Do Ethicists and Political Philosophers Vote More Often Than Other Professors?

If philosophical moral reflection improves moral behavior, one might expect ethics professors to behave morally better than socially similar non-ethicists. Under the assumption that forms of political engagement such as voting have moral worth, we looked at the rate at which a sample of professional ethicists—and political philosophers as a subgroup of ethicists—voted in eight years’ worth of elections. We compared ethicists’ and political philosophers’ voting rates with the voting rates of three other groups: philosophers not specializing in ethics, political scientists, and a comparison group of professors specializing in neither philosophy nor political science. All groups voted at about the same rate, except for the political scientists, who voted about 10–15% more often. On the face of it, this finding conflicts with the expectation that ethicists will behave more responsibly than non-ethicists

2011-2012 Mostly Music: The Spanish-French Connection

https://spiral.lynn.edu/conservatory_mostlymusic/1013/thumbnail.jp

2013-2014 Mostly Music: Haydn

https://spiral.lynn.edu/conservatory_mostlymusic/1018/thumbnail.jp

2010-2011 Philharmonia Season Program

Philharmonia No. 1 October 9, 2010 at 7:30 PM and October 10, 2010 at 4:00 PM Albert-George Schram, music director and conductor ; Elmar Oliveira, violin Feierlicher Einzug der Ritter des Johanniterordens / Richard Strauss, arranged by Karl Kramer -- Violin Concerto in E Minor, op. 64 / Felix Mendelssohn -- Symphony No. 5 in C-sharp Minor / Gustav Mahler Philharmonia No. 2 November 6, 2010 at 7:30 PM and November 7, 2010 at 4:00 PM Albert-George Schram, music director and conductor ; Tao Lin, piano Overture to Ruslan and Lyudmila / Mikhail Glinka -- Piano Concerto No. 25 in C Major, K. 503 / Wolfgang Amadeus Mozart -- Symphohy No. 2 in D Major, op. 43 / Jean Sibelius Philharmonia No. 3 December 4, 2010 at 7:30 PM and December 5, 2010 at 4:00 PM Concerto Competition Winners Philharmonia No. 4 January 29, 2011 at 7:30 PM and January 30, 2011 at 4:00 PM Gunther Schuller, guest conductor ; Lisa Leonard, piano ; Marc Reese, trumpet Die Vorstellung des Chaos from Die Schöpfung (The Representation of Chaos from the Creation) / Joseph Haydn -- Concerto for Piano, Trumpet and Strings in C Minor, op. 35 / Dmitri Shostakovich -- Symphony No. 3 in F Major, op. 90 / Johannes Brahms Philharmonia No. 5 February 19, 2011 at 7:30 PM and February 20, 2011 at 4:00 PM Jon Robertson, guest conductor ; Roberta Rust, piano Piano Concerto No. 5 in E-flat Major, op. 73 ( Emperor ) / Ludwig van Beethoven -- Symphony No. 6 in D Major, op. 60 / Antonín Dvořák Philharmonia No. 6 March 26, 2011 at 7:30 PM and March 27, 2011 at 4:00 PM Albert-George Schram, music director ; Amanda Hall, soprano ; Christin-Marie Hill, mezzo-soprano ; Scott Ramsey, tenor ; Wayne Shepperd, bass-baritone ; Joshua Habermann, Master Chorale of South Florida artistic director and conductor ; Master Chorale of South Florida Messa da Requiem / Giusepe Verdihttps://spiral.lynn.edu/conservatory_philharmonia/1022/thumbnail.jp

T cell repertoire profiling in allografts and native tissues in recipients with COVID–19 after solid organ transplantation: Insight into T cell–mediated allograft protection from viral infection

IntroductionThe effects of the SARS-CoV-2 virus on the body, and why the effects are more severe in certain patients, remain incompletely understood. One population of special interest is transplant recipients because of their immunosuppressed state. Understanding the pathophysiology of graft dysfunction in transplant patients with the COVID-19 viral syndrome is important for prognosticating the risk to the graft as well as understanding how best to prevent and, if necessary, treat graft injury in these patients.MethodsWe analyzed multiple types of solid organ transplant recipients (liver, kidney, heart or lung) at our institution who died from SARS-CoV-2 and underwent autopsy (n = 6) or whose grafts were biopsied during active SARS-CoV-2 infection (n = 8). Their serum inflammatory markers were examined together with the histological appearance, viral load, and TCR repertoire of their graft tissue and, for autopsy patients, several native tissues.ResultsHistology and clinical lab results revealed a systemic inflammatory pattern that included elevated inflammatory markers and diffuse tissue damage regardless of graft rejection. Virus was detected throughout all tissues, although most abundant in lungs. The TCR repertoire was broadly similar throughout the tissues of each individual, with greater sharing of dominant clones associated with more rapid disease course. There was no difference in viral load or clonal distribution of overall, COVID-associated, or putative SARS-CoV-2-specific TCRs between allograft and native tissue. We further demonstrated that SARSCoV-2-specific TCR sequences in transplant patients lack a donor HLArestricted pattern, regardless of distribution in allograft or native tissues,suggesting that recognition of viral antigens on infiltrating recipient cells can effectively trigger host T cell anti-viral responses in both the host and graft.DiscussionOur findings suggest a systemic immune response to the SARS-CoV-2 virus in solid organ transplant patients that is not associated with rejection and consistent with a largely destructive effect of recipient HLA-restricted T cell clones that affects donor and native organs similarly

Animals as Sentinels of Bioterrorism Agents

Pets, wildlife, or livestock could provide early warning

Mechanisms of viral entry: sneaking in the front door

Recent developments in methods to study virus internalisation are providing clearer insights into mechanisms used by viruses to enter host cells. The use of dominant negative constructs, specific inhibitory drugs and RNAi to selectively prevent entry through particular pathways has provided evidence for the clathrin-mediated entry of hepatitis C virus (HCV) as well as the caveolar entry of Simian Virus 40. Moreover, the ability to image and track fluorescent-labelled virus particles in real-time has begun to challenge the classical plasma membrane entry mechanisms described for poliovirus and human immunodeficiency virus. This review will cover both well-documented entry mechanisms as well as more recent discoveries in the entry pathways of enveloped and non-enveloped viruses. This will include viruses which enter the cytosol directly at the plasma membrane and those which enter via endocytosis and traversal of internal membrane barrier(s). Recent developments in imaging and inhibition of entry pathways have provided insights into the ill-defined entry mechanism of HCV, bringing it to the forefront of viral entry research. Finally, as high-affinity receptors often define viral internalisation pathways, and tropism in vivo, host membrane proteins to which viral particles specifically bind will be discussed throughout

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Institutional Identity

For some sufficiently long-standing institutions, such as the English Crown, there is no single thread, whether specified in terms of constitutive rules or assigned functions, that would connect the stages of that institution. Elizabeth II and Egbert are not connected by an unbroken chain of primogeniture and they have importantly different powers and functions. Derek Parfit famously sought to illuminate his account of personal identity by comparing a person to a club. If Parfit could use our intuitions about clubs to help motivate his neo-Lockean account of personal identity over time, which resists the idea that personal identity requires a common psychological thread, then I argue that an adapted version of his account of identity might, in turn, be reapplied to clubs and other institutions, such as the Crown