44 research outputs found
Bcr-abl-mediated Regulation of Sphingomyelin Synthase
- Author
- Publication venue
- 'Baishideng Publishing Group Inc.'
- Publication date
- 01/01/2012
- Field of study
SMS is an enzyme belonging to the sphingolipid metabolic pathway. Since the discovery and initial characterizations of sphingolipids (SLs) in 1884, extensive research has established that these molecules not only are structural components of eukaryotic membranes but they are also critical bioactive lipids involved in fundamental cellular processes such as proliferation, differentiation, apoptosis, inflammation, migration, and autophagy. In particular, SMS produces sphingomyelin (SM) in mammalian cells by transfering the phosphorylcholine moiety from phosphatidylcholine (PC) onto ceramide forming SM and diacylglycerol (DAG). Both ceramide and DAG are bioactive lipids with opposing functions, and SMS produces sphingomyelin (SM) while consuming ceramide (negative regulator of cell proliferation) and forming diacylglycerol (DAG) (a mitogenic factor). Therefore enhanced SMS activity could favor cell proliferation. To examine if disregulated SMS contributes to leukemogenesis, we measured SMS activity in several leukemic cell lines and found that it is highly elevated in K562 chronic myelogenous leukemia (CML) cells. The increased SMS in K562 cells was caused by the presence of the BCR-ABL oncogene, a hallmark of CML, as stable expression of BCR-ABL elevated SMS activity in the BCR-ABL negative HL-60 cells while inhibition of the tyrosine kinase activity of BCR-ABL with Imatinib mesylate, decreased SMS activity in K562 cells. The increased SMS activity was the result of up regulation of the SMSI isoform. Inhibition of SMS activity with D609 (a pharmacological SMS inhibitor) or down-regulation of SMS1 expression by siRNA, selectively inhibited the proliferation of Bcr-abl positive cells. The inhibition was associated with an increased production of ceramide and a decreased production of DAG, conditions that antagonize cell proliferation. A similar change in lipid profile was also observed upon pharmacological inhibition of Bcr-abl (K526 cells) and siRNA-mediated down-regulation of BCR-ABL (HL-60/Bcr-abl cells). These findings indicate that SMS1 is a downstream target of Bcr-abl, involved in sustaining cell proliferation of Bcr-abl positive cells. The increased SMS1 activity in bcr-abl positive cells was associated with higher levels of the SMS1 protein due to enhanced transcription, as measured by quantitative real time PCR (QRT-PCR) of heteronuclear RNA (hnRNA). In particular, the highest increase of SMS1 transcript and mRNA was observed when probing down-stream of exon 6, suggesting the preferential utilization of an alternative transcription start site (TSS) in Bcr abl positive cells. Thus this study investigated the effect of Bcr-abl on SMS1 transcription. Indeed, RLM-RACE based analysis of Bcr-abl positive cells identified multiple SMS1 TSSs, including a TSS located within intron 6 in close proximity and upstream to exon 7 (TSS C). Notably, in silica analysis of the entire SMS1 locus, including large areas of its 5\u27 and 3\u27 UTR, revealed multiple putative promoter regions, including Promoter C located upstream to TSS C. Further promoter-based studies corroborated the possibility of Bcr-abl to mediate transcription of SMS1 through the putative Promoter C and the dependence of SMS1 transcription on Bcr-abl was further confirmed by demonstrating the inhibition of Promoter C activity upon inhibition of bcr-abl activity with Imatinib. A series of deletions from the 5\u27 end of promoter C revealed a core promoter region from -110 to -113 from TSS C suggesting that the cis-element(s) needed for Bcr-abl mediated SMS1 regulation was located within this area. Overall, these results provide strong evidence of Bcr-abl \u27s regulation of SMS1 expression through enhanced transcription via a promoter switch
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
- Author
- Abbas Dehghan
- Abdonas Tamosiunas
- Abdullatif S Husseini
- Abhijit Sen
- Abla M Sibai
- Adela Chirita-Emandi
- Adolfo Rubinstein
- Afshin Ostovar
- Ahmad Ali Noorbala
- Ahmad Ali Zainuddin
- Ahmad Faudzi Yusoff
- Aicha Soumare
- Aida Pilav
- Akihiro Yoshihara
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Albert Hofman
- Albertino Damasceno
- Alberto Barceló
- Alejandro Diaz
- Aleksandar Džakula
- Aleksander Giwercman Wu
- Aleksandra Piwonska
- Alet H Wijga
- Aletta E Schutte
- Alexandre C Pereira
- Alicia Matijasevich
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline Wagner
- Alireza Ahmadvand
- Alisha N Wade
- Alison J Hayes
- Allan Linneberg
- Altan Onat
- Aluisio J D Barros
- Alun Evans
- Ambady Ramachandran
- Amina Barkat
- Amir Kasaeian
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Henriques
- Ana Jelaković
- Ana Maria B Menezes
- Ana Paula C Cândido
- Anders Grøntved
- Andre L Guimaraes
- Andre P Kengne
- Andre Pascal Kengne
- Andrea R V R Horimoto
- Andres Metspalu
- Andrzej Pajak
- Andrzej Wiecek
- Aneta Grajda
- Angela Chetrit
- Angela Döring
- Angelique W Chan
- Ann-Sofie Forslund
- Anna Bugge
- Anna G Iannone
- Annamari Lundqvist
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette Peters
- Annika Rosengren
- Anoosheh Ghasemian
- Anselmo J Mc Donald Posso
- Anthony Kafatos
- Antoinette Amuzu
- Antonia Trichopoulou
- Antonio Bernabe-Ortiz
- Antonio Cabrera de León
- Antonis Zampelas
- Anup Ghimire
- Anwar M Batieha
- Arnaud Chiolero
- Aroor Bhagyalaxmi
- Aryeh D Stein
- Assembekov Batyrbek
- Astrid Petersmann
- Atul Trivedi
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- Aung Soe Htet
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- Avula Laxmaiah
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- Publication venue
- ZU Scholars
- Publication date
- 01/01/2018
- Field of study
© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abdrakhmanova Shynar
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Agdeppa Imelda A.
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Naser
- Ahmadvand Alireza
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Hazzaa Hazzaa M.
- Al-Othman Amani Rashed
- Al-Raddadi Rajaa
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Ali Osman
- Alkerwi Ala'a
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N.
- Amouyel Philippe
- Amuzu Antoinette
- Anderssen Sigmund A.
- Angquist Lars H.
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Anselmo Olinto Maria Teresa
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Aung May Soe
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azizi Fereidoun
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- Balakrishna Nagalla
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- Banach Maciej
- Bandosz Piotr
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- Sandjaja Sandjaja
- Sandra Ruiz-Betancourt Blanca
- Sans Susana
- Sant'Angelo Victoria Farrugia
- Santa-Marina Loreto
- Santos Sanz Sara
- Santos Silva Diego Augusto
- Santos Diana A.
- Santos Ina S.
- Santos Osvaldo
- Santos Rute
- Saramies Jouko L.
- Sardinha Luis B.
- Sarrafzadegan Nizal
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Savy Mathilde
- Scazufca Marcia
- Schargrodsky Herman
- Schienkiewitz Anja
- Schindler Karin
- Schipf Sabine
- Schmidt Carsten O.
- Schmidt Ida Maria
- Schoettker Ben
- Schultsz Constance
- Schutte Aletta E.
- Sebert Sylvain
- Sein Aye Aye
- Selamat Rusidah
- Sember Vedrana
- Sen Abhijit
- Senbanjo Idowu O.
- Sepanlou Sadaf G.
- Sequera Victor
- Serra-Majem Luis
- Servais Jennifer
- Shalnova Svetlana A.
- Sharma Sanjib K.
- Shaw Jonathan E.
- Shengelia Lela
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shin Youchan
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M.
- Silva Antonio M.
- Simon Mary
- Simons Judith
- Simons Leon A.
- Sjoberg Agneta
- Sjostrom Michael
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- Snijder Marieke B.
- So Hung-Kwan
- Sobngwi Eugene
- Soderberg Stefan
- Soekatri Moesijanti Y. E.
- Soemantri Agustinus
- Solfrizzi Vincenzo
- Solomon Bethlehem D.
- Son Thai Pham Son Thai Pham
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K.
- Sorensen Thorkild I. A.
- Soric Maroje
- Soumare Aicha
- Spinelli Angela
- Spiroski Igor
- Staessen Jan A.
- Stamm Hanspeter
- Starc Gregor
- Stathopoulou Maria G.
- Staub Kaspar
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D.
- Stergiou George S.
- Stessman Jochanan
- Stevens Gretchen A.
- Stocks Tanja
- Stoeckl Doris
- Stokwiszewski Jakub
- Stratton Gareth
- Stronks Karien
- Strufaldi Maria Wany
- Sturua Lela
- Suarez-Medina Ramon
- Sun Chien-An
- Sundstrom Johan
- Sung Yn-Tz
- Sunyer Jordi
- Suriyawongpaisal Paibul
- Swinburn Boyd A.
- Sy Rody G.
- Sylva Rene Charles
- Szponar Lucjan
- Taddei Cristina
- Tai Hing Lam Tai Hing Lam
- Tai E. Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarp Jakob
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Tchibindat Felicite
- Tebar William R.
- Tell Grethe
- Tello Tania
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thuesen Betina H.
- Ticha Lubica
- Timmermans Erik J.
- Tjonneland Anne
- Tolonen Hanna K.
- Tolstrup Janne S.
- Topbas Murat
- Topor-Madry Roman
- Tormo Maria Jose
- Tornaritis Michael J.
- Torrent Maties
- Toselli Stefania
- Traissac Pierre
- Tran Quoc Bao Tran Quoc Bao
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tsao Yu-Hsiang
- Tshepo Lechaba
- Tsigga Maria
- Tsugane Shoichiro
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Tynelius Per
- Tzotzas Themistoklis
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice E.
- Ukoli Flora A. M.
- Ulmer Hanno
- Unal Belgin
- Uusitalo Hannu M. T.
- Vaitkeviciute Justina
- Valdivia Gonzalo
- Vale Susana
- Valvi Damaskini
- van der Schouw Yvonne T.
