5 research outputs found
Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy
- Author
- Publication venue
- 'The American Association of Immunologists'
- Publication date
- 01/01/2011
- Field of study
Neutrophils are the most abundant circulating FcR-expressing WBCs with potent cytotoxic ability. Currently, they are recognized as promising effector cells for Ab-mediated immunotherapy of cancer, because their capacity to kill tumor cells is greatly enhanced by tumor Ag-specific mAbs. The FcαRI represents the most potent FcR on neutrophils for induction of Ab-mediated tumor cell killing. However, the mechanisms of cell death that are induced are poorly understood. Because these mechanisms can be used for modulation of anticancer treatment, we investigated the tumor cell death induced by neutrophil-mediated Ab-dependent killing via FcαRI. Human mammary carcinoma cells were efficiently killed when incubated with human neutrophils and tumor-specific FcαRI bispecific or IgA Abs. Interestingly, we observed characteristics of autophagy such as autophagic structures by electron microscopy and LC3B(+) autophagosomes in different human epithelial carcinoma cells, which resulted in tumor cell death. To a lesser extent, necrotic features, such as cellular membrane breakdown and spillage of intracellular content, were found. By contrast, apoptotic features including fragmented nuclei, Annexin V-positivity, and presence of cleaved caspase-3 were not observed. These findings indicate that neutrophils mainly facilitate autophagy to induce tumor cell death rather than the more commonly recognized apoptotic cell death mechanisms induced by NK cells or cytotoxic T cells. This knowledge not only reveals the type of tumor cell death induced in neutrophil-mediated, Ab-dependent cellular cytotoxicity, but importantly opens up additional perspectives for modulation of anticancer therapy in, for example, apoptosis-resistant tumor cell
Adaptation and cross-adaptation of hydrochloric acid and acetic acid mixtures
- Author
- D. W. Curtis
- F. B. Kenrick
- G. A. Ferguson
- G. M. Makhloaf
- H. H. Chauncey
- H. R. Moskowitz
- H. T. Lawless
- H. T. Lawless
- J. D. Finn
- J. E. R. Frijters
- J. F. Gent
- Jan H. A. Kroeze
- L. M. Beidler
- M. G. J. Beets
- N. B. Norris
- N. W. Taylor
- P. G. J. Ganzevles
- P. G. J. Ganzevles
- P. G. J. Ganzevles
- Paul G. J. Ganzevles
- R. B. Harvey
- R. J. Gardner
- R. M. Beatty
- R. P. Erickson
- R. P. Erickson
- S. S. Stevens
- W. J. Crouzier
- W. Pilnik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Noise-Intolerance and State-Dependent Factors in Patients with Whiplash Associated Disorder
- Author
- Arrindel WA
- Barnsley L
- Barsky AJ
- Blokhorst MGBG
- Bohnen N
- Bohnen N
- Brand N
- Derogatis LR.
- Elsmore TF.
- Ferrari R.
- Gilles van Luijtelaar
- Gordon KG.
- Hockey GRJ.
- Kessels RPC
- Klein M.
- Lidbeck J.
- Mariette Blokhorst
- Michaelson P
- Paul Ganzevles
- Pennebaker JW.
- Richel Lousberg
- Spitzer WO
- Stefan Meeldijk
- Thijs van Toor
- Tjell C
- Topf M.
