinctive immunological profile in vitro and in vivo. In mouse macrophages and human peripheral blood mononuclear cells, the phospholipid TLR7 agonist conjugate was at least 100-fold more potent than the free TLR7 ligands, while the potency of PEG−phospholipid conjugate was similar to that of the unmodified TLR7 agonist. When administered systemically in mice, the phospholipid and phospholipid−PEG TLR7 conjugates induced prolonged increases in the levels of proinflammatory cytokines in serum, compared to the unmodified TLR7 activator. When the conjugates were used as adjuvants during vaccination, only the phospholipid TLR7 agonist conjugates induced both Th1 and Th2 antigen-specific immune responses. These data show that the immunostimulatory activity of a TLR7 ligand can be amplified and focused by conjugation, thus broadening the potential therapeutic application of these agents

Understanding business ecosystem using a 6C framework in Internet-of-Things-based sectors

With fast development and application, the Internet of Things (IoT) brings more opportunities to business. This research aims to investigate how IoT could lead to a co-evolving business ecosystem rather than a supply chain. It develops the 6C framework to analyze the data collected from case companies, and identifies three patterns of IoT-based business ecosystem. It also provides a summary of practical implications to guide practitioners building an IoT-based business ecosystem

What cluster gas expulsion can tell us about star formation, cluster environment and galaxy evolution

Violent relaxation -- the protocluster dynamical response to the expulsion of its leftover star forming gas -- is a short albeit crucial episode in the evolution of star clusters and star cluster systems. In this contribution, I survey how it influences the cluster age distribution, the cluster mass function and the ratio between the cluster mass and the stellar mass. I highlight the promising potential that the study of this phase holds in terms of deciphering star cluster formation and galaxy evolution, and (some of) the issues which are to be dealt with before achieving this goal.Comment: Highlight Talk at JENAM2008 Symposium "Star Clusters - Witnesses of Cosmic History"; to appear in "Reviews in Modern Astronomy" of the Astronomische Gesellschaft, S.Roeser (ed), vol.21, Wiley-VCH, in press (15 pages, 5 figs

Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding: UK Medical Research Council and Health Technology Assessment Programme