- Van Herck Koen
- van Rossem Lenie
- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varela-Moreiras Gregorio
- Varona-Perez Patricia
- Vatten Lars
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Velika Biruta
- Veronesi Giovanni
- Verschuren W. M. Monique
- Victora Cesar G.
- Viegi Giovanni
- Viet Lucie
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K.
- Visser Marjolein
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Volzke Henry
- Voutilainen Ari
- Voutilainen Sari
- Vrijheid Martine
- Vrijkotte Tanja G. M.
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Wagner Aline
- Waldhoer Thomas
- Walton Janette
- Wanderley Rildo S., Jr.
- Wang Ming-Dong
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Weber Adelheid
- Weerasekera Deepa
- Weghuber Daniel
- Wei Wenbin
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Wiecek Andrzej
- Wijga Alet H.
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Jyh Eiin
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Wu Frederick C.
- Wu Jianfeng
- Wu Shouling
- Xu Haiquan
- Xu Liang
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yaseri Mehdi
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yngve Agneta
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O.
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A.
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilova Hana
- Zapata Maria Elisa
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zeng Yi
- Zhao Dong
- Zhao Wenhua
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zhussupov Baurzhan
- Zimmermann Esther
- Zuniga Cisneros Julio
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
- Abani Obbina
- Abbas Ali
- Abbas Fatima
- Abbas Mustafa
- Abbasi Sadia
- Abbass Hakam
- Abbott Alfie
- Abdallah Nabeel
- Abdelaziz Ashraf
- Abdelfattah Mohamed
- Abdelqader Bushra
- Abdo David
- Abdul Rasheed Althaf
- Abdul Basir
- Abdul-Kadir Rezan
- Abdul-Raheem Rasheed
- Abdulakeem Ajibode
- Abdulle Amina
- Abdulmumeen Abdulfatahi
- Abdulshukkoor Niyaz
- Abdusamad Kula
- Abed El Khaleq Yazeed
- Abedalla Mai
- Abeer Ul Amna Abeer Ul Amna
- Abernethy Katrina
- Abo-Leyah Hani
- Aboaba Adebanke
- Abou-Haggar Ahmed
- Abouibrahim Mahmoud
- Abraham Miriam
- Abraham Tizzy
- Abraheem Abraheem
- Abrams Judith
- Abu Hyacinth-John
- Abu-Arafeh Ahmed
- Abubacker Syed M
- Abung Akata
- Aceampong Yaa
- Achara Amaka
- Acharya Devikumar
- Acheampong Sarah
- Acheson Janet
- Acosta Andres
- Acton Catherine
- Adabie-Ankrah Jacqueline
- Adair Sara
- Adam Fiona
- Adam Matthew
- Adamali Huzaifa
- Adams Carol
- Adams Charlotte
- Adams Kate
- Adams Lisa
- Adams Richard
- Adams Tim
- Adcock Kirsty
- Addai Jemaimah
- Adebiyi Ade
- Adegoke Ken
- Adell Vicki
- Ademokun Debo
- Adenwalla Sherna
- Adesemoye Oluwasegun A
- Adewunmi Emmanuel O
- Adeyemi Joyce
- Adhikary Rina
- Adkins Gabrielle
- Adnan Adnan
- Aeron-Thomas John
- Affleck Debbie
- Affron Dominic
- Afnan Carmel
- Afridi Muhammad
- Aftab Zainab A
- Agarwal Meenakshi
- Agbeko Rachel
- Agbo Chris
- Agent Penny
- Aggarwal Sunil
- Aghababaie Arameh
- Ahamed Sadiq Shafana
- Ahammed Nazeer Mohamed H
- Ahmad Humayun
- Ahmad Mohammad
- Ahmad Syed
- Ahmed Ali Roa
- Ahmed Asim
- Ahmed Bilal
- Ahmed Forizuddin
- Ahmed Hamze
- Ahmed Iram
- Ahmed Irshad
- Ahmed Khaled
- Ahmed Liban
- Ahmed Mahin
- Ahmed Maria C
- Ahmed Muhammad S
- Ahmed Naseer
- Ahmed Nausheen
- Ahmed Osama
- Ahmed Rajia A
- Ahmed Rizwan
- Ahmed Saif
- Ahmed Sammiya
- Ahmed Sana
- Ahmed Sara
- Ahmed Sophia
- Ahmed Syed
- Ahmed Syed Haris
- Ahmer Sana
- Ail Dhiraj
- Ainsworth Mark
- Airoldi Giulia
- Aissa Myriam
- Aitken Lindianne
- Ajay Bini
- Ajeneye Francis
- Ajibode Abdulakeem
- Ajmi Ayesha
- Akbar Tahir
- Akhtar Naim
- Akhtar Nasim
- Akhtar Nauman
- Akili Suha
- Akindolie Oludoyinsola
- Akinfenwa Yinka
- Akinkugbe Olugbenga
- Akinpelu Ibrahim
- Akinwumiju Olajide
- Aktinade Olugbenro
- Al Aaraj Ahmad
- Al Balushi Asma
- Al Dakhola Majd
- Al Swaifi Aladdin
- Al-Abadi Eslam
- Al-Asadi Abbas
- Al-Asadi Karina
- Al-Bayati Manaf
- Al-Fori Julyan
- Al-Hakim Bahij
- Al-Hity Shams
- Al-Jibury Maithem
- Al-Juboori Saba
- Al-Khalil Majid
- Al-Moasseb Hassan
- Al-Obaidi Magda
- Al-Rabahi Akram
- Al-Ramadhani Bahar
- Al-Saadi Zayneb
- Al-Shahi Salman Rustam
- Al-Shamkhani Warkaq
- Al-Sheklly Bashar
- Aladangady Narendra
- Alam Ayaz
- Alam Sajid
- Alatzoglou Kyriaki
- Albert Paul
- Albon Lorraine
- Alcorn Gemma
- Alcorn Stephen
- Aldana Aggie
- Alderdice David
- Aldouri Rayan
- Aldridge Jonathan
- Aldridge Nicolas
- Alegria Ana
- Alexander Alison
- Alexander John
- Alexander Peter D G
- Alford Charlotte
- Alghazawi Laith
- Ali Ali
- Ali Asad
- Ali Fawzia R
- Ali Hoodo
- Ali Jawad
- Ali Mariam
- Ali Mohammad
- Ali Nayab
- Ali Oudai
- Ali Sabira
- Ali Sakina
- Ali Syed
- Alina Abid
- Aliyuda Fine
- Alizadeh Katrin
- Alkhusheh Moutaz
- Allameddine Allameddine
- Allan Fiona
- Allan Rachel
- Allanson Alison
- Allcock Robert
- Allen Beverley
- Allen Eireann
- Allen Jess
- Allen Kerry
- Allen Laura
- Allen Louise
- Allen Poppy
- Allen Rebecca
- Allen Sam
- Allen Sharon
- Allen Simon
- Allison Kathryn
- Allman Bethan
- Allsop Lynne
- Alomari Lina
- Alshaer Inji
- Altaf Sara
- Alvarez Mary
- Alyas Balaal
- Alzetani Maysaa
- Amamou Susan
- Amar Noor
- Ambalavanan Sakkarai
- Ambler Sarah-Jayne
- Ambrogetti Robert
- Ambrose Chris
- Ameen Amir
- Amenyah Kenneth
- Amezaga Maria R
- Amin Allison
- Amin Amina
- Amin Kanish
- Amin Syed
- Amin Tara
- Amjad Amjad
- Amjad Neelma
- Ammoun Mariam
- Amosun Victoria
- Amsha Khaled
- Amy Pugh
- Anand Atul
- Anand Rekha
- Anandappa Samantha
- Anderson Julie
- Anderson Kevin
- Anderson Laura
- Anderson Michelle
- Anderson Nicola
- Anderson Rachel
- Anderson Rory
- Anderson Wendy
- Andreou Prematie
- Andrews Angela
- Andrews Antonette
- Andrews Jill
- Andrews Susan
- Andrikopoulos Gregory
- Aneke Kanayochukwu
- Ang Andrew
- Ang Wan Wei
- Angel Tammy
- Angela Aramburo
- Angelini Paola
- Anguvaa Lazarus
- Anichtchik Oleg
- Anim-Somuah Millicent
- Aniruddhan Krishnan
- Annett Jessica
- Anstey Patrick J
- Anstey Rebekah
- Anthony Alpha
- Anthony-Pillai Aaron
- Antill Philip
- Antonina Zhelyazkova
- Anu Varghese
- Anwar Muhammad
- Apostolides George
- Apostolopoulos Aristeidis
- Appleby Sarah
- Appleyard Diane
- Aquino Maia Far
- Araba Bianca
- Aransiola Samuel
- Araujo Mariana
- Arbon Emily
- Archer Ann
- Archer Denise
- Archer Simon
- Ardley Christian
- Arias Ana-Maria
- Arimoto Ryoki
- Arkley Charlotte
- Armah Charlotte
- Armata Ilianna
- Armitage Adam
- Armstrong Ceri
- Armstrong Maureen
- Armstrong Sonia
- Armstrong-Fisher Sylvia
- Armtrong Philippa
- Arndt Heike
- Arnison-Newgass Clare
- Arnold David
- Arnold Rachael
- Arnott Sarah
- Arora Dhawal
- Arora Kavan
- Arora Pardeep
- Arora Rishi
- Arroyo Andrea
- Arter Arslam
- Arya Ayush
- Arya Rita
- Asandei Denisa
- Asghar Adeeba
- Ashbrook-Raby Catherine
- Ashby Glen
- Ashby Helen
- Ashcroft Jan
- Ashcroft John
- Ashcroft Samuel
- Asher Deborah
- Ashfaq Ayesha
- Ashford Ben
- Ashgar Suhail
- Ashish Abdul
- Ashman-Flavell Sally
- Ashok Sundar
- Ashour Abd-El-Aziz
- Ashraf Muhammad Z
- Ashraf Saima
- Ashraq Mohammad B
- Ashton Deborah
- Ashton Susan
- Ashworth Andrew
- Ashworth Rebecca
- Aslam Arshia
- Asogan Harshini
- Asquith Abigail
- Asrar Atif
- Assaf Omar
- Astin-Chamberlain Raine
- Athay-Hunt Richard
- Athorne Deborah
- Atkins Billie
- Atkins Christopher
- Atkins Stacey
- Atkinson John
- Atkinson Vicki
- Atraskiewicz Brygitta
- Atterbury Claire
- Attia Abdul Ahmad
- Atugonza Rita
- Aubrey Paula
- Aujayeb Avinash
- Aung Aye Chan Thar
- Aung Hnin
- Aung Kyaw Thu
- Aung Ni
- Aung Yin
- Aung Zaw Myo
- Austin Emily
- Austin Karen
- Auwal Abdusshakur
- Avery Miriam
- Avis Joanne
- Aviss Georgina
- Avram Cristina
- Avram Paula
- Awadzi Gabriel
- Awan Atia
- Aya Aszad
- Ayaz Eman
- Ayers Amanda
- Azam Jawwad
- Azharuddin Mohammed
- Aziz Ghazala
- Aziz N
- Azkoul Ali
- Azman Shah Ashaari
- Azzopardi Giada
- Azzoug Hocine
- Babatunde Fiyinfoluwa
- Babi Melvin
- Babiker Babiker
- Babington Gayna
- Babirecki Matthew
- Babores Marta
- Babs-Osibodu Adetona O
- Bacciarelli Sammy
- Bachar Roudi
- Bacon Gina
- Bacon Jenny
- Badal Bibi
- Badhan Gurpreet R
- Badhrinarayanan Shreya
- Bae Joseph P
- Bafekr Mishamandani Sibel
- Baggaley Alice
- Baggott Amy
- Bagley Graham
- Bagmane Dinesh
- Bagshaw Lynsey
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- Bailey James
- Bailey Katie
- Bailey Lindsey
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- Bailey Sarah
- Bailey Stephen
- Baillie Hamish
- Baillie J Kenneth
- Bain Jennifer
