7 research outputs found
Evaluation of adjunctive HPV testing by Hybrid Capture II(® )in women with minor cytological abnormalities for the diagnosis of CIN2/3 and cost comparison with colposcopy
- Author
- A Lytwyn
- Andrea Guyot
- CBJ Woodman
- Colposcopy clinic of West Middlesex University Hospital
- G Rebello
- Governmental Statistical Service
- Healthcare Financial Management Association
- J Cuzick
- JC Shlay
- John Fox
- May S Kyi
- MM Manos
- MM Walboomers
- NHSCSP
- SA Southern
- Shakir Karim
- TC Wright
- The Atypical quamous cells of undetermined significance/Low-grade squamous intraepithelial lesions Triage Study (ALTS) group
- Publication venue
- BioMed Central
- Publication date
- 01/09/2003
- Field of study
Get PDFBACKGROUND: As a proportion of high grade cervical intraepithelial neoplasia (CIN2/3) are associated with equivocal cervical smears, which show borderline or mild dyskaryosis, follow up with repeat smears, colposcopy and biopsy is required. Since infection with oncogenic Human Papilloma Virus (HR HPV) has been found to be associated with the development of cervical cancer, HRHPV testing appears to be an alternative. OBJECTIVE: The present study assesses if HRHPV testing can predict CIN2/3 in women referred for mild dyskaryosis and borderline cytological changes in an health authority with a referral policy to colposcopy after one single mild dyskaryotic Pap smear. STUDY DESIGN: The HPV DNA Hybrid Capture II (Digene/Abbott, Maidenhead) was evaluated on 110 consenting women with mild dyskaryosis and 23 women with persistent borderline changes, who were referred for colposcopy between May and November 2001. A cost comparison between two referral policies was performed. RESULTS: CIN2/3 was diagnosed histologically in 30 of 133 women (22%) with minor cytological abnormalities. As the Receiver Operator Characteristics plot suggested a cut-off of 3 pg/ml the HRHPV HCII was evaluated at 3 RLU (relative light units) and at the manufacturer's recommendation of 1 RLU. At both cut-offs sensitivity and negative predictive value were high at 97%. Specificity was low at 37% at a cut-off of 1 pg/ml and 46% at a cut-off of 3 RLU. To remain cost neutral in comparison to immediate colposcopy the costs for one HR HPV HC II must not exceed £34.37 per test at a cut off of 3 pg/ml. CONCLUSION: The negative likelihood ratio (NLR) was of good diagnostic value with 0.089 at 1 RLU and 0.072 at 3 RLU, which reduces the post-test probability for CIN2/3 to 2% in this population. Women with minor cytological disorders can be excluded from colposcopy on a negative HR HPV result. Specificity can be improved by restricting HR HPV testing to women with persistent borderline cytological changes or to women over 30 years
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
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- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
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- Ahmed A.
- Ahmed I.
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- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
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- Albert P.
- Alegria A.
- Alexander A.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
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- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
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- Aniruddhan K.
- Antonina Z.
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- Armistead J.
- Armstrong C.
- Arnison-Newgass C.
- Arora D.
- Arya A.
- Arya R.
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- Byrne J.
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- Byrne-Watts V.
- Cale E.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
- Chambers L.
- Chan E.
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- Charles B.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
- Cheung E.
- Cheyne C.
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- Chilvers A.
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- Chineka R.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
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- Clare E.
- Clark E.
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- Clark R.
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- Clayton-Smith J.
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- Clemente de la Torre C.
- Clifford S.
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- Cocks S.
- Coe A.
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- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
- Connell L.
- Connelly K.
- Connolly G.
- Connor E.
- Conroy K.
- Conteh V.
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- Cooke G.
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- Cooray S.
- Corbett C.
- Corbishley A.
- Cornwell J.
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- Cotterill D.
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- Cremona J.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
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- de Silva T.
- De Soyza A.
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- Dear J.
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- Desai A.
- Deshpande S.
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- Dhani S.
- Dhasmana Devesh J.
- Dhillon R.
- Dicks P.
- Digby J.
- Dimitri P.
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- Ditchfield L.
- Dixon C.
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- Dobbie L.
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- Dolan D.
- Dolman M.
- Donald L.
- Donaldson D.
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- Donohoe A.
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- Duffield E.
- Duffy H.
- Duggan A.
- Dummer S.
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- Duncan R.
- Dunleavy J.
- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
- Eades C.
- Early J.
- Eatough R.
- Eddleston M.
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- Elgohary A.
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- Ellwood A.
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- Emberson Jonathan R.
