Figuras inmutables de lo político: cómo repensar la comunidad

This article will review a series of figures that we have termed “political invariants”, with which we attempt to contribute to the problematization of a construction herein, of their relevance to ‘the political’. These figures, EROS (desire) and ERIS (discord), will be tangentially applied to two closely related spheres: the public space of the city (polis) and the intimate space of the soul (psyche), and shall also be examined from the perspective of a double polarity: memory (the indelible trace of conflict) and the conquest of the unconscious as a condition of any and all possibility of freedom (stimulated by the force of desire). As such, our investigation shall take up a retrospective as well as a prospective, or forward-looking, movement bringing together in that instance the terrain of ‘the political’ with the terrain of the psychic, and from there, ‘what remains’ and ‘what can’ be in the configuration of the links between these figures and the community.Se propone en este artículo destacar una serie de figuras que hemos denominado “invariantes de lo político”, desde las cuales se aspira a contribuir a la problematización de la construcción actual del vínculo político. Tales figuras, EROS (deseo) y ERIS (discordia), van a ser desplegadas tangencialmente sobre dos espacios estrechamente ligados: el espacio común de la ciudad (polis) y el espacio íntimo del alma (psique), así como postuladas desde una doble polaridad: la memoria (la huella imborrable del conflicto) y la conquista de lo inconsciente como condición de toda posibilidad de libertad (vehiculada por el esfuerzo deseante). Nuestra reflexión se basa entonces en un movimiento retrospectivo y prospectivo que aúna en su devenir el terreno de lo político con el terreno de lo psíquico y, desde ahí, lo que queda y lo que se puede en la configuración del vínculo comunitario

Figuras inmutables de lo político: cómo repensar la comunidad

Se propone en este artículo destacar una serie de figuras que hemos denominado “invariantes de lo político”, desde las cuales se aspira a contribuir a la problematización de la construcción actual del vínculo político. Tales figuras, EROS (deseo) y ERIS (discordia), van a ser desplegadas tangencialmente sobre dos espacios estrechamente ligados: el espacio común de la ciudad (polis) y el espacio íntimo del alma (psique), así como postuladas desde una doble polaridad: la memoria (la huella imborrable del conflicto) y la conquista de lo inconsciente como condición de toda posibilidad de libertad (vehiculada por el esfuerzo deseante). Nuestra reflexión se basa entonces en un movimiento retrospectivo y prospectivo que aúna en su devenir el terreno de lo político con el terreno de lo psíquico y, desde ahí, lo que queda y lo que se puede en la configuración del vínculo comunitario

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Search for anomalous couplings in boosted WW/WZ -> l nu q(q)over-bar production in proton-proton collisions at root s=8TeV

Peer reviewe

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions

Search for new phenomena in final states with two opposite-charge, same-flavor leptons, jets, and missing transverse momentum in pp collisions at √s=13 TeV

Search results are presented for physics beyond the standard model in final states with two opposite-charge, same-flavor leptons, jets, and missing transverse momentum. The data sample corresponds to an integrated luminosity of 35.9 fb−1 of proton-proton collisions at s√=13 TeV collected with the CMS detector at the LHC in 2016. The analysis uses the invariant mass of the lepton pair, searching for a kinematic edge or a resonant-like excess compatible with the Z boson mass. The search for a kinematic edge targets production of particles sensitive to the strong force, while the resonance search targets both strongly and electroweakly produced new physics. The observed yields are consistent with the expectations from the standard model, and the results are interpreted in the context of simplified models of supersymmetry. In a gauge mediated supersymmetry breaking (GMSB) model of gluino pair production with decay chains including Z bosons, gluino masses up to 1500–1770 GeV are excluded at the 95% confidence level depending on the lightest neutralino mass. In a model of electroweak chargino-neutralino production, chargino masses as high as 610 GeV are excluded when the lightest neutralino is massless. In GMSB models of electroweak neutralino-neutralino production, neutralino masses up to 500-650 GeV are excluded depending on the decay mode assumed. Finally, in a model with bottom squark pair production and decay chains resulting in a kinematic edge in the dilepton invariant mass distribution, bottom squark masses up to 980–1200 GeV are excluded depending on the mass of the next-to-lightest neutralino

Search for electroweak production of charginos and neutralinos in multilepton final states in proton-proton collisions at root s=13 TeV

Results are presented from a search for the direct electroweak production of charginos and neutralinos in signatures with either two or more leptons (electrons or muons) of the same electric charge, or with three or more leptons, which can include up to two hadronically decaying tau leptons. The results are based on a sample of protonproton collision data collected at p s = 13TeV, recorded with the CMS detector at the LHC, corresponding to an integrated luminosity of 35.9 fb1. The observed event yields are consistent with the expectations based on the standard model. The results are interpreted in simpli ed models of supersymmetry describing various scenarios for the production and decay of charginos and neutralinos. Depending on the model parameters chosen, mass values between 180GeV and 1150 GeV are excluded at 95% CL. These results signi cantly extend the parameter space probed for these particles in searches at the LHC. In addition, results are presented in a form suitable for alternative theoretical interpretations.Sponsoring Consortium for Open Access Publishing in Particle Physic

Ideal, identidad e identificación. Aproximaciones desde lo inconsciente y lo político

The objective of this discussion is to continue the study of the mutual inference of the political and the unconscious in contemporary society, through the analysis of what I call The "I-Complex", which is composed of the concepts "ideal", "identity" and "identification".La presente comunicación tiene por objeto retomar el estudio del mutuo inferir de lo político y lo inconsciente en la sociedad actual, a través del análisis de lo que llamaremos el complejo I, tejido compuesto por los conceptos ideal, identidad e identificación. Sirviéndonos de parte de los aparatos teóricos de Lacan y Deleuce, se mostrará cómo el sujeto (en su inexpugnable performatividad y dependencia del Otro/otro social) se halla determinado por innumerables trazos de identificación colectiva autorizados por aquel que ocupa la posición de ideal en el sistema de producción-reproducción social y activados sobre el "acolchamiento" de los distintos significantes que configuran las significaciones imaginarias sociales dominantes y modelan los procesos de identidad. Con todo ello, se intentará mostrar el modo en que tales mecanismos se ven alterados progresivamente por la axiomática propia del capitalismo y cómo las respectivas formaciones de lo inconsciente y lo político (en sus múltiples articulaciones discursivas) han derivado en una triple crisis de esta red ideal-identificación-identidad que conduce a la expropiación de lo común de la comunidad misma y a la consiguiente alienación del sujeto en su propia forma de desear