- Baines Sanchia
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- Baird Aimi
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- Baker Kenneth
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- Baker Terri-Anne
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- Baker-Moffatt Michelle
- Bakere Hugh
- Bakerly Nawar
- Bakhtiar Nauman
- Bakoulas Panos
- Balaam Julie
- Balachandran Niranjan
- Balan Andrea
- Balaskas Theodosios
- Balasubramaniam Madhu
- Balcombe Alison
- Baldwin Alexander
- Baldwin Ashley
- Baldwin Caron
- Baldwin Danielle
- Baldwin-Jones Rebekah
- Balfour James
- Bali Gagan
- Balkee Sonya
- Ball Ceri
- Ballard Kasia
- Ballinger Amy
- Balluz Ismael
- Balmforth Craig
- Balogh Emese
- Baluwala Amir
- Bambridge Gabby
- Bamford Alasdair
- Bamford Amy
- Bamford Peter
- Bamgboye Adefunke
- Bancroft Elizabeth
- Bancroft Hollie
- Bancroft Tanya
- Banda Joyce
- Bandaru Krishna
- Bandi Srini
- Bandla Nageswar
- Bandyopadhyam Somaditya
- Banerjee Amit
- Banerjee Millie
- Banerjee Ritwik
- Banks Harrison
- Banks Lauren
- Banks Luke
- Banks Paul
- Bannister Oliver
- Bansal Bharat
- Banthorpe Robert
- Banton Laura
- Baptist Mariamma
- Baqai Tanya
- Baral Ananya Mouli
- Baramova Desislava
- Barber Alex
- Barber Russel
- Barbon Emma
- Barbosa Miriam
- Barbosa Monica
- Barbour Jamie
- Barclay Alexander
- Barclay Claire
- Bardsley George
- Bareford Stephanie
- Bari Shahedal
- Barker Amy
- Barker Debbie
- Barker Helen
- Barker Joseph
- Barker Leon
- Barker Oliver
- Barker-Williams Kerry
- Barkha Sinha
- Barla Juliana
- Barlow Gavin
- Barlow Richard
- Barlow Valerie
- Barnacle James
- Barnard Alex
- Barnes Debi
- Barnes Nicky
- Barnes Theresa
- Barnetson Calum
- Barnett Amy
- Barnett Matthew
- Barnett-Vanes Ashton
- Barnsley William
- Barr Andrew
- Barr David
- Barratt Shaney
- Barrera Manuella
- Barrett Amy
- Barrett Fiona
- Barrett Jessica
- Barry Joe
- Bartholomew Jazz
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- Bartlett Georgina
- Barton Greg
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- Barton Lorna
- Barton Rachael
- Baruah Rosaleen
- Baryschpolec Sonia
- Bashyal Archana
- Basker Betsy
- Basoglu Ayten
- Bass Gilda
- Bassett G
- Bassett John
- Bassford Chris
- Bassi Pavinder
- Bassis Betsy
- Bassoy Bengisu
- Bastion Victoria
- Basumatary Anupam
- Bate Tristan
- Bateman Harry J
- Bateman Ian
- Bateman Kathryn
- Bateman Vhairi
- Bates Eleanor
- Bates Hayley
- Bates Michelle
- Bates Simon
- Batham Sally
- Batista Ana
- Batla Amit
- Batra Dushyant
- Batty Donna
- Batty Harry
- Batty Thomas
- Baughan Peter
- Baum Miranda
- Bautista Carina
- Bawa Fareha
- Bawani Fatima S
- Bax Simon
- Baxter Lydia
- Baxter Matt
- Baxter Nicola
- Baxter Zachary
- Bayes Hannah
- Baylem Charlotte
- Bayliss Lee
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- Belfield Holly
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- Bell Dina
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- Bell Joshua
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- Berry Zoe
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- Bewick Tom
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- Bhatt Karan
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- Bibby Anna
- Bibi Fatima
- Bibi Naheeda
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- Bidgood Sarah
- Bigg Julie
- Biggs Sarah
- Biju Alphonsa
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- Black Ethel
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- Black Mairead
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- Blackledge Bethan
- Blackler Joanne
- Blackley Samantha
- Blackman Helen
- Blackmore Stuart
- Blackstock Caroline
- Blackwood Loraine
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- Blamey Helen
- Bland Alison
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- Blankley Simon
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- Blaxland Jenny
- Blaylock Katie
- Blazeby Jane
- Blears Carol
- Blencowe Natalie
- Blofield Donna
- Bloom Ben
- Bloomfield Jack
- Bloss Angela
- Bloxham Hannah
- Blundell Louise
- Blunsum Andrew
- Blunt Mark
- Blyth Ian
- Blyth Kevin
- Blythe Andrew
- Blythe Karen
- Boampoaa Marilyn
- Bobie Boniface
- Bobruk Karen
- Bodalia Pritesh
- Bodasing Neena
- Bodenham Tanya
- Bodh Sherin
- Boehmer Gabriele
- Boffito Marta
- Bohmova Kristyna
- Bokhandi Sumit
- Bokhar Maria
- Bokhari Saba
- Bokhari Sakina
- Bokhari Syed Owais
- Boles Ambrose
- Bollington Sarah
- Bolton Sam
- Bomken Charlotte
- Bond Charlotte
- Bond Hayley
- Bond Helena
- Bond Stuart
- Bond Thomas
- Bone Alice
- Boniface Georgia
- Bonnert Wendy
- Bonney Lizzy
- Boorman Leigh
- Booth Catherine
- Borbone Joanne
- Borhani Cameron
- Borman Naomi
- Borrell Rachel
- Boshir Mamu
- Bottrill Fiona
- Bough Laura
- Boughton Hayley
- Boult Zoe
- Bourke Miriam
- Bourke Stephen
- Bourne Michelle
- Bousfield Rachel
- Boustred Lucy
- Bowen Darren
- Bowen Kaye
- Bowes Alexandra
- Bowes Amy
- Bowker Philip
- Bowman Louise
- Bowman Simon
- Bowmer Rachel
- Bowring Angie
- Bowyer Geoff
- Bowyer Helen
- Boyd Carmel
- Boyd Jenny
- Boyd Laura
- Boyd Maxine
- Boyle Namoi
- Boyle Pauline
- Boyle Rosalind
- Boyles Louise
- Bozdag Osman
- Brace Leanna
- Brack David
- Brackstone Charlotte
- Bradburn Rob
- Bradder Jodie
- Bradley Barry
- Bradley Clare Jane
- Bradley Pamela
- Bradley Patrick
- Bradley Paul
- Bradley-Potts Joanne
- Bradshaw Lynne
- Bradshaw Sarah
- Bradshaw Zena
- Brady Rebecca
- Brady Shirin
- Braganza Denise
- Brailsford Suhail
- Braithwaite Jill
- Branch Marie
- Brankin-Frisby Thomas
- Brannigan Jamie
- Brassington Louise
- Brattan Sophie
- Bray Fiona
- Bray Nancy
- Brazier Angela
- Brazil Manny
- Brear Lucy
- Brear Tracy
- Brearey Stephen
- Bremner Laura
- Brend Morwenna
- Bretland Giovanna
- Brewer Chris
- Bridge Hannah
- Bridgwood Gavin
- Briggs Hayley
- Briggs Mark
- Brigham Sara
- Bright John
- Brightling Chris
- Brimfield Lutece
- Brinkworth Elaine
- Brittain-Long Robin
- Britten Vianne
- Brittin Terri
- Broad Lauren
- Broad Sarah
- Broadhurst Rosie
- Broadley Andrew
- Broadway Marie
- Brockelsby Christopher
- Brocken Megan
- Brockley Tomos
- Broderick Andrew
- Brodsky Mary
- Brogan Fiona
- Broggio David
- Brohan Liz
- Brokke Felicity
- Brolly Jacob
- Bromley David
- Brooke-Ball Hannah
- Brooker Verity
- Brookes Ceri
- Brookes Matthew
- Brooks Alison
- Brooks Karen
- Brooks Nicole
- Brooks Philip
- Brooks Rachel
- Brooks Sophie
- Broomhead Natalie
- Broughton Chloe
- Broughton Nathaniel
- Brouns Matt
- Browett Marie
- Brown Alison
- Brown Ammani
- Brown Carly
- Brown Catrin
- Brown Chloe
- Brown Elizabeth
- Brown Ellen
- Brown Heather
- Brown Janet
- Brown Louise
- Brown Niall
- Brown Pauline
- Brown Rachel
- Brown Richard
- Brown Robert
- Brown Steven
- Brown Tom
- Brown Wayne
- Browne Bria
- Browne Charlotte
- Browne Duncan
- Browne Mitchell
- Brownlee Stephen
- Brraka Alba
- Bruce David
- Bruce Johanna
- Bruce Michelle
- Brudlo Wojciech
- Brunskill Nigel
- Brunton Alan
- Brunton Margaret
- Bryan Mandy
- Bryant Meera
- Buazon April
- Buch Maya
- Buchan Julie
- Buchan Ruaridh
- Buchanan Alexis
- Buchanan Ruaridh
- Buche Danielle
- Buck Amanda
- Buckland Matthew
- Buckley Laura
- Buckley Philip
- Buckley Sarah
- Buckman Carol
- Buckmire Kathleen
- Bugg George
- Bujazia Ramadan
- Bukhari Marwan
- Bukhari Shanze
- Bulbulia Richard
- Bull Alex
- Bull Damian
- Bull Rhian
- Bull Thomas
- Bulteel Naomi
- Bumunarachchi Kasun
- Bungue-Tuble Roneleeh
- Burchett Caroline
- Burda Dorota
- Burden Christy
- Burden Thomas G
- Burgess Mika
- Burgess Paula
- Burgess Richard
- Burgess Sophia
- Burgett Paula
- Burman Adrian
- Burnard Sara
- Burnett Caroline
- Burnett John
- Burns Amanda
- Burns Amy
- Burns Collette
- Burns James
- Burns Karen
- Burns Samuel
- Burns Sarah
- Burrage Daniel
- Burrage Sadie
- Burrows Kate
- Burston Claire
- Burton Ben
- Burton Fiona
- Burton Matthew
- Busby Angela
- Butcher Deborah
- Butler Aaron
- Butler Jessica
- Butler Joanne
- Butler Joshua
- Butler Lesley
- Butler Peter
- Butler Susan
- Butt Al-Tahoor
- Butt Mohammad M
- Butt Sophia
- Butterworth Caryl
- Butterworth-Cowin Nicola
- Buttery Robert
- Buttle Tom
- Button Heather
- Buttress Daniel
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/02/2021
- Field of study
SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication
A century of trends in adult human height
- Author
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert
- Aekplakorn Wichai
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmadvand Alireza
- Ahrens Wolfgang
- Al-Hazzaa Hazzaa M.
