Matrimonio signo del amor de Dios

El trabajo de investigación pretende describir como actúa Dios en el sacramento del matrimonio signo de su amor, teniendo el problema que a causa de un contexto sociocultural materialista y relativista, el matrimonio va perdiendo su verdadero significado y lugar que le corresponde en la vida cristiana, siendo para muchos algo común y corriente dentro de la sociedad del descarte. El método utilizado es descriptivo y teológico. El objetivo es explicar sobre la belleza del matrimonio teniendo en cuenta que no es un simple desear o querer del ser humano, sino que es parte del proyecto Divino. Donde los cónyuges colaboran con Dios mediante la misión encomendada. En tal sentido, esta investigación es importante porque concientiza a la humanidad que el matrimonio no es una carga para quienes lo acogen, sino más bien es fruto de la gratuidad del amor de Dios, mediante el cual la gracia de Dios invade a los cónyuges, permitiéndoles caminar juntos hacia la santidad y participar de la felicidad plena. Por tanto, se ha llegado a la siguiente conclusión: El matrimonio encuentra su fuente en el amor de Dios, se casan siendo felices para transmitir la vida a través del amor; es fecundo, lo puede todo, las exigencias son mutuas donde los cónyuges responde responsablemente, colaboran y caminan juntos a la santidad; siendo manifestación de la ternura de Dios en la tierra.Tesi

Implementación y configuración bajo nethserver solucionando necesidades especificas con GNU/Linux

Este articulo es presentado para demostrar a través de una serie de imágenes la instalación y configuración de GNU/Linux Nethserver, siendo este un sistema operativo una base para disponer de los servicios de infraestructura IT. Se realiza una configuración previa de Nethserver y red, para el desarrollo de distintas temáticas que manejan temas como DHCP, DNS y Controlador de dominio, Proxy, Cortafuegos, File Server y Print Server, y por ultimo VPN. En la ejecución de estos temas se instalaron y configuraron aplicaciones fundamentales para el desarrollo de estas y se obtuvieron resultados favorables entorno a lo solicitado; de esta manera dejando en evidencia unos breves escritos los cuales detallan paso a paso el desarrollo.This article is presented to demonstrate through a series of images the installation and configuration of GNU/Linux Nethserver, this being an operating system that is the basis for having IT infrastructure services. A prior configuration of Nethserver and network is carried out, for the development of different themes that handle topics such as DHCP, DNS and Domain Controller, Proxy, Firewall, File Server and Print Server, and finally VPN. In the execution of these topics, fundamental applications for their development were installed and configured and favorable results were obtained in the requested environment; in this way revealing some brief writings which detail the development step by step

Efficacy, Safety and Cost-Effectiveness of Methotrexate, Adalimumab or Their Combination in Non-infectious Non-anterior Uveitis: A Protocol for a Multicentre, Randomised, Parallel Three Arms, Active-Controlled, Phase III Open Label With Blinded Outcome Assessment Study

