The Role of Ownership Concentration and Dividend Policy on Firm Performance: Evidence from an Emerging Market of Pakistan

Purpose- The main aim of this study is to determine the role of ownership concentration and dividend policy on the firm performance of chemical sector firms of Pakistan. Design/Methodology- This research used the secondary data collected from the annual reports of the companies listed at the Karachi Stock Exchange (KSE). However, inclusion criteria are the 26 listed firms from 2012 to 2017, giving a total of 156 observations. This study used the Generalized Least Squares Model. Findings- The findings reveal that ownership concentration has a significant positive association with firm financial performance. This stated that larger shareholders could attribute to the alignment of managerial incentives with shareholder interests. They also monitor the team very effectively and efficiently. The dividend policy has a significant positive relationship with ROA. Leverage and tangibility have a significant negative relationship with firm performance. Practical Implications- These results potentially can be relevant for policymakers and academic research as well as also helpful for managers and policymakers

Efficacy assessment of garlic extract as a natural aphid control agent on infected tomato plants

This controlled pot experiment aimed to assess the effectiveness of garlic extract as a natural aphid control agent on infected tomato plants (Solanum lycopersicum). The study investigated the impact of different doses of garlic extract on plant height, leaf damage, fruit production, and overall yield. The garlic extract was prepared by diluting crushed garlic bulbs with water to achieve the desired concentrations. The experiment employed a randomized complete block design with four treatment groups: a control group (0%), low dose (10%), medium dose (30%), and high dose (50%) of garlic extract. The treatments were applied using a handheld sprayer, and the plants were monitored for aphid populations using visual inspection and sticky traps. Data collected were subjected to statistical analysis, including analysis of variance (ANOVA), to determine significant differences between treatments. The results revealed that higher doses of garlic extract led to increased plant height, decrease in leaf damage caused by aphids, higher fruit production, and improved overall yield. The control group exhibited the lowest values for all parameters, while treatments with garlic extract showed significant improvements. The highest yields were observed in Treatment 50%, where plants treated with the highest dose of garlic extract yielded 41.2 kg per treatment. These findings demonstrate the potential of garlic extract as an effective aphid control agent, capable of enhancing tomato crop yield and economic returns for farmers

Prevalence and Molecular Diagnosis of Babesia ovis and Theileria ovis in Lohi Sheep at Livestock Experiment Station (LES), Bahadurnagar, Okara, Pakistan

  Background: Babesia ovis and Theileria ovis are among the important and main etiological agents causing ovine babesiosis and ovine theileriosis, causing severe economic losses among sheep and goats. The aim of the present study was to determine the prevalence and molecular diagnosis of B. ovis and T. ovis in Lohi sheep at Livestock Experiment Station Bahadurnagar, Okara, Pakistan. Methods: The prevalence of B. ovis and T. ovis was investigated in 200 Lohi sheep of mixed age and sex by PCR during 2011. The assay was employed us-ing primers Bbo-F & Bbo-R, specific for a 549-bp fragment in B. ovis genomic DNA and primers TSsr 170F & TSsr 670R, specific for a 520-bp fragment in T. ovis genomic DNA. The animals were also screened for both haemoparasites through stained thin blood smears. Results: Thirty two (16%), 48 (24%) and 26 (13%) were the number of ani-mals found positive for B. ovis, T. ovis and for mixed infection with both para-sites respectively, through microscopy. Sixty eight (34%), 73 (37%) and 42 (21%) were the number of animals found positive for B. ovis, T. ovis and for mixed infection with both parasites respectively, through PCR test. Conclusion: The results indicate the high sensitivity of PCR for surveying babesiosis and theileriosis and there is noteworthy prevalence of these diseases in sheep at an experimental station where environmental conditions are rela-tively controlled as compared to field conditions

Validation and Reliability Testing of the Child Oral Impacts on Daily Performances (C-OIDP): Cross-Cultural Adaptation and Psychometric Properties in Pakistani School-Going Children

Background: This study aimed to develop an Urdu version of Child-Oral Impact on Daily Performance (C-OIDP) and assess its reliability and validity for children’s oral health-related quality of life (OHRQoL) assessment in Pakistan. Methods: A total of 200 school-going children aged 11–14 were recruited from two public schools. For the adaptation process, the original English version of C-OIDP was translated into Urdu, reviewed by an expert committee, back-translated into Urdu, and then reviewed again by the same expert committee and pilot tested on 10 children. A clinical examination was carried out to record dental and gingival status followed by a face-to-face interview to measure oral health-related quality of life in children using C-OIDP-U. Reliability, internal consistency, construct and discriminant validity were assessed. Results: The Cronbach’s alpha for C-OIDP-U was 0.69, the mean C-OIDP-U score was 10.2 ± 8.1 and 77.3% of the children reported at least one oral impact. Eating (40.3%) and difficulty in cleaning mouth (38.7%) were the two most impacted daily performances. For construct validity, the associations were significant between the C-OIDP-U score and all subjective oral health measures (p < 0.001). For discriminant validity, a significant association was observed between the C-OIDP-U score and clinical oral variables, children with DMFT + dmft ≥ 1, Gingival index > 1 and having malocclusion reported a higher C-OIDP-U score when compared to their counterparts. Conclusion: This study showed that C-OIDP is a valid, reliable and efficient instrument of OHRQoL for use in Pakistani children

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research