- Al-Othman Amani Rashed
- Ali Mohamed M.
- Alkerwi Ala’a
- Alvarez-Pedrerol Mar
- Aly Eman
- Amouyel Philippe
- Amuzu Antoinette
- Andersen Lars Bo
- Anderssen Sigmund A.
- Anjana Ranjit Mohan
- Aounallah-Skhiri Hajer
- Arfan Ikram M.
- Ariansen Inger
- Aris Tahir
- Arlappa Nimmathota
- Arveiler Dominique
- Assah Felix K.
- Avdicová Mária
- Azizi Fereidoun
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Bandosz Piotr
- Banegas José R.
- Bao Khanh Le Nguyen
- Bao Tran Quoc
- Barbagallo Carlo M.
- Barceló Alberto
- Barkat Amina
- Barros Mauro V.
- Bata Iqbal
- Batieha Anwar M.
- Batista Rosangela L.
- Baur Louise A.
- Beaglehole Robert
- Benet Mikhail
- Bennett James E.
- Bentham James
- Bernabe-Ortiz Antonio
- Bernotiene Gailute
- Bettiol Heloisa
- Bhagyalaxmi Aroor
- Bharadwaj Sumit
- Bhargava Santosh K.
- Bhatti Zaid
- Bhutta Zulfiqar A.
- Bi Hongsheng
- Bi Yufang
- Bixby Honor
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Björkelund Cecilia
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boddy Lynne M.
- Boehm Bernhard O.
- Boeing Heiner
- Boissonnet Carlos P.
- Boker Lital Keinan
- Bongard Vanina
- Bovet Pascal
- Braeckman Lutgart
- Bragt Marjolijn C.E.
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Juergen
- Brenner Hermann
- Brewster Lizzy M.
- Brian Garry R.
- Bruno Graziella
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Burns Con
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cama Tilema
- Cameron Christine
- Camolas José
- Can Günay
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carvalho Maria J.
- Casanueva Felipe F.
- Casas Juan Pablo
- Caserta Carmelo A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nishi
- Chen Chien Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching Yu
- Chetrit Angela
- Chiolero Arnaud
- Chiou Shu Ti
- Chirita-Emandi Adela
- Cho Belong
- Cho Yumi
- Christensen Kaare
- Chudek Jerzy
- Cifkova Renata
- Claessens Frank
- Clays Els
- Concin Hans
- Cooper Cyrus
- Cooper Rachel
- Coppinger Tara C.
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie
- Cowell Chris
- Craig Cora L.
- Crujeiras Ana B.
- Cândido Ana Paula C.
- Dallongeville Jean
- Damasceno Albertino
- Damsgaard Camilla T.
- Danaei Goodarz
- Dankner Rachel
- Dauchet Luc
- De Backer Guy
- De Bacquer Dirk
- de Gaetano Giovanni
- De Henauw Stefaan
- De León Antonio Cabrera
- De Smedt Delphine
- Deepa Mohan
- Deev Alexander D.
- Dehghan Abbas
- Del Cristo Rodriguez-Perez María
- Delisle Hélène
- Delpeuch Francis
- Deschamps Valérie
- Dhana Klodian
- Di Castelnuovo Augusto F.
- Di Cesare Mariachiara
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Djalalinia Shirin
- Do Carmo Franco Maria
- Do Ha T.P.
- Dobson Annette J.
- Donfrancesco Chiara
- Donoso Silvana P.
- Doua Kouamelan
- Drygas Wojciech
- Dzerve Vilnis
- Döring Angela
- D’Arrigo Graziella
- d’Orsi Eleonora
- Egbagbe Eruke E.
- Eggertsen Robert
- Ekelund Ulf
- El Ati Jalila
- Elliott Paul
- Engle-Stone Reina
- Erasmus Rajiv T.
- Erem Cihangir
- Eriksen Louise
- Escobedo-de la Peña Jorge
- Evans Alun
- Ezzati Majid
- Faeh David
- Fall Caroline H.
- Farzadfar Farshad
- Felix-Redondo Francisco J.
- Ferguson Trevor S.
- Fernanda Lima-Costa M.
- Fernández-Bergés Daniel
- Ferrante Daniel
- Ferrari Marika
- Ferreccio Catterina
- Ferrieres Jean
- Finn Joseph D.
- Fischer Krista
- Flores Eric Monterubio
- Foo Leng Huat
- Forslund Ann Sofie
- Forsner Maria
- Fortmann Stephen P.
- Fortunato Léa
- Fouad Heba M.
- Francis Damian K.
- Franco Oscar H.
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Furusawa Takuro
- Föger Bernhard
- Gaciong Zbigniew
- Gafencu Mihai
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean Michel
- Gasull Magda
- Gates Louise
- Geleijnse Johanna M.
- Ghasemian Anoosheh
- Giampaoli Simona
- Gianfagna Francesco
- Giovannelli Jonathan
- Giwercman Aleksander
- Goldsmith Rebecca A.
- González Rivas Juan P.
- Gonçalves Helen
- Gorbea Mariano Bonet
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dušan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregor Ronald D.
- Grodzicki Tomasz
- Gross Marcela Gonzalez
- Gruden Grabriella
- Grujic Vera
- Grøntved Anders
- Gu Dongfeng
- Gualdi-Russo Emanuela
- Guan Ong Peng
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L.
- Gulliford Martin C.
- Gunnlaugsdottir Johanna
- Gunter Marc
- Guo Xiuhua
- Guo Yin
- Gupta Prakash C.
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Hajifathalian Kaveh
- Halkjær Jytte
- Hambleton Ian R.
- Hamid Zargar Abdul
- Hardy Rebecca
- Hata Jun
- Hayes Alison J.
- He Jiang
- Hendriks Marleen Elisabeth
- Herrala Sauli
- Heshmat Ramin
- Hihtaniemi Ilpo Tapani
- Ho Sai Yin
- Ho Suzanne C.
- Hobbs Michael
- Hofman Albert
- Hormiga Claudia M.
- Horta Bernardo L.
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Husseini Abdullatif
- Huu Chinh Nguyen
- Huybrechts Inge
- Hwalla Nahla
- Iacoviello Licia
- Iannone Anna G.
- Ibrahim Mohsen M.
- Ikeda Nayu
- Irazola Vilma E.
- Islam Muhammad
- Ivkovic Vanja
- Iwasaki Masanori
- Jackson Rod T.
- Jacobs Jeremy M.
- Jafar Tazeen
- Jaime Miranda J.
- Jamil Kazi M.
- Jamrozik Konrad
- Janszky Imre
- Jasienska Grazyna
- Jelakovic Bojan
- Jiang Chao Qiang
- Joffres Michel
- Johansson Mattias
- Jonas Jost B.
- Joshi Pradeep
- Juolevi Anne
- Jurak Gregor
- Jureša Vesna
- Jørgensen Torben
- Kaaks Rudolf
- Kafatos Anthony
- Kalter-Leibovici Ofra
- Kapantais Efthymios
- Kasaeian Amir
- Katz Joanne
- Kaur Prabhdeep
- Kavousi Maryam
- Keil Ulrich
- Keinänen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kemper Han C.G.
- Kengne Andre P.
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young Ho
- Khaw Kay Tee H.
- Khouw Ilse M.S.L.
- Kiechl Stefan
- Killewo Japhet
- Kim Jeongseon
- Klimont Jeannette
- Klumbiene Jurate
- Koirala Bhawesh
- Kolle Elin
- Kolsteren Patrick
- Kontis Vasilis
- Korrovits Paul
- Koskinen Seppo
- Kouda Katsuyasu
- Koziel Slawomir
- Kratzer Wolfgang
- Krishna Kumar R.
- Krokstad Steinar
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kujala Urho M.
- Kula Krzysztof
- Kulaga Zbigniew
- Kumar Rachakulla Hari
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laamiri Fatima Zahra
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Laugsand Lars E.
- Laxmaiah Avula
- Le Tuyen D.