[Abstract] Introduction: Non-infectious uveitis include a heterogeneous group of sight-threatening and incapacitating conditions. Their correct management sometimes requires the use of immunosuppressive drugs (ISDs), prescribed in monotherapy or in combination. Several observational studies showed that the use of ISDs in combination could be more effective than and as safe as their use in monotherapy. However, a direct comparison between these two treatment strategies has not been carried out yet. Methods and analysis: The Combination THerapy with mEthotrexate and adalImumAb for uveitis (CoTHEIA) study is a phase III, multicentre, prospective, randomised, single-blinded with masked outcome assessment, parallel three arms with 1:1:1 allocation, active-controlled, superiority study design, comparing the efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis. We aim to recruit 192 subjects. The duration of the treatment and follow-up will last up to 52 weeks, plus 70 days follow-up with no treatment. The complete and maintained resolution of the ocular inflammation will be assessed by masked evaluators (primary outcome). In addition to other secondary measurements of efficacy (quality of life, visual acuity and costs) and safety, we will identify subjects’ subgroups with different treatment responses by developing prediction models based on machine learning techniques using genetic and proteomic biomarkers. Ethics and dissemination: The protocol, annexes and informed consent forms were approved by the Reference Clinical Research Ethic Committee at the Hospital Clínico San Carlos (Madrid, Spain) and the Spanish Agency for Medicines and Health Products. We will elaborate a dissemination plan including production of materials adapted to several formats to communicate the clinical trial progress and findings to a broad group of stakeholders. The promoter will be the only access to the participant-level data, although it can be shared within the legal situation. Trial registration number: 2020-000130-18; NCT04798755.This work was supported by the Instituto de Salud Carlos III, grant number [ICI19/00020]. Sponsor: Fundación para la Investigacion Biomédica del Hospital Clínico San Carlos. Executive Committee: Administrative and executive arm of the clinical trial, providing overall oversight for the study and making decisions on day-to-day operational issues (Study Coordinator (Luis Rodriguez-Rodriguez), a representative from the Spanish Clinical Trial Network (Amanda López Picado), and 5 Site Directors (these seats will be rotatory, with changes every 6 months months)); Data Coordinating and Analysis Committee: Supervising data collection,management and quality control, designing the statistical analysis plan, performing unmasked data analysis and preparing interim and final reports for the Data Security Monitoring Board and the Executy Committee (Study Coordinator (Luis Rodriguez-Rodriguez), a representative from the Spanish Clinical Trial Network (Amanda López Picado) and Ester Carreño); Biobank and Biomarker Identification Committee (Maintaining an up-to-date manual of operations for blood extraction, processing and storage, and monitoring procedures adherence, supervising biological sample collection, sample shipment coordination, coordinating the phamacogenetic and proteomic analysis (Study Coordinator (Luis Rodriguez-Rodriguez), a representative from the Instituto de Salud Carlos III Biobank Platform (Elena Molino), a representative the Instituto de Investigación Biomédica de A Coruña, a representative from, the Data Coordinating and Analysis Committee); Data Security Monitoring Committee (PierGiogio Neri, Andrew Dick, Loreto Carmona

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997Ł2010

Abstract Background: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIVinfected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. Methods: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 personyears (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. Results: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997. Conclusion: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection

Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050

Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached$8. 8 trillion (95% uncertainty interval UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total,$40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this,$13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and$1.4 billion was repurposed from existing health projects. $3.1 billion (22.4$2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7$1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions

Design and implementation of support and planning for 360º recording. Recording techniques (video and audio) and resolution of problems derived from it: application to the recording of institutional and scientific dissemination videos. Part IV

