7 research outputs found
A framework for increasing the availability of life cycle inventory data based on the role of multinational companies
- Author
- A Dahlsrud
- A Roches
- Aidong Yang
- Andrew Griffiths
- B Resta
- BP Weidema
- C Jimenez-Gonzalez
- CJ Meinrenken
- CT Ang
- D Pennington
- DB Kim
- F Berkhout
- F Stoessel
- F Testa
- G Finnveden
- G Rebitzer
- G Rebitzer
- J Bare
- J Sadhukhan
- Jamal Hussain Miah
- JB Guinée
- JH Miah
- JH Miah
- Jhuma Sadhukhan
- JS Popp
- K Kellens
- KA Scanlon
- L Mila i Canals
- M Dowson
- M Finkbeiner
- M Goedkoop
- M Mistry
- M Recchioni
- MI Almeida
- N Jungbluth
- Namy Espinoza-Orias
- O Jolliet
- P Lesage
- Ryan McNeill
- S Islam
- S Ramos
- S Suh
- S-K Ning
- Sharla Halvorson
- Stephen Morse
- T Nemecek
- TJ Skone
- Urs Schenker
- V Bellon-Maurel
- YH Dong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 04/10/2017
- Field of study
Get PDFPurpose
The aim of the paper is to assesses the role and effectiveness of a proposed novel strategy for Life Cycle Inventory (LCI) data collection in the food sector and associated supply chains. The study represents one of the first of its type and provides answers to some of the key questions regarding the data collection process developed, managed and implemented by a multinational food company across the supply chain.
Methods
An integrated LCI data collection process for confectionery products was developed and implemented by Nestlé, a multinational food company. Some of the key features includes: (1) management and implementation by a multinational food company, (2) types of roles to manage, provide and facilitate data exchange, (3) procedures to identify key products, suppliers and customers, (4) LCI questionnaire and cover letter, and (5) data quality management based on the pedigree matrix. Overall, the combined features in an integrated framework provides a new way of thinking about the collection of LCI data from the perspective of a multinational food company.
Results
The integrated LCI collection framework spanned across five months and resulted in 87 new LCI datasets for confectionery products from raw material, primary resource use, emission and waste release data collected from suppliers across 19 countries. The data collected was found to be of medium-to-high quality compared with secondary data. However, for retailers and waste service companies only partially completed questionnaires were returned. Some of the key challenges encountered during the collection and creation of data included: lack of experience, identifying key actors, communication and technical language, commercial compromise, confidentiality protection, and complexity of multi-tiered supplier systems. A range of recommendations are proposed to reconcile these challenges which include: standardisation of environmental data from suppliers, concise and targeted LCI questionnaires, and visualising complexity through drawings.
Conclusions
The integrated LCI data collection process and strategy has demonstrated the potential role of a multinational company to quickly engage and act as a strong enabler to unlock latent data for various aspects of the confectionery supply chain. Overall, it is recommended that the research findings serve as the foundations to transition towards a standardised procedure which can practically guide other multinational companies to considerably increase the availability of LCI data
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
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- Abernethy K.
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- Abraham M.
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- Abrams J.
- Abu H.
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- Acton C.
- Adam F.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
- Amezaga M.
- Amin A.
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- Byrne J.
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- Byrne-Watts V.
- Cale E.
- Calisti G.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
- Chambers L.
- Chan E.
- Chan R.
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- Charles B.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
- Cheung E.
- Cheyne C.
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- Chilvers A.
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- Chineka R.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
- Clark G.
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- Clark R.
- Clarke A.
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- Clayton-Smith J.
- Cleaver C.
- Clemente de la Torre C.
- Clifford S.
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- Cocks S.
- Coe A.
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- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
- Connell L.
- Connelly K.
- Connolly G.
- Connor E.
- Conroy K.
- Conteh V.
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- Cooke G.
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- Cooper D.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Cotterill D.
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- Cremona J.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
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- Dawson A.
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- de Silva T.
- De Soyza A.
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- Dear J.
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- Desai A.
- Deshpande S.
- Dey P.
- Dhaliwal K.
- Dhani S.
- Dhasmana Devesh J.
- Dhillon R.
- Dicks P.
- Digby J.
- Dimitri P.
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- Dixon C.
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- Dobbie L.
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- Dolan D.
- Dolman M.
- Donald L.
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- Donlon S.
- Donohoe A.
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- Drewett O.
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- Duggan A.
- Dummer S.
- Duncan C.
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- Duncan R.
- Dunleavy J.
- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
- Eades C.
- Early J.
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- Eddleston M.
- Edgerley K.
- Edmond N.
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- Elgohary A.
- Ellis C.
- Ellwood A.
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- Emberson Jonathan R.
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- Emonts M.
- Essa F.
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- Evans R.
- Everden C.
- Everden S.
- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
- Farooq H.
- Farrell B.
- Farzana S.
- Fatemi A.
- Fatemi M.
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- Faust Saul N.
- Fearby S.
- Felton T.
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- Fenn A.
- Fenner I.
- Fenton C.
- Ferenando G.
- Ferguson C.
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- Ferguson V.
- Fernandez Lopez S.
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- Flaherty J.
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- Fowler Robert
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Johnstone E.
- Jones A.
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- Judge P.
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- Kailey A.
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- Lo S.
- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Logan M.
- Logue C. A.
- Lokanathan S.
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- Majumdar Jaydip
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- Publication venue
- Nature Publishing Group
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- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Optimized Energy Management Schemes for Electric Vehicle Applications: A Bibliometric Analysis towards Future Trends
- Publication venue
- 'MDPI AG'
- Publication date
- 01/11/2021
- Field of study
Get PDFConcerns over growing greenhouse gas (GHG) emissions and fuel prices have prompted researchers to look into alternative energy sources, notably in the transportation sector, accounting for more than 70% of carbon emissions. An increasing amount of research on electric vehicles (EVs) and their energy management schemes (EMSs) has been undertaken extensively in recent years to address these concerns. This article aims to offer a bibliometric analysis and investigation of optimized EMSs for EV applications. Hundreds (100) of the most relevant and highly influential manuscripts on EMSs for EV applications are explored and examined utilizing the Scopus database under predetermined parameters to identify the most impacting articles in this specific field of research. This bibliometric analysis provides a survey on EMSs related to EV applications focusing on the different battery storages, models, algorithms, frameworks, optimizations, converters, controllers, and power transmission systems. According to the findings, more articles were published in 2020, with a total of 22, as compared to other years. The authors with the highest number of manuscripts come from four nations, including China, the United States, France, and the United Kingdom, and five research institutions, with these nations and institutions accounting for the publication of 72 papers. According to the comprehensive review, the current technologies are more or less capable of performing effectively; nevertheless, dependability and intelligent systems are still lacking. Therefore, this study highlights the existing difficulties and challenges related to EMSs for EV applications and some brief ideas, discussions, and potential suggestions for future research. This bibliometric research could be helpful to EV engineers and to automobile industries in terms of the development of cost-effective, longer-lasting, hydrogen-compatible electrical interfaces and well-performing EMSs for sustainable EV operations
Thigh-length compression stockings and DVT after stroke
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- Yelnoorkar F
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M
- Abbasi S
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- Abdelaziz A
- Abdelfattah M
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- Abdusamad K
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Get PDFBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research