- Vanagaite Vingen J
- Vingen J Vanagaite
- Wiethof M.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Methodological Factors in Odor Detection by Humans
- Author
- ASTM International
- B Rousseau
- C Dacremont
- C Dacremont
- C Hawkes
- C van Thriel
- CJ Wysocki
- CJ Wysocki
- G Reineccius
- George Preti
- GR Huggins
- HT Lawless
- I Menashe
- J Lötsch
- J Lötsch
- JC Stevens
- JC Stevens
- JC Walker
- JC Walker
- JD Pierce
- JE Amoore
- JE Cometto-Muñiz
- JE Cometto-Muñiz
- JE Cometto-Muñiz
- JE Cometto-Muñiz
- JE Cometto-Muñiz
- JE Cometto-Muñiz
- JER Frijters
- L Jacquot
- LJ Gemert Van
- M Devos
- M Gallagher
- M Scheibe
- Michelle Gallagher
- MR Linschoten
- NP Cheremisinoff
- P Dalton
- P Juslin
- Paul M. Wise
- PGJ Ganzevles
- PM Wise
- PM Wise
- RL Doty
- SH Gaffney
- T Miyazawa
- T Tsukatani
- Toshio Miyazawa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Heat transfer—a review of 2002 literature
- Author
- Aamir
- Abbassi
- Abbassi
- Abdelghani-Idrissi
- Abe
- Abel
- Abid
- Abraham
- Abraham
- Abramson
- Abu-Mulaweh
- Abu-Mulaweh
- Abu-Zaid
- Adapa
- Addlesee
- Adjlout
- Adref
- Agarwal
- Agha
- Aguilar
- Ahmad
- Ahmed
- Ahmed
- Ahmed
- Ahn
- Ahn
- Ahn
- Aissia
- Ajaev
- Akamatsu
- Al Samman
- Al-Ahmadi
- Al-Amiri
- Al-Busoul
- Al-Farayedhi
- Al-Nimr
- Al-Odat
- Al-Omari
- Al-Qahtani
- Al-Qahtani
- Al-Sanea
- Al-Sibai
- Alam
- Alarcon
- Alarcon
- Alazmi
- Aldabbagh
- Aldabbagh
- Alekseev
- Alex
- Alexeenko
- Alexeenko
- Alhama
- Ali
- Ali
- Aliabadi
- Alizadeh
- Allouis
- Almanza
- Alotaibi
- Altac
- Altac
- Altalc
- Alva
- Alves
- Amano
- Amara
- Ambrosini
- Ambrosini
- Anand
- Anderson
- Anderson
- Andreas
- Andreozzi
- Andreozzi
- Angelidis
- Angirasa
- Angirasa
- Annen
- Antar
- Aoki
- Araki
- Argyropoulos
- Arieli
- Armaly
- Asai
- Asako
- Asako
- Asbik
- Ashrafizadeh
- Asllanaj
- Astarita
- Astin
- Atalla
- Attia
- Aubrecht
- Auracher
- Auriault
- Avancha
- Avelino
- Avramenko
- Ay
- Aye
- Azad
- Azad
- Azzi
- Babeyko
- Babkin
- Badescu
- Bae
- Baek
- Baillis
- Baillis
- Baker
- Balakrishnan
- Balat-Pichelin
- Baldauf
- Baldauf
- Balderas-Lopez
- Balle
- Ballestrin
- Baloch
- Bandyopadhyay
- Bansal
- Bansod
- Banu
- Bao
- Barbante
- Barbosa
- Barbosa
- Barbosa
- Barbosa
- Barichello
- Barletta
- Barlow
- Barth
- Barton
- Bartosiewicz
- Barvinschi
- Basak
- Basu
- Bates
- Bates
- Bayoulmi
- Baytas
- Baytas
- Bazarov
- Bazdidi-Tehrani
- Beausoleil-Morrison
- Becker
- Behzadmehr
- Bejan
- Bekri
- Belessiotis
- Belghazi
- Belghazi
- Bellas
- Bellehumeur
- Belnap
- Ben Kheder
- Bena
- Benjapiyaporn
- Bennacer
- Benz
- Bera
- Bera
- Bernardin
- Bert
- Berthusen
- Bertocchi
- Beysens
- Bhagoria
- Bhattacharya
- Bhattacharya
- Bhattacharya
- Bhattacharyya
- Bilen
- Bilen
- Bilen
- Bilgen
- Bilgen
- Bilir
- Bin Kim
- Birouk
- Blackburn
- Bliznetsov
- Bograchev
- Bojic
- Bojic
- Boland
- Bouaziz
- Bouchard
- Bourayou
- Bourloutski
- Bousquet-Melou
- Boyd
- Boyd
- Bradean
- Brandt
- Brauer
- Brautsch
- Brautsch
- Breuss
- Brevet
- Brix
- Brooker
- Brouwers
- Brown
- Browne
- Brucato
- Brulls
- Bryan
- Bubnovich
- Buchlin
- Buck
- Burch
- Bussmann
- Butrymowicz
- Butterworth
- Buttsworth
- Buttsworth
- Butty
- Buzin
- Byerley
- Bykova
- Byun
- Ca
- Cabeza
- Cadafalch
- Cai
- Caixeta
- Camci
- Camci
- Campanone
- Can
- Cant
- Cao
- Cao
- Carciofi
- Caro-Corrales
- Carrington
- Carvalho
- Casano
- Castanet
- Catton
- Cavallero