- Leclercq Catherine
- Lee Jeannette
- Lee Jeonghee
- Lehtimäki Terho
- Lekhraj Rampal
- León-Muñoz Luz M.
- Li Yanping
- Lilly Christa L.
- Lim Wei Yen
- Lin Hsien Ho
- Lin Xu
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Liu Jing
- Lorbeer Roberto
- Lotufo Paulo A.
- Lozano José Eugenio
- Lu Yuan
- Luksiene Dalia
- Lundqvist Annamari
- Lunet Nuno
- Lytsy Per
- Ma Guansheng
- Ma Jun
- Machado-Coelho George L.L.
- Machi Suka
- Maggi Stefania
- Magliano Dianna J.
- Maire Bernard
- Makdisse Marcia
- Malekzadeh Reza
- Malhotra Rahul
- Malyutina Sofia
- Manios Yannis
- Mann Jim I.
- Manzato Enzo
- Margozzini Paula
- Markey Oonagh
- Marques-Vidal Pedro
- Marrugat Jaume
- Martin-Prevel Yves
- Martinez Eduardo Salazar
- Martorell Reynaldo
- Masoodi Shariq R.
- Mathiesen Ellisiv B.
- Matsha Tandi E.
- Mazur Artur
- Mbanya Jean Claude N.
- McFarlane Shelly R.
- McGarvey Stephen T.
- McKee Martin
- McLachlan Stela
- McLean Rachael M.
- McNulty Breige A.
- Mediene-Benchekor Sounnia
- Meirhaeghe Aline
- Meisinger Christa
- Menezes Ana Maria B.
- Mensink Gert B.M.
- Meshram Indrapal I.
- Metspalu Andres
- Mi Jie
- Michaelsen Kim F.
- Mikkel Kairit
- Miller Jody C.
- Miquel Juan Francisco
- Mišigoj-Durakovic Marjeta
- Mohamed Mostafa K.
- Mohammad Kazem
- Mohammadifard Noushin
- Mohan Viswanathan
- Molbo Drude
- Molnár Dénes
- Mondo Charles K.
- Monterrubio Eric A.
- Monyeki Kotsedi Daniel K.
- Moreira Leila B.
- Morejon Alain
- Moreno Luis A.
- Morgan Karen
- Mortensen Erik Lykke
- Moschonis George
- Mossakowska Malgorzata
- Mostafa Aya
- Mota Jorge
- Motlagh Mohammad Esmaeel
- Motta Jorge
- Mu Thet Thet
- Muiesan Maria Lorenza
- Murphy Neil
- Mursu Jaakko
- Murtagh Elaine M.
- Musa Kamarul Imran
- Musil Vera
- Møller Niels C.
- Müller-Nurasyid Martina
- Nagel Gabriele
- Nakamura Harunobu
- Nang Ei Ei K.
- Nangia Vinay B.
- Nankap Martin
- Narake Sameer
- Navarrete-Muñoz Eva Maria
- Neal William A.
- Nenko Ilona
- Neovius Martin
- Nervi Flavio
- Neuhauser Hannelore K.
- Nguyen Nguyen D.
- Nguyen Quang Ngoc
- Nieto-Martínez Ramfis E.
- Ning Guang
- Ninomiya Toshiharu
- Nishtar Sania
- Noale Marianna
- Norat Teresa
- Noto Davide
- Nsour Mohannad Al
- Námešná Jana
- O'Reilly Dermot
- Oh Kyungwon
- Olayan Iman H.
- Olinto Maria Teresa Anselmo
- Oltarzewski Maciej
- Omar Mohd A.
- Onat Altan
- Ordunez Pedro
- Ortiz Ana P.
- Osler Merete
- Osmond Clive
- Ostojic Sergej M.
- Otero Johanna A.
- Overvad Kim
- Owusu-Dabo Ellis
- Paccaud Fred Michel
- Paciorek Christopher J.
- Padez Cristina
- Pahomova Elena
- Pajak Andrzej
- Palli Domenico
- Palloni Alberto
- Palmieri Luigi
- Panda-Jonas Songhomitra
- Panza Francesco
- Parnell Winsome R.
- Parsaeian Mahboubeh
- Pecin Ivan
- Pednekar Mangesh S.
- Peeters Petra H.
- Peixoto Sergio Viana
- Peltonen Markku
- Pereira Alexandre C.
- Peters Annette
- Petkeviciene Janina
- Peykari Niloofar
- Pham Son Thai
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pistelli Francesco
- Pitakaka Freda
- Piwonska Aleksandra
- Plans-Rubió Pedro
- Poh Bee Koon
- Porta Miquel
- Portegies Marileen L.P.
- Poulimeneas Dimitrios
- Pradeepa Rajendra
- Prashant Mathur
- Price Jacqueline F.
- Puiu Maria
- Punab Margus
- Pérez Cynthia M.
- Qasrawi Radwan F.
- Qorbani Mostafa
- Raddadi Rajaa Al
- Radic Ivana
- Radisauskas Ricardas
- Rahman Mah mudur
- Raitakari Olli
- Raj Manu
- Ramachandran Ambady
- Ramke Jacqueline
- Ramos Rafel
- Rampal Sanjay
- Rao Kodavanti Mallikharjuna
- Rao Sudha Ramachandra
- Rasmussen Finn
- Redon Josep
- Reganit Paul Ferdinand M.
- Ribeiro Robespierre
- Riboli Elio
- Rigo Fernando
- Riley Leanne M.
- Rinke de Wit Tobias F.
- Ritti-Dias Raphael M.
- Rivera Juan A.
- Robinson Sian M.
- Robitaille Cynthia
- Rodríguez-Artalejo Fernando
- Rodríguez-Villamizar Laura A.
- Rojas-Martinez Rosalba
- Rojroong-Wasinkul Nipa
- Romaguera Dora
- Romdhane Habiba Ben
- Ronkainen Kimmo
- Rosengren Annika
- Rouse Ian
- Rubinstein Adolfo
- Rui Ornelas
- Ruiz-Betancourt Blanca Sandra
- Russo Horimoto Andrea R.V.
- Rutkowski Marcin
- Rühli Frank J.
- Sabanayagam Charumathi
- Sachdev Harshpal S.
- Saidi Olfa
- Salanave Benoit
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
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- Yusof Safiah Md
- Yusoff Muhammad Fadhli Mohd
- Zhou Bin
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 26/07/2016
- Field of study
Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.
- Author
- Ahmed Munaza
- Aitken Stuart
- Aitman Timothy
- Akawi Nadia
- Al Turki Saeed
- Alachkar Hana
- Ali Sonia
- Allen Hana Lango
- Allen Louise
- Allsup David
- Alvi Mohsan
- Ambegaonkar Gautum
- Ambridge Kirsty
- Anderson Carl
- Anderson Julie
- Anjum Uruj
- Anney Richard
- Antony Dinu
- Antrobus Richard
- Archer Hayley
- Armstrong Ruth
- Armstrong Ruth
- Arno Gavin
- Artigas Maria Soler
- Arumugakani Gururaj
- Ashford Sofie
- Astle William
- Attwood Antony
- Austin Steve
- Awada Jana
- Ayub Muhammad
- Bacchelli Chiara
- Bakchoul Tamam
- Balasubramaniam Senduran
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Bariana Tadbir K.
- Barnicoat Angela
- Barrett Daniel M.
- Barrett Jeffrey C.
- Barrett Jeffrey C.
- Barroso Inês
- Batstone Paul
- Baty David
- Baxendale Helen
- Bayzetinova Tanya
- Beales Phil
- Bennett Chris
- Bennett David
- Bentham Jamie
- Berg Jonathan
- Bernhard Birgitta
- Bethune Claire
- Bevan A. Paul
- Bhattacharya Shoumo
- Bibi Shahnaz
- Birney Ewan
- Bitner-Glindzicz Maria
- Bitner-Glindzicz Maria
- Blackwood Douglas
- Blair Edward
- Bleda Marta
- Blyth Moira
- Bobrow Martin
- Bochukova Elena
- Boggard Harm
- Bohanna David
- Bolton Patrick
- Bolton-Maggs Paula
- Booth Claire
- Bounds Rebecca
- Bourdon Louise
- Bourn David
- Boustred Chris
- Bradley John R.
- Bradley Lisa
- Brady Angela
- Brady Angie
- Breen Gerome
- Brent Simon
- Brewer Carole
- Brown Matthew
- Browning Michael
- Brunstrom Kate
- Bryant Emily
- Bryson Christine
- Bunyan David J.
- Burn John
- Burns Siobhan
- Calissano Mattia
- Calleja Paul
- Canham Natalie
- Canham Natalie
- Carmichael Jenny
- Carss Keren
- Carss Keren
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- Veltman Marijke
- Vijayarangakannan Parthiban
- Vijayarangakannan Parthiban
- Visscher Peter M.
- Vogt Julie
- Vogt Julie
- von Ziegenweldt Julie
- Vonk Noordegraaf Anton
- Wain Louise V.
- Wakeling Emma
- Wakeling Emma
- Wallwark Sarah
- Walters James T.R.
- Wang Guangbiao
- Wang Jun
- Wang Yu
- Wanjiku Ivy
- Ward Kirsten
- Warner Timothy Q.
- Wassmer Evangeline
- Wassmer Evangeline
- Waters Jonathon
- Watkins Hugh
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- Wellesley Diana
- Westbury Sarah
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- Widaa Sara
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- Wilkins Martin
- Wilkinson Emily
- Willcocks Lisa
- Williams Denise
- Williams Hywel
- Williams Nicola
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- Williamson Kathleen A.
- Wilson Crispian
- Wilson Louise
- Wong Kim
- Woods Geoff
- Woods Geoffrey
- Wort John
- Wragg Christopher
- Wright Caroline F.
- Wright Michael
- Xu ChangJiang
- Yang Jian
- Yates Laura
- Yau Michael
- Yeatman Nigel
- Yong Patrick
- Young Tim
- Yu Ping
- Zhang Fend
- Zhang Pingbo
- Publication venue
- AJHG
- Publication date
- 01/01/2019
- Field of study
The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
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- Arnold John
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- Arora Anand
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- Asghar Adeeba
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- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
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- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
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- de Courcy-Golder Kim
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- de la Fuente Carmen
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- Goddard Wendy
- Godement Mathieu
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- Goebeler M.E.
