52 research outputs found
Enabling High-Power SmallSats with Advanced Thermal Management
- Publication venue
- DigitalCommons@USU
- Publication date
- 07/08/2019
- Field of study
High-power Small Satellites have the potential to provide new and advanced capabilities; however, significant challenges prevent wide-spread use. Of these, thermal management of high-heat loads is significant. Although advances in thermal acquisition, transport, and storage are available; thermal dissipation technologies for high-power systems are lacking. Several design concepts are presented focused on high-efficiency, lightweight deployable radiating technologies. Analysis showed that realistic deployable radiator designs offer 220% more thermal dissipation than body-mounted radiator designs, which directly correlates to the same amount of increase in feasible total bus power. Using deployable radiators, a nominal 6U Small Satellite can realistically dissipate around 200 W
Helicobacter pylori glycan biosynthesis modulates host immune cell recognition and response
- Author
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/03/2024
- Field of study
IntroductionThe pathogenic bacterium Helicobacter pylori has evolved glycan-mediated mechanisms to evade host immune defenses. This study tests the hypothesis that genetic disruption of H. pylori glycan biosynthesis alters immune recognition and response by human gastric epithelial cells and monocyte-derived dendritic cells.MethodsTo test this hypothesis, human cell lines were challenged with wildtype H. pylori alongside an array of H. pylori glycosylation mutants. The relative levels of immune response were measured via immature dendritic cell maturation and cytokine secretion.ResultsOur findings indicate that disruption of lipopolysaccharide biosynthesis diminishes gastric cytokine production, without disrupting dendritic cell recognition and activation. In contrast, variable immune responses were observed in protein glycosylation mutants which prompted us to test the hypothesis that phase variation plays a role in regulating bacterial cell surface glycosylation and subsequent immune recognition. Lewis antigen presentation does not correlate with extent of immune response, while the extent of lipopolysaccharide O-antigen elaboration does.DiscussionThe outcomes of this study demonstrate that H. pylori glycans modulate the host immune response. This work provides a foundation to pursue immune-based tailoring of bacterial glycans towards modulating immunogenicity of microbial pathogens
Global Patterns and Controls of Nutrient Immobilization On Decomposing Cellulose In Riverine Ecosystems
- Author
- Albariño Ricardo J.
- Arango Clay
- Aroviita Jukka
- Baxter Colden V.
- Bellinger Brent J.
- Boyero Luz
- Bruder Andreas
- Burdon Francis J.
- Callisto Marcos
- Camacho Antonio
- Capps Krista
- Coimbra Cristina
- Colas Fanny
- Cornut Julien
- Costello David M.
- Crespo-Pérez Verónica
- Cross Wyatt F.
- da Silva Aurea L. Lemes
- Danger Michael
- de Eyto Elvira
- Derry Alison M.
- Douglas Michael M.
- Elosegi Arturo
- Ferreira Verónica
- Ferriol Carmen
- Fleituch Tadeusz
- Frainer André
- Frost Paul C.
- Garcia Erica A.
- García Liliana
- García Pavel
- Gessner Mark O.
- Giling Darren P.
- Gonzales-Pomar R. Karina
- Graça Manuel A.S.
- Griffiths Natalie A.
- Grossart Hans-Peter
- Guérold François
- Halvorson Halvor M.
- Hepp Luiz U.
- Higgins Scott N.
- Hishi Takuo
- Iwata Tomoya
- Iñiguez-Armijos Carlos
- Kirkwood Andrea E.
- Koning Aaron A.
- Kosten Sarian
- Kuehn Kevin A.
- Laudon Hjalmar
- Leavitt Peter R.
- Leroux Shawn G.
- LeRoy Carri
- Lisi Peter J.
- Marcarelli Amy M.
- Masese Frank O.
- Mathie Devan M.
- McIntyre Peter B.
- McKie Brendan G.
- Medeiros Adriana O.
- Miliša Marko
- Miyake Yo
- Mooney Robert
- Moulton Tim
- Nimptsch Jorge
- Paavola Riku
- Pardo Isabel
- Parnikova Ivan Y.