Los resultados obtenidos en el PIE 387 se pueden visitar en las siguientes páginas web: - Proyecto 360: Cortometraje ¿Marco? https://www.youtube.com/watch?v=AeKNyN631Q0&t=60s - Proyectos de divulgación científica CSIC: 1. Instituto de investigación del Hospital Gregorio Marañón-CSIC: https://youtu.be/_GYO955Q-vo 2. CENIM-CSIC: https://youtu.be/meabgI0YWok 3. ITEFI-CSIC: https://youtu.be/l7ngKGqrRYsLa grabación 360º, cada vez más presente en el entorno audiovisual por la aparición del Metaverso como nuevo espacio de comunicación, está derivando hacia variaciones sustanciales en la forma de narrar y producir contenidos audiovisuales con respecto a las técnicas tradicionales. La posibilidad de sumergir al espectador en un entorno totalmente inmersivo en el que cada punto de vista de atención es seleccionado por el propio espectador, implica un cambio de paradigma en el papel que ejerce el director o realizador como creador y narrador de los acontecimientos. El espectador elige su propio punto de vista para contemplar la escena narrada. El dominio de la tecnología es fundamental para llegar a la excelencia en la producción audiovisual. Profundizar e investigar todas las posibilidades técnicas de la grabación 360º antes de aplicarlo al mundo profesional es el objetivo en el que llevamos trabajando una serie de profesores adscritos en este proyecto desde el curso 2018-2019. El objetivo es, mediante el trabajo con alumnos a través de prácticas aplicadas a la experiencia real, diseñar un protocolo que permita planificar creaciones de grabación 360º tanto en lo relacionado con el vídeo como con el audio. Creemos que ese protocolo empieza a estar consolidad a tenor de los resultados conseguidos. Para ello, llevamos dos cursos colaborando con la profesora Dña. Teresa García Nieto, dentro del proyecto ‘Científic@s en prácticas’ mediante un convenio con el CSIC. En concreto, los proyectos de Innovación Educativa que lidera la profesora Nieto son el proyecto nº 262 Innova-Docencia (curso 2020-2021) y el Proyecto nº 189 (curso 2021-2022) titulado “Universidad y sociedad: comunicación, integración y colaboración con empresas e instituciones públicas y organizaciones no lucrativas. Nuevas aplicaciones”. Además de realizar los vídeos institucionales para laboratorios institucionales del CSIC, como el laboratorio de Arqueobiología http://cchs.csic.es/es/research-lab/laboratorios-id-arqueologia-laboratorio-arqueobiologia-arqbio , hacemos la grabación 360 para conjugar técnicas tradicionales con inmersivas. Y en todo el proceso, están los alumnos implicados, una vez que reciben la formación específica por parte del profesorado adscrito al proyecto. El objetivo es crear producciones audiovisuales en 360º que divulguen la labor desarrollada en el organismo, integrando a los alumnos del Grado de Comunicación Audiovisual, para que aprendan esta técnica de grabación e implementen nuevas fórmulas narrativas asociadas a la misma. El proyecto ‘Científic@s en prácticas’ consiste en tratar de captar vocación científica entre alumnos preuniversitarios, por lo que creemos que la producción audiovisual puede servir de estímulo para que estos alumnos de la ESO puedan comprender la naturaleza de los objetivos del proyecto en el que participan. El proyecto resulta innovador por dos motivos principales: el alumnado aprende directamente sobre un proyecto real la aplicación de nuevas tecnologías de producción audiovisual y, al mismo tiempo, aprenden a elaborar protocolos mediante el aprendizaje de metodologías de investigación derivadas de aplicaciones y estudios sobre el proceso. Además, dada la novedad de esta tecnología 360º, ninguna asignatura del Grado de Comunicación Audiovisual, Publicidad o Periodismo aborda esta materia entre sus contenidos.Depto. de Ciencias de la Comunicación AplicadaFac. de Ciencias de la InformaciónFac. de Bellas ArtesFALSEsubmitte

Proyecto De Tesis I - CI186 - 202102

Descripción: Curso de especialidad en la carrera de ingeniería civil de carácter teórico-práctico dirigido a los estudiantes del 9no ciclo. El curso Proyecto de Tesis I busca que los estudiantes de Ingeniería Civil apliquen sus capacidades adquiridas durante todos sus estudios, en completar una investigación, que plantea resolver una problemática en una de las líneas de la carrera. Con la ayuda de un docente asesor especialista en el tema lograran redactar el informe de tesis al 50%, este informe será revisado por otro docente especialista que proporciona sugerencias de mejoras a la investigación. Por último, los estudiantes exponen ante un jurado especialista sus resultados quienes evalúan y también hacen sugerencia de mejoras a la investigación. Propósito: En el Perú actualmente existe un gran número de estudiantes de Ingeniería Civil que no cuentan con el título profesional, por no realizar la tesis de investigación, lo cual disminuye significativamente su desarrollo profesional y sus oportunidades laborales. El curso de proyecto de Tesis 1 permite que los estudiantes puedan desarrollar el 50% de la Tesis de investigación, siendo la misma certificada por un asesor y un jurado evaluador. Contribuye con el desarrollo de las competencias generales de Pensamiento Crítico, Razonamiento Cuantitativo, Pensamiento Innovador y las competencias específicas 1, 4 y 7 de ABET, todas a nivel de logro 3