- Golden David
- Goldman John
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- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
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- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
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- Harris John
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- Harrison Susan
- Harrow Kath
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- Hey Samuel
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- Higgins Alisa M.
- Hill Claire
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- Hornsby James
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- Horvat Christopher M.
- Howcroft Clare
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- Huang David T.
- Hughes Debbie
- Hugill Keith
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- Kiiski Heikki
- Kilner Mari
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- Kimpton Sarah
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- Kirk Jill
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- Kong Jing
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- Kosa Alma
- Kremling Julius
- Kreß Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
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- Kuitunen Anne
- Kumar Anand
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- Latham Victoria
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- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
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- Lean Richard
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- Leavis Helen
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- Levett Chris
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- Lewis Roger J.
- Lewis Sarah
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- Liao Angela
- Lim Rosario
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- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
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- Lock Stephen
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- Lomme Kaatje
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- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
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- McGoldrick Clare
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- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
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- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
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- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
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- Vymazal Tamas
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- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
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- Wang Jing
- Wang Kefang
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- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
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- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
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- Whitticase Richard
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- Wijnands Patricia
- Wilby Liz
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- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
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- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
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- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
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- Daubin Cédric
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- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
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- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
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- Delgado Patricia
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- Dimoula Aikaterini
- Dimski Thomas
- Ding Min
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- Ding Yajun
- Ding Yanming
- Dlamini-Sserumaga Lomangisi
- Dobric Milena
- Dolenc Simon
- Dolgusevs Mihails
- Domenech Laura Claramunt
- Dong Jingwen
- Dong Yunchun
- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
- Duan Huan
- Dugernier Thierry
- Duggal Abhijit
- Dullenkopf Alexander
- Dungca Adonis
- Dunne Lisa
- Duran Karely
- Déserts Marc Danguy des
- D’Ambrosio Francesco
- D’Ambrosio Paolo
- Ebaid Maie
- Ebaid Maie Salem
- Efe Serdar
- Efthimiou Aikaterini
- Efthymiou Anna
- Egi Moritoki
- Egorova Natalya
- Ei Poe Poe
- Elatrous Souheil
- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
- Erdivanli Başar
- Erdogan Elif
- Eroglu Ahmet
- Ershova Olga
- Escalante Rosana Gabriela
- Espinosa Cristina Paños
- Esposito Romina
- Essardy Fatiha
- Etourneau Fabienne
- Evers Mirjam
- Fadeeva Liudmila
- Fan Limei
- Fang Xiuhua
- Farkas Jean-christophe
- Farmakis Epaminontas
- Farnell-Ward Sarah
- Farre Olga
- Fartoukh Muriel
- Favre René
- Feghaly Michel El
- Fei Qin
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- Feranandes Ana Margarida
- Fernadez Inmaculada Lorenzo
- Fernandes Fatima
- Fernandez Alejandra Azahara Marguello
- Fernandez Maria Alejandra
- Fernandez Maria Cristina Iglesias
- Fernandez Oscar
- Fernandez Ruben
- Fernandez Silvia
- Fernández Ana Wensell
- Ferreira Amelia
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- Ferretti Christian
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- Fielding Clare
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- Figaro-Barclay Dianne
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- Fijen Jan-Willem
- Filipescu Daniela Carmen
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- Finnstrom Inger Johanne
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- Gallion Marc
- Gama Luz Marina Silva
- Ganeshalingam Vaarisan
- Gao Guangyuan
- Gao Jie
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- Garcia Amilcar
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- Gharios Elie
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- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de Jesús Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Šuput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali Kağnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana Alícia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sánchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana María De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell Fernández
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas Stübner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
- Anita Jans
- Anita Vuković
- Anita-Chrysolyte Kusi-Appiah
- Anja Diers
- Anja Hansen
- Ann-Sofie Malvemyr
- Anna Alexandrou
- Anna Diaz
- Anna Efthymiou
- Anna Kyriakoudi
- Anna Leonova
- Anna Vita Bruno
- Anne Fishman
- Anne Langvad
- Anne Marie Kodal
- Anne Sofie Bomholt Pedersen
- Anne Williams
- Anne-Sophie Debue
- Annette Carey
- Annette Toellefsen
- Anthony Adenekan
- Anthony Radavidson
- Antigoni Karathanou
- Anton Turčan
- Antonella Cotoia
- Antonella Mo
- Antoni Margarit Ribas
- Antonia Liarmakopoulou
- Antonija Petosic
- Antonino Rizzo
- Antonio Abdala
- Antonio Barone
- Antonio Landaverde
- Antonio Manzo
- Antonio Margarit Ribas
- Antony Eneas
- Apostolos Bakas
- Arena Raimondo
- Arif Moghal
- Aristeidis Vakalos
- Arlette Van Den Elst
- Armanda Bozena
- Armando Schmukler
- Armorel Salberg
- Artemis Patsalos
- Arturo Briva
- Arvind Baronia
- Asbjorn Blondal
- Ascanio Tridente
- Ashish K Khanna
- Ashish K Khanna
- Ashish Khanna
- Ashley Szabo Eltorai
- Ashok Sundai Raj
- Ashwaq Ali
- Asmah Zainudin
- Asu Ozgultekin
- Ata Mahmoodpoor
- Athena Lavrentieva
- Attilio Quaini
- Audrey Fioretti
- Audrey Massard
- Auke Reidinga
- Auli Palmu
- Avşar Zerman
- Aya Alabuzidi
- Ayako Noguchi
- Ayça Gümüş
- Azmin Huda Abdul Rahim
- Babangida John Sankey
- Badiola Hilario
- Banu Taşdemir
- Baoke Zhang
- Barbara Garcia
- Barbro Meland
- Bart Ramaker
- Basri Mat Nor
- Battsetseg Baasanjav
- Başar Erdivanli
- Başar Erdivanli
- Beatrice Pastore
- Begoña Zalba-Etayo
- Belen Burgos Conde
- Belinda Guadi-Gosh
- Ben Attwood
- Benjamin Bongiorno
- Benjamin Gerretsen
- Benoît Chinardet
- Berenice Navarro
- Bernardo Panka
- Bernardo Panka
- Bernd Oliver Rose
- Bert Loef
- Betty Star Kampayana
- Beverley Thomas
- Beysim Özcan
- Beysim Özcan
- Bhagyesh Shah
- Biljana Kuzmanovska
- Bindu Thankamma
- Bing Song
- Binny Tuinstra
- Birgitte Fosser Johansen
- Birthe Husted
- Biyan Li
- Bjoern Monsen
- Bjorn Bratsberg
- Bodin Khwannimit
- Bogdan Raitsiou
- Bojan Jovanovic
- Bonnie Bowes
- Boğaç Özserezli
- Bram Kilapong
- Bram Kilapong
- Branislava Stefanovic
- Brian Marsh
- Brigitte Tejeda-Huezo
- Brita Fosser Olsen
- Britt Galaaen
- Britt Sjobo
- Britta Jepsen
- Bronagh Blackwood
- Bruno Miguel Bispo
- Bruno Sousa
- Bruno Sousa
- Brynja Rygvadottir
- Burhan Hadri
- Burhan Hadri
- Byung Ju Kang
- Caihong Hui
- Caiju Song
- Caitriona Cody
- Can Turan
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- Charlotte Young
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- Cheng
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- Dana Tomescu
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- Daniel Horner
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- Danielle Hacking
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- David Shaw
- Davide Massimo Ghioldi
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- Deirdre Doyle
- Dejan Veličković
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- Delphine Ngo
- Demet Tok Aydin
- Detlef Kindgen-Milles
- Devrim Akdağ
- Deyan Cao
- Diana Alvarez
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- Feifei Luo
- Feifei Zhang
- Fekri Abroug
- Fengling Yang
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- Jonghyun Baek
- Jongmin Lee
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- José Ivan Rodriguez de Molina Serrano
- José Manuel Garcia Pena
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- José Rojas-Suarez
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- Juan P Romero-Gonzalez
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- Juan Wu
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- Kewei Liu
- Khaled Al Qawasmeh
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- Khalid Abidi
- Khalid Mahmood Khan Nafees
- Khalid Mahmood Khan Nafees
- Kishore Mangal
- Kit Weng Foong
- Koen De Decker
- Koji Fujimoto
- Konlawij Trongtrakul
- Konlawij Trongtrakul
- Konlawij Trongtratul
- Konstantina Nestora
- Konstantinos Mandis
- Konstantinos Pagioulas
- Konstantinos Psarulis
- Kounougeri Katerina
- Kristina Mariana Matei Stalika
- Kristina Reinertsen Monstad
- Kristy Masters
- Kumi Maruyama
- Kunal Karamchandani
- Kyeongman Jeon
- Kyriaki Tsikritsaki
- Kyung Chan Kim
- Laetitia Boyer
- Laila Kamaliah Kamalul Bahrin
- Lakshay Bhakhtiani
- Lamia Besbes
- Lamia Ouanes Besbes
- Lamprini Avramopoulou
- Laura Bormans
- Laura Cespedes
- Laura Claramunt Domenech
- Laura Martinez Reyes
- Laura Maulicino
- Laura Pedro
- Laura Van Gulik
- Lea Albrecht
- Leah Flores
- Leanne Parsons
- Lee Yeon-Joo
- Lei Chen
- Lei Lei
- Lei Tan
- Lei Yang
- Leif Saager
- Leif Saager
- Leif Saager
- Lena Napolitano
- Lenneke Haas
- Lesia Zgrzheblovska
- Lesia Zgrzheblovska
- Leticia Serpa
- Lettie Van Den Berg
- Li Chuntang Li
- Li Gao
- Li Hong
- Li Ping Hu
- Li Xixi
- Li Yin
- Libing Zhang
- Lidia Glinka
- Lidia Traina
- Liesbet Demarré
- Lihong Liu
- Liivi Maddison
- Liivi Maddison
- Lijuan Zhao
- Lili Hu
- Lili Tuo
- Limei Fan
- Limei Miao
- Lin InSu
- Lina Xiao
- Lina Xu
- Lina Zhao
- Ling Li
- Ling Liu
- Ling Zhang
- LingLing Wang
- Linlin Luan
- LiPing Huang
- Lisa Dunne
- Lisa Høgvall
- Liu Hong
- Liudmila Fadeeva
- Liudmila Grishina
- Liuyan Ge
- Liz Wilby
- Llesley Chadwick
- Lomangisi Dlamini-Sserumaga
- Lorena Del Rio Cabajo
- Lorna Merritt-Charles
- Lorna Merritt-Charles
- Lorraine Thompson
- Losune Cano Sanchez
- Lotta Johansson
- Lotti Orvelius
- Louise Barr
- Louise Bruhn
- Louise Maltby
- Louise Rose
- Louise Rose
- Louise Rose
- Lu Liu
- Luc-Marie Jacquet
- Lucia Hernandez-Ponce
- Lucia Mirabella
- Lucia Stivanello
- Luciano Bonaccorso
- Lucie Mouton
- Luis Alejandro Sanchez-Hurtado
- Luis Camputaro
- Luis Gorordo-Delsol
- Luis Mario Tamayo
- Luis Mendes
- Luis Pedro Ambriz Nava
- Luis Sánchez-Hurtado
- Luz Coronado Sanz
- Luz Marina Silva Gama
- Ly Yuemen
- Lydia Gallego Aguirre
- Lynette Morrison
- Lynette Newby
- Lynne Williams
- Léa Soulisse
- M Del Rosario Villar Redondo
- M Llaurado-Serra
- Ma Hong
- Maarit Ahtiala
- Madeleine Powell
- Madhu Balasubramanian
- Madiha Hashmi
- Madiha Hashmi Ffarcsi
- Mae Templeton
- Magnus Teig
- Maie Ebaid
- Maie Salem Ebaid
- Maija Anniina Valta
- Maija Valta
- Maja Sostaric
- Maja Stanojević
- Majd Tabib
- Maksim Tribulev
- Mala Elgammudi
- Malcolm C Correia
- Malgorzata Mikaszewska-Sokolewicz
- Malgorzata Mikaszewska-Sokolewicz
- Man Liu
- Man Ye
- Mandy Hughes
- Mandy Tallot
- Manish Gupta
- Manoj Kamal
- Manuel Lois
- Maram Milud Said Al-Alawi
- Marat Magomedov
- Marc Bota
- Marc Danguy des Déserts
- Marc Gallion
- Marcela Mastantuono
- Marcela Vizcaychipi
- Marcelo Pederzani
- Marcelo Simi
- Marcos Hernandez-Romero
- Margaret Lynn Jong
- Margarida Ferreira Figueiredo
- Margarita Campos-Perez
- Margherita Boschetto
- Margijske Vanroest
- Maria Alejandra Fernandez
- Maria Angeles Hurtado Sanchez
- Maria Aranzazu Isasi
- Maria Ayala
- Maria Carmen Gorgolas
- Maria Cossu
- Maria Cristina Iglesias Fernandez
- Maria Del Mar Diaz Salcedo
- Maria Donvito
- Maria Fernanda García
- Maria Foka
- Maria Galiana
- Maria Gracia San Antonio
- Maria Idalia Sepulveda
- Maria Liz Moreira
- Maria Luisa Blasco
- Maria Mylordou
- Maria Pilar Sogues Blanco
- Maria Rosa Taibi
- Maria Schofield Legorburo
- Maria Stafylaraki
- Maria Varela
- Maria-Elena Ochoa
- Mariangeles Gabriela Nocheretti
- Marianne Maus
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- Marija Rajković
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- Mario Ramirez
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- Marios Georgiou
- Marisa Onrust
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- Marit Nyhus
- Mark Fielding
- Mark Fielding
- Mark Pulletz
- Mark Van Den Brink
- Mark van der Kuil
- Marta Borkowska
- Marta Tubacka
- Martin Christ
- Martin Kütimets
- Martin Lang
- Martin Rinket
- Martin Roller
- Martin Sills
- Martin Spångfors
- Martina Lausch
- Mary Coman
- María Luisa Bravo Arcas
- María Ocotlan Gonzalez Herrera
- Masakatsu Nananmori
- Masako Shimizu
- Matias Guereschi
- Matias Jesús Flamm Zamorano
- Matjaž Groznik
- Matteo Bossolasco
- Matthew Jackson
- Matthia Mergeay
- Matty Koopmans
- Matías Baini
- Maxim Petrushin
- Mayang Indah Lestari
- Mayra Martinez-Gonzalez
- Mayumi Tsujimoto
- Mazal Azencot
- Meena Manandhar
- Megan McQuirter
- Mei Jiang
- Mei Ye
- Mei Yu Hsu
- Meili Chen
- Melike Cengiz
- Mendsaikhan Naranpurev
- Mendsaikhan Naranpurev
- Meneses Dayan
- Mengmeng Lv
- Meraj Ahmad
- Mercedes Del Cotillo
- Mercè Girona
- Meritxell Tapia Fores
- Merja Merilainen
- Meropi Mpouzika
- Mervyn Mer
- Metaxia Papanikolaou
- Mette From
- Mette Lund
- Mhamed Sami Mebazaa
- Mia Hylen
- Mia Thorning Miller
- Miao Li
- Miao Liu
- Michael Isanan
- Michael Piradov
- Michal Borys
- Michel El Feghaly
- Michele Clark
- Michelle Barakat-Johnson
- Michelle Kotze
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- Mieke Deschepper
- Miguel Angel Gimenez Lajara
- Miguel Ángel Sosa
- Mihai Popescu
- Mihail Luchian
- Mihails Dolgusevs
- Mihails Dolgusevs
- Milena Dobric
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- Milica Lukic
- Min Ding
- Min Song
- Min Xiao
- Min Yu
- Mina Elkhayari
- Mina Mathaios
- Minna Peltomaa
- Miquel Sanz
- Mireia Llaurado-Serra
- Mireia Llaurado-Serra
- Mirjam Evers
- Mirjana Shosholcheva
- Mirjana Shosolcheva
- Miroslaw Czuczwar
- Misa Fister
- Missael Vladimir Espinoza Villafuerte
- Mohamed Abdurazzag Ali Ghula
- Mohamed Benlamin
- Mohan Gurjar
- Mohan Gurjar
- Mohd Basri Mat Nor
- Mohd Nazri Ali
- Mohd Zulfakar Mazlan
- Mohd Zulfakar Mazlan
- Mona Ringdal
- Monica Adriana Scutariu
- Monica Garcia Diaz
- Monica Gomez
- Monica Popescu
- Monica Recio Losilla
- Monica Rocco
- Monika Rothenfusser
- Montserrat Venturas Nieto
- Morena Milic
- Moris Rosati
- Moritoki Egi
- Morten Bestle
- Mrina Oikonomou
- Mu Jianhong
- Muhammed Elhadi
- Muhommed Ridwaan Syed
- Mukta Singh
- Murat Emre Tokur
- Muriel Fartoukh
- Mustafa Akker
- Mustafa Ay
- Na Jia
- Na Zhang
- Nadezhda Zubareva
- Nadine Flessel
- Nafseen Mostafa
- Nafseen Mostafa
- Nahla Ismail
- Nancy Hernandez-Sanchez
- Naraindath N Boedjawan
- Natalia Franco
- Natalia Hagau
- Natalia Monges
- Natalie Fox
- Natalie Remor
- Natalya Egorova
- Nathalie Fox
- Nathalie Gautheret
- Nathalie Heitzler
- Nawfel Ben-Hamouda
- Nayeli Rocio Cañas Padilla
- Nebia Peker
- Nehat Baftiu
- Neil Smith
- Nejc Umek
- Nelson Antunes
- Nerilee Baker
- Nestor Caicedo
- Neus Calpe
- Ngu Pei Hua
- Nicola Allison
- Nicola Horrigan
- Nicola McCann
- Nicola Vaughan-Jones
- Nicolas De Schryver
- Nie Bocui