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- Emonts M.
- Essa F.
- Evans B.
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- Everden C.
- Everden S.
- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Faust Saul N.
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- Fenton C.
- Ferenando G.
- Ferguson C.
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- Ferguson V.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Irons R.
- Irving R.
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- Jack C.
- Jackman S.
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- Jeebun V.
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- Johnstone D.
- Johnstone E.
- Jones A.
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- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Lodhia K.
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- Logue C. A.
- Lokanathan S.
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Thigh-length compression stockings and DVT after stroke
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Progressive Nationalism and Female Rule in Post-colonial South and Southeast Asia
- Author
- Anderson Benedict
- Anderson Nancy Fix
- Andrea Fleschenberg
- Anwar Raja
- Aquino Corazon C.
- Basu Aparna
- Bhutto Benazir
- D'Amico Francine
- Eagly Alice H.
- Eklöf Stefan
- Everett Jana
- Forbes Geraldine
- Gandhi M. K.
- Gehrig Kathinka
- Gerlach Ricarda
- Glasbrenner Eva-Maria
- Hoogensen Gunhild
- Houtman Gustaaf
- Jayawardena Kumari
- Kahin George McT.
- Kazuki Iwanaga
- Kedourie Elie
- Legge J. D.
- Lewis Martin W.
- May Brian
- McIntyre Angus
- Mernissi Fatima
- Molony Barbara
- Mosse George L.
- Nehru Jawaharlal
- Nehru Jawaharlal
- Opfell Olga S.
- Pateman Carole
- Quintos de Jesus Melinda
- Reid Anthony
- Reid Anthony
- San Suu Kyi Aung
- Sanday Peggy Reeves
- Scott Joan Wallach
- Silverstein Josef
- Sinha Mrinalini
- Soekarnoputri Megawati
- Sukarno
- Sukarno
- Tarling Nicholas
- Taylor Robert H.
- Thomas P. J.
- Thompson Mark R.
- Tétreault Mary Ann
- Waylen Georgina
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full textIsomerase-Catalyzed Binding of Interleukin-1 Receptor-Associated Kinase 1 to the EVH1 Domain of Vasodilator-Stimulated Phosphoprotein
- Author
- Akimoto M.
- Alexander I. Greenwood
- Bachmann C.
- Ball L. J.
- Ball L. J.
- Bannon J. H.
- Bear J. E.
- Boeda B.
- Carpenter S.
- Casanova J. L.
- Chen Y. J.
- Colgan J.
- Connors K. A.
- Conze D. B.
- Coppolino M. G.
- Creamer H. R.
- Dawson J. E.
- De S.
- Delaglio F.
- DeLano W. L.
- Domann E.
- Dong W.
- Dunne A.
- Farrow N. A.
- Fedorov A. A.
- Flannery S.
- Gan L.
- Gertler F. B.
- Goddard T. D.
- Goh E. T.
- Goh K. L.
- Gothel S. F.
- Grevengoed E. E.
- Guex N.
- Haffner C.
- Hagerman P. J.
- Haghayeghi A.
- Janssens S.
- Jeahoo Kwon
- Kawagoe T.
- Kay B. K.
- Kim J. H.
- Kloks C. P.
- Kollewe C.
- Kovrigin E. L.
- Koziczak-Holbro M.
- Krause M.
- Krause M.
- Krause M.
- Lemmon M. A.
- Lin C. C.
- Lin S. C.
- Linda K. Nicholson
- Lye E.
- Maa M.-C.
- Mallis R. J.
- Martin M. U.
- May R. C.
- McConnell H. M.
- McCulloch C. A.
- McGettrick A. F.
- McTaggart S. J.
- Moresco E. M.
- Mori S.
- Motshwene P. G.
- Neumann D.
- Ng K. K.
- Niebuhr K.
- Palmer A. G.
- Park H. H.
- Piotukh K.
- Pistor S.
- Prehoda K. E.
- Qin J.
- Reimer U.
- Reinhard M.
- Reinhard M.
- Roitt I. M.
- Rottner K.
- Sarkar P.
- Schmidpeter P. A.
- Song K. W.
- Sun L.
- Thies M. J.
- Tun-Kyi A.
- Uematsu S.
- Vallee-Belisle A.
- Vasioukhin V.
- Volkman B. F.
- Watters T. M.
- Wedemeyer W. J.
- Wehrle-Haller B.
- Weiss A.
- Wilson N. S.
- Yi L.
- Zoldak G.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
No full textAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
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- Ail D
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- Ainsworth M
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Get PDFBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research