- Cavallini
- Cavallini
- Celata
- Cervantes
- Cerza
- Chacha
- Chai
- Chai
- Chakrabandhu
- Chakraborty
- Chakraborty
- Chakroun
- Chamkha
- Chamkha
- Chamkha
- Chamkha
- Chamkha
- Chamkha
- Chamkha
- Chan
- Chandio
- Chang
- Chang
- Chang
- Chang
- Chang
- Chang
- Chang
- Chanteloup
- Chatterjee
- Chattopadhyay
- Chedester
- Chehroudi
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Cheng
- Cheng
- Cheng
- Cheng
- Cheng
- Cheng
- Cheng
- Chern
- Chibana
- Chiriac
- Chiu
- Cho
- Cho
- Cho
- Choi
- Choi
- Choi
- Chong
- Chorda
- Chou
- Choudhary
- Chow
- Christlieb
- Christopher
- Chu
- Chu
- Chung
- Chung
- Chung
- Chung
- Chung
- Chwa
- Cianfrini
- Cieslinski
- Ciofalo
- Coelho
- Coelho
- Coelho
- Coelho
- Colak
- Comini
- Consalvi
- Cooper
- Corberan
- Costa
- Couto
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- Cristofari
- Crittenden
- Croce
- Crone
- Cruz
- Cui
- Cui
- Cutbirth
- da Silva
- Dabringhausen
- Dai
- Dantas
- Daryabeigi
- Das
- Das
- Datta
- Davey
- Davey
- Davidson
- Dayan
- De
- de Castro
- de Diego
- De Francisco
- de Lorenzo
- de Oliveira
- De Paul
- de Socio
- De Socio
- de Vries
- Dedic
- Degan
- Degan
- Degheidy
- Dekhtyar
- Del Col
- Demir
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- Deng
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- Deng
- Dennis
- Derevich
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- Devireddy
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- Didi
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- Dimaano
- Dincer
- Dincer
- Ding
- Ding
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- Djilali
- Dombrovsky
- Dong
- Dong
- Downing
- Driesse
- Du
- Du
- Duan
- Dubrulle
- Dubuffet
- Dufreche
- Dul’kin
- Dumas
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- Durst
- Dutta
- Dutta
- Eck
- Einer-Jensen
- Ekkad
- Ekkad
- El Ganaoui
- El-Adawi
- El-Din
- El-Genk
- El-Moghazy
- El-Moghazy
- El-Sayed
- El-Shaboury
- El-Tantawy
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- Elaloufi
- Elbashbeshy
- Eldabe
- Elsari
- Entezam
- Erickson
- Evstratov
- Eymet
- Fan
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- Fan
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- Fang
- Farid
- Farrell
- Fedorov
- Feng
- Feng
- Ferjancic
- Fernandes
- Ferrasse
- Ferriere
- Ferriere
- Feuermann
- Feuermann
- Fichera
- Fiedler
- Fincke
- Fisenko
- Fleck
- Fleischer
- Florides
- Florides
- Fohr
- Fomin
- Fomin
- Fossa
- Fraser
- Frederick
- Friis
- Fu
- Fu
- Fujita
- Fujita
- Fukai
- Fukui
- Fukui
- Fumo
- Furukawa
- Furukawa
- Furuya
- Fuss
- Gachkevich
- Gaitonde
- Gajo
- Gamma
- Ganesan
- Ganzevles
- Garandet
- Garbalinska
- Garber
- Gaston
- Gaur
- Gawlik
- Gbahoue
- Gejadze
- Georgallis
- George
- Ghali
- Ghali
- Ghali
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- Ghiaasiaan
- Ghisalberti
- Ghojel
- Ghoshdastidar
- Giangi
- Gidwani
- Gillis
- Giner
- Ginkin
- Gjerkes
- Glahn
- Glod
- Glouannec
- Goerke
- Gokon
- Golfier
- Golriz
- Golubev
- Gonzalez
- Gotz
- Goutiere
- Govender
- Govindaraju
- Goyeneche
- Goyheneche
- Grazzini
- Greiner
- Greiner
- Gremyachkin
- Gretler
- Griffith
- Grigoriev
- Grisogono
- Groenhout
- Grossman
- Grum
- Gu
- Gu
- Gubaidullin
- Guet
- Guglielmini
- Gumnitskii
- Gunnewiek
- Gunther
- Guo
- Guo
- Guo
- Guo
- Guo
- Guo
- Guo
- Guo
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- Gurrum
- Gustrau
- Guzik
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- Ha
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- Haala
- Habib
- Habib
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- Haddad
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- Honda
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- Hossain
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- Hsieh
- Hsieh
- Hsieh
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- Hu
- Hu
- Huai
- Huang
- Huang
- Huang
- Huang
- Huang
- Huang
- Huang
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- Hunter
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- Hwang
- Hwang
- Hwang
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- Ishihara
- Ishikawa
- Ishikawa
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- Jagadeesh
- Jaklic
- James
- Jeanmeure
- Jendele
- Jenkins
- Jeong
- Jeong
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- Jha
- Ji
- Jia
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- Jiang
- Jiang
- Jilani
- Johnston
- Johnston
- Jones
- Joseph
- Jouhara
- Joulain
- Jue
- Jugjai
- Juncu
- Jung
- Kabashnikov
- Kabov
- Kaenton
- Kahraman
- Kaiser
- Kakimoto
- Kakimoto
- Kalinchak
- Kalita
- Kalman
- Kalyon
- Kamide
- Kaminski
- Kaminskii
- Kamiuto
- Kanda
- Kandlikar
- Kandlikar
- Kandlikar
- Kaneda
- Kang
- Kang
- Kang
- Kang
- Kang
- Kang
- Kapitan
- Karcher
- Karcher
- Karsli
- Katagiri
- Kataoka
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- Kazeminejad
- Kazi
- Keblinski
- Kedzierski
- Kedzierski
- Kelkar
- Keller
- Kelly
- Kendoush
- Kew
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- Khaled
- Khalifa
- Khan
- Khanafer
- Khanafer
- Khanafer
- Khapaev
- Khedari
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- Khodabandeh
- Khodabandeh
- Khonakdar
- Ki
- Ki
- Kieft
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
- Kim
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- Kitamura
- Kiwan
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- Qu
- Qu
- Qu
- Quadir
- Quarini
- Quaschning
- Queheillalt
- Rahman
- Rahman
- Raicu
- Raimundo
- Rainieri
- Rainieri
- Raisi
- Raj
- Raju
- Ramachandran
- Ramaswamy
- Rangel-German
- Ranjan
- Rao
- Rao
- Rasgado
- Rashkovan
- Rat
- Ratanadecho
- Reay
- Reddy
- Reddy
- Rees
- Reese
- Reim
- Rembold
- Renstrom
- Ribeiro
- Ribeiro
- Richter
- Ridha
- Riffat
- Rincon
- Rini
- Rivas
- Robidou
- Rodriguez
- Romero
- Roques
- Rose
- Ross
- Roulet
- Roxas-Dimaano
- Roy
- Roy
- Roy
- Roychowdhury
- Roychowdhury
- Ruan
- Ruan
- Rubinstein
- Rubiolo
- Ruiz
- Runstedtler
- Rutqvist
- Ryan
- Ryu
- Sabatino
- Sabir
- Sacadura
- Sadoqi
- Saghir
- Saha
- Sahin
- Sahin
- Sahoo
- Sahoo
- Saikrishnan
- Saitoh
- Sakalis
- Salesse
- Sami
- San
- Sandberg
- Sandnes
- Sanga
- Saravanan
- Saravanan
- Sargison
- Sargison
- Sari
- Sari
- Sarkar
- Sarma
- Sarma
- Sarris
- Satapathy
- Sato
- Satoh
- Saury
- Savin
- Savino
- Sawaya
- Saxena
- Scarpa
- Scartezzini
- Schafer
- Schaller
- Schartel
- Schobeiri
- Schuchkin
- Schutyser
- Schwabe
- Seddeek
- Sediki
- Seeniraj
- Seeniraj
- Segal
- Sehgal
- Seiler
- Selmi
- Seok
- Serajzadeh
- Sero-Guillaume
- Serp
- Sert
- Seshadri
- Seuffert
- Sghaier
- Shafii
- Shah
- Shahraki
- Shakeri
- Shamim
- Shekarchi
- Shen
- Shen
- Shenefelt
- Shepel
- Sher
- Sheridan
- Sheridan
- Sheu
- Shevchuk
- Shi
- Shi
- Shi
- Shi
- Shih
- Shilton
- Shimotori
- Shin
- Shivakumara
- Short
- Short
- Shu
- Shu
- Shuchi
- Shuja
- Shuja
- Shuja
- Shuja
- Shukla
- Shyy
- Shyy
- Sideridis
- Sidiropoulos
- Siebert
- Sieniutycz
- Siewert
- Sikka
- Simoes-Moreira
- Simpson
- Singh
- Singh
- Singh
- Sippola
- Siqueira
- Sirena
- Siroux
- Skelly
- Skudarnov
- Slaouti
- Smereka
- Smit
- Smit
- Smith
- Smith
- Smolentsev
- Smyrnaios
- Sohn
- Son
- Son
- Son
- Song
- Song
- Song
- Song
- Sophy
- Soria
- Sorsak
- Sridharan
- Srinivasakannan
- Srivastava
- Stehlik
- Stein
- Stelian
- Stephan
- Stock
- Stoddard
- Stosic
- Strelov
- Strohle
- Struchtrup
- Stutzmann
- Su
- Sucec
- Sucec
- Sugiyama
- Sumathy
- Sun
- Sun
- Sun
- Sunil
- Suzuki
- Syahrul
- Syrjala
- Szczygiel
- Szimmat
- Szmyd
- Tagawa
- Tagawa
- Tagawa
- Takhar
- Talukdar
- Talukdar
- Tan
- Tan
- Tanabe
- Tanaka
- Tanaka
- Tancrez
- Tangthieng
- Tangthieng
- Tanny
- Tao
- Tarnawski
- Tarzimanov
- Tasnim
- Tatara
- Tatemoto
- Tatsumi
- Tatsumoto
- Tatsumoto
- Tatsumoto
- Tattiyakul
- Tawfek
- Temu
- Terekhov
- Terekhov
- Teskeredzic
- Tesse
- Theofanous
- Theofanous
- Theuns
- Thiebaut
- Thiele
- Thivet
- Thole
- Thommes
- Thompson
- Timchenko
- Tiryakioglu
- Toe
- Toh
- Torii
- Torii
- Tovazhnyansky
- Trautman
- Travnikov
- Triboix
- Tripanagnostopoulos
- Tripanagnostopoulos
- Tsai
- Tseng
- Tsilingiris
- Tsourakis
- Tsuchida
- Tu
- Tucker
- Tunc
- Tunnell
- Turgeon
- Turgeon
- Tzou
- Tzou
- Tzou
- Uda
- Udaykumar
- Udaykumar
- Ulmer
- Um
- Um
- Umekawa
- Usmani
- Utriainen
- Utriainen
- Vaessen
- Valencia
- Vallous
- Valueva
- van Berkel
- van den Berg
- van der Schaaf
- van der Tempel
- Van Nijnatten
- Vanhoutte
- Vant-Hull
- Vardelle
- Varga
- Vargas
- Vaszi
- Velasco
- Verma
- Vicente
- Vicente
- Vignola
- Vijayaraghavan
- Vitkin
- Vitrac
- Vlasogiannis
- Volchkov
- von Wolfersdorf
- Vreeman
- Wadekar
- Wadso
- Waheed
- Wahlby
- Wakeland
- Walker
- Walker
- Wallin
- Wan
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Warrier
- Warrier
- Wasekar
- Watel
- Wei
- Wei
- Wei
- Welch
- Wen
- Wen
- Wen
- Wen
- Wendl
- Wieckert
- Wierzbowski
- Wiesche
- Wilchinsky
- Wildfong
- Wildhagen
- Willenborg
- Willett
- Willett
- Willis
- Willis
- Wiskel
- Wiskel
- Wittmaack
- Wong
- Wooden
- Wozniak
- Wray
- Wright
- Wroblewski
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wyrwal
- Xia
- Xia
- Xie
- Xin
- Xiong
- Xu
- Xu
- Xu
- Xu
- Xu
- Xu
- Xu
- Xuan
- Yamada
- Yamaguchi
- Yamaguchi
- Yamaguchi
- Yamali
- Yamamura
- Yamasuea
- Yamauchi
- Yamawaki
- Yamsaengsung
- Yamsaengsung
- Yan
- Yan
- Yan
- Yan
- Yan
- Yanaoka
- Yang
- Yang
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yarin
- Yarin
- Ye
- Ye
- Ye
- Ye
- Ye
- Yee
- Yeh
- Yeh
- Yeh
- Yeh
- Yen
- Yeoh
- Yeoh
- Yeoh
- Yeoh
- Yi
- Yilbas
- Yilbas
- Yilbas
- Yilbas
- Yilbas
- Yilbas
- Yilmaz
- Yilmaz
- Yokomine
- Yoneda
- Yong
- Yoo
- Yoo
- Yoon
- Yoon
- Yoon
- Yousefi
- Yovanovich
- Yu
- Yu
- Yu
- Yu
- Yu
- Yu
- Yu
- Yu
- Yu
- Yu
- Yu
- Yu
- Yun
- Yun
- Zamfirescu
- Zapalowicz
- Zarza
- Zeng
- Zess
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zheng
- Zheng
- Zheng
- Zheng
- Zheng
- Zheng
- Zheng
- Zheng
- Zhidov
- Zhigilei
- Zhong
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhu
- Zhu
- Zhu
- Zhu
- Zhu
- Zhu
- Zien
- Zilitinkevich
- Zimmerer
- Zimparov
- Ziskind
- Zitny
- Zollner
- Zondag
- Zun
- Zurcher
- Zurcher
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study