- Patrick Christopher J.
- Peeters Edwin T.H.M.
- Pozo Jesus
- Reid Brian
- Richardson John S.
- Rincón José
- Risnoveanu Geta
- Robinson Christopher T.
- Royer Todd V.
- Santamans Anna C.
- Shah Jennifer J. Follstad
- Simiyu Gelas
- Skuja Agnija
- Smykla Jerzy
- Sponseller Ryan
- Texeira-de Mello Franco
- Tiegs Scott D.
- Vilbaste Sirje
- Villanueva Verónica D.
- Webster J. R.
- Woelfl Stefan
- Xenopolous Marguerite A.
- Yates Adam
- Yule Catherine M.
- Zhang Yixin
- Zwart Jacob A.
- Publication venue
- The Aquila Digital Community
- Publication date
- 01/03/2022
- Field of study
Microbes play a critical role in plant litter decomposition and influence the fate of carbon in rivers and riparian zones. When decomposing low-nutrient plant litter, microbes acquire nitrogen (N) and phosphorus (P) from the environment (i.e., nutrient immobilization), and this process is potentially sensitive to nutrient loading and changing climate. Nonetheless, environmental controls on immobilization are poorly understood because rates are also influenced by plant litter chemistry, which is coupled to the same environmental factors. Here we used a standardized, low-nutrient organic matter substrate (cotton strips) to quantify nutrient immobilization at 100 paired stream and riparian sites representing 11 biomes worldwide. Immobilization rates varied by three orders of magnitude, were greater in rivers than riparian zones, and were strongly correlated to decomposition rates. In rivers, P immobilization rates were controlled by surface water phosphate concentrations, but N immobilization rates were not related to inorganic N. The N:P of immobilized nutrients was tightly constrained to a molar ratio of 10:1 despite wide variation in surface water N:P. Immobilization rates were temperature-dependent in riparian zones but not related to temperature in rivers. However, in rivers nutrient supply ultimately controlled whether microbes could achieve the maximum expected decomposition rate at a given temperature
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
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- Altaf S.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Arrangements and Topological Planes
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Dividend Taxes and Income Shifting
- Author
- A Alstadsaeter
- A Alstadsaeter
- A Alstadsaeter
- A Alstadsaeter
- A Alstadsaeter
- A C Harberger
- A C Harberger
- Annette Alstadsæter
- B Becker
- B R Moulton
- E Fjaerli
- E Saez
- J Agell
- J B Slemrod
- J E Stiglitz
- J Heckman
- J Pirttil�
- Krzyzaniak
- M Apel
- M Jacob
- M Jacob
- M S Feldstein
- Martin Jacob
- Norway Oslo
- P B S�rensen
- P B S�rensen
- P.-O Edin
- R H Gordon
- Stockholm Fritzes
- T Lindhe
- T Lindhe
- T Lindhe
- Y Lee
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Thigh-length compression stockings and DVT after stroke
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- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Bailout Clauses and the Price of Credit: The Dutch Experience for Housing Corporations
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Two-dimensional supramolecular networks via C-H···Cl and N-H···Cl interactions utilizing bidentate neutral pyridine amide coordinated MnIICl2 tectons
- Author
- A. Das
- A. K. Patra
- A. K. Patra
- A. K. Singh
- A. K. Singh
- A. Morsali
- A. V. Khripun
- B. Moulton
- C. B. Aakeröy
- C. B. Aakeröy
- C. J. O’Connor
- D. Braga
- G. R. Desiraju
- G. R. Desiraju
- G. R. Desiraju
- H. Mishra
- L. Brammer
- L. Brammer
- L. Brammer
- L. J. Farrugia
- M. Prabhakar
- P. K. Thallapally
- Q. Y. Yang
- R. Taylor
- Rabindranath Mukherjee
- T. Steiner
- V. Balamurugan
- V. Balamurugan
- V. Balamurugan
- V. Balamurugan
- V. Balamurugan
- W. J. Geary
- W. Jacob
- Wilson Jacob
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …