12 research outputs found
Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes
- Publication venue
- Wiley Open Access
- Publication date
- 26/07/2023
- Field of study
Get PDFThis study aimed to simulate ventricular responses to elevations in myocyte pacing and adrenergic stimulation using a novel electrophysiological rat model and investigate ion channel responses underlying action potential (AP) modulations. Peak ion currents and AP repolarization to 50% and 90% of full repolarization (APD50-90) were recorded during simulations at 1â10âHz pacing under control and adrenergic stimulation conditions. Further simulations were performed with incremental ion current block (L-type calcium current, ICa; transient outward current, Ito; slow delayed rectifier potassium current, IKs; rapid delayed rectifier potassium current, IKr; inward rectifier potassium current, IK1) to identify current influence on AP response to exercise. Simulated APD50-90 closely resembled experimental findings. Rate-dependent increases in IKs (6%â101%), IKr (141%â1339%), and ICa (0%â15%) and reductions in Ito (11%â57%) and IK1 (1%â9%) were observed. Meanwhile, adrenergic stimulation triggered moderate increases in all currents (23%â67%) except IK1. Further analyses suggest AP plateau is most sensitive to modulations in Ito and ICa while late repolarization is most sensitive to IK1, ICa, and IKs, with alterations in IKs predominantly stimulating the greatest magnitude of influence on late repolarization (35%â846% APD90 prolongation). The modified Leeds rat model (mLR) is capable of accurately modeling APs during physiological stress. This study highlights the importance of ICa, Ito, IK1, and IKs in controlling electrophysiological responses to exercise. This work will benefit the study of cardiac dysfunction, arrythmia, and disease, though future physiologically relevant experimental studies and model development are required
Design of a micromanipulation system for high temperature operation in an environmental scanning electron microscope (ESEM)
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
Full text linkDimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; pâ=â0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
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- Allanson A.
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- Aniruddhan K.
- Antonina Z.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chan E.
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- Charles B.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
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- Cherrie M.
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- Cheyne C.
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- Chilvers A.
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- Chineka R.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
- Clark G.
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- Clayton-Smith J.
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- Clemente de la Torre C.
- Clifford S.
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- Cocks S.
- Coe A.
- Coey D.
- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
- Connell L.
- Connelly K.
- Connolly G.
- Connor E.
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- Conteh V.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Cotterill D.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
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- De Soyza A.
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- Dear J.
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- Desai A.
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- Dhani S.
- Dhasmana Devesh J.
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- Dicks P.
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- Dimitri P.
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- Dobbie L.
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- Dolan D.
- Dolman M.
- Donald L.
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- Donohoe A.
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- Duffy H.
- Duggan A.
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- Duncan R.
- Dunleavy J.
- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- DâCosta J.
- DâMello A.
- Eades C.
- Early J.
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- Elgohary A.
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- Emberson Jonathan R.
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- Essa F.
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- Everden C.
- Everden S.
- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Jeebun V.
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- Johnstone D.
- Johnstone E.
- Jones A.
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- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Logue C. A.
- Lokanathan S.
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; pâ=â0.40). There was no significant effect of DMF on any secondary outcome
Thigh-length compression stockings and DVT after stroke
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
High Expression of Pulmonary Proteinase-activated Receptor 2 in Acute and Chronic Lung Injury in Preterm Infants
- Author
- Akers IA
- Al-Ani B
- Alm AK
- Asokananthan N
- Bö
- Caj Haglund
- Cederqvist K
- Cederqvist K
- Cenac N
- Cocks TM
- Cocks TM
- D'Andrea MR
- Dery O
- Groneck P
- Hartwig W
- Hollenberg MD
- Itkonen O
- Jobe AJ
- Katariina Cederqvist
- Knight DA
- Kong W
- Kotecha S
- LoMonaco MB
- Merritt TA
- Merritt TA
- Miotto D
- Morley D Hollenberg
- Nystedt S
- Nystedt S
- Pache JC
- PÀivi HeikkilÀ
- Riitta Karikoski
- Saugstad OD
- Schmidt B
- Shennan AT
- Speer CP
- Stevenson DK
- Stiskal JA
- Sture Andersson
- Toti P
- Vergnolle N
- Vliagoftis H
- Vu TK
- Watterberg KL
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
No full textClass Trips and the Meaning of British Citizenship: The Regent Street Polytechnic at Home and Abroad, 1871â1903
- Author
- A Farrar
- A Farrar
- A Games
- A Lester
- A Ong
- A Shaw
- A Vincent
- AJ Hammerton
- AJ Spalding
- ALD Hamilton
- B Beaven
- B Simon
- B Weeden
- C Morgan
- C Waters
- CJ Finger
- CJ Peer
- CJ Peer
- CJ Peer
- CJ Rhodes
- D Chirico
- D Copelman
- D Homfray
- E Healey
- E.W.W.
- EJR Eaglesham
- EM Hogg
- EM Wood
- F Slade
- F Williams
- F.G.H.
- G Holyoake
- G Wiles
- GN Hooper
- H Hendrick
- H Lunn
- H Lunn
- H Morley
- H Wit de
- HG Cocks
- HJ Flower
- HO Arnold-Forster
- Hogg
- HS Lunn
- Inquisitor
- Inquisitor
- J Adler
- J Stevenson
- J Urry
- JD Browne
- JD Gustav-Wrathall
- JS Dexter
- K Canning
- K McClelland
- LCB Seaman
- LME Goodlad
- M Cook
- M Daunton
- M Hunt
- Morley
- N Thomas
- O Löfgren
- P Bailey
- Public Record Office
- Q Hogg
- R Dredge
- R Kosher
- R Price
- RAR Buckland
- RG Studd
- S Foster
- S Joyce
- S Koven
- S Lello
- SA Tooley
- SL Singer
- Solly
- T Dawe
- T Jeffrey
- TN Bonner
- UNESCO National Co-Operating Body for Education
- V Hailsham
- W Besant
- W Koestenbaum
- W Runciman
- W Stead
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
No full textThe Struggle for Political Democracy: Emancipation, Gender, and Geography
- Author
- Barnes A
- Bennett T
- Bussey G
- Ceadel M
- CHAR
- Cocks J
- Cohen J L
- Council R W
- Davidoff L
- Davidoff L
- Dwork D
- Freud A
- Geras N
- Gross E
- Hall S
- Held D
- Hollis P
- Holton S H
- Jones G S
- Keane J
- Laclau E
- Laclau E
- Lawson J
- Lester M
- Lester M
- Lester V D
- Lowndes G A N
- McKay C
- Mitchell D
- Morris M
- Nairn T
- Pankhurst E S
- Pankhurst E S
- Pankhurst E S
- Pankhurst E S
- Pateman C
- Pateman C
- Pateman C
- Pierson C
- Poplar Metropolitan Borough Council
- Rendall J
- Said E W
- Said E W
- Sheridan S
- Siltanen J
- Smith L H A
- Stevenson J
- Thompson J
- Valentine L
- Vicinus M
- Wiltsher A
- Publication venue
- 'Pion Ltd'
- Publication date
- Field of study
No full textThe relationship between mass spectrometric, thermolytic and photolytic reactivity
- Author
- A. Cornu
- A. G. Loudon
- A. G. Loudon
- A. G. Loudon
- A. Jones
- A. L. Burlingame
- A. Maccoll
- A. Maccoll
- A. T. Cocks
- C. Fenselau
- C. Fenselau
- C. Fenselau
- C. Wentrap
- C. Wentrap
- D. C. Jongh De
- D. C. Jongh De
- D. F. Lindow
- D. L. Fanter
- D. P. Stevenson
- D. W. McNeil
- D. W. Turner
- E. Hedaya
- E. K. Fields
- E. K. Fields
- E. K. Fields
- E. K. Fields
- E. K. Fields
- E. K. Fields
- E. K. Fields
- E. K. Fields
- E. P. Smith
- E. S. Lewis
- F. D. Lewis
- F. M. Delles
- F. P. Boer
- F. R. Stermitz
- F. W. McLafferty
- G. W. Volker
- H. Budzikiewicz
- H. M. Frey
- H. M. Grubb
- H. Wynberg
- I. Howe
- J. Aspden
- J. C. Tov
- J. C. Tov
- J. C. Tov
- J. G. Calvert
- J. G. Pritchard
- J. H. Beynon
- J. Jalonen
- J. L. Cotter
- J. L. Cotter
- J. MĂžller
- J. R. Hass
- J. Reisch
- J. S. Smith
- K. A. Holbrook
- K. E. Wilzback
- K. Tsujimoto
- L. Friedman
- L. Friedman
- M. A. Baldwin
- M. E. Rennekamp
- M. Friedman
- M. J. S. Dewar
- M. J. S. Dewar
- M. J. Turro
- M. M. Bursey
- M. Ohashi
- M. P. Buu-Hoi
- M. P. Cava
- N. C. Yang
- N. J. Leonard
- N. J. Turro
- O. A. Mamer
- O. A. Mamer
- O. A. Mamer
- P. J. Wagner
- P. Mayo de
- P. R. Briggs
- Q. M. Porter
- R. A. W. Johnstone
- R. B. Woodward
- R. C. Dougherty
- R. C. Dougherty
- R. C. Dougherty
- R. F. C. Brown
- R. F. C. Brown
- R. F. Cretanovic
- R. F. G. Brown
- R. F. Klemm
- R. G. Cooks
- R. H. Shapiro
- R. Lawrence
- R. R. Sauers
- S. Meyerson
- T. F. Thomas
- T. Ichimura
- T. J. Adley
- T. Matsuura
- U. Lille
- W. G. Dauben
- W. M. Williams
- W. S. Briggs
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1974
- Field of study
No full textBed type and flow mechanism of deep water sub-lacustrine fan fringe facies: an example from the Middle Permian Lucaogou Formation in Southern Junggar Basin of NW China
- Author
- A Bernhardt
- A Carroll
- A Fildani
- A Prélat
- AR Carroll
- AR Carroll
- AR Carroll
- AR Carroll
- BC Kneller
- BC Kneller
- C Davis
- C Gladstone
- C Zavala
- C Zou
- CJ Stevenson
- CS Pierce
- DAV Stow
- DJ Piper
- DJW Piper
- DM Hodgson
- DR Lowe
- DR Lowe
- DR Pyles
- E Mutti
- EJ Sumner
- F Pohl
- G Gao
- G Postma
- G Postma
- H Fossen
- H Wu
- HA Macdonald
- HG Reading
- HL Brooks
- IA Kane
- J Carlson
- J Charvet
- J Liu
- J Wang
- JB Southard
- JG Marr
- JH Baas
- JRL Allen
- JRL Allen
- JRL Allen
- KT Pickering
- KT Pickering
- L Kuang
- LA Amy
- LRM Cocks
- M Fonnesu
- M Fonnesu
- M Hofstra
- M Ito
- M Patacci
- MR Gregory
- NJ Bayliss
- P Mueller
- P Zhao
- PDW Haughton
- PDW Haughton
- PJ Talling
- PJ Talling
- PJ Talling
- Q Luo
- RC Yang
- RG Walker
- RN Hiscott
- RW Butler
- S Etienne
- S Nie
- S Tao
- SE Peters
- SJ Southern
- T Yang
- W Xiao
- WC Van der Merwe
- WR Normark
- X Shan
- X Shan
- Y Su
- YK Sohn
- YS So
- YT Spychala
- YT Spychala
- Z Cao
- Z Cao
- ZR Jobe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full text