- Niels Van Regenmortel
- Nigel White
- Nik Azman Nik Adib
- Nika Zorko
- Nikita Matiushkov
- Nikki Sarkar
- Nikolaj Kamenshchikov
- Nikolaos Kakaras
- Nikolaos Kazakos
- Nikolaos Pantelas
- Nikolina Udiljak
- Nina Kolbe
- Ning Li
- Nisha Bhandari Subedi
- Nivisha Parag
- Nobuaki Shime
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- Orla Smith
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- Oscar Fernández Rostello
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- Pablo Monedero
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- Pascal Beuret
- Pasquale Iozzo
- Patricia Albert
- Patricia Brizuela
- Patricia Delgado
- Patricia Gordon
- Patricia Wijnands
- Patrick Biston
- Patrick M Honore
- Patrick M Honore
- Patrick M Honoré
- Patrick Meybohm
- Patrick Toppin
- Paul Caddell
- Paul Eric Reyes
- Paul Hayden
- Paul Kuijpers
- Paul Pulak
- Paula Cabrita
- Paula Cristina Nogueira
- Paula Villegas
- Pauline Fivecoat
- Paulo Alves
- Paulo Carlos Garcia
- Pavlina Kleanthous
- Pedro Gutierrez
- Pedro Mogrovejo
- Pedro Silva
- Penny Parsons
- Peter Creber
- Peter Delve
- Peter Firment
- Peter Marko
- Peter Van Vliet
- Petr Piza
- Petra Crone
- Petra Polgarova
- Phil Broadhurst
- Philipp Douschan
- Philipp Eller
- Philipp Eller
- Philipp Simon
- Philippe Montravers
- Phumele Jali
- Pia Molina
- Pierina Arias Campos
- Pieter Hoste
- Pilar Martinez
- Pina Migliorino
- Pınar Karabacak
- Poe Poe Ei
- Poon Shing Tak
- Prabha Gautam
- Prabha Gautam
- Preveen Banwarie
- Prisca Olabisi Adejumo
- Prune Avogadro
- Przemyslaw Jasiewicz
- Purificacion Sanchez Zamora
- Qi Bo
- Qi Li
- Qi Zeng
- Qian Zhao
- Qiang Lin
- Qiao Yang
- Qin Fei
- Qing Feng Jiao
- Qing Li
- Qingli Zhao
- Qingping Huang
- Qiong Liang
- Qiong Ran
- Qun Xia Jiang
- Rachael Parke
- Rachael Parke
- Rachel Baumber
- Rachel Jarman
- Radmilo Jankovic
- Radmilo Jankovic
- Radmilo Jankovic
- Rafael Gonzalez
- Rafael Sierra
- Rajnish Saha
- Ramanathan Lakshmanan
- Ramon Molina Chueca
- Rand Butcher
- Rannveig J Jonasdottir
- Ranveig Lind
- Raquel Cavaco
- Raquel Garcia Alvarez
- Raquel Jimenez
- Rayanne Santos
- Raysa Cristina Schmidt
- Regina Martinez
- Regina Mulvey
- Reimer Riessen
- Renata Curic Radivojevic
- Reni Jacob
- René Favre
- René Schmutz
- Rhian Bull
- Rica Dagooc
- Ricardo Gregorio
- Richard Lebon
- Richard Whitticase
- Rihard Knafelj
- Rihard Knafelj
- Rik T Gerritsen
- Rima Song
- Rishi Ghosh
- Rita Foss Hargott
- Ritoo Kapoor
- Rob Wilting
- Robert Villa
- Robert Wise
- Roberto Gonzalez
- Rodney Rosalia
- Romina Esposito
- Romina Marconi
- Romuald Hentchoya
- Romuald Hentchoya
- Rong Fen Huang
- Rong Hua Zhao
- Ronghua Zhao
- Rongjun Ling Hu
- Rosa Del Bosque Diez
- Rosa Garcia
- Rosaleen Baruah
- Rosana Gabriela Escalante
- Rosanna Vaschetto
- Rosario Cosano
- Rosario Spina
- Rose Ekama Ilesanmi
- Rose Ilesanmi
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- Rosie Reece-Anthony
- Rosina Shayamano
- Ruben Fernandez
- RuiXia Wang
- Ruth Palfrey
- Ryohey Yamamoto
- Ryszard Gawda
- Sabah Abu Shawish
- Sabina Dhakal Pathak
- Sabrina Pelz
- Saeed Mahmood
- Saira Gomez
- Sait Karakurt
- Salma Kamoun
- Salvatore Girianni
- Salvatore Maurizio Maggiore
- Samantha Hagan
- Samantha North
- Samantha Smith
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- Sandra McPherson
- Sandrine Balon
- Sang-Miin Lee
- Sang-Min Lee
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- Santhana Kannan
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- Sarah Brumwell
- Sarah Buckley
- Sarah Farnell-Ward
- Sarah Grotheer
- Sarah Jane Turner
- Sarah Jones
- Sasha Sankar-Maharaj
- Satoru Hashimoto
- Saulius Vosylius
- Savino Spadaro
- Sean Bagshaw
- Sean Bagshaw
- Sean Bagshaw
- Sean Bagshaw
- Sean Bagshaw
- Sebastian Geijer
- Sebastian Schüppel
- Sebastian Stehr
- Sema Turan
- Semih Aydemir
- Senay Goksu
- Seok Chan Kim
- Seok Jeong Lee
- Serap Avcı Ay
- Serdar Efe
- Sergio Reyes Iburrigarro
- Seung Yong Park
- Seval İzdes
- Seyed Mohammadreza Hashemian
- Shaly George
- Shanshan Lv
- Shanthi Ratnam
- Shanthi Ratnam
- Shanti Ratnam
- Shanti Rudra Deva
- Sharon McDowell-Skaines
- Shella Delossantos
- Shelley Schmollgruber
- Sherissa Microys
- Sherliza Wahab
- ShiFen Wu
- Shu Chuan Chang
- Shuchi Kaushik
- Shuhui Wang
- Shumin Jiang
- Shunsuke Taito
- Shunzhu Yang
- Shuo Wang
- Sibel Ocak Serin
- Silvia Angelica Jorge
- Silvia Call Manosa
- Silvia Calvino Günther
- Silvia Calvino-Gunther
- Silvia Calvino-Gunther
- Silvia Chaparro
- Silvia De Rosa
- Silvia Fernandez
- Silvie Allaert
- Silvina Bravo
- Silvio A Ñamendys-Silva
- Simant Jha
- Simeon Olanipekun
- Simeon Olanipekun
- Simon Dolenc
- Simon Mandaroux
- Simon Whiteley
- Simona Casaioli
- Sini John
- Siobhan O'Nuallain
- Siri Hansen
- Sirley Gill
- Siti Rohayah Sulaiman
- Siv Karin Malmin
- Siw Trudvang
- Slobodan Mihaljevic
- So Young Park
- Soad Imhmed R Alkhumsi
- Sofia Dias
- Sofia Kanakaki
- Sofia Putruele
- Sofia Zepoy
- Solenne Ory
- Sonia O Labeau
- Sonia Stiban
- Sonika Agarwal
- Sophie Liu
- Souheil Elatrous
- Souzana Anisoglou
- Srđan Gavrilovic
- Stacey Watts
- Stanislas Ledochowski
- Stefan Goller
- Stefan Schaller
- Stefano Coremans
- Stella Soundoulounaki
- Stella Uba
- Stephan Graeser
- Stephanie Harris
- Stephen Brett
- Stephen J Brett
- Stephen M Pastores
- Stijn I Blot
- Stijn Van de Velde
- Styliani Bastani
- Styliani Kourelea
- Suha Bozbay
- Sun Lijuan
- Sun Zhiping
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sung Wai Ho
- Sunghoon Park
- Sunthiti Morakul
- Susana Ferreira
- Susana Pinto
- Susanna Hojden
- Susanne Fischer
- Suzana Bianchini
- Suzana Pečenković
- Suzanne Barrowcliffe
- Suzanne Bench
- Swagata Tripathy
- Swagotika Salo
- Sylvi Vullum
- Syragoula Tsikriki
- Sébastien Jochmans
- Sébastien Pili-Floury
- Taha Khaled
- Tai Sun Park
- Takoua Merhabene
- Talia Ben-Jacob
- Tamas Szakmany
- Tamas Vymazal
- Tanja Depuydt
- Tanja Goranovic
- Tao Zan
- Tara Clesi
- Tarek Dendane
- Tarja Tervo-Heikkinen
- Tatiana Patrichi
- Tatjana Beker
- Taís Pantaleao
- Teena Maguire
- Theogene Twagirumugabe
- Theogene Twagirumugabe
- Theonymfi Papavasilopoulou
- Thierry Dugernier
- Thomai Tholioti
- Thomas Dimski
- Thomas Leong
- Thomas Llewellym
- Tianfei Chen
- Ticiane Campanili
- Tien Meng Khoo
- Tim Chimunda
- Timothy Eng
- Tina Charlotte Bitsch Hansen
- Tina Damgaar Thomsen
- Tine Melgaard Frandsen
- Ting Han
- Tingting Li
- Tingting Yu
- Tobias Heinicke
- Tobias Odenthal
- Tobias Schulze
- Tom Dormans
- Tomas Jovaisa
- Tomas Jovaisa
- Tomas Vymazal
- Tomasz Torlinski
- Tomislav Mirkovic
- Tonia Onyeka
- Touraj Rastegar
- Treiza Trueman-Dawkins
- Trina Zhivotneva
- Troy Browne
- Turkay Akbas
- Ulf Guenther
- Ulla Kesti
- Ulla Sandberg
- Ulrica Mickelsson
- Ulrich Jaschinski
- Umeda Aya
- Una Gunter
- Uri Gorokhovatsky
- Uta Kolussi
- V Gusarov
- Vaarisan Ganeshalingam
- Vaibhav Bhargava
- Valentina Bendelari
- Valentina Di Gravio
- Vanda Seromenho
- Vanesa Mercado Telleria
- Vanesa Mercado Telleria
- Vanja Gievski
- Vanja Misic
- Vasileios Bekos
- Vasiliki Chantziara
- Vasilios Koulouras
- Vasilios Koulouras
- Veronica Curilen
- Veronika Kotanidi
- Vesna Bumbasirevic
- Vicent Salvà-Costa
- Victor Gonzalez
- Victoria Houghton
- Victoria Khoronenko
- Victoria Marriott
- Vilas Kushare
- Vincent Castelain
- Vincent Fraipont
- Vincianne Pleitinckx
- Virginie Souppart
- Virpi Lusenius
- Vishnu Das Sasidharan Nair
- Vitaly Gusarev
- Vitaly Gusarov
- Vitor Gomes
- Vitor Manuel Vaz Pinto
- Viveca Hamback Hellkvist
- Višnja Nesek Adam
- Vladimir Gurevich
- Vladimir Kulakov
- Vladislav Belskiy
- Volkan Inal
- Volodymyr Babych
- Vongayi Ogbeide
- W Nazaruddin W Hassan
- Walid Naija
- Walid Sellami
- Walter Swinnen
- Wan Nasrudin Wan Ismail
- Wang Zhijuan
- Wangari Waweru-Siika
- Wangari Waweru-Siika
- Wangyan Jin
- Wei Sun
- Wei Wang
- Wei Wei
- Wei Zhang
- Wei Zhang
- Weilian Yuan
- Weiwei Li
- Wenche Arntsen
- Wendy Brown
- Wendy Chaboyer
- Wendy Chaboyer
- Wendy Milner
- Wenjie Ju
- Wenmei Wang
- Wenmin Chen
- Wenwen Zhao
- Wenzhen Cao
- Wesal Ali Belkhair
- Willem Dieperink
- Windu Baskoro
- Won-Yeon Lee
- Wu Yuchen
- Xia Cui
- Xia Huang
- Xianhong Zheng
- Xianping Luo
- Xiao Fang Tian
- Xiao Xu
- XiaoChun Hu
- Xiaodi Liu
- Xiaofang Luo
- Xiaohan Li
- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
- Xiaoqiong Deng
- Xiaowu Bai
- Xiaoyan Chen
- Xiaoyan Chen
- Xiaoying Wu
- XiaoZhe Liu
- Ximena Villanueva
- Xingguo Li
- Xinhua Xia
- Xinhua Xia
- Xinjian Li
- Xinran Ding
- Xinxia Li
- Xinxia Li
- Xiuhua Fang
- Xiuhua Fang
- Xiujuan Xue
- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat