Solución de dos Escenarios presentes en Entornos Corporativos Bajo el Uso Tecnología CISCO

Este informe se realiza para culminar el diplomado de profundización de cisco, las prácticas se desarrollaron en packet tracert que nos permitió crear los escenarios, los cuales nos pueden ayudar en nuestra vida aplicando estos conocimientos. En este ejercicio se solucionara dos escenarios seleccionados, se documentará cada paso de la configuración de los dispositivos en cada escenario de la red solucionados en la red, al final se verificara la conectividad por medio de comandos, se manejan la conectividad de los equipos configurándolos con dirección ip e ipv6, con protocolos de enrutamiento dinámico, configuración de acceso mediante ssh o telnet, configuración de DHCP y NAT, se configura NTP, se verifica la conectividad para dar solución a los ejercicios.This report is done to complete the Cisco in-depth diploma, the practices were developed in packet tracert that allowed us to create the scenarios, which can help us in our lives by applying this knowledge. In this exercise, two selected scenarios will be solved, each step of the configuration of the devices in each scenario of the network solved in the network will be documented, at the end the connectivity will be verified by means of commands, the connectivity of the equipment is managed by configuring them with IP and IPv6 address, with dynamic routing protocols, access configuration through ssh or telnet, DHCP and NAT configuration, NTP is configured, connectivity is verified to solve the exercises

Diatoms as a paleoproductivity proxy in the NW Iberian coastal upwelling system (NE Atlantic)

The objective of the current work is to improve our understanding of how water column diatom's abundance and assemblage composition is seasonally transferred from the photic zone to seafloor sediments. To address this, we used a dataset derived from water column, sediment trap and surface sediment samples recovered in the NW Iberian coastal upwelling system. Diatom fluxes (2.2 (+/- 5.6) 10(6) valves m(-2) d(-1)) represented the majority of the siliceous microorganisms sinking out from the photic zone during all studied years and showed seasonal variability. Contrasting results between water column and sediment trap diatom abundances were found during downwelling periods, as shown by the unexpectedly high diatom export signals when diatom- derived primary production achieved their minimum levels. They were principally related to surface sediment remobilization and intense Minho and Douro river discharge that constitute an additional source of particulate matter to the inner continental shelf. In fact, contributions of allochthonous particles to the sinking material were confirmed by the significant increase of both benthic and freshwater diatoms in the sediment trap assemblage. In contrast, we found that most of the living diatom species blooming during highly productive upwelling periods were dissolved during sinking, and only those resistant to dissolution and the Chaetoceros and Leptocylindrus spp. resting spores were susceptible to being exported and buried. Fur-thermore, Chaetoceros spp. dominate during spring-early summer, when persistent northerly winds lead to the upwelling of nutrient-rich waters on the shelf, while Leptocylindrus spp. appear associated with late-summer upwelling relaxation, characterized by water column stratification and nutrient depletion. These findings evidence that the contributions of these diatom genera to the sediment's total marine diatom assemblage should allow for the reconstruction of different past upwelling regimes.CAIBEX [CTM2007-66408-C02-01/MAR]; REIMAGE [CTM2011-30155-C03-03]; Spanish Government, EXCAPA project [10MDS402013PR]; Xunta de Galicia; EU FEDER [INTERREG 2009/2011-0313/RAIA/E]; RAIA. co [INTERREG2011/2013-052/RAIA.co/1E]; CALIBERIA project [PTDC/MAR/102045/2008]; Fundacao para a Ciencia e a Tecnologia (FCT-Portugal) [COMPETE/FEDER-FCOMP01-0124-FEDER-010599]; Xunta de Galicia (Spain) [SFRH/BPD/111433/2015]; FCT (Portugal) [SFRH/BPD/111433/2015]; [SFRH/BD/88439/2012

Complicaciones según manejo quirúrgico en pacientes con vólvulo de sigmoides en los Hospitales del Ministerio de Salud del Cusco 2015 - 2019

ANTECEDENTES: El vólvulo de sigmoides representa más del 50% de las obstrucciones intestinales, en el Perú la incidencia llega al 75%, es una emergencia frecuente y requiere un diagnóstico precoz y manejo oportuno, el estudio tiene como objetivo determinar si existe asociación entre el manejo quirúrgico y las complicaciones post operatorias en pacientes con vólvulo de sigmoides en los Hospitales del Ministerio de Salud Cusco en el periodo 2015 – 2019. METODO: El presente trabajo es de tipo cualitativo de corte transversal, retrospectivo y analítico. El diseño es observacional. Se revisaron 350 historias clínicas de pacientes atendidos en los hospitales del Ministerio de Salud del Cusco en el periodo del 2015 – 2019. Para el análisis estadístico se utilizó SPSS 21.0 y Microsoft Office Excel 2016. RESULTADOS: El vólvulo de sigmoides afecta más al género masculino (77.4%) con edades entre 60 y 69 años de procedencia rural (67.7%). Las complicaciones fueron más frecuentes en pacientes masculinos (26.2%) > 80 años (36%) de procedencia urbana (26.5%). El manejo quirúrgico más usado fue anastomosis primaria (76.8%) seguida por colostomía tipo Hartmann (22.6%). Las complicaciones se presentaron en el 41.8% (33/79) de colostomía Hartmann y 19.3% (52/269) de anastomosis primaria. Del total el 24.9% presentó complicaciones, las más frecuentes fueron: dehiscencia de anastomosis (11.6%) seguida de evisceración e infección de sitio operatorio (10.1%) cada una, el 46.5% son catalogadas como “otras”. La relación entre los parámetros pre, intra y postoperatorios frente a las complicaciones fueron significativos. La mortalidad fue del 6.6.%. CONCLUSIONES: Existe relación estadísticamente significativa entre el manejo quirúrgico y las complicaciones post operatorias en pacientes con vólvulo de sigmoides.BACKGROUND: Sigmoid volvulus accounts for more than 50% of intestinal obstructions, in Peru the incidence reaches 75%, it is a frequent emergency and requires early diagnosis and prompt management. The study aims to determine whether there is an association between surgical management and post-operative complications in patients with sigmoid volvulus in the Hospitals of the Ministry of Health in Cusco in the period 2015-2019. METHOD: This work is qualitative, cross-sectional, retrospective and analytical. The design is observational. 350 medical records of patients operated on for sigmoid volvulus who met the inclusion and exclusion criteria in the hospitals of the Ministry of Health of Cusco in the period of 2015-2019 were reviewed. For the statistical analysis, SPSS 21.0 and Microsoft Office Excel 2016. RESULTS: Sigmoid volvulus affects more males (77.4%) with ages between 60 and 69 years of rural origin (67.7%). Complications were more frequent in male patients (26.2%)> 80 years (36%) of urban origin (26.5%). The most widely used surgical management was primary anastomosis (76.8%) followed by a Hartmann-type colostomy (22.6%). Complications occurred in 41.8% (33/79) of Hartmann colostomy and 19.3% (52/269) of primary anastomosis. Of the total, 24.9% presented complications, the most frequent were: anastomosis dehiscence (11.6%) followed by evisceration and infection of the operative site (10.1%) each, 46.5% are classified as "other". The relationship between the pre, intra, and postoperative parameters versus complications were significant. Mortality was 6.6.% BACKGROUND: Sigmoid volvulus accounts for more than 50% of intestinal obstructions, in Peru the incidence reaches 75%, it is a frequent emergency and requires early diagnosis and prompt management. The study aims to determine whether there is an association between surgical management and post-operative complications in patients with sigmoid volvulus in the Hospitals of the Ministry of Health in Cusco in the period 2015-2019. METHOD: This work is qualitative, cross-sectional, retrospective and analytical. The design is observational. 350 medical records of patients operated on for sigmoid volvulus who met the inclusion and exclusion criteria in the hospitals of the Ministry of Health of Cusco in the period of 2015-2019 were reviewed. For the statistical analysis, SPSS 21.0 and Microsoft Office Excel 2016. RESULTS: Sigmoid volvulus affects more males (77.4%) with ages between 60 and 69 years of rural origin (67.7%). Complications were more frequent in male patients (26.2%)> 80 years (36%) of urban origin (26.5%). The most widely used surgical management was primary anastomosis (76.8%) followed by a Hartmann-type colostomy (22.6%). Complications occurred in 41.8% (33/79) of Hartmann colostomy and 19.3% (52/269) of primary anastomosis. Of the total, 24.9% presented complications, the most frequent were: anastomosis dehiscence (11.6%) followed by evisceration and infection of the operative site (10.1%) each, 46.5% are classified as "other". The relationship between the pre, intra, and postoperative parameters versus complications were significant. Mortality was 6.6.% BACKGROUND: Sigmoid volvulus accounts for more than 50% of intestinal obstructions, in Peru the incidence reaches 75%, it is a frequent emergency and requires early diagnosis and prompt management. The study aims to determine whether there is an association between surgical management and post-operative complications in patients with sigmoid volvulus in the Hospitals of the Ministry of Health in Cusco in the period 2015-2019. METHOD: This work is qualitative, cross-sectional, retrospective and analytical. The design is observational. 350 medical records of patients operated on for sigmoid volvulus who met the inclusion and exclusion criteria in the hospitals of the Ministry of Health of Cusco in the period of 2015-2019 were reviewed. For the statistical analysis, SPSS 21.0 and Microsoft Office Excel 2016. RESULTS: Sigmoid volvulus affects more males (77.4%) with ages between 60 and 69 years of rural origin (67.7%). Complications were more frequent in male patients (26.2%)> 80 years (36%) of urban origin (26.5%). The most widely used surgical management was primary anastomosis (76.8%) followed by a Hartmann-type colostomy (22.6%). Complications occurred in 41.8% (33/79) of Hartmann colostomy and 19.3% (52/269) of primary anastomosis. Of the total, 24.9% presented complications, the most frequent were: anastomosis dehiscence (11.6%) followed by evisceration and infection of the operative site (10.1%) each, 46.5% are classified as "other". The relationship between the pre, intra, and postoperative parameters versus complications were significant. Mortality was 6.6.% CONCLUSIONS: There is a statistically significant relationship between surgical management and postoperative complications in patients with sigmoid volvulus.Tesi

Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Evasion.

Group A Streptococcus (GAS) is a human-specific pathogen that evades the host immune response through the elaboration of multiple virulence factors. Although many of these factors have been studied, numerous proteins encoded by the GAS genome are of unknown function. Herein, we characterize a biomimetic red blood cell (RBC)-captured protein of unknown function-annotated subsequently as S protein-in GAS pathophysiology. S protein maintains the hydrophobic properties of GAS, and its absence reduces survival in human blood. S protein facilitates GAS coating with lysed RBCs to promote molecular mimicry, which increases virulence in vitro and in vivo. Proteomic profiling reveals that the removal of S protein from GAS alters cellular and extracellular protein landscapes and is accompanied by a decrease in the abundance of several key GAS virulence determinants. In vivo, the absence of S protein results in a striking attenuation of virulence and promotes a robust immune response and immunological memory

Shape resonances in nested diffraction gratings

The diffraction problem of a plane wave impinging on a grating formed by nested cavities is solved by means of the modal method, for $s$ and $p$ polarization modes. The cavities are formed by perfectly conducting sheets that describe rectangular profiles. The electromagnetic response of the grating is analyzed, paying particular attention to the generation of resonances within the structure. The dependence of the resonances on the geometrical parameters of the grating is studied, and results of far and near field are shown. The results are checked and compared with those available in the literature for certain limit cases.Comment: 18 pages, 8 figure

The Jalisco Seismic Accelerometric Telemetric Network (RESAJ)

The Jalisco region of western Mexico is the locus of interaction among the North America, Cocos, and Rivera plates, giving rise to the Jalisco block. This region is one of the most tectonically active in Mexico, and here took place the largest instrumentally recorded earthquake in Mexico the twentieth century, on 3 June 1932 (M 8.2), three important tsunamis in the last 100 yrs, and two of the most active volcanoes in Mexico. Nevertheless, the first seismicity studies here, undertaken with temporary networks, did not commence until 1994. In 2008, the Government of Jalisco and the University of Guadalajara funded a research project to install a seismic network in this region. The principal objective was to study the seismic hazard in the region and characterize seismic parameters in the different areas to design building codes. The Red Sismica y Acelerometrica Telemetrica de Jalisco (RESAJ) project was thus initiated in 2009. Its Central Lab is at Centro de Sismologia y Volcanologia de Occidente (SisVOc), located at the Universidad de Guadalajara in Puerto Vallarta. Currently, the RESAJ has 26 telemetered and 2 autonomous stations. The RESAJ serves as the seismological lab for the postgraduate program at SisVOc.Comment: Seismological Research Letters 201

Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans.

Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method. We assessed the genetic diversity of HLA class I and class II in this population, and determined the most probable ancestry of Lacandon Maya HLA class I and class II haplotypes. Importantly, this Native American group showed a high degree of both HLA homozygosity and linkage disequilibrium across the HLA region and also lower class II HLA allelic diversity than most previously reported populations (including other Native American groups). Distinctive alleles present in the Lacandon population include HLA-A*24:14 and HLA-B*40:08. Furthermore, in Lacandons we observed a high frequency of haplotypes containing the allele HLA-DRB1*04:11, a relatively frequent allele in comparison with other neighboring indigenous groups. The specific demographic history of the Lacandon population including inbreeding, as well as pathogen selection, may have elevated the frequencies of a small number of HLA class II alleles and DNA blocks. To assess the possible role of different selective pressures in determining Native American HLA diversity, we evaluated the relationship between genetic diversity at HLA-A, HLA-B and HLA-DRB1 and pathogen richness for a global dataset and for Native American populations alone. In keeping with previous studies of such relationships we included distance from Africa as a covariate. After correction for multiple comparisons we did not find any significant relationship between pathogen diversity and HLA genetic diversity (as measured by polymorphism information content) in either our global dataset or the Native American subset of the dataset. We found the expected negative relationship between genetic diversity and distance from Africa in the global dataset, but no relationship between HLA genetic diversity and distance from Africa when Native American populations were considered alone

Aproveitamento da farinha do mesocarpo do babaçu (Orbignya martiana) para obtenção de etanol

O babaçu (Orbignya martiana) faz parte da família das palmeiras (Palmae) e é composto de epicarpo, mesocarpo, endocarpo e amêndoas; o mesocarpo representa 20% do fruto inteiro e é composto de até 60% de amido, que poderia ser utilizado na produção de etanol. Neste trabalho teve-se por objetivo desenvolver e aperfeiçoar o processo de produção de álcool a partir do mesocarpo do babaçu, bem como calcular os rendimentos do processo. Durante a fermentação, o mosto foi analisado quanto ao teor de açúcares residuais, pH, acidez e densidade relativa. As variáveis otimizadas foram pH e temperatura, por meio da análise da conversão do amido em glicose. As condições otimizadas para a α-amilase foram 100°C a pH 6, e para amiloglucosidase foram 60°C, pH 4. A hidrólise enzimática apresentou, nessas condições, um rendimento de 93%. O tempo de fermentação foi estipulado em 12h, conforme os parâmetros fermentativos analisados. A quantidade de álcool produzida, aproximadamente 3°GL, não foi afetada pela agitação. Essa concentração mostra que a fermentação apresentou um rendimento de 98%. Palavras-chave: Orbignya martiana. Babaçu. Amido. Fermentação Alcoólica. Etanol

A long-period transiting substellar companion in the super-Jupiters to brown dwarfs mass regime and a prototypical warm-Jupiter detected by TESS

We report on the confirmation and follow-up characterization of two long-period transiting substellar companions on low-eccentricity orbits around TIC 4672985 and TOI-2529, whose transit events were detected by the TESS space mission. Ground-based photometric and spectroscopic follow-up from different facilities, confirmed the substellar nature of TIC 4672985 b, a massive gas giant, in the transition between the super Jupiters and brown dwarfs mass regime. From the joint analysis we derived the following orbital parameters: P = 69.0480 d, Mp = 12.74 Mjup, Rp = 1.026 Rjup and e = 0.018. In addition, the RV time series revealed a significant trend at the 350 m/s/yr level, which is indicative of the presence of a massive outer companion in the system. TIC 4672985 b is a unique example of a transiting substellar companion with a mass above the deuterium-burning limit, located beyond 0.1 AU and in a nearly circular orbit. These planetary properties are difficult to reproduce from canonical planet formation and evolution models. For TOI-2529 b, we obtained the following orbital parameters: P = 64.5949 d, Mp = 2.340 Mjup, Rp = 1.030 Rjup and e = 0.021, making this object a new example of a growing population of transiting warm giant planets.Comment: Accepted in A&

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)